Nanoscale structuring of tungsten tip yields most coherent electron point-source

This report demonstrates the most spatially-coherent electron source ever reported. A coherence angle of 14.3 +/- 0.5 degrees was measured, indicating a virtual source size of 1.7 +/-0.6 Angstrom using an extraction voltage of 89.5 V. The nanotips under study were crafted using a spatially-confined, field-assisted nitrogen etch which removes material from the periphery of the tip apex resulting in a sharp, tungsten-nitride stabilized, high-aspect ratio source. The coherence properties are deduced from holographic measurements in a low-energy electron point source microscope with a carbon nanotube bundle as sample. Using the virtual source size and emission current the brightness normalized to 100 kV is found to be 7.9x10^8 A/sr cm^2

Use of electronic medical records (EMR) for oncology outcomes research: assessing the comparability of EMR information to patient registry and health claims data

Electronic medical records (EMRs) are used increasingly for research in clinical oncology, epidemiology, and comparative effectiveness research (CER)

Towards a Conceptual Model and Reasoning Structure for Insider Threat Detection

The insider threat faced by corporations and governments today is a real and significant problem, and one that has become increasingly difficult to combat as the years have progressed. From a technology standpoint, traditional protective measures such as intrusion detection systems are largely inadequate given the nature of the ‘insider’ and their legitimate access to prized organisational data and assets. As a result, it is necessary to research and develop more sophisticated approaches for the accurate recognition, detection and response to insider threats. One way in which this may be achieved is by understanding the complete picture of why an insider may initiate an attack, and the indicative elements along the attack chain. This includes the use of behavioural and psychological observations about a potential malicious insider in addition to technological monitoring and profiling techniques. In this paper, we propose a framework for modelling the insider-threat problem that goes beyond traditional technological observations and incorporates a more complete view of insider threats, common precursors, and human actions and behaviours. We present a conceptual model for insider threat and a reasoning structure that allows an analyst to make or draw hypotheses regarding a potential insider threat based on measurable states from real-world observations

Understanding Insider Threat: A Framework for Characterising Attacks

The threat that insiders pose to businesses, institutions and governmental organisations continues to be of serious concern. Recent industry surveys and academic literature provide unequivocal evidence to support the significance of this threat and its prevalence. Despite this, however, there is still no unifying framework to fully characterise insider attacks and to facilitate an understanding of the problem, its many components and how they all fit together. In this paper, we focus on this challenge and put forward a grounded framework for understanding and reflecting on the threat that insiders pose. Specifically, we propose a novel conceptualisation that is heavily grounded in insider-threat case studies, existing literature and relevant psychological theory. The framework identifies several key elements within the problem space, concentrating not only on noteworthy events and indicators- technical and behavioural- of potential attacks, but also on attackers (e.g., the motivation behind malicious threats and the human factors related to unintentional ones), and on the range of attacks being witnessed. The real value of our framework is in its emphasis on bringing together and defining clearly the various aspects of insider threat, all based on real-world cases and pertinent literature. This can therefore act as a platform for general understanding of the threat, and also for reflection, modelling past attacks and looking for useful patterns

Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure

Background: The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. Methods: We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. Results: During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P=0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro–B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. Conclusions: Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329. opens in new tab; EudraCT number, 2016-002299-28. opens in new tab.

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Using Internet Activity Profiling for Insider-Threat Detection

The insider-threat problem continues to be a major risk to both public and private sectors, where those people who have privileged knowledge and access choose to abuse this in some way to cause harm towards their organisation. To combat against this, organisations are beginning to invest heavily in deterrence monitoring tools to observe employees activity, such as computer access, Internet browsing, and email communications. Whilst such tools may provide some way towards detecting attacks afterwards, what may be more useful is preventative monitoring, where user characteristics and behaviours inform about the possibility of an attack before it happens. Psychological research advocates that the behaviour and preference of a person can be explained to a great extent by psychological constructs called personality traits, which could then possibly indicate the likelihood of an individual being a potential insider threat. By considering how browsing content relates to psychological constructs (such as OCEAN), and how an individualâ??s browsing behaviour deviates over time, potential insider-threats could be uncovered before significant damage is caused. The main contribution in this paper is to explore how Internet browsing activity could be used to predict the individualâ??s psychological characteristics in order to detect potential insider-threats. Our results demonstrate that predictive assessment can be made between the content available on a website, and the associated personality traits, which could greatly improve the prospects of preventing insider attacks