5,593 research outputs found
PDB108 Quantifying The Short-Term Impact of Changes In Hba1c, Weight And Insulin Regimen on Health Related Quality-of-Life
On the compactness of the set of invariant Einstein metrics
Let be a connected simply connected homogeneous manifold of a
compact, not necessarily connected Lie group . We will assume that the
isotropy -module has a simple spectrum, i.e. irreducible
submodules are mutually non-equivalent.
There exists a convex Newton polytope , which was used for the
estimation of the number of isolated complex solutions of the algebraic
Einstein equation for invariant metrics on (up to scaling). Using the
moment map, we identify the space of invariant Riemannian
metrics of volume 1 on with the interior of this polytope .
We associate with a point of the boundary a homogeneous
Riemannian space (in general, only local) and we extend the Einstein equation
to . As an application of the Aleksevsky--Kimel'fel'd
theorem, we prove that all solutions of the Einstein equation associated with
points of the boundary are locally Euclidean.
We describe explicitly the set of solutions at the
boundary together with its natural triangulation.
Investigating the compactification of ,
we get an algebraic proof of the deep result by B\"ohm, Wang and Ziller about
the compactness of the set of Einstein
metrics. The original proof by B\"ohm, Wang and Ziller was based on a different
approach and did not use the simplicity of the spectrum.
In Appendix we consider the non-symmetric K\"ahler homogeneous spaces
with the second Betti number . We write the normalized volumes
of the corresponding Newton polytopes and discuss the number of
complex solutions of the algebraic Einstein equation and the finiteness
problem.Comment: 25 pages, 4 figures. Some proofs, 3 references, and Appendix adde
High-throughput molecular imaging via deep-learning-enabled Raman spectroscopy.
Raman spectroscopy enables nondestructive, label-free imaging with unprecedented molecular contrast, but is limited by slow data acquisition, largely preventing high-throughput imaging applications. Here, we present a comprehensive framework for higher-throughput molecular imaging via deep-learning-enabled Raman spectroscopy, termed DeepeR, trained on a large data set of hyperspectral Raman images, with over 1.5 million spectra (400 h of acquisition) in total. We first perform denoising and reconstruction of low signal-to-noise ratio Raman molecular signatures via deep learning, with a 10× improvement in the mean-squared error over common Raman filtering methods. Next, we develop a neural network for robust 2-4× spatial super-resolution of hyperspectral Raman images that preserve molecular cellular information. Combining these approaches, we achieve Raman imaging speed-ups of up to 40-90×, enabling good-quality cellular imaging with a high-resolution, high signal-to-noise ratio in under 1 min. We further demonstrate Raman imaging speed-up of 160×, useful for lower resolution imaging applications such as the rapid screening of large areas or for spectral pathology. Finally, transfer learning is applied to extend DeepeR from cell to tissue-scale imaging. DeepeR provides a foundation that will enable a host of higher-throughput Raman spectroscopy and molecular imaging applications across biomedicine
The Bregman chord divergence
Distances are fundamental primitives whose choice significantly impacts the
performances of algorithms in machine learning and signal processing. However
selecting the most appropriate distance for a given task is an endeavor.
Instead of testing one by one the entries of an ever-expanding dictionary of
{\em ad hoc} distances, one rather prefers to consider parametric classes of
distances that are exhaustively characterized by axioms derived from first
principles. Bregman divergences are such a class. However fine-tuning a Bregman
divergence is delicate since it requires to smoothly adjust a functional
generator. In this work, we propose an extension of Bregman divergences called
the Bregman chord divergences. This new class of distances does not require
gradient calculations, uses two scalar parameters that can be easily tailored
in applications, and generalizes asymptotically Bregman divergences.Comment: 10 page
Modeling concept drift: A probabilistic graphical model based approach
An often used approach for detecting and adapting to concept drift when doing classi cation is to treat the data as i.i.d. and use changes in classi cation accuracy as an indication of concept drift. In this paper, we take a different perspective and propose a framework, based on probabilistic graphical models, that explicitly represents concept drift using latent variables. To ensure effcient inference and learning, we resort to a variational Bayes inference scheme. As a proof of concept, we demonstrate and analyze the proposed framework using synthetic data sets as well as a real fi nancial data set from a Spanish bank
Self-avoiding walks and connective constants
The connective constant of a quasi-transitive graph is the
asymptotic growth rate of the number of self-avoiding walks (SAWs) on from
a given starting vertex. We survey several aspects of the relationship between
the connective constant and the underlying graph .
We present upper and lower bounds for in terms of the
vertex-degree and girth of a transitive graph.
We discuss the question of whether for transitive
cubic graphs (where denotes the golden mean), and we introduce the
Fisher transformation for SAWs (that is, the replacement of vertices by
triangles).
We present strict inequalities for the connective constants
of transitive graphs , as varies.
As a consequence of the last, the connective constant of a Cayley
graph of a finitely generated group decreases strictly when a new relator is
added, and increases strictly when a non-trivial group element is declared to
be a further generator.
We describe so-called graph height functions within an account of
"bridges" for quasi-transitive graphs, and indicate that the bridge constant
equals the connective constant when the graph has a unimodular graph height
function.
A partial answer is given to the question of the locality of
connective constants, based around the existence of unimodular graph height
functions.
Examples are presented of Cayley graphs of finitely presented
groups that possess graph height functions (that are, in addition, harmonic and
unimodular), and that do not.
The review closes with a brief account of the "speed" of SAW.Comment: Accepted version. arXiv admin note: substantial text overlap with
arXiv:1304.721
Do mutual funds have consistency in their performance?
Using a comprehensive data set of 714 Chinese mutual funds from 2004 to 2015, the study investigates these funds’ performance persistence by using the Capital Asset Pricing model, the Fama-French three-factor model and the Carhart Four-factor model. For persistence analysis, we categorize mutual funds into eight octiles based on their one year lagged performance and then observe their performance for the subsequent
12 months. We also apply Cross-Product Ratio technique to assess the performance
persistence in these Chinese funds. The study finds no significant evidence of persis- tence in the performance of the mutual funds. Winner (loser) funds do not continue to be winner (loser) funds in the subsequent time period. These findings suggest that future performance of funds cannot be predicted based on their past performance.info:eu-repo/semantics/publishedVersio
Dynamics of nitrous oxide production pathways analysed by <sub>15</sub>N<sub>18</sub>O dual isotope labelling – data from a full-scale wastewater treatment plant
Changes in bone mineral density of the distal femur after revision total knee arthroplasty with metaphyseal press-fit stem
The Effective Fragment Molecular Orbital Method for Fragments Connected by Covalent Bonds
We extend the effective fragment molecular orbital method (EFMO) into
treating fragments connected by covalent bonds. The accuracy of EFMO is
compared to FMO and conventional ab initio electronic structure methods for
polypeptides including proteins. Errors in energy for RHF and MP2 are within 2
kcal/mol for neutral polypeptides and 6 kcal/mol for charged polypeptides
similar to FMO but obtained two to five times faster. For proteins, the errors
are also within a few kcal/mol of the FMO results. We developed both the RHF
and MP2 gradient for EFMO. Compared to ab initio, the EFMO optimized structures
had an RMSD of 0.40 and 0.44 {\AA} for RHF and MP2, respectively.Comment: Revised manuscrip
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