684 research outputs found
Visibility diagrams and experimental stripe structure in the quantum Hall effect
We analyze various properties of the visibility diagrams that can be used in
the context of modular symmetries and confront them to some recent experimental
developments in the Quantum Hall Effect. We show that a suitable physical
interpretation of the visibility diagrams which permits one to describe
successfully the observed architecture of the Quantum Hall states gives rise
naturally to a stripe structure reproducing some of the experimental features
that have been observed in the study of the quantum fluctuations of the Hall
conductance. Furthermore, we exhibit new properties of the visibility diagrams
stemming from the structure of subgroups of the full modular group.Comment: 8 pages in plain TeX, 7 figures in a single postscript fil
Stress transmission in granular matter
The transmission of forces through a disordered granular system is studied by
means of a geometrical-topological approach that reduces the granular packing
into a set of layers. This layered structure constitutes the skeleton through
which the force chains set up. Given the granular packing, and the region where
the force is applied, such a skeleton is uniquely defined. Within this
framework, we write an equation for the transmission of the vertical forces
that can be solved recursively layer by layer. We find that a special class of
analytical solutions for this equation are L\'evi-stable distributions. We
discuss the link between criticality and fragility and we show how the
disordered packing naturally induces the formation of force-chains and arches.
We point out that critical regimes, with power law distributions, are
associated with the roughness of the topological layers. Whereas, fragility is
associated with local changes in the force network induced by local granular
rearrangements or by changes in the applied force. The results are compared
with recent experimental observations in particulate matter and with computer
simulations.Comment: 14 pages, Latex, 5 EPS figure
Modular Groups, Visibility Diagram and Quantum Hall Effect
We consider the action of the modular group on the set of
positive rational fractions. From this, we derive a model for a classification
of fractional (as well as integer) Hall states which can be visualized on two
``visibility" diagrams, the first one being associated with even denominator
fractions whereas the second one is linked to odd denominator fractions. We use
this model to predict, among some interesting physical quantities, the relative
ratios of the width of the different transversal resistivity plateaus. A
numerical simulation of the tranversal resistivity plot based on this last
prediction fits well with the present experimental data.Comment: 17 pages, plain TeX, 4 eps figures included (macro epsf.tex), 1
figure available from reques
A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors
Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and similarly for B7.1 (CD80), through binding to CTLA-4. Moreover, direct interactions between B7-H1 and B7.1 molecules are also likely to participate in the immunoevasion mechanism. In this study, we used a mouse model of tumor dormancy, DA1-3b leukemia cells. We previously showed that a minor population of DA1-3b cells persists in equilibrium with the immune system for long periods of time, and that the levels of surface expression of B7-H1 and B7.1 molecules correlates with the dormancy time. We found that leukemia cells DA1-3b/d365 cells, which derived from long-term dormant tumors and overexpressed B7-H1 and B7.1 molecules, were highly permissive to Ad5FB4, a human adenovirus serotype 5 (Ad5) vector pseudotyped with chimeric human-bovine fibers. Both B7-H1 and B7.1 were required for Ad5FB4-cell binding and entry, since (i) siRNA silencing of one or the other B7 gene transcript resulted in a net decrease in the cell binding and Ad5FB4-mediated transduction of DA1-3b/d365; and (ii) plasmid-directed expression of B7.1 and B7-H1 proteins conferred to Ad5FB4-refractory human cells a full permissiveness to this vector. Binding data and flow cytometry analysis suggested that B7.1 and B7-H1 molecules played different roles in Ad5FB4-mediated transduction of DA1-3b/d365, with B7.1 involved in cell attachment of Ad5FB4, and B7-H1 in Ad5FB4 internalization. BRET analysis showed that B7.1 and B7-H1 formed heterodimeric complexes at the cell surface, and that Ad5FB4 penton, the viral capsomere carrying the fiber projection, could negatively interfere with the formation of B7.1/B7-H1 heterodimers, or modify their conformation. As interactors of B7-H1/B7.1 molecules, Ad5FB4 particles and/or their penton capsomeres represent potential therapeutic agents targeting cancer cells that had developed immunoevasion mechanisms
Correction par bloc des transitoires de la caméra infrarouge ISOPIIOT C-100 avec un modèle non linéaire dissymétrique
Les photo-détecteurs utilisés en astronomie infrarouge à très bas niveau de flux présentent généralement une rémanence lors d'un changement d'illumination. Ce phénomène transitoire est non linéaire et dissymétrique selon que le flux entrant croît ou décroît. Pour le détecteur ISOPHOT C-100 embarqué sur le satellite ISO, nous avons montré qu'un modèle semi-empirique permet de décrire avec une bonne précision (de l'ordre de quelques pour-cent) ces transitoires. Une méthode d'inversion permet de corriger ces transitoires. Les limitations de l'approche sont détaillées
Compensating Commitments: The Law and Economics of Commitment Bonds That Compensate for the Possibility of Forfeiture
This Article introduces compensating commitment bonds, which make it more affordable for a government, entity, or individual to commit to some course of action. These bonds, like traditional government or corporate bonds, can generate revenue for committing parties. A bond seller makes a commitment and promises to pay a forfeit if the seller fails to meet the bond conditions. The bond buyer pays the seller to be contractually designated as the recipient of any amounts the bond seller forfeits. This approach has potential application in a range of legal situations. Governments and other parties may use such bonds to facilitate commitments to principles from which they later may face temptation to deviate. Such bonds also can facilitate legislative compromise or the settlement of private legal disputes. The Article identifies a variety of incentive-equivalent commitment bond structures as well as the circumstances under which a particular implementation is likely to be most effective. It also explores hurdles to the use of such bonds, including the concerns that the courts might find a legislature’s use of such bonds to entrench its preferences unconstitutional and that a legislature might issue such bonds but cancel them after failing to maintain a commitment
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