Análisis comparativo del protocolo acortado de la prueba de inclinación vs el protocolo convencional

"Existe una prueba clínica diagnóstica para pacientes con sospecha de síncope vasovagal (SVV), disautonomía y taquicardia postural paroxística, la cual nos ayuda a la correcta clasificación y orientación del diagnóstico. La Prueba de inclinación (PI), es un examen que consta de dos fases, una pasiva y una activa, en la fase pasiva el paciente se cambia de posición supina a posteriormente inclinado (75°); en la fase activa se hace lo mismo y se agrega un medicamento vasodilatador, se analizan las constantes vitales, frecuencia cardiaca, presión arterial y saturación de oxígeno. Con base en el comportamiento y la variación de estas constantes junto con la respuesta clínica, se ubica al paciente en el grupo que le corresponde (respuesta clínica y respuesta hemodinámica) y se inicia tratamiento. En el instituto nacional de cardiología Ignacio Chávez, al ser un centro de referencia nacional con alta demanda de pacientes, el departamento de Electrocardiología decidió acortar su protocolo de la prueba de inclinación para los pacientes con sospecha de síncope, disminuyendo el tiempo total de la prueba y aumentando el número de pruebas de inclinación al día para así poder cubrir las necesidades del servicio"

Diseño e implementación de un modelo de gestión de red para la red de área local del edificio central de la Universidad Técnica del Norte en base al modelo de gestión OSI con el protocolo SNMP

Plantear un modelo de administración y gestión de la red de área local del Edificio Central de la Universidad Técnica del Norte, a través de la implementación de una herramienta de gestión, en base al modelo de gestión OSI con el protocolo SNMP, para mejorar el rendimiento de la red.La administración de redes es un conjunto de técnicas tendientes a mantener una red operativa, eficiente, segura, constantemente monitoreada y con una planeación adecuada y debidamente documentada. Tiene como objetivo mejorar la continuidad en la operación de la red con mecanismos adecuados de control y monitoreo, así como hacer uso eficiente de la red y utilizar mejor los recursos de la misma. Hoy en día las instituciones públicas dependen más que nunca de su infraestructura informática. La disponibilidad constante, sin interrupciones, y el rendimiento óptimo de la red, se han convertido en factores fundamentales ya que el más pequeño problema con la red puede tener efectos negativos. La red interna del Edificio Central de la Universidad Técnica del Norte, al tener una gran cantidad de usuarios es una red que está sujeta a cambios e inconvenientes frecuentes. La complejidad de la red hace que la tarea de mantener el correcto funcionamiento de la misma sea difícil. Al suscitarse un problema en alguno de los componentes de la red, éste no se notifica de manera automáticamente, además es necesario que el administrador de red y su equipo de trabajo verifiquen personalmente el funcionamiento de los equipos para encontrar la falla. Otro inconveniente es que al no tener registros que acerca de los eventos que se producen en la red no se pueden aplicar medidas preventivas. Se implementa un modelo de gestión de red en el Edificio Central de la Universidad Técnica del Norte en base a las áreas funcionales que contempla el modelo de gestión de red ISO/OSI, siendo éstas: Gestión de configuraciones, gestión de fallos, gestión de contabilidad, gestión de prestaciones y gestión de seguridad. Mediante la implementación de software de distribución libre se consigue un sistema de gestión de red que cubre las cinco áreas funcionales mencionadas, brindando una red continuamente monitoreada, en donde los problemas que se pueden suscitar son detectados a brevedad. Se establecen políticas y manuales de procedimientos en concordancia con las cinco áreas funcionales que propone el modelo de gestión de red ISO/OSI, para que sirvan como guía para la adecuada utilización del sistema de gestión de red y sus componentes

Metodología de detección y mitigación de ataques DDOS en entornos SDN basado en la norma ISO/IEC 27001 para mejorar la seguridad en el plano de control

Desarrollar una metodología de detección y mitigación de ataques DDoS en entornos SDN basado en la norma ISO/IEC 27001 para mejorar la seguridad en el plano de control.El presente trabajo se realizó con el objetivo de desarrollar una Metodología para la implementación de una solución de seguridad relacionada a la detección y mitigación de ataques DDoS en el plano de control de SDN, capaz de ser utilizada como guía para los profesionales de la rama y demás interesados en la seguridad de la información. La metodología se desarrolló en base a la norma ISO 27001 y su alineación con el ciclo PDCA, de donde se tomaron las directrices generales para la realización de cada uno de los subprocesos de la metodología planteada: Identificación de riesgos, Planificación, Selección del mecanismo, Pruebas, Implementación, Monitoreo y Mejora. La validación de la metodología se realizó mediante la aplicación de todas las actividades definidas dentro de los subprocesos mencionados en un escenario de simulación controlado, para ello se utilizó la herramienta Mininet y el controlador POX. Como resultado de la aplicación exitosa de la metodología se obtuvo la solución a la problemática planteada, a través de la implementación de un mecanismo de detección de ataques DDoS basado en el cálculo de la entropía de la red y mitigación mediante el bloqueo del puerto del switch desde donde se genera el tráfico malicioso. La solución resultó ser rápida y efectiva frente a distintos tipos de ataques DDoS: TCP, UDP e ICMP flood.Maestrí

Teaching human anatomy based on 3d anatomical models in the Obstetric Career

ABSTRACT The subject of Human Anatomy treats in a theoretical and practical way the morphology of the different systems of a living being, being one of the preclinical subject's base for every career in the health, through which the future professional is used to diagnose and cure various pathologies.Worldwide the teaching of this subjecthas beenthroughthe master class where the teacher is the one who explains on an illustrative plate to a course of about 40 students, Ecuadorian universities that offer health careers are not the exception. At present there are teachers who resort to these traditional practices, which causes the students community to resort to self-education. This is limited to the acquisition of knowledge in the appropriate manner, resulting in disadvantages in the development of the analytical plan. To this end, the objective is to develop a methodology with learning strategies and techniques through the use of virtual environments and learning methods to improve academic performance inthe firstsemesterofthe ObstetricsCareerofthe CentralUniversityofEcuador. In order to achieve this objective, a methodology based on Design Science has been created, which aims to solve social problems through the use and application of technological devices. These devices such as 3D models have been implemented together with the Design Science methodology to positively influence academic performance. (221) In order to achieve this objective,a methodologybased onDesignScience has beencreated,which aims tosolve social problems through the use and application of technological devices. These devices such as 3D models have been implemented together with the Design Science methodology to positively influence academic performance. (221) Inorder to achieve this objective, a methodology based on Design Science has beencreated, which aims to solve social problems through the use and applicationof technological devices. These devices such as 3D models have beenimplemented together with the Design Science methodology to positively influence academic performance. (221) KEYWORDS: Academic performance; Human Anatomy; Virtual classroom; 3D anatomical models

Impacto de la metrología en el sistema de salud colombiano

Desde tiempos ancestrales el hombre ha hecho uso de la medición como herramienta para su desarrollo y evolución. El objetivo de esta publicación es realizar el análisis y evaluación del impacto de la metrología en el sistema de salud colombiano. Para ello se establecen inicialmente los conceptos y definiciones sobre la metrología, sus principales componentes y su historia. Enseguida se identifican cuáles son los organismos que rigen los procesos metrológicos a nivel mundial y se describe su función, los criterios de aceptación y los requisitos para la aplicación y ejecución de los procedimientos de medición tanto a nivel mundial como en Colombia. Sin embargo, a pesar de la existencia de dichos criterios y requisitos para la aplicabilidad de la metrología, el cocimiento del operador de los instrumentos de medición sobre estas normas permanece reducido. Es por ello que la supervisión de los mismos se ha convertido en un requisito claro. Actualmente la organización Internacional de Normalización ISO y La Comisión Electrotécnica Internacional IEC, forman el sistema especializado para la normalización mundial y son los encargados de formular las diferentes normas. En este documento analizaremos la norma ISO/IEC17025 de 2005 en la cual se establecen de manera clara los requisitos y requerimientos generales para la competencia de los laboratorios de ensayo y de calibración. La Norma ISO/IEC 17025 ha sido preparada por los comités de dichos organismos para la evaluación de la conformidad CASCO.1 Luego de establecer cuáles son los principales componentes y criterios de la metrología, de identificar los diferentes organismos que regulan las actividades en dicha área y la normatividad actual que rige este aspecto, se analizara la situación actual de la misma en nuestro país y posteriormente se observara la relación existente entre la metrología y el sistema de salud nacional. Finalmente se realiza la identificación de las consecuencias actuales y futuras de la metrología y el impacto en el sistema de salud nacional y se presentarán los resultados obtenidos. Adicionalmente se dejan las recomendaciones para el trabajo futuro y las respectivas referencias.RESUMEN INTRODUCCION 1. PLANTEAMIENTO DEL PROBLEMA 1.1 Criterios 1.2 Formulación del problema 2. JUSTIFICACION 3. OBJETIVOS 3.1 Objetivo general 3.2 Objetivos específicos 4. MARCO DE REFERENCIA 4.1 Marco histórico 4.2 Marco conceptual Tipos de metrología Organismos que rigen los procesos metrológicos Situación actual de la metrología en Colombia Los sistemas de salud 4.3 Marco legal Decreto2269 de 1933 – Norma ISO 17025 Norma ISO 9000 Norma ISO 9001 y Norma ISO 14000 Guía del consumidor colombiano 4.4 Calibración de equipos biomédicos Monitor de signos vitales 5. METODOLOGIA 5.1 Impacto 5.2 Análisis y evaluación del impacto 5.3 Recursos Recursos Humanos 6. RESULTADOS 7. DISCUSION 7.1 Beneficios 7.2 Aportes 7.3 Recomendaciones 8. CRONOGRAMA DE ACTIVIDADES 9. CONCLUSIONES REFERENCIASPregradoTecnólogo en Mantenimiento de Equipos BiomédicosTecnología en Mantenimiento de Equipos Biomédico

Plan de Negocio Cratif: El toque perfecto.

La empresa Cratif, esta dirigida a satisfacer las necesidades de todo tipo de mercado; teniendo como principal exigencia la personalización de eventos y productos. Adaptándose a la continua evolución de la moda y sus tendencias, tratando de mantener la vanguardia en diversidad de opciones

Study of the Antihypertensive Peptides Derived from Alpha-Lactalbumin Hydrolysate after Simulation of Digestion

Alpha-lactalbumin is a whey protein that is a cheese-making industrial residue of high biological value. The antihypertensive capacity of three peptides obtained from the simulated gastrointestinal digestion of alpha-lactalbumin hydrolysates was studied. The alpha-lactalbumin hydrolysis was performed using the Alcalase enzyme and was subsequently subjected to a simulated digestion process using pepsin and pancreatin enzymes to mimic digestion conditions. The peptides were identified from a RP-HPLC fractionation of the digest and subsequent identification by mass spectrometry analysis. Three peptides from the alpha-lactalbumin sequence were obtained: IWCKDDQNPH (P1), KFLDDDLTDDIM (P2), and DKFLDDDLTDDIM (P3). The in vitro antihypertensive activity of the peptides was determined by studying the inhibition of the angiotensin-converting enzyme, with P1 being the only peptide with antihypertensive activity detected by this methodology (IC₅₀ = 3.91 ± 0.2 mg/mL). In order to correlate the structural (molecular dynamics simulations) and physicochemical properties with potential mechanisms of antihypertensive capacity, in silico methods were performed. The peptides P1, P2, and P3 had a negative global charge and were hydrophilic. After molecular modeling, the peptide structures were submitted to a refinement based on an energy minimization and further molecular dynamics simulation to assess their global size and conformational space. After a 50-nanosecond simulation, the global structures, solvated and immersed in an ionic water solution similar to that of blood, were studied in their solvent-accessible surfaces. A secondary structure (alpha-helix) was observed in the P1 peptide, but in general, all peptides showed an extended folding. The surfaces were charge code colored and in a visual inspection it could be conjectured that all of them exposed the charge, mainly a negative charge, to the solvent surface, in agreement with the GRAVY index, which was also evaluated. In conclusion, the structure and amino acid composition of peptide 1 assessed by in silico studies agrees with the antihypertensive activity obtained by the in vitro study.Centro de Investigación y Desarrollo en Criotecnología de Alimento

Preliminary in vivo characterization of a theranostic aptamer: Sgc8-c- DOTA-67Ga

Nucleic acid aptamers can recognise their target with high affinity and specificity, and their potential as molecular imaging agents and use in theranostics are being explored. Compared with antibodies, aptamers can be easily synthesized and chemically modified, rendering them a valuable tool for in vivo approaches. Herein, we investigated a 41nt DNA aptamer as a theranostic agent for lymphoma and melanoma. This aptamer exhibits specific binding and high affinity for the PTK7 receptor that is overexpressed in many cancer cells. A 5’-amino-derivative of the Sgc8-c aptamer was bound to the metal chelator DOTA (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) and labelled with the radionuclide 67Ga, forming the aptamer probe Sgc8- c-DOTA-67Ga. Different conditions during synthesis, purification and identification of the intermediate and final radiolabelled probe, were examined. Aptamer modification and radiolabelling were performed with high yields, resulting in a probe that was stable in neutral buffered solution. Binding to PTK7 was studied in CCRFCEM, A20 and B16F1 cell lines, and in purified PTK7-1 receptor, to confirm specificity. The in vitro cell lines showed different levels of uptake, and the signal increased over time. In vivo binding properties were studied in A20 and B16F10 tumour-bearing mice and images were acquired using X-rays and gamma imaging modalities for both models. Preliminary results in both tumour models showed good aptamer uptake by tumour. Hepatobiliar metabolism was observed with Sgc8-c-DOTA-67Ga and no signal was detected in normal tissue. In summary, these results support the utility of labelled aptamers as theranostic agents in different imaging modalities and theranostic

Growth of pineapple plantlets during acclimatisation can be monitored through automated image analysis of the canopy

[EN] Pineapple is an economically important tropical fruit crop, but the lack of adequate planting material limits its productivity. A range of micropropagation protocols has been developed over the years to address this shortfall. Still, the final stage of micropropagation, i.e. acclimatisation, remains a challenge as pineapple plantlets grow very slowly. Several studies have been conducted focusing on this phase and attempting to improve plantlet growth and establishment, which requires tools for the non-destructive evaluation of growth during acclimatisation. This report describes the use of semi-automated and automated image analysis to quantify canopy growth of pineapple plantlets, during five months of acclimatisation. The canopy area progressively increased during acclimatisation, particularly after 90 days. Regression analyses were performed to determine the relationships between the automated image analysis and morphological indicators of growth. The mathematical relationships between estimations of the canopy area and the fresh and dry weights of intact plantlets, middle-aged leaves (D leaves) and roots showed determination coefficients (R2) between 0.84 and 0.92. We propose an appropriate tool for the simple, objective and non-destructive evaluation of pineapple plantlets growth, which can be generally applied for plant phenotyping, to reduce costs and develop streamlined pipelines for the assessment of plant growthThis research was not covered by any specific grant but supported by internal funds from the Bioplant Centre (Cuba), the Agricultural Research Council-Tropical and Subtropical Crops (South Africa), and the Universitat Politecnica de Valencia (Spain). Authors are also grateful to Mrs Lelurlis Napoles for her experienced technical assistance.Soto, G.; Lorente, G.; Mendoza, J.; Báez, ED.; Lorenzo, CM.; Rodríguez, R.; Hajari, E.... (2020). Growth of pineapple plantlets during acclimatisation can be monitored through automated image analysis of the canopy. The Eurobiotech Journal. 4(4):223-229. https://doi.org/10.2478/ebtj-2020-0026S22322944Chen H, Hu B, Zhao L, Shi D, She Z, Huang X, Priyadarshani S, Niu X, Qin Y. Differential expression analysis of reference genes in pineapple (Ananas comosus l.) during reproductive development and response to abiotic stress, hormonal stimuli. Trop Plant Biol 2019; 12: 67-77.Nath V, Kumar G, Pandey S, Pandey S. Impact of climate change on tropical fruit production systems and its mitigation strategies. In: Sheraz Mahdi S (ed.) Climate Change and Agriculture in India: Impact and Adaptation. 2019. Springer, Berlin, pp. 129-146.Priyadarshani S, Cai H, Zhou Q, Liu Y, Cheng Y, Xiong J, Patson DL, Cao S, Zhao H, Qin Y. An efficient Agrobacterium mediated transformation of pineapple with GFP-tagged protein allows easy, non-destructive screening of transgenic pineapple plants. Biomolecules 2019; 9(10): 617.Wali N. Pineapple (Ananas comosus). In: Nabavi S, Sanches Silva A (eds.) Nonvitamin and nonmineral nutritional nupplements. 2019. Elsevier, pp. 367-373.Escalona M, Lorenzo JC, González B, Daquinta M, Borroto C, González JL, Desjardines Y. Pineapple micropropagation in temporary immersion systems. Plant Cell Rep 1999; 18: 743-748.Gómez D, Escalante D, Hajari E, Vicente O, Sershen, Lorenzo JC. Assessing the effects of in vitro imposed water stress on pineapple growth in relation to biochemical stress indicators using polynomial regression analysis. Not Bot Horti Agrobot Cluj 2020; 48: 162-170.Daquinta M, Benegas R. Brief review of tissue culture of pineapple. Pineap News 1997; 3: 7-9.Botella J, Fairbairn D. Present and future potential of pineapple biotechnology. Acta Hort 2005; 622: 23-28.Wang M-L, Uruu G, Xiong L, He X, Nagai C, Cheah K, Hu J, Nan G-L, Sipes B, Atkinson H. Production of transgenic pineapple (Ananas comosus (L.) Merr.) plants via adventitious bud regeneration. In Vitro Cell Dev Biol-Plant 2009; 45: 112-121.Loyola-González O, Medina-Pérez MA, Hernández-Tamayo D, Monroy R, Carrasco-Ochoa JA, García-Borroto M. A pattern-based approach for detecting pneumatic failures on Temporary Immersion Bioreactors. Sensors 2019; 19(2): 414.Parveen S, Mir H, Ranjan T, Pal AK, Kundu M. Effect of surface sterilants on in vitro establishment of pineapple (Ananas comosus (L.) Merill.) cv. Kew. Curr J Appl Sci Technol 2019; 33(2): 1-6.Venâncio JB, Araújo WF, Chagas EA. Acclimatization of micropropagated seedlings of pineapple cultivars on organic substrates. Científica 2019; 47: 52-61.Yanes-Paz E, González J, Sánchez R (2000) A technology of acclimatization of pineapple vitroplants. Pineap News 2000; 7: 5-6.González R, Laudat T, Arzola M, Méndez R, Marrero P, Pulido L, Dibut B, Lorenzo JC. Effect of Azotobacter chroococcum on in vitro pineapple plants’ growth during acclimatization. In Vitro Cell Dev Biol-Plant 2010; 47(3): 387-390.González R, Serrato R, Molina J, Aragón C, Olalde V, Pulido L, Dibut B, Lorenzo JC. Biochemical and physiological changes produced by Azotobacter chroococcum (INIFAT5 strain) on pineapple in vitro-plantlets during acclimatization. Acta Physiol Plant 2013; 35: 3483-3487.Mengesha A, Ayenew B, Tadesse T. Acclimatization of in vitro propagated pineapple (Ananas comosus (L.), var. Smooth cayenne) plantlets to ex vitro condition in Ethiopia. Am J Plant Sci 2013; 4(2): 317-323.Rodríguez-Escriba RC, Rodríguez R, López D, Lorente GY, Pino Y, Aragón CE, Garza Y, Podestá FE, González-Olmedo JL. High light intensity increases the CAM expression in “MD-2” micro-propagated pineapple plants at the end of the acclimatization stage. Am J Plant Sci 2015; 6(19): 3109-3118.Rodríguez-Escriba RC, Rodríguez-Cartaya ID, Lorente GY, López D, Izquierdo RE, Borroto LS, Garza-García Y, Aragón CE, Podestá FE, Rodríguez R. Efecto del déficit hídrico sobre cambios morfo-fisiológicos y bioquímicos en plantas micropropagadas de piña MD-2 en la etapa final de aclimatización. Cult Trop 2016; 37: 64-73.Lorente-González GY, Pino-Legrat Y, Rodríguez-Escriba RC, Pérez-Borroto LS, Nápoles-Borrero L, Mendoza-Rodríguez J, Cardoso D, Alonso A, Rodríguez-Sánchez R, González-Olmedo J. Foliar fertilization of ‘MD-2’ pineapple plants (Ananas comosus var. comosus) during the acclimatization phase. Newsletter of the Pineapple Working Group, International Society for Horticultural Science 2018; 25: 13-17.Atkinson JA, Lobet G, Noll M, Meyer PE, Griffiths M, Wells DM. Combining semi-automated image analysis techniques with machine learning algorithms to accelerate large-scale genetic studies. GigaScience 2017; 6: gix084.Pound MP, Atkinson JA, Townsend AJ, Wilson MH, Griffiths M, Jackson AS, Bulat A, Tzimiropoulos G, Wells DM, Murchie EH. Deep machine learning provides state-of-the-art performance in image-based plant phenotyping. GigaScience 2017; 6: gix083.Gupta SD, Ibaraki Y, Pattanayak A. Development of a digital image analysis method for real-time estimation of chlorophyll content in micropropagated potato plants. Plant Biotech Rep 2013; 7: 91-97.Niazian M, Sadat-Noori SA, Abdipour M, Tohidfar M, Mortazavian SMM. Image processing and artificial neural network-based models to measure and predict physical properties of embryogenic callus and number of somatic embryos in ajowan (Trachyspermum ammi (L.) Sprague). In Vitro Cell Dev Biol-Plant 2018; 54: 54-68.Ollier M, Talle V, Brisset AL, Le Bihan Z, Duerr S, Lemmens M, Goudemand E, Robert O, Hilbert JL, Buerstmayr H. Whitened kernel surface: A fast and reliable method for assessing Fusarium severity on cereal grains by digital picture analysis. Plant Breed 2019; 138: 69-81.Wang G, Sun Y, Wang J. Automatic image-based plant disease severity estimation using deep learning. Comp Intel Neurosci 2017; 2017: 2917536.Asaari MSM, Mishra P, Mertens S, Dhondt S, Inzé D, Wuyts N, Scheunders P. Close-range hyperspectral image analysis for the early detection of stress responses in individual plants in a high-throughput phenotyping platform. ISPRS J Photogram Rem Sens 2018; 138: 121-138.Py C, Lacoeuille JJ, Teisson C. L´ananas, sa culture, ses produits. Techniques agricoles et productions tropicales vol. 33. Maisoenneuve and Larose 1984; Paris, pp. 44-45.Ivanov Z. The Agricultural Experimentation 1989. Pueblo y Educación, Havana, pp. 332.Aguilar M, Pozo J, Aguilar F, García A, Fernández I, Negreiros J, Sánchez-Hermosilla J. Application of close-range photogrammetry and digital photography analysis for the estimation of leaf area index in a greenhouse tomato culture. Int Arch Photogram Rem Sens Spat Inf Sci 2010; 38(5): 5-10.Minervini M, Abdelsamea MM, Tsaftaris SA. Image-based plant phenotyping with incremental learning and active contours. Ecol Inf 2014; 23: 35-48.Minervini M, Giuffrida MV, Perata P, Tsaftaris SA. Phenotiki: An open software and hardware platform for affordable and easy image‐based phenotyping of rosette‐shaped plants. The Plant J 2017; 90: 204-216.Ubbens J, Cieslak M, Prusinkiewicz P, Stavness I. The use of plant models in deep learning: an application to leaf counting in rosette plants. Plant Meth 2018; 14: 6.Rincón Guerrero N, Olarte Quintero MA, Pérez Naranjo JC. Leaf area measurement in photographs taken with a webcam, a cell phone or a semi professional camera. Rev Fac Nac Agron Medellín 2012; 65: 6399-6405.Guo W, Zheng B, Duan T, Fukatsu T, Chapman S, Ninomiya S (2017) EasyPCC: benchmark datasets and tools for high-throughput measurement of the plant canopy coverage ratio under field conditions. Sensors 2017; 17: 798.Chien C-L, Tseng D-C (2011) Color image enhancement with exact HSI color model. Int J Innov Comp Inf Cont 2011; 7: 6691-6710

Tannat grape pomace as an ingredient for potential functional biscuits: bioactive compound identification, in vitro bioactivity, food safety, and sensory evaluation

Grape pomace, the main by-product of wine process, shows high potential for the development of functional foods, being a natural source of bioactive compounds and dietary fiber. Thus, the present study proposes the development of five potential functional biscuits. The five formulations were achieved by varying the Tannat grape pomace powder (TGP, 10–20% w/w total wet dough) and sweetener sucralose (2–4% w/w total wet dough) content through a factorial design with central points. TGP microbiological and pesticides analysis were performed as a food safety requirement. Identification of bioactive compounds by HPLC-DAD-MS, in vitro bioactivity (total phenol content, antioxidant by ABTS and ORAC-FL, antidiabetic and antiobesity by inhibition of α-glucosidase and pancreatic lipase, respectively) and sensory properties of the biscuits were evaluated. TGP microbiological and pesticides showed values within food safety criteria. Sensory profiles of TGP biscuits were obtained, showing biscuits with 20% TGP good sensory quality (7.3, scale 1–9) in a cluster of 37 out of 101 consumers. TGP addition in biscuits had a significant (p < 0.05) effect on total phenolic content (0.893–1.858 mg GAE/g biscuit) and bioactive properties when compared to controls: 11.467–50.491 and 4.342–50.912 μmol TE/g biscuit for ABTS and ORAC-FL, respectively; inhibition of α-glucosidase and pancreatic lipase, IC50 35.572–64.268 and 7.197–47.135 mg/mL, respectively. HPLC-DAD-MS results showed all the identified phenolic compounds in 20/4% biscuit (TGP/sucralose%) were degraded during baking. Malvidin-3-O-(6′-p-coumaroyl) glucoside, (+)-catechin, malvidin-3-O-glucoside, and (−)-epicatechin were the main phenolic compounds (in descendent order of content) found. The bioactive properties could be attributed to the remaining phenolic compounds in the biscuits. In conclusion, TGP biscuits seemed to be a promising functional food with potential for ameliorating oxidative stress, glucose and fatty acids levels with good sensory quality