9 research outputs found
Estrategia para conservar las poblaciones de buitres del viejo mundo utilizando el enfoque de una salud
One Health brings the powerful interrelationship between human and wildlife health together
with ecosystem health. The initial concept of One Health was formulated decades ago and focused on
disease transfer from wildlife to human populations. More recently, the concept has been used to associate
resilience to disease with the health of the ecosystem and resilience to environmental stressors. The need for
a One Health approach is particularly evident in the plight of Old World vultures, which are facing a
conservation crisis due to drastic reductions in populations across their entire range. Moreover, vulture
conservation exemplifies many contemporary tenets of One Health; vultures are critical to a sustainable and
resilient ecosystem, which in turn is essential for the socio-ecological health of human communities. In this
review, we examine the complex factors contributing to the demise of Old World vulture populations, using
the lens of One Health to conceptualize the primary drivers impacting the health and sustainability of these
populations. The One Health concept provides the basis for the development of a framework that
incorporates a multidimensional approach and includes human health, wildlife health, environmental and
disease-related stressors, disease incidences, societal pressures, and environmental contaminants.
Integrating societal needs with management aimed at maintaining healthy vulture populations is key for
successfully using a One Health framework to optimize the health of human and wildlife populations and
ensure ecosystem health.El enfoque ‘‘Una Salud’’ promueve una poderosa interrelacio´n entre la salud de los humanos y
de la fauna salvaje asociados a la salud de los ecosistemas. El concepto inicial de Una Salud fue formulado
de´cadas atra´s y se enfocaba en la transferencia de enfermedades de la fauna salvaje a las poblaciones
humanas. Ma´s recientemente, el concepto ha sido usado para asociar la resiliencia a las enfermedades con la
salud de los ecosistemas y la resiliencia a factores de estre´s ambiental. La necesidad de utilizar el enfoque de
Una Salud es particularmente evidente ante la dif´ıcil situacio´n de los buitres del Viejo Mundo, los cuales se enfrentan a una situacio´n de crisis de conservacio´n debido a la reduccio´n dra´stica en sus poblaciones a lo
largo de toda su a´rea de distribucio´n. Adema´s, la conservacio´n de los buitres ejemplifica mucho de los
principios contempora´neos de Una Salud; los buitres son cr´ıticos para un ecosistema sostenible y resiliente,
lo que a su vez es esencial para la salud socio-ecolo´gica de las comunidades humanas. En esta revisio´n,
examinamos los factores complejos que contribuyen al descenso de las poblaciones de buitres del Viejo
Mundo, usando el enfoque de Una Salud para conceptualizar los factores principales que impactan en la
salud y la sostenibilidad de estas poblaciones. El concepto de Una Salud proporciona las bases para el
desarrollo de un marco de referencia que incorpora un enfoque multidimensional, incluyendo la salud
humana y de la vida silvestre, factores estresantes ambientales y de enfermedades, incidencia de
enfermedades, presiones sociales y qu´ımicos ambientales. Integrar las necesidades de la sociedad con la
gestio´n destinada a mantener poblaciones saludables de buitres es clave para usar exitosamente el marco de
referencia de Una Salud y as´ı optimizar la salud de las poblaciones humanas y de la fauna salvaje asegurando
la salud del ecosistema.The National Science Foundationhttps://bioone.org/journals/journal-of-raptor-researcham2022Zoology and Entomolog
A comparative analysis of cardiovascular disease risk factors for volunteer firefighters
Prévalence des facteurs de risque de maladie cardiovasculaire chez des pompiers américains : mesure du cholestérol, de la tension artérielle, de la condition physique et de l'activité physique
Estrategia para conservar las poblaciones de buitres del viejo mundo utilizando el enfoque de una salud
One Health brings the powerful interrelationship between human and wildlife health together with ecosystem health. The initial concept of One Health was formulated decades ago and focused on disease transfer from wildlife to human populations. More recently, the concept has been used to associate resilience to disease with the health of the ecosystem and resilience to environmental stressors. The need for a One Health approach is particularly evident in the plight of Old World vultures, which are facing a conservation crisis due to drastic reductions in populations across their entire range. Moreover, vulture conservation exemplifies many contemporary tenets of One Health; vultures are critical to a sustainable and resilient ecosystem, which in turn is essential for the socio-ecological health of human communities. In this review, we examine the complex factors contributing to the demise of Old World vulture populations, using the lens of One Health to conceptualize the primary drivers impacting the health and sustainability of these populations. The One Health concept provides the basis for the development of a framework that incorporates a multidimensional approach and includes human health, wildlife health, environmental and disease-related stressors, disease incidences, societal pressures, and environmental contaminants. Integrating societal needs with management aimed at maintaining healthy vulture populations is key for successfully using a One Health framework to optimize the health of human and wildlife populations and ensure ecosystem health
Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity
Delivery systems designed to have
triggered release after passively
targeting the tumor may improve small molecule chemotherapeutic delivery.
Particle replication in nonwetting templates was used to prepare nanoparticles
to passively target solid tumors in an A549 subcutaneous xenograft
model. An acid labile prodrug was delivered to minimize systemic free
docetaxel concentrations and improve tolerability without compromising
efficacy
Newborn screening for spinal muscular atrophy: Anticipating an imminent need
Spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality. Children with type I SMA typically die by the age of 2 years. Recent progress in gene modification and other innovative therapies suggest that improved outcomes may soon be forthcoming. In animal models, therapeutic intervention initiated before the loss of motor neurons alters SMA phenotype and increases lifespan. Presently, supportive care including respiratory, nutritional, physiatry, and orthopedic management can ameliorate clinical symptoms and improve survival rates if SMA is diagnosed early in life. Newborn screening could help optimize these potential benefits. A recent report demonstrated that SMA detection can be multiplexed at minimal additional cost with the assay for severe combined immunodeficiency, already implemented by many newborn screening programs. The public health community should remain alert to the rapidly changing developments in early detection and treatment of SMA