39 research outputs found
"Ours is a business civilization" : the University of Oklahoma Bass Business History Collection with annotated bibliography of fifty treasures
Imagine having the opportunity to explore oversize seventeenth-century parchment edicts of kings, stacks of gold-plated coins, boxes of 1930s stock certificates, and modern ledger books; to review inestimable incunabula from before Gutenberg; and to flip through personal files of business tycoons, maps of railroads, and scores of historically significant photographs. That was the opportunity afforded Oxford University scholar Chris Nitschke when, in 2017, he visited the University of Oklahoma Bass Business History Collection to find the specific archival resources he needed.“I first heard of the Bass Business History Collection when I researched archival collections for my dissertation,” said Nitschke. “I admit I was surprised at first to learn that Oklahoma University would hold the archives of J. & W. Seligman & Co., a private bank founded in the nineteenth century. Yet it [traveling to Oklahoma] gave me a chance to shake things up a little bit in terms of destinations on my East Coast–heavy research trip.”Nitschke came to the University of Oklahoma specifically to research the material in the Seligman Archives, one of the most important segments of the Bass Collection. “The Seligman Archives had looked very useful the first time I had looked at the online finding aid, and getting here did not change things. A more detailed printed finding aid allowed me to locate some additional material I would have overlooked otherwise. The material I targeted all along—original letter books by the partners of Seligman’s international bank—proved incredibly valuable.”After a few days of research in Bass, Nitschke found what he was looking for: “Fortunately they [the Seligman letter books] covered just about the time period I was interested in . . . the Harry Bass Collection is in excellent shape.”The experience of this international researcher is not unique to students and other researchers: the Bass Business Collection is a hidden gem of immense value.This publication, printed by The University of Oklahoma Printing Services, is issued by the University of Oklahoma. 2500 copies have been prepared and distributed at no cost to the taxpayers of the State of Oklahoma.N
125 Years of Books to Internet: The Quasquicentennial of the University of Oklahoma Libraries
Settled upon the Great Plains in 1890, the University of Oklahoma has a long and distinguished history. And the University of Oklahoma Libraries have as storied a history as the University they are nestled within. From one bookcase of fifty-three
books brought in by train by the first president, to the current holdings of more than six million volumes, the University of Oklahoma Libraries have grown and changed along with the twists and turns of America. One hundred and twenty-five years after their founding—through wars, depressions, the Dust Bowl, budget cuts, microfiche, and now the Internet—the University of Oklahoma Libraries have not only persevered but prospered, and have grown into the largest research library in the state as well as one of the premiere libraries in the United States.This publication, printed by The University of Oklahoma Printing Services, is issued by the University of Oklahoma. 2500 copies have been prepared and distributed at no cost to the taxpayers of the State of Oklahoma.N
The Leviathan: How to Move 2.9 Million Government Documents Offsite
The concept of moving a university’s historic, 2.9 million item government documents collection offsite was daunting. The actual move of the collection took 24 months. In this move, much was learned about developing a project management plan, including: consult the literature early, anticipate confusion points within the collection, discuss wear-and-tear issues, and understand the effect the move would have on service. The final move required 31 working days over five months of shifting. Afterward, it was found that the repercussions of a move – especially on staff and reference work – can often be more jarring than the move itself.Ye
The Fifth Data Release of the Sloan Digital Sky Survey
This paper describes the Fifth Data Release (DR5) of the Sloan Digital Sky
Survey (SDSS). DR5 includes all survey quality data taken through June 2005 and
represents the completion of the SDSS-I project (whose successor, SDSS-II will
continue through mid-2008). It includes five-band photometric data for 217
million objects selected over 8000 square degrees, and 1,048,960 spectra of
galaxies, quasars, and stars selected from 5713 square degrees of that imaging
data. These numbers represent a roughly 20% increment over those of the Fourth
Data Release; all the data from previous data releases are included in the
present release. In addition to "standard" SDSS observations, DR5 includes
repeat scans of the southern equatorial stripe, imaging scans across M31 and
the core of the Perseus cluster of galaxies, and the first spectroscopic data
from SEGUE, a survey to explore the kinematics and chemical evolution of the
Galaxy. The catalog database incorporates several new features, including
photometric redshifts of galaxies, tables of matched objects in overlap regions
of the imaging survey, and tools that allow precise computations of survey
geometry for statistical investigations.Comment: ApJ Supp, in press, October 2007. This paper describes DR5. The SDSS
Sixth Data Release (DR6) is now public, available from http://www.sdss.or
The Seventh Data Release of the Sloan Digital Sky Survey
This paper describes the Seventh Data Release of the Sloan Digital Sky Survey
(SDSS), marking the completion of the original goals of the SDSS and the end of
the phase known as SDSS-II. It includes 11663 deg^2 of imaging data, with most
of the roughly 2000 deg^2 increment over the previous data release lying in
regions of low Galactic latitude. The catalog contains five-band photometry for
357 million distinct objects. The survey also includes repeat photometry over
250 deg^2 along the Celestial Equator in the Southern Galactic Cap. A
coaddition of these data goes roughly two magnitudes fainter than the main
survey. The spectroscopy is now complete over a contiguous area of 7500 deg^2
in the Northern Galactic Cap, closing the gap that was present in previous data
releases. There are over 1.6 million spectra in total, including 930,000
galaxies, 120,000 quasars, and 460,000 stars. The data release includes
improved stellar photometry at low Galactic latitude. The astrometry has all
been recalibrated with the second version of the USNO CCD Astrograph Catalog
(UCAC-2), reducing the rms statistical errors at the bright end to 45
milli-arcseconds per coordinate. A systematic error in bright galaxy photometr
is less severe than previously reported for the majority of galaxies. Finally,
we describe a series of improvements to the spectroscopic reductions, including
better flat-fielding and improved wavelength calibration at the blue end,
better processing of objects with extremely strong narrow emission lines, and
an improved determination of stellar metallicities. (Abridged)Comment: 20 pages, 10 embedded figures. Accepted to ApJS after minor
correction
The Third Data Release of the Sloan Digital Sky Survey
This paper describes the Third Data Release of the Sloan Digital Sky Survey
(SDSS). This release, containing data taken up through June 2003, includes
imaging data in five bands over 5282 deg^2, photometric and astrometric
catalogs of the 141 million objects detected in these imaging data, and spectra
of 528,640 objects selected over 4188 deg^2. The pipelines analyzing both
images and spectroscopy are unchanged from those used in our Second Data
Release.Comment: 14 pages, including 2 postscript figures. Submitted to AJ. Data
available at http://www.sdss.org/dr
The Second Data Release of the Sloan Digital Sky Survey
The Sloan Digital Sky Survey (SDSS) has validated and made publicly available its Second Data Release. This data release consists of 3324 deg2 of five-band (ugriz) imaging data with photometry for over 88 million unique objects, 367,360 spectra of galaxies, quasars, stars, and calibrating blank sky patches selected over 2627 deg2 of this area, and tables of measured parameters from these data. The imaging data reach a depth of r ≈ 22.2 (95% completeness limit for point sources) and are photometrically and astrometrically calibrated to 2% rms and 100 mas rms per coordinate, respectively. The imaging data have all been processed through a new version of the SDSS imaging pipeline, in which the most important improvement since the last data release is fixing an error in the model fits to each object. The result is that model magnitudes are now a good proxy for point-spread function magnitudes for point sources, and Petrosian magnitudes for extended sources. The spectroscopy extends from 3800 to 9200 Å at a resolution of 2000. The spectroscopic software now repairs a systematic error in the radial velocities of certain types of stars and has substantially improved spectrophotometry. All data included in the SDSS Early Data Release and First Data Release are reprocessed with the improved pipelines and included in the Second Data Release. Further characteristics of the data are described, as are the data products themselves and the tools for accessing them
The First Data Release of the Sloan Digital Sky Survey
The Sloan Digital Sky Survey has validated and made publicly available its
First Data Release. This consists of 2099 square degrees of five-band (u, g, r,
i, z) imaging data, 186,240 spectra of galaxies, quasars, stars and calibrating
blank sky patches selected over 1360 square degrees of this area, and tables of
measured parameters from these data. The imaging data go to a depth of r ~ 22.6
and are photometrically and astrometrically calibrated to 2% rms and 100
milli-arcsec rms per coordinate, respectively. The spectra cover the range
3800--9200 A, with a resolution of 1800--2100. Further characteristics of the
data are described, as are the data products themselves.Comment: Submitted to The Astronomical Journal. 16 pages. For associated
documentation, see http://www.sdss.org/dr
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival