Black Women’s Perceptions of K-12 Experiences that Influenced their Preparation for College

This critical phenomenological inquiry explored the college preparation experiences of ten high-ability, Black, women who grew up in poverty to identify influences from various family, school, and community environments contributing to their college readiness. I used a conceptual framework informed by both Kimberlé Crenshaw’s (1991) intersectionality and Urie Bronfenbrenner’s (1979) ecological systems theory to frame this study and critically examine their responses. This specific paper reports 5 of the 9 themes that yielded from the inquiry: (1) prophetic excellence: family and friends support and expectations; (2) it takes a village: community culture and resources; (3) from chaperone to mentor: exploring the depth of K-12 academic relationships and experiences; (4) preparing for a home away from home: college exploration and preparation; (5) demystifying the process: I don\u27t know what I do or don\u27t need to know. Implications for anti-racist perspectives to inform the practices of counselor educators, school counselors, and school communities are discussed

Cross-Cultural Supervision: Racial/Ethnic Minority Supervisees\u27 Perspectives

Examining the clinical supervision experiences of minority supervisees with different backgrounds than their White supervisors is essential. Weak supervisory relationships can adversely affect a supervisee’s professional competency, which in turn can negatively influence the client. This study explored the experiences of ten Racial/ethnic minority supervisees in a cross-cultural supervision setting. Using consensual qualitative research (CQR), three domains emerged: (a) cultural sensitivity, (b) cultural competency, and (c) relationship building. The outcome of this study highlights the types of training in counselor education that supervisors should consider when working with supervisees from different cultural backgrounds

Preparing Doctoral Students to Succeed in Counselor Education Programs

Although many doctoral students in counselor education (CE) programs successfully complete their programs and obtain a doctoral degree, some students drop out for a variety of reasons (Protivnak & Foss, 2009). Given the negative consequences that accompany doctoral student attrition for non-completers and their university (Willis & Carmichael, 2011), scholars have begun to explore students’ experiences in CE doctoral programs (Hoskins & Goldberg, 2005; Protivnak & Foss, 2009). Despite the growing body of literature on students’ program experiences in CE doctoral programs, in general, little emphasis has been placed on how programs prepare students for success. In particular, to date, the literature related to how CE-sponsored programming orients students for doctoral training in CE is largely unknown. Such knowledge has the potential to shed light on student attrition and retention and further professional development issues in students. As such, this study aimed to fill this void by exploring aspects of CE doctoral student orientations and students’ perceptions of the degree to which these orientations met their needs

Cross-Cultural Supervision: Racial/Ethnic Minority Supervisees’ Perspectives

Examining the clinical supervision experiences of minority supervisees with different backgrounds than their White supervisors is essential. Weak supervisory relationships can adversely affect a supervisee’s professional competency, which in turn can negatively influence the client. This study explored the experiences of ten Racial/ethnic minority supervisees in a cross-cultural supervision setting. Using consensual qualitative research (CQR), three domains emerged: (a) cultural sensitivity, (b) cultural competency, and (c) relationship building. The outcome of this study highlights the types of training in counselor education that supervisors should consider when working with supervisees from different cultural backgrounds

The Human Phenotype Ontology in 2024: phenotypes around the world.

The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs

Final results of EFC6663: a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia.

Early phase studies of alvocidib showed activity in relapsed CLL including patients with high risk genomic features and those refractory to fludarabine. A multi-center, international, phase II study of alvocidib in fludarabine refractory CLL was undertaken to validate these early results. Patients with fludarabine refractory CLL or prolymphocytic leukemia arising from CLL were treated with single agent alvocidib. The primary outcome measure was overall response rate, with secondary outcomes including survival, toxicity, and response duration. One hundred and sixty five patients were enrolled and 159 patients were treated. The median age was 61 years, the median number of prior therapies was 4, and 96% of patients were fludarabine refractory. The investigator-assessed overall response rate was 25%; the majority of responses were partial. Response rates were lower among patients with del(17p) (14%), but equivalent in patients with del(11q) or bulky lymphadenopathy. Median progression free and overall survival were 7.6 and 14.6 months, respectively. Tumor lysis occurred in 39 patients (25%), and 13 received hemodialysis. Diarrhea, fatigue, and hematologic toxicities were common. Alvocidib has clinical activity in patients with advanced, fludarabine refractory CLL. Future studies should focus on discovery of biomarkers of clinical response and tumor lysis, and enhanced supportive care measures

Single-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis.

Funder: ADA Science & Research Institute (Volpe Research Scholar Award), Chan Zuckerberg Initiative (Pediatric Networks for the Human Cell Atlas), American Academy of Implant Dentistry Foundation (Large Research Grant)Periodontitis affects billions of people worldwide. To address relationships of periodontal niche cell types and microbes in periodontitis, we generated an integrated single-cell RNA sequencing (scRNAseq) atlas of human periodontium (34-sample, 105918-cell), including sulcular and junctional keratinocytes (SK/JKs). SK/JKs displayed altered differentiation states and were enriched for effector cytokines in periodontitis. Single-cell metagenomics revealed 37 bacterial species with cell-specific tropism. Fluorescence in situ hybridization detected intracellular 16 S and mRNA signals of multiple species and correlated with SK/JK proinflammatory phenotypes in situ. Cell-cell communication analysis predicted keratinocyte-specific innate and adaptive immune interactions. Highly multiplexed immunofluorescence (33-antibody) revealed peri-epithelial immune foci, with innate cells often spatially constrained around JKs. Spatial phenotyping revealed immunosuppressed JK-microniches and SK-localized tertiary lymphoid structures in periodontitis. Here, we demonstrate impacts on and predicted interactomics of SK and JK cells in health and periodontitis, which requires further investigation to support precision periodontal interventions in states of chronic inflammation