In silico analysis of the efficacy of some natural compounds as antituberculosis agents

207-213Tuberculosis (TB) remains a disease of global importance with approximately two million deaths annually worldwide. Effective treatment of TB has been hampered by the emergence of drug resistant strains of Mycobacterium tuberculosis. Natural products have a proven global history of treating TB diseases and ailments. Available vast reservoir of chemically diverse natural products that provide new templates for drug design can be scrutinized and the most efficient may be chosen by molecular docking studies with the TB proteins. In the present study, an attempt has been made to find out a potential natural product to inhibit M. tuberculosis – protein kinase B (PknB) protein by molecular docking method. Docking has been performed for around 40 natural products against M. tuberculosis – PknB protein target to determine their potentiality against TB diseases. The anti-TB ability has been analysed in terms of binding energy. The results indicate that 80% of the natural products (B.E ≥ -7 kcal/mol) under study, exhibit good anti-TB activity. It is known that most of the natural product under study is found to possess greater binding activity than that of the conventional anti-TB drugs

The Position of the Camp Indicating Nedunalvaadai

It is the ancient Tamil literature that shows us what tamil nadu was like during the Sangam age. Nedunalvadai is a mirror of the inner and outer life of the Sangam Tamils. Ten songs are rich in vocabulary and semantics. The aim is to conquer Kotravai in Nedunalvadai, the soldier who is wounded in the field of battle, the venthan who sees the fall, the condition of the venthan who sees the fall, the aim of leaving the camp and winning quickly. The smell of the wind blowing in nedunalvadai causes great sorrow to the leader because of the separation of the leader, and the time is pleasant for the chief to console the other warriors who have fallen on the battlefield. This article deals with the status of camping in this book, which is the inner most part of the woman and the outer most of the man

An updated feminist view of intimate partner violence

In this article, we explore intimate partner violence (IPV) from an intersectional, feminist perspective. We describe how an updated feminist view guides us to a perspective on IPV that is more strongly grounded in an anti-oppressive, non-violent, socially just feminist stance than a second-wave gender-essential feminist stance that suggests that patriarchy is the cause of IPV. At the time we began to work together it seemed that a researcher had to be identified as a “family violence” researcher or a “feminist” researcher of violence against women, and that it wasn’t possible to be a feminist researcher who looked beyond patriarchy as the cause of IPV. We advocate critically thinking about essentialist practices in clinical work so that we can maintain an anti-oppressive, socially just, non-violent approach to working with clients who experience IPV

The Influence of High-Energy Lithium Ion Irradiation on Electrical Characteristics of Silicon and GaAs Solar Cells

Space-grade Si and GaAs solar cells were irradiated with 15 & 40 MeV Li ions. Illuminated (AM0 condition) and unilluminated I-V curves reveal that the effect of high-energy Li ion irradiation has produced similar effects to that of proton irradiation. However, an additional, and different, defect mechanism is suggested to dominate in the heavier-ion results. Comparison is made with proton-irradiated solar-cell work and with non-ionizing energy-loss (NIEL) radiation-damage models.Comment: 8 pages, 12 figures, Data presented at 2006 NSREC, Final Version to be published in IEEE Transactions on Nuclear Science, 53, NO. 6, December 2006. Index Terms: GaAs, Ion-irradiation, Lithium, NIEL, Photovoltaic cells, Radiation effects, Silico

Electrochemically codeposited reduced graphene oxide and palladium nanoparticles: An efficient heterogeneous catalyst for Heck coupling reaction

AbstractThe catalytic activity of electrochemically codeposited reduced graphene oxide and palladium (ERGO-Pd) was examined for Heck coupling reactions. It showed excellent catalytic activity and stability for Heck coupling reaction. The prepared catalyst (ERGO-Pd) can be used up to the 5th cycle with negligible loss in activity

FUTURE OF OMAN TOURISM PERCEPTION OF THE STUDENTS IN TOURISM STUDIES

Oman’s ‘Vision 2040’ aims at diversifying its economic activities from oil and gas sector to tourism sector.  The vision and mission statement aims at developing tourism as a sustainable economic sector. The objective of the study is to analyze the various factors affecting the students’ perceptions towards choosing Tourism studies as their mainstream. The study was conducted with 223 students of tourism studies who were selected on the basis of random sampling and were contacted through a well-defined questionnaire. The primary data was collected, compiled, and thoroughly analyzed to arrive at conclusions. A critical analysis was carried out using the null hypothesis, chi-square, and ranking tests. The study reveals that the factors like non-discrimination of gender, promotion opportunities, and physical working conditions play a crucial role in motivating most of the students in choosing tourism studies. Further, this paper critically analyzes the discouraging factors for their aversion towards the tourism industry. Our empirical results reveal that the high risk of accidents, non-tourism spouse preferences, Omani traditional values discourage the attitude towards choosing tourism as their future job and hence the tourism studies. The study further demonstrates that there is a strong association between the motivating factors and the reasons for students choosing tourism as their studies. There exists a necessity for the Government and the related sponsoring institutions to look into these factors and encourage our young tourism students who will in return render their full support towards diversifying Oman’s future economy towards tourism

The genetic basis of energy conservation in the sulfate-reducing bacterium Desulfovibrio alaskensis G20.

Sulfate-reducing bacteria play major roles in the global carbon and sulfur cycles, but it remains unclear how reducing sulfate yields energy. To determine the genetic basis of energy conservation, we measured the fitness of thousands of pooled mutants of Desulfovibrio alaskensis G20 during growth in 12 different combinations of electron donors and acceptors. We show that ion pumping by the ferredoxin:NADH oxidoreductase Rnf is required whenever substrate-level phosphorylation is not possible. The uncharacterized complex Hdr/flox-1 (Dde_1207:13) is sometimes important alongside Rnf and may perform an electron bifurcation to generate more reduced ferredoxin from NADH to allow further ion pumping. Similarly, during the oxidation of malate or fumarate, the electron-bifurcating transhydrogenase NfnAB-2 (Dde_1250:1) is important and may generate reduced ferredoxin to allow additional ion pumping by Rnf. During formate oxidation, the periplasmic [NiFeSe] hydrogenase HysAB is required, which suggests that hydrogen forms in the periplasm, diffuses to the cytoplasm, and is used to reduce ferredoxin, thus providing a substrate for Rnf. During hydrogen utilization, the transmembrane electron transport complex Tmc is important and may move electrons from the periplasm into the cytoplasmic sulfite reduction pathway. Finally, mutants of many other putative electron carriers have no clear phenotype, which suggests that they are not important under our growth conditions, although we cannot rule out genetic redundancy

Influence of Farming Culture on Rituals of North Malabar Region of Kerala State

This paper forms a part of the theses entitled “Influence of farming culture on the folk arts and rituals of North Malabar region of Kerala state”. The objective of the study was to identify specific elements as influenced by farming culture and to assess their scientific rationale, if any. The research design followed was exploratory and ex post facto in nature. The study revealed that most of the rituals have been originated from an ancient agrarian society which had a deep-rooted stand in farming culture. It was also seen that these rituals, through superstitions, taboos, etc., prompted the public to conserve the ecosystem. They promoted eco-friendly sustainable farming supplementing the endeavor towards a greener Kerala