Community-based exercise and physical activity programmes led by exercise professionals for osteoarthritis

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:. To assess the benefits and harms of community-based exercise and physical activity programmes led by non-healthcare exercise professionals for osteoarthritis, compared to those delivered by healthcare professionals, self-directed interventions, home-based programmes or continued general practitioner (GP) care

Habitat preferences and functional traits drive longevity in Himalayan high-mountain plants

Plant lifespan has important evolutionary, physiological, and ecological implications related to population persistence, community stability, and resilience to ongoing environmental change impacts. Although biologists have long been puzzled over the extraordinary variation in plant lifespan and its causes, our understanding of interspecific variability in plant lifespan and the key internal and external factors influencing longevity remains limited. Here, we demonstrate the concurrent impacts of environmental, morphological, physiological, and anatomical constraints on interspecific variation in longevity among > 300 vascular dicot plant species naturally occurring at an elevation gradient (2800–6150 m) in the western Himalayas. First, we show that plant longevity (ranging from 1 to 100 years) is largely related to species' habitat preferences. Ecologically stressful habitats such as alpine and subnival host long-lived species, while productive ruderal and wetland habitats contain a higher proportion of shorter-lived species. Second, longevity is influenced by growth form with monocarpic forbs having the shortest lifespan and woody shrubs having the highest. Small-statured cushion plants with compact canopies and deep roots, most found on cold and infertile alpine and subnival soils, had a higher chance of achieving longevity. Third, plant traits reflecting plant adaptations to stress and disturbance affect interspecific differences in plant longevity. We show that longevity and growth are negatively correlated. Slow-growing species are those that have a higher chance of reaching a high age. Finally, higher longevity was associated with high leaf carbon and phosphorus, low root phosphorus and nitrogen, and with large bark-xylem ratio. Our findings suggest that plant longevity in high elevation is intricately determined by a combination of habitat preferences and growth form, as well as the plant growth rate and physiological processes.publishedVersio

The Iterative Signature Algorithm for the analysis of large scale gene expression data

We present a new approach for the analysis of genome-wide expression data. Our method is designed to overcome the limitations of traditional techniques, when applied to large-scale data. Rather than alloting each gene to a single cluster, we assign both genes and conditions to context-dependent and potentially overlapping transcription modules. We provide a rigorous definition of a transcription module as the object to be retrieved from the expression data. An efficient algorithm, that searches for the modules encoded in the data by iteratively refining sets of genes and conditions until they match this definition, is established. Each iteration involves a linear map, induced by the normalized expression matrix, followed by the application of a threshold function. We argue that our method is in fact a generalization of Singular Value Decomposition, which corresponds to the special case where no threshold is applied. We show analytically that for noisy expression data our approach leads to better classification due to the implementation of the threshold. This result is confirmed by numerical analyses based on in-silico expression data. We discuss briefly results obtained by applying our algorithm to expression data from the yeast S. cerevisiae.Comment: Latex, 36 pages, 8 figure

Effectiveness of physiotherapy exercise following hip arthroplasty for osteoarthritis: a systematic review of clinical trials

Background: Physiotherapy has long been a routine component of patient rehabilitation following hip joint replacement. The purpose of this systematic review was to evaluate the effectiveness of physiotherapy exercise after discharge from hospital on function, walking, range of motion, quality of life and muscle strength, for osteoarthritic patients following elective primary total hip arthroplasty. Methods: Design: Systematic review, using the Cochrane Collaboration Handbook for Systematic Reviews of Interventions and the Quorom Statement. Database searches: AMED, CINAHL, EMBASE, KingsFund, MEDLINE, Cochrane library (Cochrane reviews, Cochrane Central Register of Controlled Trials, DARE), PEDro, The Department of Health National Research Register. Handsearches: Physiotherapy, Physical Therapy, Journal of Bone and Joint Surgery (Britain) Conference Proceedings. No language restrictions were applied. Selection: Trials comparing physiotherapy exercise versus usual/standard care, or comparing two types of relevant exercise physiotherapy, following discharge from hospital after elective primary total hip replacement for osteoarthritis were reviewed. Outcomes: Functional activities of daily living, walking, quality of life, muscle strength and range of hip joint motion. Trial quality was extensively evaluated. Narrative synthesis plus meta-analytic summaries were performed to summarise the data. Results: 8 trials were identified. Trial quality was mixed. Generally poor trial quality, quantity and diversity prevented explanatory meta-analyses. The results were synthesised and meta-analytic summaries were used where possible to provide a formal summary of results. Results indicate that physiotherapy exercise after discharge following total hip replacement has the potential to benefit patients. Conclusion: Insufficient evidence exists to establish the effectiveness of physiotherapy exercise following primary hip replacement for osteoarthritis. Further well designed trials are required to determine the value of post discharge exercise following this increasingly common surgical procedure