Associations Between Temperamental Negative Affectivity and Parental Anxiety Across Childhood

Extant research suggests a link between child temperamental negativity and parental anxiety and depression. However, most studies focus on temperamental negativity generally, and over fairly short longitudinal time spans. The present study extended the time span well beyond immediate postnatal infancy and explored associations between specific child temperament dimensions, both positive and negative, and parental psychopathology. We expected positive relationships between temperamental negative affectivity and parental mental health problems, but an inverse relation involving temperamental effortful control. Data were collected on child temperament, and parental anxiety and depression, using a cross-sectional design and anonymous survey methodology across five child age groups: infancy (INF; 3 - 13 months, N ≅ 83), toddler (TOD; 14 - 36 months, N ≅ 94), early childhood (EC; 3 - 7 years, N ≅ 81), middle/late childhood (MLC; 8 - 10 years, N ≅ 31), and early adolescence (EA; 10 - 15 years, N ≅ 38). REDCap survey links were published on several dozen social media outlets and relevant listservs. Across all datasets, parental respondents primarily identified as white and female. Child gender distribution was approximately equal between girls and boys. We used the Rothbart family of instruments to assess temperamental negative affectivity and effortful control in each sample (i.e., IBQ-R Short Form, ECBQ Short Form, CBQ Short Form, TMCQ Standard Form, and EATQ-R Short Form, respectively). Parental anxiety was measured by the Generalized Anxiety Disorder Assessment (GAD-7), and parental depression was measured by the Patient Health Questionnaire-9 (PHQ-9). Associations involving child negative affectivity were generally consistent with expectations. Results indicated positive correlations between parental anxiety and child negative affectivity in 4 out of 5 groups (INF: r(83) = .25, p = .02; TOD: r(94) = .27, p = .01; EC: r(81) = .37, p \u3c .001; EA: r(39) = .57, p \u3c .001), and between parental depression and child negative affectivity in all age groups (INF: r(81) = .26, p = .02; TOD: r(91) = .22, p = .03; EAC: r(80) = .26, p = .02; MLC: r(30) = .42, p = .02; EAA: r(37) = .42, p = .01). Effortful control was negatively, but less robustly, correlated with parental anxiety (TOD: r(94) = -.22, p = .03; EAA: r(39) = -.44, p = .02) and depression (TOD: r(91) = -.29, p = .01; MLC: r(30) = .45, p = .01). Although we make no assumptions regarding directions of effect between child temperament and parental mental health, bidirectional influences seem likely. For example, parental mental health problems probably exacerbate temperamental negative affectivity, and temperamental negative affectivity probably exacerbates parental mental health problems. This study provides an important expansion of the timeframes of associations between parental mental health and child temperament

The Tumor Suppressor HHEX Inhibits Axon Growth when Prematurely Expressed in Developing Central Nervous System Neurons

Neurons in the embryonic and peripheral nervoussystem respond to injury by activating transcriptional programs supportive of axon growth, ultimately resulting in functional recovery. In contrast, neurons in the adult central nervous system (CNS) possess a limited capacity to regenerate axons after injury, fundamentally constraining repair. Activating pro-regenerative gene expression in CNS neurons is a promising therapeutic approach, but progress is hampered by incomplete knowledge of the relevant transcription factors. An emerging hypothesis is that factors implicated in cellular growth and motility outside the nervous system may also control axon growth in neurons. We therefore tested sixty-nine transcription factors, previously identified as possessing tumor suppressive or oncogenic properties in non-neuronal cells, in assays of neurite outgrowth. This screen identified YAP1 and E2F1 as enhancers of neurite outgrowth, and PITX1, RBM14, ZBTB16, and HHEX as inhibitors. Follow-up experiments are focused on the tumor suppressor HHEX, one of the strongest growth inhibitors. HHEX is widely expressed in adult CNS neurons, including corticospinal tract neurons after spinal injury, but is present only in trace amounts in immature cortical neurons and adult peripheral neurons. HHEX overexpression in early postnatal cortical neurons reduced both initial axonogenesis and the rate of axon elongation, and domain deletion analysis strongly implicated transcriptional repression as the underlying mechanism. These findings suggest a role for HHEX in restricting axon growth in the developing CNS, and substantiate the hypothesis that previously identified oncogenes and tumor suppressors can play conserved roles in axon extension

Simple guide to starting a research group

Conducting cutting-edge research and scholarship becomes more complicated with each passing year; forming a collaborative research group offers a way to navigate this increasing complexity. Yet many individuals whose work might benefit from the formation of a collaborative team may feel overwhelmed by the prospect of attempting to build and maintain a research group. We propose this simple guide for starting and maintaining such an enterprise

高効率線形送信法におけるPWM包絡線発生法の研究

電気通信大学200

Social Cognitive Outcomes are Associated With Improvements in Mobility Performance Following Lifestyle Intervention in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy

Objective To compare the effects of an exercise and dietary intervention with those of standard-of-care management upon change in lift and carry performance and mobility-related self-efficacy beliefs and explore associations in prostate cancer patients undergoing androgen deprivation therapy. Methods 32 prostate cancer patients (M age = 66.2 years; SD = 7.8) undergoing androgen deprivation therapy were randomly assigned to a 3-month exercise and dietary lifestyle intervention (n = 16) or standard-of-care management (n = 16). Outcome assessments were obtained at baseline, 2- and 3-month follow-up. Results The lifestyle intervention resulted in significantly greater improvements in lift and carry performance (p = 0.01) at 2 Months (d = 1.01; p \u3c 0.01) and 3 Months (d = 0.95; p \u3c 0.01) and superior improvements in mobility-related self-efficacy at 2 Months (d = 0.38) and 3 Months (d = 0.58) relative to standard-of-care. Mobility-related self-efficacy (r = -.66; p = 0.006) and satisfaction with function (r = -.63; p = 0.01) were significantly correlated with lift and carry performance at 3 Months. Conclusions The exercise and dietary lifestyle intervention yielded superior improvements in lift and carry performance and mobility-related self-efficacy relative to standard-of-care and key social cognitive outcomes were associated with more favorable mobility performance

Effects of a group-mediated cognitive behavioral lifestyle intervention on select social cognitive outcomes in prostate cancer patients undergoing androgen deprivation therapy

Objective. To compare the effects of a group-mediated cognitive behavioral (GMCB) exercise and dietary (EX+D) intervention with those of standard-of-care (SC) treatment on select social cognitive outcomes in prostate cancer (PCa) patients undergoing androgen deprivation therapy (ADT). Methods. In the single-blind, 2-arm, randomized controlled Individualized Diet and Exercise Adherence–Pilot (IDEA-P) trial, 32 PCa patients (mean age = 66.2 years; SD = 7.8) undergoing ADT were randomly assigned to a 12-week EX+D intervention (n = 16) or SC treatment (n = 16). The exercise component of the personalized EX+D intervention integrated a combination of supervised resistance and aerobic exercise performed twice per week. The dietary component involved counseling and education to modify dietary intake and composition. Blinded assessments of social cognitive outcomes were obtained at baseline and 2-month and 3-month follow-up. Results. Intent-to-treat analysis of covariance demonstrated that the EX+D intervention resulted in significantly greater improvements in scheduling (P \u3c .05), coping (P \u3c .01), and exercise self-efficacy (P \u3c .05), and satisfaction with function (P \u3c .01) at 3 months relative to SC. Results of partial correlation analysis also demonstrated that select social cognitive outcomes were significantly correlated with primary trial outcomes of mobility performance and exercise participation (P \u3c .05) at 3-month follow-up. Conclusions: The GMCB lifestyle intervention yielded more favorable improvements in relevant social cognitive outcomes relative to SC among PCa patients undergoing ADT. Additionally, more favorable social cognitive outcomes were associated with superior mobility performance and exercise participation following the independent maintenance phase of the EX+D intervention

Enabling precision medicine in neonatology, an integrated repository for preterm birth research.

Preterm birth, or the delivery of an infant prior to 37 weeks of gestation, is a significant cause of infant morbidity and mortality. In the last decade, the advent and continued development of molecular profiling technologies has enabled researchers to generate vast amount of 'omics' data, which together with integrative computational approaches, can help refine the current knowledge about disease mechanisms, diagnostics, and therapeutics. Here we describe the March of Dimes' Database for Preterm Birth Research (http://www.immport.org/resources/mod), a unique resource that contains a variety of 'omics' datasets related to preterm birth. The database is open publicly, and as of January 2018, links 13 molecular studies with data across tens of thousands of patients from 6 measurement modalities. The data in the repository are highly diverse and include genomic, transcriptomic, immunological, and microbiome data. Relevant datasets are augmented with additional molecular characterizations of almost 25,000 biological samples from public databases. We believe our data-sharing efforts will lead to enhanced research collaborations and coordination accelerating the overall pace of discovery in preterm birth research

Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes

Insulin-stimulated glucose transport is a characteristic property of adipocytes and muscle cells and involves the regulated delivery of glucose transporter (GLUT4)-containing vesicles from intracellular stores to the cell surface. Fusion of these vesicles results in increased numbers of GLUT4 molecules at the cell surface. In an attempt to overcome some of the limitations associated with both primary and cultured adipocytes, we expressed an epitope- and GFP-tagged version of GLUT4 (HA–GLUT4–GFP) in HeLa cells. Here we report the characterisation of this system compared to 3T3-L1 adipocytes. We show that insulin promotes translocation of HA–GLUT4–GFP to the surface of both cell types with similar kinetics using orthologous trafficking machinery. While the magnitude of the insulin-stimulated translocation of GLUT4 is smaller than mouse 3T3-L1 adipocytes, HeLa cells offer a useful, experimentally tractable, human model system. Here, we exemplify their utility through a small-scale siRNA screen to identify GOSR1 and YKT6 as potential novel regulators of GLUT4 trafficking in human cells

Mechanisms Suppressing Superheavy Element Yields in Cold Fusion Reactions

Superheavy elements are formed in fusion reactions which are hindered by fast nonequilibrium processes. To quantify these, mass-angle distributions and cross sections have been measured, at beam energies from below-barrier to 25% above, for the reactions of 48Ca,50Ti, and 54Cr with 208 Pb. Moving from 48Ca to 54Cr leads to a drastic fall in the symmetric fission yield, which is reflected in the measured mass-angle distribution by the presence of competing fast nonequilibrium deep inelastic and quasifission processes. These are responsible for reduction of the compound nucleus formation probablity PCN (as measured by the symmetric-peaked fission cross section), by a factor of 2.5 for 50Ti and 15 for 54Cr in comparison to 48 Ca. The energy dependence of PCN indicates that cold fusion reactions (involving 208Pb) are not driven by a diffusion process.The authors acknowledge the Australian Research Council for support through Discovery Grants No. DP140101337, No. DP160101254, No. DP170102318, No. FL110100098, and No. DE140100784. Financial support from the NCRIS HIA capability for operation of the Heavy Ion Accelerator Facility is acknowledged. The authors acknowledge the support of the German Academic Exchange Service (DAAD) via funds of the German Federal Ministry of Education and Research (BMBF)

Quiescent Isolation: The Extremely Extended HI Halo of the Optically Compact Dwarf Galaxy ADBS 113845+2008

We present new optical imaging and spectroscopy and HI spectral line imaging of the dwarf galaxy ADBS 113845+2008 (hereafter ADBS 1138). This metal-poor (Z~30% Z_Sun), "post-starburst" system has one of the most compact stellar distributions known in any galaxy to date (B-band exponential scale length =0.57 kpc). In stark contrast to the compact stellar component, the neutral gas is extremely extended; HI is detected to a radial distance of ~25 kpc at the 10^19 cm^-2 level (>44 B-band scale lengths). Comparing to measurements of similar "giant disk" dwarf galaxies in the literature, ADBS 1138 has the largest known HI-to-optical size ratio. The stellar component is located near the center of a broken ring of HI that is ~15 kpc in diameter; column densities peak in this structure at the ~3.5x10^20 cm^-2 level. At the center of this ring, in a region of comparatively low HI column density, we find ongoing star formation traced by H alpha emission. We sample the rotation curve to the point of turn over; this constrains the size of the dark matter halo of the galaxy, which outweighs the luminous component (stars + gas) by at least a factor of 15. To explain these enigmatic properties, we examine "inside-out" and "outside-in" evolutionary scenarios. Calculations of star formation energetics indicate that "feedback" from concentrated star formation is not capable of producing the ring structure; we posit that this is a system where the large HI disk is evolving in quiescent isolation. In a global sense, this system is exceedingly inefficient at converting neutral gas into stars.Comment: Astrophysical Journal, in pres