425 research outputs found
PREPARATION AND EVALUATION OF EXTENDED RELEASE NIMESULIDE TABLET BASED ON DIFFUSION CONTROLLED MECHANISM
Now a days the concept of controlled release is quiet popular amongst the formulation scientists. The aim of thisstudy was to develop a once-daily sustained release matrix tablet of Nimesulide using hydroxyl propylmethylcellulose (HPMC K4M) as release controlling factor and to evaluate drug release parameters as per variousrelease kinetic models. The tablets were prepared using wet granulation method. Total of five batches were preparedfrom which two selected batches were further evaluated. Different dissolution models were applied to drug releasedata in order to evaluate release mechanisms and kinetics. The ânâ Value of both batches indicates that the drugrelease mechanism follows âAnomalous Transportâ. From all these data it is quite clear that batch F2 is optimized asits release kinetic was found to be as per Korsmeyer Peppas model rather than first order of F4
Knowledge, attitudes and breast-feeding practices of postnatal mothers in Central India
Background: Breast feeding is vital for the health of baby & mother. It is of advantage to baby, mother, family, society and nation. Present study was carried out to evaluate knowledge, attitude and breast feeding practices of postnatal women.Methods: This cross-sectional study was carried out at immunization centre. 208 postnatal women were interviewed.Results: Out of 208 postnatal women, 148 women (71.15%) had delivery by caesarean section while 60 women (28.84%) had vaginal delivery. 118 women (56.73%) started breast feeding the baby within 2 hours of delivery, 52 women (25%) started breast feeding the baby after 24 hours of delivery, 26 women (12.5%) started breast feeding the baby after 2-6 hours of delivery while 12 women (5.76%) started breast feeding the baby after 6-24 hours of delivery. 174 women (83.65%) were giving exclusive breast feeding to their babies, 32 women (15.38%) were giving mixed feeding to their babies due to failure to thrive because of inadequate breast secretions. 28 (13.46%) preferred to give formula feeds while 7 (3.36%) preferred to give cowâs milk when needed. 180 (86.53%) intend or started weaning after 6 months while 28 women (13.46%) started weaning to their babies due to failure of baby to thrive or inadequate lactation.Conclusions: Awareness of breast feeding was good. Majority preferred exclusive breast feeding. Still, antenatal counseling about breast feeding can be further of advantage
Finite-Sum Smooth Optimization with SARAH
The total complexity (measured as the total number of gradient computations)
of a stochastic first-order optimization algorithm that finds a first-order
stationary point of a finite-sum smooth nonconvex objective function
has been proven to be at least
for where
denotes the attained accuracy for the outputted approximation
(Fang et al., 2018). In this paper, we provide a convergence analysis for a
slightly modified version of the SARAH algorithm (Nguyen et al., 2017a;b) and
achieve total complexity that matches the lower-bound worst case complexity in
(Fang et al., 2018) up to a constant factor when for nonconvex problems. For convex optimization, we
propose SARAH++ with sublinear convergence for general convex and linear
convergence for strongly convex problems; and we provide a practical version
for which numerical experiments on various datasets show an improved
performance
Dust Properties in the FUV in Ophiuchus
We have derived the albedo () and phase function asymmetry factor () of
interstellar dust grains at 1100 \AA ~ using archival {\it Voyager}
observations of diffuse radiation in Ophiuchus. We have found that the grains
are highly forward scattering with 0.55 0.25 and 0.40
0.10. Even though most of the gas in this direction is in the Ophiuchus
molecular cloud, the diffuse FUV radiation is almost entirely due to scattering
in a relatively thin foreground cloud. This suggests that one cannot assume
that the UV background is directly correlated with the total amount of gas in
any direction.Comment: 11 pages, 7 figures, 2 tables, ApJ, accepte
OVI Asymmetry and an Accelerated Outflow in an Obscured Seyfert: FUSE and HST STIS Spectroscopy of Markarian533
We present far-ultraviolet spectra of the Seyfert2 galaxy Mrk533 obtained
with FUSE. These spectra show narrow asymmetrical OVI 1032,1038 emission lines
with stronger wings shortward of the peak wavelength, but the degree of
asymmetry of these wings in velocity is much lower than that of the wings of
the lines of lower ionization. In the combined OVI profile there are marginal
indications of local absorptions in the outflow. The CIII 977 line is seen
weakly with a similar profile, but with very low signal to noise. These FUV
spectra are among the first for a Seyfert of type2, i.e., a purportedly
obscured Seyfert. The HST STIS spectral image of Mrk533 allows delineation of
the various components of the outflow, and we infer that the outflow is
accelerated. We discuss the results in terms of nuclear geometry and
kinematics.Comment: 19 pages, 5 figures, including 1 colour figure. Accepted in Ap
Cosmetic outcome as rated by patients, doctors, nurses and BCCT.core software assessed over 5 years in a subset of patients in the TARGIT-A trial
Background: The purpose of this research was to assess agreement between four rating systems of cosmetic outcome measured in a subset of patients with early breast cancer participating in the randomised TARGIT-A trial. TARGIT-A compared risk-adapted single-dose intra-operative radiotherapy (TARGIT-IORT) to whole breast external beam radiotherapy (EBRT).
Methods: Patients, their Radiation Oncologist and Research Nurse completed a subjective cosmetic assessment questionnaire before radiotherapy and annually thereafter for five years. Objective data previously calculated by the validated BCCT.core software which utilizes digital photographs to score symmetry, colour and scar was also used. Agreement was assessed by the Kappa statistic and longitudinal changes were assessed by generalized estimating equations.
Results: Overall, an Excellent-Good (EG) cosmetic result was scored more often than a Fair-Poor (FP) result for both treatment groups across all time points, with patients who received TARGIT-IORT scoring EG more often than those who received EBRT however this was statistically significant at Year 5 only. There was modest agreement between the four rating systems with the highest Kappa score being moderate agreement which was between nurse and doctor scores at Year 1 with Kappa = 0.46 (p \u3c 0.001), 95% CI (0.24, 0.68).
Conclusion: Despite similar overall findings between treatment groups and rating systems, the inter-rater agreement was only modest. This suggests that the four rating systems utilized may not necessarily be used interchangeably and it is arguable that for an outcome such as cosmetic appearance, the patientâs point of view is the most important.
Trial Registration: TARGIT-A ISRCTN34086741, Registered 21 July 2004, retrospectively registered
Interventions to Promote Cancer Awareness and Early Presentation: Systematic Review
Low cancer awareness contributes to delay in presentation for cancer symptoms and may lead to delay in cancer diagnosis. The aim of this study was to review the evidence for the effectiveness of interventions to raise cancer awareness and promote early presentation in cancer to inform policy and future research. We searched bibliographic databases and reference lists for randomised controlled trials of interventions delivered to individuals, and controlled or uncontrolled studies of interventions delivered to communities. We found some evidence that interventions delivered to individuals modestly increase cancer awareness in the short term and insufficient evidence that they promote early presentation. We found limited evidence that public education campaigns reduce stage at presentation of breast cancer, malignant melanoma and retinoblastoma
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