499 research outputs found
Calcium-Permeable AMPA Receptors in the Retina
The retina transforms light entering the eye into a sophisticated neural representation of our visual world. Specialized synapses, cells, and circuits in the retina have evolved to encode luminance, contrast, motion, and other complex visual features. Although a great deal has been learned about the cellular morphology and circuitry that underlies this image processing, many of the synapses in the retina remain incompletely understood. For example, excitatory synapses in the retina feature the full panoply of glutamate receptors, but in most cases specific roles for different receptor subtypes are unclear. In this brief review, I will discuss recent progress toward understanding how Ca2+-permeable AMPA receptors (CP-GluARs) contribute to synaptic transmission and newly discovered forms of synaptic plasticity in the retina
Imperfect Space Clamp Permits Electrotonic Interactions between Inhibitory and Excitatory Synaptic Conductances, Distorting Voltage Clamp Recordings
The voltage clamp technique is frequently used to examine the strength and composition of synaptic input to neurons. Even accounting for imperfect voltage control of the entire cell membrane (âspace clampâ), it is often assumed that currents measured at the soma are a proportional indicator of the postsynaptic conductance. Here, using NEURON simulation software to model somatic recordings from morphologically realistic neurons, we show that excitatory conductances recorded in voltage clamp mode are distorted significantly by neighboring inhibitory conductances, even when the postsynaptic membrane potential starts at the reversal potential of the inhibitory conductance. Analogous effects are observed when inhibitory postsynaptic currents are recorded at the reversal potential of the excitatory conductance. Escape potentials in poorly clamped dendrites reduce the amplitude of excitatory or inhibitory postsynaptic currents recorded at the reversal potential of the other conductance. In addition, unclamped postsynaptic inhibitory conductances linearize the recorded current-voltage relationship of excitatory inputs comprising AMPAR and NMDAR-mediated components, leading to significant underestimation of the relative contribution by NMDARs, which are particularly sensitive to small perturbations in membrane potential. Voltage clamp accuracy varies substantially between neurons and dendritic arbors of different morphology; as expected, more reliable recordings are obtained from dendrites near the soma, but up to 80% of the synaptic signal on thin, distant dendrites may be lost when postsynaptic interactions are present. These limitations of the voltage clamp technique may explain how postsynaptic effects on synaptic transmission could, in some cases, be attributed incorrectly to presynaptic mechanisms
Migraine Frequency and Health Utilities: Findings from a Multisite Survey
AbstractObjectivesAssess the relationship between migraine frequency and health utility.MethodsPatients aged â„18 years diagnosed with episodic migraine were enrolled at three US sites representing varied models of health-care delivery. All subjects completed a questionnaire that included demographic and clinical information, a migraine-specific disability questionnaire, and the Health Utilities Index Mark 3 (HUI3). The HUI3 is a generic health status and health-related quality-of-life measure. HUI3 health status data are translated into utility scores anchored by 0 (dead) and 1 (perfect health).ResultsThe study enrolled 150 patients. The mean age was 44 years and 87% were female. Mean (±SD) monthly migraine frequency was 4.4 ± 3.6, with 34% reporting â€2 migraines per month and 20% reporting >6 migraines per month. The mean (±SD) HUI3 score was 0.62 ± 0.26. After controlling for study center, demographics, comorbidities, migraine characteristics, and level of migraine disruptiveness, migraine frequency was found to be significantly (P < 0.05) and negatively associated with HUI3 scores. Subjects with >6 migraines per month had an adjusted mean HUI3 score of 0.41; the corresponding mean for those reporting â€2 migraines per month was 0.67. Migraine frequency was positively associated with higher levels of disability for the emotion, cognition, and pain components of the HUI3.ConclusionsAmong this group of care-seeking patients, migraineurs' health utilities were inversely related to headache frequency. Although these data may not be generalizable to the entire migraine population, they may be useful in assessing the comparative cost-effectiveness of preventive migraine therapies
Population policies and education: exploring the contradictions of neo-liberal globalisation
The world is increasingly characterised by profound income, health and social inequalities (Appadurai, 2000). In recent decades development initiatives aimed at reducing these inequalities have been situated in a context of increasing globalisation with a dominant neo-liberal economic orthodoxy. This paper argues that neo-liberal globalisation contains inherent contradictions regarding choice and uniformity. This is illustrated in this paper through an exploration of the impact of neo-liberal globalisation on population policies and programmes. The dominant neo-liberal economic ideology that has influenced development over the last few decades has often led to alternative global visions being overlooked. Many current population and development debates are characterised by polarised arguments with strongly opposing aims and views. This raises the challenge of finding alternatives situated in more middle ground that both identify and promote the socially positive elements of neo-liberalism and state intervention, but also to limit their worst excesses within the population field and more broadly. This paper concludes with a discussion outling the positive nature of middle ground and other possible alternatives
AEGIS: Demographics of X-ray and Optically Selected AGNs
We develop a new diagnostic method to classify galaxies into AGN hosts,
star-forming galaxies, and absorption-dominated galaxies by combining the [O
III]/Hbeta ratio with rest-frame U-B color. This can be used to robustly select
AGNs in galaxy samples at intermediate redshifts (z<1). We compare the result
of this optical AGN selection with X-ray selection using a sample of 3150
galaxies with 0.3<z<0.8 and I_AB<22, selected from the DEEP2 Galaxy Redshift
Survey and the All-wavelength Extended Groth Strip International Survey
(AEGIS). Among the 146 X-ray sources in this sample, 58% are classified
optically as emission-line AGNs, the rest as star-forming galaxies or
absorption-dominated galaxies. The latter are also known as "X-ray bright,
optically normal galaxies" (XBONGs). Analysis of the relationship between
optical emission lines and X-ray properties shows that the completeness of
optical AGN selection suffers from dependence on the star formation rate and
the quality of observed spectra. It also shows that XBONGs do not appear to be
a physically distinct population from other X-ray detected, emission-line AGNs.
On the other hand, X-ray AGN selection also has strong bias. About 2/3 of all
emission-line AGNs at L_bol>10^44 erg/s in our sample are not detected in our
200 ks Chandra images, most likely due to moderate or heavy absorption by gas
near the AGN. The 2--7 keV detection rate of Seyfert 2s at z~0.6 suggests that
their column density distribution and Compton-thick fraction are similar to
that of local Seyferts. Multiple sample selection techniques are needed to
obtain as complete a sample as possible.Comment: 24 pages, 14 figures, submitted to ApJ. Version 2 matches the ApJ
accepted version. Sec 3 was reorganized and partly rewritten with one
additional figure (Fig.3
The Lick AGN Monitoring Project 2011: Dynamical Modeling of the Broad Line Region in Mrk 50
We present dynamical modeling of the broad line region (BLR) in the Seyfert 1
galaxy Mrk 50 using reverberation mapping data taken as part of the Lick AGN
Monitoring Project (LAMP) 2011. We model the reverberation mapping data
directly, constraining the geometry and kinematics of the BLR, as well as
deriving a black hole mass estimate that does not depend on a normalizing
factor or virial coefficient. We find that the geometry of the BLR in Mrk 50 is
a nearly face-on thick disk, with a mean radius of 9.6(+1.2,-0.9) light days, a
width of the BLR of 6.9(+1.2,-1.1) light days, and a disk opening angle of
25\pm10 degrees above the plane. We also constrain the inclination angle to be
9(+7,-5) degrees, close to face-on. Finally, the black hole mass of Mrk 50 is
inferred to be log10(M(BH)/Msun) = 7.57(+0.44,-0.27). By comparison to the
virial black hole mass estimate from traditional reverberation mapping
analysis, we find the normalizing constant (virial coefficient) to be log10(f)
= 0.78(+0.44,-0.27), consistent with the commonly adopted mean value of 0.74
based on aligning the M(BH)-{\sigma}* relation for AGN and quiescent galaxies.
While our dynamical model includes the possibility of a net inflow or outflow
in the BLR, we cannot distinguish between these two scenarios.Comment: Accepted for publication in ApJ. 8 pages, 6 figure
Theory and Applications of Non-Relativistic and Relativistic Turbulent Reconnection
Realistic astrophysical environments are turbulent due to the extremely high
Reynolds numbers. Therefore, the theories of reconnection intended for
describing astrophysical reconnection should not ignore the effects of
turbulence on magnetic reconnection. Turbulence is known to change the nature
of many physical processes dramatically and in this review we claim that
magnetic reconnection is not an exception. We stress that not only
astrophysical turbulence is ubiquitous, but also magnetic reconnection itself
induces turbulence. Thus turbulence must be accounted for in any realistic
astrophysical reconnection setup. We argue that due to the similarities of MHD
turbulence in relativistic and non-relativistic cases the theory of magnetic
reconnection developed for the non-relativistic case can be extended to the
relativistic case and we provide numerical simulations that support this
conjecture. We also provide quantitative comparisons of the theoretical
predictions and results of numerical experiments, including the situations when
turbulent reconnection is self-driven, i.e. the turbulence in the system is
generated by the reconnection process itself. We show how turbulent
reconnection entails the violation of magnetic flux freezing, the conclusion
that has really far reaching consequences for many realistically turbulent
astrophysical environments. In addition, we consider observational testing of
turbulent reconnection as well as numerous implications of the theory. The
former includes the Sun and solar wind reconnection, while the latter include
the process of reconnection diffusion induced by turbulent reconnection, the
acceleration of energetic particles, bursts of turbulent reconnection related
to black hole sources as well as gamma ray bursts. Finally, we explain why
turbulent reconnection cannot be explained by turbulent resistivity or derived
through the mean field approach.Comment: 66 pages, 24 figures, a chapter of the book "Magnetic Reconnection -
Concepts and Applications", editors W. Gonzalez, E. N. Parke
Investor Competition Over Information and the Pricing of Information Asymmetry
Whether the information environment affects the cost of capital is a fundamental question in
accounting and finance research. Relying on theories about competition between informed
investors as well as the pricing of information asymmetry, we hypothesize a cross-sectional
variation in the pricing of information asymmetry that is conditional on competition. We develop
and validate empirical proxies for competition using the number and concentration of
institutional investor ownership. Using these proxies, we find a lower pricing of information
asymmetry when there is more competition. Overall, our results suggest that competition
between informed investors has an important effect on how the information environment affects
the cost of capital.Deloitte Foundatio
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