The rheophysics of two athermal systems: dry granular media and non-Brownian suspensions

Summary The steady-state, pressure-controlled simple shear flow constitutes a paradigm for the study of flows of dense athermal systems such as dry grains or non-Brownian suspensions. The introduction of two dimensionless numbers called inertial and viscous was an important step. In an attempt to provide a common rheophysical framework to both systems, we relate their flow properties in the dense regime close to jamming transition to two basic constitutive laws or equations of state : both the free volume and the ratio of shear stress to particle pressure (in excess of a static friction coefficient) vary as power laws, with system-dependent exponents, of a Deborah number. The first law is derived from the Boltzmann equation expressed in the approximation of relaxation. The second law is deduced from the expression of the probability for a particle to belong to a transient cluster of particles in contact

DRC 2 : Dynamically Reconfigurable Computing Circuit based on Memory Architecture

International audienceThis paper presents a novel energy-efficient and Dynamically Reconfigurable Computing Circuit (DRC²) concept based on memory architecture for data-intensive (imaging, …) and secure (cryptography, …) applications. The proposed computing circuit is based on a 10-Transistor (10T) 3-Port SRAM bitcell array driven by a peripheral circuitry enabling all basic operations that can be traditionally performed by an ALU. As a result, logic and arithmetic operations can be entirely executed within the memory unit leading to a significant reduction in power consumption related to the data transfer between memories and computing units. Moreover, the proposed computing circuit can perform extremely-parallel operations enabling the processing of large volume of data. A test case based on image processing application and using the saturating increment function is analytically modeled to compare conventional and DRC²-based approaches. It is demonstrated that DRC²-based approach provides a reduction of clock cycle number of up to 2x. Finally, potential applications and must-be-considered changes at different design levels are discussed

Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study

BACKGROUND: The purpose of this study was to measure regional contractile function in the normal rat using cardiac cine and tagged cardiovascular magnetic resonance (CMR) during incremental low doses of dobutamine and at rest. METHODS: Five rats were investigated for invasive left ventricle pressure measurements and five additional rats were imaged on a clinical 1.5 T MR system using a cine sequence (11-20 phases per cycle, 0.28/0.28/2 mm) and a C-SPAMM tag sequence (18-25 phases per cycle, 0.63/1.79/3 mm, tag spacing 1.25 mm). For each slice, wall thickening (WT) and circumferential strains (CS) were calculated at rest and at stress (2.5, 5 and 10 microg/min/kg of dobutamine). RESULTS: Good cine and tagged images were obtained in all the rats even at higher heart rate (300-440 bpm). Ejection fraction and left ventricular (LV) end-systolic volume showed significant changes after each dobutamine perfusion dose (p < 0.001). Tagged CMR had the capacity to resolve the CS transmural gradient and showed a significant increase of both WT and CS at stress compared to rest. Intra and interobserver study showed less variability for the tagged technique. In rats in which a LV catheter was placed, dobutamine produced a significant increase of heart rate, LV dP/dtmax and LV pressure significantly already at the lowest infusion dose. CONCLUSION: Robust cardiac cine and tagging CMR measurements can be obtained in the rat under incremental dobutamine stress using a clinical 1.5 T MR scanner

Synchronization of patient data among health facilities through electronic medical records system: a case study of Kabgayi District Hospital

Background: The use of modern technology in healthcare system aims to increase the reliability, accessibility and productivity of delivered services. In most developing countries, particularly in sub-Saharan Africa, Electronic Medical Records (EMRs) has been dominated by paper-based system. In Rwanda, EMRs started in 2011 with a baseline of 8% and reached 50% in 2017 within 516 health facilities, but patient data synchronization among health facilities is still a problem. The aim of this research was to identify factors hindering EMRs implementation and propose applied solutions.Methods: A cross-sectional descriptive study design with qualitative and quantitative approach was used. A purposive method to select the research participants among the target population was also used.Results: It was found that, despite the improvement of hospitals’ management and healthcare efficiency via EMRs system, factors affecting synchronization of patients’ data among health facilities still persist. The study also revealed the need for the interoperability in the integration of EMRs system among health facilities.Conclusion: The OpenMRS EMR-based data synchronization can reduce gaps in HIV care. It avoids a duplication of patient identification number (PID) at the same health facility for more than one visit and missing data among health facilities. As part of implementable solutions for effective service delivery, cloud-based server and patient identification were suggested as solutions for much more success in Open MRS EMRs system.Keywords: Electronic Medical Record, Data synchronization, Cloud computing technolog

Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long-term survivors after allogeneic hematopoietic stem cell transplantation

We quantified and studied the impact of post transfusional iron overload alone in post allogeneic HSCT. Median number of RBCs was 18. Ferritin was 532 μg/L. Liver iron content (LIC) was 117 μmoles/gdw. Correlation RBCs and ferritin was (r=0.81); RBCs and LIC was (r=0.84). The high ferritin group differed from normal ferritin group in terms of RBCs transfused (

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition

The intestine-specific caudal-related homeobox gene-2 (CDX2) homeobox gene, while being a tumor suppressor in the gut, is ectopically expressed in a large proportion of acute leukemia and is associated with poor prognosis. Here, we report that turning on human CDX2 expression in the hematopoietic lineage of mice induces acute monoblastic leukemia, characterized by the decrease in erythroid and lymphoid cells at the benefit of immature monocytic and granulocytic cells. One of the highly stimulated genes in leukemic bone marrow cells was BMP and activin membrane-bound inhibitor (Bambi), an inhibitor of transforming growth factor-β (TGF-β) signaling. The CDX2 protein was shown to bind to and activate the transcription of the human BAMBI promoter. Moreover, in a leukemic cell line established from CDX2-expressing mice, reducing the levels of CDX2 or Bambi stimulated the TGF-β-dependent expression of Cd11b, a marker of monocyte maturation. Taken together, this work demonstrates the strong oncogenic potential of the homeobox gene CDX2 in the hematopoietic lineage, in contrast with its physiological tumor suppressor activity exerted in the gut. It also reveals, through BAMBI and TGF-β signaling, the involvement of CDX2 in the perturbation of the interactions between leukemia cells and their microenvironment

Translating the multi-actor approach to research into practice using a workshop approach focusing on species mixtures

The EIP-Agri multiactor approach was exemplified during a 3-day workshop with 63 project participants from the EU H2020 funded project "Redesigning European cropping systems based on species MIXtures". The objective was to share firsthand experience of participatory research among researchers who were mostly not familiar with this approach. Workshop participants were divided into smaller multidisciplinary groups and given the opportunity to interact with representatives from eight actor positions in the value chain of the agrifood cooperative Terrena located in Western France. The four stages of the workshop were: (1) key actor interviews, (2) sharing proposed solutions for overcoming barriers, and (3) developing possible interdisciplinary concepts. Expressions of frustration were recorded serving both as a motivation for group members to become more aware of the scientific concerns and practices of their colleagues, as well as a recognition that some researchers have better skills integrating qualitative approaches than others. Nevertheless, the workshop format was an effective way to gain a common understanding of the pertinent issues that need to be addressed to meet overall multiactor-approach objectives. Working with the actor networks was identified and emphasized as a means to overcome existing barriers between academia and practice in order to coproduce a shared vision of the benefits of species mixture benefits. (C) The Author(s) 2021. Published by Higher Education Press

Plan Simple de Gestion : un outil de gestion de la ressource bois énergie dans les espaces périurbains

Projet UE Makala "Gérer durablement la ressource bois énergie

SoK: Contemporary Issues and Challenges to Enable Cyber Situational Awareness for Network Security

Cyber situational awareness is an essential part of cyber defense that allows the cybersecurity operators to cope with the complexity of today's networks and threat landscape. Perceiving and comprehending the situation allow the operator to project upcoming events and make strategic decisions. In this paper, we recapitulate the fundamentals of cyber situational awareness and highlight its unique characteristics in comparison to generic situational awareness known from other fields. Subsequently, we provide an overview of existing research and trends in publishing on the topic, introduce front research groups, and highlight the impact of cyber situational awareness research. Further, we propose an updated taxonomy and enumeration of the components used for achieving cyber situational awareness. The updated taxonomy conforms to the widely-accepted three-level definition of cyber situational awareness and newly includes the projection level. Finally, we identify and discuss contemporary research and operational challenges, such as the need to cope with rising volume, velocity, and variety of cybersecurity data and the need to provide cybersecurity operators with the right data at the right time and increase their value through visualization