Influence of spin fluctuations near the Mott transition: a DMFT study

Dynamics of magnetic moments near the Mott metal-insulator transition is investigated by a combined slave-rotor and Dynamical Mean-Field Theory solution of the Hubbard model with additional fully-frustrated random Heisenberg couplings. In the paramagnetic Mott state, the spinon decomposition allows to generate a Sachdev-Ye spin liquid in place of the collection of independent local moments that typically occurs in the absence of magnetic correlations. Cooling down into the spin-liquid phase, the onset of deviations from pure Curie behavior in the spin susceptibility is found to be correlated to the temperature scale at which the Mott transition lines experience a marked bending. We also demonstrate a weakening of the effective exchange energy upon approaching the Mott boundary from the Heisenberg limit, due to quantum fluctuations associated to zero and doubly occupied sites.Comment: 6 pages, 3 figures. V3 was largely expande

Trend analysis and variability of satellite-based soil moisture data for the Lower Bhavani basin, Tamil Nadu using Google Earth Engine

Soil moisture is a significant hydrological component that is dynamic in nature. The variation in soil moisture in the basin scale would affect the vegetation, ecology and environment. Soil moisture trend analysis aids in providing the variation of soil moisture over the basin. The present study aimed to analyse the soil moisture trend in Lower Bhavani basin, Tamil Nadu from 2003-2022. Satellite-based soil moisture Global Land Data Assimilation System (GLDAS) data was extracted from the Google Earth Engine (GEE) platform to analyse the variation and trend over the period of time. The highest and lowest soil moisture was observed during monsoon and summer months and its percentage variation was studied. Using Man-Kendall test and Sen’s slope, trend analysis was calculated for two decades (2003-2012 and 2013-2022). In 2003-2012, an increasing trend of soil moisture was observed during winter (October to February); from 2013-2022, an increasing trend was observed during both winter (October to February) and monsoon seasons (June to September). The remaining season did not follow any trend, and there was no decreasing trend in soil moisture. The trend analysis of the study will help to monitor and manage the environmental system across the Lower Bhavani basin

An Investigation into Cell Suspension Parameters of Moringa

The abstract presents an investigation into cell suspension parameters of Moringa, focusing on optimizing growth conditions for enhanced cell culture. Moringa, known for its nutritional and medicinal value, holds potential for various applications. This study delves into the effects of key parameters including growth media composition, pH levels, temperature, agitation, and inoculum density on cell suspension cultures of Moringa. Through systematic experimentation and analysis, the research identifies optimal conditions that promote cell growth, metabolite production, and biomass accumulation. The findings shed light on the intricate interplay between these parameters and their impact on cellular behavior. Furthermore, the study contributes to the broader understanding of plant cell suspension systems and their potential applications in biotechnology, pharmaceuticals, and agriculture. The insights gained from this investigation pave the way for scalable and sustainable cultivation of Moringa cells, fostering advancements in diverse sectors reliant on this remarkable plan

Coordination of Tissue Cell Polarity by Auxin Transport and Signaling

Plants coordinate the polarity of hundreds of cells during vein formation, but how they do so is unclear. The prevailing hypothesis proposes that GNOM, a regulator of membrane trafficking, positions PIN-FORMED auxin transporters to the correct side of the plasma membrane; the resulting cell-to-cell, polar transport of auxin would coordinate tissue cell polarity and induce vein formation. Contrary to predictions of the hypothesis, we find that vein formation occurs in the absence of PIN-FORMED or any other intercellular auxin-transporter; that the residual auxin-transport-independent vein-patterning activity relies on auxin signaling; and that a GNOM-dependent signal acts upstream of both auxin transport and signaling to coordinate tissue cell polarity and induce vein formation. Our results reveal synergism between auxin transport and signaling, and their unsuspected control by GNOM in the coordination of tissue cell polarity during vein patterning, one of the most informative expressions of tissue cell polarization in plants

NEERKURI BY SAGE THERAIYAR - A REVIEW ON SIDDHA WAY OF URINE EXAMINATION IN THE LIGHT OF CONTEMPORARY CLINICAL METHODS

The Siddha system is said to have emerged in antiquity, from the highly evolved consciousness of the Siddhars. The clarified intellect and heightened intuition of Sage Theraiyar, resulting from Yogic powers, enabled to expound to the world the signs of a disease in the Urine of a person in his treatise “Theraiyar Neerkuri Vaithyam†a book that details urine examination findings for diagnostic and prognostic purposes. The present paper deals with scientific validation of Neerkuri (urine examination), an important diagnostic tool in Siddha system of medicine. The methodology of diagnosis in Siddha system is based on eight fold examination of pulse, tactile perception, tongue, color and complexion, speech, eyes, stools and urine. Of all these parameters, Urine examination has gained paramount importance next to pulse examination. This paper parallels analyses the signs of urine examination between a few quotes from Sage Theraiyar text and modern text. This is an attempt to understand the Siddha system of diagnosing pathological conditions which are a non-invasive, highly cost effective procedure which can be used for both diagnostic and prognostic purposes

Cyclostationary Algorithm for Signal Analysis in Cognitive 4G Networks with Spectral Sensing and Resource Allocation

Cognitive Radio (CR) effectively involved in the management of spectrum to perform improved data transmission. CR system actively engaged in the data sensing, learning and dynamic adjustment of radio spectrum parameters with management of unused spectrum in the signal. The spectrum sensing is indispensable in the CR for the management of Primary Users (PUs) and Secondary users (SUs) without any interference. Spectrum sensing is considered as the effective adaptive signal processing model to evaluate the computational complexity model for the signal transmission through Matched filtering, Waveform and Cyclostationary based Energy sensing model. Cyclostationary based model is effective for the energy based sensing model based on unique characteristics with estimation of available channel in the spectrum to extract the received signal in the PU signal. Cyclostationary based model uses the spectrum availability without any periodic property to extract the noise features. This paper developed a Adaptive Cross Score Cyclostationary (ACSCS) to evaluate the spectrum sensing in the CR network. The developed ACSCS model uses the computational complexity with estimation of Signal-to-Interference-and-Noise Ratio (SINR) elimination of cost function. ACSCS model uses the Adaptive Least square Spectral Self-Coherence Restoral (SCORE) with the Adaptive Cross Score (ACS) to overcome the issues in CR. With the derived ACSCS algorithm minimizes the computational complexity based on cost function compared with the ACS algorithm. To minimize the computational complexity pipeline triangular array based Gram-Schmidt Orthogonalization (GSO) structure for the optimization of network. The simulation performance analysis with the ACSCS scheme uses the Rician Multipath Fading channel to estimate detection probability to sense the Receiver Operating Characteristics, detection probability and probability of false alarm using Maximum Likelihood (ML) detector. The ACSC model uses the Square-law combining (SLC) with the moment generation function in the multipath fading channel for the channel sensing with reduced computational complexity. The simulation analysis expressed that ACSC scheme achieves the maximal detection probability value of 1. The analysis expressed that proposed ACSC scheme achieves the improved channel estimation in the 4G communication environment

Bandwidth allocation in cooperative wireless networks: Buffer load analysis and fairness evaluation.

In modern cooperative wireless networks, the resource allocation is an issue of major significance. The cooperation of source and relay nodes in wireless networks towards improved performance and robustness requires the application of an efficient bandwidth sharing policy. Moreover, user requirements for multimedia content over wireless links necessitate the support of advanced Quality of Service (QoS) features. In this paper, a novel bandwidth allocation technique for cooperative wireless networks is proposed, which is able to satisfy the increased QoS requirements of network users taking into account both traffic priority and packet buffer load. The performance of the proposed scheme is examined by analyzing the impact of buffer load on bandwidth allocation. Moreover, fairness performance in resource sharing is also studied. The results obtained for the cooperative network scenario employed, are validated by simulations. Evidently, the improved performance achieved by the proposed technique indicates that it can be employed for efficient traffic differentiation. The flexible design architecture of the proposed technique indicates its capability to be integrated into Medium Access Control (MAC) protocols for cooperative wireless networks

Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

BACKGROUND: Few data exist on the comparative safety and immunogenicity of different COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of booster vaccines, we investigated the reactogenicity and immunogenicity of seven different COVID-19 vaccines as a third dose after two doses of ChAdOx1 nCov-19 (Oxford-AstraZeneca; hereafter referred to as ChAd) or BNT162b2 (Pfizer-BioNtech, hearafter referred to as BNT). METHODS: COV-BOOST is a multicentre, randomised, controlled, phase 2 trial of third dose booster vaccination against COVID-19. Participants were aged older than 30 years, and were at least 70 days post two doses of ChAd or at least 84 days post two doses of BNT primary COVID-19 immunisation course, with no history of laboratory-confirmed SARS-CoV-2 infection. 18 sites were split into three groups (A, B, and C). Within each site group (A, B, or C), participants were randomly assigned to an experimental vaccine or control. Group A received NVX-CoV2373 (Novavax; hereafter referred to as NVX), a half dose of NVX, ChAd, or quadrivalent meningococcal conjugate vaccine (MenACWY) control (1:1:1:1). Group B received BNT, VLA2001 (Valneva; hereafter referred to as VLA), a half dose of VLA, Ad26.COV2.S (Janssen; hereafter referred to as Ad26) or MenACWY (1:1:1:1:1). Group C received mRNA1273 (Moderna; hereafter referred to as m1273), CVnCov (CureVac; hereafter referred to as CVn), a half dose of BNT, or MenACWY (1:1:1:1). Participants and all investigatory staff were blinded to treatment allocation. Coprimary outcomes were safety and reactogenicity and immunogenicity of anti-spike IgG measured by ELISA. The primary analysis for immunogenicity was on a modified intention-to-treat basis; safety and reactogenicity were assessed in the intention-to-treat population. Secondary outcomes included assessment of viral neutralisation and cellular responses. This trial is registered with ISRCTN, number 73765130. FINDINGS: Between June 1 and June 30, 2021, 3498 people were screened. 2878 participants met eligibility criteria and received COVID-19 vaccine or control. The median ages of ChAd/ChAd-primed participants were 53 years (IQR 44-61) in the younger age group and 76 years (73-78) in the older age group. In the BNT/BNT-primed participants, the median ages were 51 years (41-59) in the younger age group and 78 years (75-82) in the older age group. In the ChAd/ChAD-primed group, 676 (46·7%) participants were female and 1380 (95·4%) were White, and in the BNT/BNT-primed group 770 (53·6%) participants were female and 1321 (91·9%) were White. Three vaccines showed overall increased reactogenicity: m1273 after ChAd/ChAd or BNT/BNT; and ChAd and Ad26 after BNT/BNT. For ChAd/ChAd-primed individuals, spike IgG geometric mean ratios (GMRs) between study vaccines and controls ranged from 1·8 (99% CI 1·5-2·3) in the half VLA group to 32·3 (24·8-42·0) in the m1273 group. GMRs for wild-type cellular responses compared with controls ranged from 1·1 (95% CI 0·7-1·6) for ChAd to 3·6 (2·4-5·5) for m1273. For BNT/BNT-primed individuals, spike IgG GMRs ranged from 1·3 (99% CI 1·0-1·5) in the half VLA group to 11·5 (9·4-14·1) in the m1273 group. GMRs for wild-type cellular responses compared with controls ranged from 1·0 (95% CI 0·7-1·6) for half VLA to 4·7 (3·1-7·1) for m1273. The results were similar between those aged 30-69 years and those aged 70 years and older. Fatigue and pain were the most common solicited local and systemic adverse events, experienced more in people aged 30-69 years than those aged 70 years or older. Serious adverse events were uncommon, similar in active vaccine and control groups. In total, there were 24 serious adverse events: five in the control group (two in control group A, three in control group B, and zero in control group C), two in Ad26, five in VLA, one in VLA-half, one in BNT, two in BNT-half, two in ChAd, one in CVn, two in NVX, two in NVX-half, and one in m1273. INTERPRETATION: All study vaccines boosted antibody and neutralising responses after ChAd/ChAd initial course and all except one after BNT/BNT, with no safety concerns. Substantial differences in humoral and cellular responses, and vaccine availability will influence policy choices for booster vaccination. FUNDING: UK Vaccine Taskforce and National Institute for Health Research

Persistence of immune responses after heterologous and homologous third COVID-19 vaccine dose schedules in the UK: eight-month analyses of the COV-BOOST trial

Background: COV-BOOST is a multicentre, randomised, controlled, phase 2 trial of seven COVID-19 vaccines used as a third booster dose in June 2021. Monovalent messenger RNA (mRNA) COVID-19 vaccines were subsequently widely used for the third and fourth-dose vaccination campaigns in high-income countries. Real-world vaccine effectiveness against symptomatic infections following third doses declined during the Omicron wave. This report compares the immunogenicity and kinetics of responses to third doses of vaccines from day (D) 28 to D242 following third doses in seven study arms. Methods: The trial initially included ten experimental vaccine arms (seven full-dose, three half-dose) delivered at three groups of six sites. Participants in each site group were randomised to three or four experimental vaccines, or MenACWY control. The trial was stratified such that half of participants had previously received two primary doses of ChAdOx1 nCov-19 (Oxford–AstraZeneca; hereafter referred to as ChAd) and half had received two doses of BNT162b2 (Pfizer–BioNtech, hereafter referred to as BNT). The D242 follow-up was done in seven arms (five full-dose, two half-dose). The BNT vaccine was used as the reference as it was the most commonly deployed third-dose vaccine in clinical practice in high-income countries. The primary analysis was conducted using all randomised and baseline seronegative participants who were SARS-CoV-2 naïve during the study and who had not received a further COVID-19 vaccine for any reason since third dose randomisation. Results: Among the 817 participants included in this report, the median age was 72 years (IQR: 55–78) with 50.7% being female. The decay rates of anti-spike IgG between vaccines are different among both populations who received initial doses of ChAd/ChAd and BNT/BNT. In the population that previously received ChAd/ChAd, mRNA vaccines had the highest titre at D242 following their vaccine dose although Ad26. COV2. S (Janssen; hereafter referred to as Ad26) showed slower decay. For people who received BNT/BNT as their initial doses, a slower decay was also seen in the Ad26 and ChAd arms. The anti-spike IgG became significantly higher in the Ad26 arm compared to the BNT arm as early as 3 months following vaccination. Similar decay rates were seen between BNT and half-BNT; the geometric mean ratios ranged from 0.76 to 0.94 at different time points. The difference in decay rates between vaccines was similar for wild-type live virus-neutralising antibodies and that seen for anti-spike IgG. For cellular responses, the persistence was similar between study arms. Conclusions: Heterologous third doses with viral vector vaccines following two doses of mRNA achieve more durable humoral responses compared with three doses of mRNA vaccines. Lower doses of mRNA vaccines could be considered for future booster campaigns