48 research outputs found
FORMIRANJE OPTIMALNOG PORTFELJA OBVEZNICA NA HRVATSKOM I POLJSKOM TRŽIÅ TU KAPITALA POMOÄU MARKOWITZEVOG MODELA : Diplomski rad
Cilj ovog istraživanja je formiranje i usporedba efikasnih portfelja s hrvatskog i poljskog
tržiŔta kapitala. Portfelji su formirani od obveznica kojima se trgovalo na oba tržiŔta. Prilikom
izrade, u praktiÄnom dijelu rada, izvrÅ”ena je analiza obveznica koriÅ”tenjem Markowitzeve
moderne teorije portfelja kako bi se donio zakljuÄak o prihvaÄanju ili odbacivanju
postavljenih hipoteza.
Nakon analize za svako tržiÅ”te kapitala donosi se zakljuÄak kako se na hrvatskom tržiÅ”tu
kapitala mogu ostvariti veÄi prinosi ali uz veÄi rizik, za razliku od poljskog tržiÅ”ta kapitala,
gdje investitori ostvaruju manji prinos uz manji rizik.
Cilj je bio dokazati da Äe formirani efikasni portfelj na poljskom tržiÅ”tu kapitala imati bolji
odnos prinosa i rizika od obvezniÄkog portfelja s hrvatskog tržiÅ”ta kapitala. MeÄutim,
istraživanjem se ustvrdilo da obvezniÄki portfelj formiran na hrvatskom tržiÅ”tu kapitala ima
bolji odnos prinosa i rizika kada se rezultati usporeÄuju pri manjim razinama rizika, nego
portfelj formiran na poljskom tržiÅ”tu kapitala. Stoga se hipoteza koja je postavljena na naÄin
da poljsko tržiŔte kapitala ima bolje performanse s obzirom na prinos i rizik odbacuje jer ne
odgovara dobivenim rezultatima.The aim of this research was to form and compare efficient portfolios from the Croatian and
Polish capital markets. Portfolios were formed from bonds traded on both markets.
Markowitz's modern portfolio theory was used during the making accept or reject hypotheses.
During compiling, in the practical part of the paper, a bond analysis was performed according
to the Markowitzās modern portfolio theory in order to conclude on the acceptance or
rejection of the set hypothesis.
After analyzing each capital market, it is concluded that on the Croatian capital market can be
achieved higher yields, but with higher risk, compared to the Polish capital market, where
investors yield lower returns but with a lower level of risk.
The aim was to prove that an efficient portfolio of the Polish capital market would have a
better relationship between the yield and the risk than the bond portfolio from the Croatian
capital market.
However, the research has shown that the bond portfolio formed on the Croatian capital
market has a better relationship of yield and risk when the results are compared at the lower
levels of risk than the portfolio formed on the Polish capital market. For that reason, the
hypothesis that is set in such a way that the Polish capital market has better performance with
respect to yield and the risk is discarded because it does not match the obtained results
FORMIRANJE OPTIMALNOG PORTFELJA OBVEZNICA NA HRVATSKOM I POLJSKOM TRŽIÅ TU KAPITALA POMOÄU MARKOWITZEVOG MODELA : Diplomski rad
Cilj ovog istraživanja je formiranje i usporedba efikasnih portfelja s hrvatskog i poljskog
tržiŔta kapitala. Portfelji su formirani od obveznica kojima se trgovalo na oba tržiŔta. Prilikom
izrade, u praktiÄnom dijelu rada, izvrÅ”ena je analiza obveznica koriÅ”tenjem Markowitzeve
moderne teorije portfelja kako bi se donio zakljuÄak o prihvaÄanju ili odbacivanju
postavljenih hipoteza.
Nakon analize za svako tržiÅ”te kapitala donosi se zakljuÄak kako se na hrvatskom tržiÅ”tu
kapitala mogu ostvariti veÄi prinosi ali uz veÄi rizik, za razliku od poljskog tržiÅ”ta kapitala,
gdje investitori ostvaruju manji prinos uz manji rizik.
Cilj je bio dokazati da Äe formirani efikasni portfelj na poljskom tržiÅ”tu kapitala imati bolji
odnos prinosa i rizika od obvezniÄkog portfelja s hrvatskog tržiÅ”ta kapitala. MeÄutim,
istraživanjem se ustvrdilo da obvezniÄki portfelj formiran na hrvatskom tržiÅ”tu kapitala ima
bolji odnos prinosa i rizika kada se rezultati usporeÄuju pri manjim razinama rizika, nego
portfelj formiran na poljskom tržiÅ”tu kapitala. Stoga se hipoteza koja je postavljena na naÄin
da poljsko tržiŔte kapitala ima bolje performanse s obzirom na prinos i rizik odbacuje jer ne
odgovara dobivenim rezultatima.The aim of this research was to form and compare efficient portfolios from the Croatian and
Polish capital markets. Portfolios were formed from bonds traded on both markets.
Markowitz's modern portfolio theory was used during the making accept or reject hypotheses.
During compiling, in the practical part of the paper, a bond analysis was performed according
to the Markowitzās modern portfolio theory in order to conclude on the acceptance or
rejection of the set hypothesis.
After analyzing each capital market, it is concluded that on the Croatian capital market can be
achieved higher yields, but with higher risk, compared to the Polish capital market, where
investors yield lower returns but with a lower level of risk.
The aim was to prove that an efficient portfolio of the Polish capital market would have a
better relationship between the yield and the risk than the bond portfolio from the Croatian
capital market.
However, the research has shown that the bond portfolio formed on the Croatian capital
market has a better relationship of yield and risk when the results are compared at the lower
levels of risk than the portfolio formed on the Polish capital market. For that reason, the
hypothesis that is set in such a way that the Polish capital market has better performance with
respect to yield and the risk is discarded because it does not match the obtained results
FORMIRANJE OPTIMALNOG PORTFELJA OBVEZNICA NA HRVATSKOM I POLJSKOM TRŽIÅ TU KAPITALA POMOÄU MARKOWITZEVOG MODELA : Diplomski rad
Cilj ovog istraživanja je formiranje i usporedba efikasnih portfelja s hrvatskog i poljskog
tržiŔta kapitala. Portfelji su formirani od obveznica kojima se trgovalo na oba tržiŔta. Prilikom
izrade, u praktiÄnom dijelu rada, izvrÅ”ena je analiza obveznica koriÅ”tenjem Markowitzeve
moderne teorije portfelja kako bi se donio zakljuÄak o prihvaÄanju ili odbacivanju
postavljenih hipoteza.
Nakon analize za svako tržiÅ”te kapitala donosi se zakljuÄak kako se na hrvatskom tržiÅ”tu
kapitala mogu ostvariti veÄi prinosi ali uz veÄi rizik, za razliku od poljskog tržiÅ”ta kapitala,
gdje investitori ostvaruju manji prinos uz manji rizik.
Cilj je bio dokazati da Äe formirani efikasni portfelj na poljskom tržiÅ”tu kapitala imati bolji
odnos prinosa i rizika od obvezniÄkog portfelja s hrvatskog tržiÅ”ta kapitala. MeÄutim,
istraživanjem se ustvrdilo da obvezniÄki portfelj formiran na hrvatskom tržiÅ”tu kapitala ima
bolji odnos prinosa i rizika kada se rezultati usporeÄuju pri manjim razinama rizika, nego
portfelj formiran na poljskom tržiÅ”tu kapitala. Stoga se hipoteza koja je postavljena na naÄin
da poljsko tržiŔte kapitala ima bolje performanse s obzirom na prinos i rizik odbacuje jer ne
odgovara dobivenim rezultatima.The aim of this research was to form and compare efficient portfolios from the Croatian and
Polish capital markets. Portfolios were formed from bonds traded on both markets.
Markowitz's modern portfolio theory was used during the making accept or reject hypotheses.
During compiling, in the practical part of the paper, a bond analysis was performed according
to the Markowitzās modern portfolio theory in order to conclude on the acceptance or
rejection of the set hypothesis.
After analyzing each capital market, it is concluded that on the Croatian capital market can be
achieved higher yields, but with higher risk, compared to the Polish capital market, where
investors yield lower returns but with a lower level of risk.
The aim was to prove that an efficient portfolio of the Polish capital market would have a
better relationship between the yield and the risk than the bond portfolio from the Croatian
capital market.
However, the research has shown that the bond portfolio formed on the Croatian capital
market has a better relationship of yield and risk when the results are compared at the lower
levels of risk than the portfolio formed on the Polish capital market. For that reason, the
hypothesis that is set in such a way that the Polish capital market has better performance with
respect to yield and the risk is discarded because it does not match the obtained results
Unveiling Anticancer Potential of COX-2 and 5-LOX Inhibitors: Cytotoxicity, Radiosensitization Potential and Antimigratory Activity against Colorectal and Pancreatic Carcinoma
Apart from cytotoxicity, inhibitors of the COX-2 enzyme have demonstrated additional effects important for cancer treatment (such as radiosensitization of tumor cells and cell antimigratory effects); however, the relationship between the inhibition of other inflammation-related enzyme 5-LOX inhibitors and anticancer activity is still not well understood. In our study, the cytotoxicity of thirteen COX-2 and 5-LOX inhibitors previously presented by our group (1ā13) was tested on three cancer cell lines (HCT 116, HT-29 and BxPC-3) and one healthy cell line (MRC-5). Compounds 3, 5, 6 and 7 showed moderate cytotoxicity, but good selectivity towards cancer cell lines. IC50 values were in the range of 22.99ā51.66 ĀµM (HCT 116 cell line), 8.63ā41.20 ĀµM (BxPC-3 cell line) and 24.78ā81.60 ĀµM (HT-29 cell line; compound 7 > 100 ĀµM). In comparison to tested, commercially available COX-2 and 5-LOX inhibitors, both cytotoxicity and selectivity were increased. The addition of compounds 6 and 7 to irradiation treatment showed the most significant decrease in cell proliferation of the HT-29 cell line (p < 0.001). The antimigratory potential of the best dual COX-2 and 5-LOX inhibitors (compounds 1, 2, 3 and 5) was tested by a wound-healing assay using the SW620 cell line. Compounds 1 and 3 were singled out as compounds with the most potent effect (relative wound closure was 3.20% (24 h), 5,08% (48 h) for compound 1 and 3.86% (24 h), 7.68% (48 h) for compound 3). Considering all these results, compound 3 stood out as the compound with the most optimal biological activity, with the best dual COX-2 and 5-LOX inhibitory activity, good selectivity towards tested cancer cell lines, significant cell antimigratory potential and a lack of toxic effects at therapeutic doses
Frequency of tuberculosis at autopsies in a large hospital in Zagreb, Croatia: a 10-year retrospective study
Aim To assess the frequency and forms of pulmonary tuberculosis
at autopsy in a high-traffic hospital in the capital
city of a country with a low tuberculosis incidence.
Methods We performed a retrospective search of autopsy
data from the period 2000 to 2009 at Sestre Milosrdnice
University Hospital Center, Zagreb, Croatia. We also examined
patientsā records and histological slides.
Results Of 3479 autopsies, we identified 61 tuberculosis
cases, corresponding to a frequency of 1.8%. Active tuberculosis
was found in 33 cases (54%), 23 of which (70%)
were male. Of the 33 active cases, 25 (76%) were clinically
unrecognized and 19 (76%) of these were male.
Conclusion Clinically undiagnosed tuberculosis accounted
for a substantial proportion of active tuberculosis cases
diagnosed at autopsy. Autopsy data may be an important
complement to epidemiological data on tuberculosis frequency
Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin
The objective of this study was to evaluate potential of two chemically characterized edible wild onion species, Allium flavum and Allium carinatum, to reduce side effects of cytostatic doxorubicin (Dox). Since Dox application is mainly limited due to its high cardiotoxicity, while there are no approved cardioprotective agents for the prevention of Dox adverse effects, new co-treatments are urgently needed. Here, we showed that methanol extracts expressed high antioxidant activity and synergistically increased Dox anticancer activity against human hepatoma (HepG2) and lung carcinoma (A549) cells, while protected normal human fibroblasts (MRC-5) from Dox cytotoxicity. Analysis of the antioxidative enzymes level (catalase and superoxide dismutases) showed that the catalase level was differently altered in cancer cells compared to normal cells upon applied treatments. In vivo toxicity evaluation in the zebrafish model revealed significantly lower toxicity of extracts compared to Dox, and no teratogenic effects at applied doses. We found that extracts successfully rescued the Dox-treated embryos of life-threating cardiomyopathy, while at the same time reduced developmental toxicity and neutropenia. Further analysis demonstrated that extracts had higher anti-angiogenic activity than sunitinib or auranofin, clinically used anti-angiogenic drugs. In addition, angiogenesis was markedly more suppressed in Dox-extract cotreatments than upon single treatments
Prolificacy of kupreska pramenka ewe and daily gains of lambs in the island of Brac conditions
Cilj istraživanja bio je utvrditi neke proizvodne odlike ovaca kupreÅ”ke pramenke, nastale u planinskim uvjetima s oÅ”trom i hladnom zimom te obilnom paÅ”om tijekom vegetacije, u ekoloÅ”kim uvjetima otoka BraÄa. Istraživanje u trajanju od 2 godine (2001. i 2002.) provedeno je na jednom obiteljskom poljoprivrednom gospodarstvu na otoku BraÄu koje se tradicionalno bavi uzgojem ovaca za meso i mlijeko. U istraživanje je bila ukljuÄena 161 ovca (78 u 2001., 83 u 2002. godini) i njihova janjad (93 u 2001. i 99 u 2002. godini, ukupno 192). ProsjeÄna plodnost ovaca iznosila je 119% i nije utvrÄen signifikantan utjecaj godine na plodnost (P>0,05). ProsjeÄna porodna masa muÅ”ke janjadi iznosila je 4,51 kg, a ženske 4,36 kg, dok je prosjeÄna tjelesna masa muÅ”ke janjadi u dobi od 35 dana iznosila 12,25 kg, a ženske 11,7 kg. Janjad je na kraju tova (58 dana) težila prosjeÄno 18,50 kg. ProsjeÄni dnevni prirast muÅ”ke i ženske janjadi bio je gotovo identiÄan, a iznosio je 248,7 g u muÅ”ke i 240,6 g u ženske janjadi.The aim of the research was to determine some production characteristics of kupreska pramenka on the island of Brac, kept in highland environmental conditions with sharp and cold winter and plenty of pasture during the vegetation. The research was conducted on the family farm Salamunovic on the island of Brac, during 2001 and 2002 year. The Salamunovic family traditionally breeds sheep for lamb meat and milk production. 161 ewes (78 in 2001, 83 in 2002) and lambs (93 in 2001 and 99 in 2002, 192 in all) were included in this research. The average prolificacy of ewes was 119% and the influence of year was not found significant for prolificacy (P>0,05). The average birth weight of male lambs was 4.51 kg, and female lambs 4.36 kg. At the age of 35 days the average body weight of male lambs was 12.12 kg and females 11,7 kg. At the end of the fattening period (58 days) the final weight of lambs was 18.50 kg. Average daily gains of lambs were almost the same; male lambs weiched 248.7 g and females 240.6 g
EMPOWERING ANTIFUNGAL DRUGS DISCOVERY THROUGH THE ZEBRAFISH-INFECTIOUS DISEASES MODELLING
Fungal infections, once considered a rare disease,
have become an everyday problem in modern
societies, posing major challenges to global
health. It is estimated that more than one billion
people are affected by fungal infections and 1.6
million people succumb to these diseases every
year. Of the 600 species of fungi capable of causing
infections in humans, species of the genus
Candida cause more than 85% of infections, especially
C. albicans, which has become a serious
threat to human health in immunocompromised
and immunosuppressed individuals. Unfortunately,
the current arsenal of clinical drugs relies
on only four classes of approved drugs (polyenes,
azoles, echinocandins and allylamines), which
are only partially effective, resulting in incomplete
eradication of the fungal infection. In
addition, the serious side effects, ranging from
systemic or organ-specific toxicity to poor bioavailability
and low activity, significantly hamper
the clinical use of antifungals. These problems
call for new effective and safe antifungal agents,but also for appropriate preclinical models to accurately
study potential adverse effects on the
human population and test their efficacy against
fungal infections. In this sense, zebrafish (Danio
rerio) embryos have become one of the most
powerful preclinical animal models in infection
biology and drug discovery, offering the unique
opportunity to simultaneously monitor the safety
and efficacy of the applied molecule in real
time. With the aim of providing a preclinical platform
for the identification of new safe antifungal
drugs to effectively control C. albicans infection,
we comprehensively tested the toxicity of 13
clinical antifungal drugs in the zebrafish embryo
model. The 21 toxicity endpoints, including
survival, teratogenicity, cardiotoxicity and hepatotoxicity,
were evaluated and compared with
adverse effects described in rats and humans. Of
the clinical drugs, the efficacy of fluconazole and
voriconazole was evaluated in the zebrafish - C.
albicans model of systemic and wound biofilm
infection.Book of abstract: From biotechnology to human and planetary health XIII congress of microbiologists of Serbia with international participation Mikromed regio 5, ums series 24: 4th ā 6th april 2024, Mona Plaza hotel, Belgrade, Serbi
Unveiling Anticancer Potential of COX-2 and 5-LOX Inhibitors: Cytotoxicity, Radiosensitization Potential and Antimigratory Activity against Colorectal and Pancreatic Carcinoma
Apart from cytotoxicity, inhibitors of the COX-2 enzyme have demonstrated additional effects important for cancer treatment (such as radiosensitization of tumor cells and cell antimigratory effects); however, the relationship between the inhibition of other inflammation-related enzyme 5-LOX inhibitors and anticancer activity is still not well understood. In our study, the cytotoxicity of thirteen COX-2 and 5-LOX inhibitors previously presented by our group (1-13) was tested on three cancer cell lines (HCT 116, HT-29 and BxPC-3) and one healthy cell line (MRC-5). Compounds 3, 5, 6 and 7 showed moderate cytotoxicity, but good selectivity towards cancer cell lines. IC50 values were in the range of 22.99-51.66 ĀµM (HCT 116 cell line), 8.63-41.20 ĀµM (BxPC-3 cell line) and 24.78-81.60 ĀµM (HT-29 cell line; compound 7 > 100 ĀµM). In comparison to tested, commercially available COX-2 and 5-LOX inhibitors, both cytotoxicity and selectivity were increased. The addition of compounds 6 and 7 to irradiation treatment showed the most significant decrease in cell proliferation of the HT-29 cell line (p < 0.001). The antimigratory potential of the best dual COX-2 and 5-LOX inhibitors (compounds 1, 2, 3 and 5) was tested by a wound-healing assay using the SW620 cell line. Compounds 1 and 3 were singled out as compounds with the most potent effect (relative wound closure was 3.20% (24 h), 5,08% (48 h) for compound 1 and 3.86% (24 h), 7.68% (48 h) for compound 3). Considering all these results, compound 3 stood out as the compound with the most optimal biological activity, with the best dual COX-2 and 5-LOX inhibitory activity, good selectivity towards tested cancer cell lines, significant cell antimigratory potential and a lack of toxic effects at therapeutic doses