76 research outputs found
Effective-one-body waveforms for binary neutron stars using surrogate models
Gravitational-wave observations of binary neutron star systems can provide
information about the masses, spins, and structure of neutron stars. However,
this requires accurate and computationally efficient waveform models that take
<1s to evaluate for use in Bayesian parameter estimation codes that perform
10^7 - 10^8 waveform evaluations. We present a surrogate model of a nonspinning
effective-one-body waveform model with l = 2, 3, and 4 tidal multipole moments
that reproduces waveforms of binary neutron star numerical simulations up to
merger. The surrogate is built from compact sets of effective-one-body waveform
amplitude and phase data that each form a reduced basis. We find that 12
amplitude and 7 phase basis elements are sufficient to reconstruct any binary
neutron star waveform with a starting frequency of 10Hz. The surrogate has
maximum errors of 3.8% in amplitude (0.04% excluding the last 100M before
merger) and 0.043 radians in phase. The version implemented in the LIGO
Algorithm Library takes ~0.07s to evaluate for a starting frequency of 30Hz and
~0.8s for a starting frequency of 10Hz, resulting in a speed-up factor of ~10^3
- 10^4 relative to the original Matlab code. This allows parameter estimation
codes to run in days to weeks rather than years, and we demonstrate this with a
Nested Sampling run that recovers the masses and tidal parameters of a
simulated binary neutron star system.Comment: 17 pages, 11 figures, submitted to PR
Microscopic and ultrastructural characteristics of acute gill lesions in koi carp Cyprinus carpio following immersion challenge using Flavobacterium columnare
Data mining in the development of mobile health apps : assessing in-app navigation through Markov chain analysis
Background: Mobile apps generate vast amounts of user data. In the mobile health (mHealth) domain, researchers are increasingly discovering the opportunities of log data to assess the usage of their mobile apps. To date, however, the analysis of these data are often limited to descriptive statistics. Using data mining techniques, log data can offer significantly deeper insights.
Objective: The purpose of this study was to assess how Markov Chain and sequence clustering analysis can be used to find meaningful usage patterns of mHealth apps.
Methods: Using the data of a 25-day field trial (n=22) of the Start2Cycle app, an app developed to encourage recreational cycling in adults, a transition matrix between the different pages of the app was composed. From this matrix, a Markov Chain was constructed, enabling intuitive user behavior analysis.
Results: Through visual inspection of the transitions, 3 types of app use could be distinguished (route tracking, gamification, and bug reporting). Markov Chain-based sequence clustering was subsequently used to demonstrate how clusters of session types can otherwise be obtained.
Conclusions: Using Markov Chains to assess in-app navigation presents a sound method to evaluate use of mHealth interventions. The insights can be used to evaluate app use and improve user experience
Parameterized tests of the strong-field dynamics of general relativity using gravitational wave signals from coalescing binary black holes: Fast likelihood calculations and sensitivity of the method
Thanks to the recent discoveries of gravitational wave signals from binary
black hole mergers by Advanced Laser Interferometer Gravitational Wave
Observatory and Advanced Virgo, the genuinely strong-field dynamics of
spacetime can now be probed, allowing for stringent tests of general relativity
(GR). One set of tests consists of allowing for parametrized deformations away
from GR in the template waveform models and then constraining the size of the
deviations, as was done for the detected signals in previous work. In this
paper, we construct reduced-order quadratures so as to speed up likelihood
calculations for parameter estimation on future events. Next, we explicitly
demonstrate the robustness of the parametrized tests by showing that they will
correctly indicate consistency with GR if the theory is valid. We also check to
what extent deviations from GR can be constrained as information from an
increasing number of detections is combined. Finally, we evaluate the
sensitivity of the method to possible violations of GR.Comment: 19 pages, many figures. Matches PRD versio
Functional Characterization of Opioid Receptor Ligands by Aequorin Luminescence-Based Calcium Assay
Reconstructing the thermal structure of the upper ocean : insights from planktic foraminifera shell chemistry and alkenones in modern sediments of the tropical eastern Indian Ocean
Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Paleoceanography 26 (2011): PA3219, doi:10.1029/2011PA002132.Shell chemistry of planktic foraminifera and the alkenone unsaturation index in 69 surface sediment samples in the tropical eastern Indian Ocean off West and South Indonesia were studied. Results were compared to modern hydrographic data in order to assess how modern environmental conditions are preserved in sedimentary record, and to determine the best possible proxies to reconstruct seasonality, thermal gradient and upper water column characteristics in this part of the world ocean. Our results imply that alkenone-derived temperatures record annual mean temperatures in the study area. However, this finding might be an artifact due to the temperature limitation of this proxy above 28°C. Combined study of shell stable oxygen isotope and Mg/Ca ratio of planktic foraminifera suggests that Globigerinoides ruber sensu stricto (s.s.), G. ruber sensu lato (s.l.), and G. sacculifer calcify within the mixed-layer between 20 m and 50 m, whereas Globigerina bulloides records mixed-layer conditions at ∼50 m depth during boreal summer. Mean calcifications of Pulleniatina obliquiloculata, Neogloboquadrina dutertrei, and Globorotalia tumida occur at the top of the thermocline during boreal summer, at ∼75 m, 75–100 m, and 100 m, respectively. Shell Mg/Ca ratios of all species show a significant correlation with temperature at their apparent calcification depths and validate the application of previously published temperature calibrations, except for G. tumida that requires a regional Mg/Ca-temperature calibration (Mg/Ca = 0.41 exp (0.068*T)). We show that the difference in Mg/Ca-temperatures of the mixed-layer species and the thermocline species, particularly between G. ruber s.s. (or s.l.) and P. obliquiloculata, can be applied to track changes in the upper water column stratification. Our results provide critical tools for reconstructing past changes in the hydrography of the study area and their relation to monsoon, El Niño-Southern Oscillation, and the Indian Ocean Dipole Mode.This project was funded by the German Ministry of
Education and Research (BMBF project PABESIA) and the “Deutsche
Forschungsgemeinschaft” (DFG project HE 3412/15–1)
Discouraging Bullying: The Role of Ethical Leadership and its Effects on the Work Environment
bullying, ethical leadership, workload, work conditions,
Characterization of tachykinin-related peptides from different insect species on Drosophila tachykinin receptor-expressing cell line
Drosophila tachykinin receptor, a neurokinin receptor cloned from the fruit fly Drosophila melanogaster, is a G-protein-coupled receptor, which upon activation by a peptide agonist induces a transient increase in the concentration of intracellular calcium. The functional assay based on aequorin-derived luminescence triggered by receptor-mediated changes in Ca2+ levels was used to examine and compare the effect of tachykinin-related peptides from different species. Among the endogenous Drosophila peptides, Drm-TK I induced the strongest calcium response. The most potent tachykinin-related peptides from Leucophaea maderae, Locusta migratoria, and Calliphora vomitoria, were partial agonists at the Drosophila tachykinin receptor.status: publishe
- …