Containment - exploring the concept of agency in children’s statutory encounters with social workers

This article examines children’s agency in their interactions with social workers during statutory encounters in a child protection context. It draws from a UK wide ethnographic study. It finds that much of social workers’ responses to children’s agency in this context are best understood as a form of ‘containment’. In doing so, it offers an original and significant contribution to the theoretical understanding of children’s agency, as well as its application in social work practice

Effects of Persuasive Dialogues: Testing Bot Identities and Inquiry Strategies

Intelligent conversational agents, or chatbots, can take on various identities and are increasingly engaging in more human-centered conversations with persuasive goals. However, little is known about how identities and inquiry strategies influence the conversation's effectiveness. We conducted an online study involving 790 participants to be persuaded by a chatbot for charity donation. We designed a two by four factorial experiment (two chatbot identities and four inquiry strategies) where participants were randomly assigned to different conditions. Findings showed that the perceived identity of the chatbot had significant effects on the persuasion outcome (i.e., donation) and interpersonal perceptions (i.e., competence, confidence, warmth, and sincerity). Further, we identified interaction effects among perceived identities and inquiry strategies. We discuss the findings for theoretical and practical implications for developing ethical and effective persuasive chatbots. Our published data, codes, and analyses serve as the first step towards building competent ethical persuasive chatbots.Comment: 15 pages, 10 figures. Full paper to appear at ACM CHI 202

UroMark-a urinary biomarker assay for the detection of bladder cancer.

BACKGROUND: Bladder cancer (BC) is one of the most common cancers in the western world and ranks as the most expensive to manage, due to the need for cystoscopic examination. BC shows frequent changes in DNA methylation, and several studies have shown the potential utility of urinary biomarkers by detecting epigenetic alterations in voided urine. The aim of this study is to develop a targeted bisulfite next-generation sequencing assay to diagnose BC from urine with high sensitivity and specificity. RESULTS: We defined a 150 CpG loci biomarker panel from a cohort of 86 muscle-invasive bladder cancers and 30 normal urothelium. Based on this panel, we developed the UroMark assay, a next-generation bisulphite sequencing assay and analysis pipeline for the detection of bladder cancer from urinary sediment DNA. The 150 loci UroMark assay was validated in an independent cohort (n = 274, non-cancer (n = 167) and bladder cancer (n = 107)) voided urine samples with an AUC of 97%. The UroMark classifier sensitivity of 98%, specificity of 97% and NPV of 97% for the detection of primary BC was compared to non-BC urine. CONCLUSIONS: Epigenetic urinary biomarkers for detection of BC have the potential to revolutionise the management of this disease. In this proof of concept study, we show the development and utility of a novel high-throughput, next-generation sequencing-based biomarker for the detection of BC-specific epigenetic alterations in urine

Infant and child feeding practices: a preliminary investigation

The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.The objective of this preliminary investigation was to examine the feeding practices of infants and pre-school children in Adelaide, and thereby contribute to the development of appropriate preventive dental strategies. A stratified random sample of 160 two year old and three year old pre-school children in the Adelaide Statistical District was obtained. Information about feeding practices and use of comforters or ‘dummies’ was obtained through a self-administered questionnaire completed by parents of the selected children. Information was collected for the age periods of 0–3 months, 4–6 months, 7–12 months, 13–24 months and 25–36 months. Most of the children (81.8 per cent) were breast-fed at some stage. However the percentage of children being breast-fed decreased markedly across age periods, particularly to 13–24 months, when only 15.9 per cent of children were being breast-fed. Over half of the children had been bottle-fed with infant formula at some stage. The highest percentage of children being bottle-fed with infant formula occurred in the 4–6 months (42.6 per cent) closely followed by the 7–12 months age period (37.4 per cent). Nearly two-thirds of children were bottle-fed with cow's milk at some stage. The highest percentage of children being bottle-fed with cow's milk occurred in the 13–24 months age period (49.6 per cent). A quarter (24.5 per cent) of the children were put to bed at some stage with a bottle containing cariogenic fluids. The majority of children used a ‘dummy’ at some stage during both day-time and night-time. Parents are in need of advice on appropriate feeding patterns for infants and young children.Amjad H. Wyne,A. John Spencer and Fearnley S. Szuste

Impact of an Early Invasive Strategy versus Conservative Strategy for Unstable Angina and Non-ST Elevation Acute Coronary Syndrome in Patients with Chronic Kidney Disease: A Systematic Review.

BACKGROUND: Clinical practice guidelines support an early invasive approach after NSTE-ACS in patients with chronic kidney disease (CKD). There is no direct randomised controlled trial evidence in the CKD population, and whether the benefit of an early invasive approach is maintained across the spectrum of severity of CKD remains controversial. METHODS: We conducted a systematic review to evaluate the association between an early invasive approach and all-cause mortality in patients with CKD. We searched MEDLINE and EMBASE (1990-May 2015) and article reference lists. Data describing study design, participants, invasive management strategies, renal function, all-cause mortality and risk of bias were extracted. RESULTS: 3,861 potentially relevant studies were identified. Ten studies, representing data on 147,908 individuals with NSTE-ACS met the inclusion criteria. Qualitative heterogeneity in the definitions of early invasive approach, comparison groups and renal dysfunction existed. Meta-analysis of the RCT derived and observational data were generally supportive of an early invasive approach in CKD (RR0.76 (95% CI 0.49-1.17) and RR0.50 (95%CI 0.42-0.59) respectively). Meta-analysis of the observational studies demonstrated a large degree of heterogeneity (I2 79%) driven in part by study size and heterogeneity across various kidney function levels. CONCLUSIONS: The observational data support that an early invasive approach after NSTE-ACS confers a survival benefit in those with early-moderate CKD. Local opportunities for quality improvement should be sought. Those with severe CKD and the dialysis population are high risk and under-studied. Novel and inclusive approaches for CKD and dialysis patients in cardiovascular clinical trials are needed

Magnetospheres and Disk Accretion in Herbig Ae/Be Stars

We present evidence of magnetically-mediated disk accretion in Herbig Ae/Be stars. Magnetospheric accretion models of Balmer and sodium profiles calculated with appropriate stellar and rotational parameters are in qualitative agreement with the observed profiles of the Herbig Ae star UX Ori, and yield a mass accretion rate of ~ 10^{-8} Msun/yr. If more recent indications of an extremely large rotation rate for this object are correct, the magnetic field geometry must deviate from that of a standard dipole in order to produce line emission consistent with observed flux levels. Models of the associated accretion shock qualitatively explain the observed distribution of excess fluxes in the Balmer discontinuity for a large ensemble of Herbig Ae/Be stars, and imply typically small mass accretion rates, < 10^{-7} Msun/yr. In order for accretion to proceed onto the star, significant amounts of gas must exist inside the dust destruction radius, which is potentially problematic for recently advocated scenarios of "puffed" inner dust wall geometries. However, our models of the inner gas disk show that for the typical accretion rates we have derived, the gas should be generally optically thin, thus allowing direct stellar irradiation of the inner dust edge of the disk.Comment: 32 pages, 12 figures, accepted by Ap

Four Molecular Superconductors Isolated as Nanoparticles

(TMTSF)2PF6 and (TMTSF)2ClO4 Bechgaard salts, (BEDT‐TTF)2I3, and TTF[Ni(dmit)2]2 [TMTSF = tetramethyltetraselenafulvalene; BEDT‐TTF = bis(ethylenedithio)tetrathiafulvalene; TTF = tetrathiafulvalene; dmit = 1,3‐dithiole‐2‐thione‐4,5‐dithiolate] are among the most popular molecular superconductors. They are grown as nanoparticles that exhibit properties in agreement with those of the bulk. The shape, size, and homogeneity of particles depend on the stabilizing agent and synthesis conditions. We report on the more recent conditions investigated (i) to produce nanoparticles of 35 nm for β‐(BEDT‐TTF)2I3, (ii) to reduce the particle size to 10–15 nm for TTF[Ni(dmit)2]2 and 3–5 nm for (TMTSF)2ClO4, and (iii) to improve the growth duration from days to one hour for (TMTSF)2PF6. Finally, we report evidence of superconductivity in (TMTSF)2ClO4 particles

Spin density wave and superconducting properties of nanoparticle organic conductor assemblies

The magnetic susceptibilities of nanoparticle assemblies of two Bechgaard salts (TMTSF)2PF6 and (TMTSF)2ClO4, have been studied vs temperature and magnetic field. In the bulk these materials exhibit a spin density wave formation (TSDW=12K) and superconductivity (Tc=1.2K), respectively. We show from inductive (susceptibility) measurements that the nanoparticle assemblies exhibit ground-state phase transitions similar to those of randomly oriented polycrystalline samples of the parent materials. Resistivity and diamagnetic shielding measurements yield additional information on the functional nanoparticle structure in terms of stoichiometric and nonstoichiometric composition

A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells

Although the vital role of the androgen receptor (AR) has been well demonstrated in primary prostate cancers, its role in the androgen-insensitive prostate cancers still remains unclear. Here, we used a small hairpin RNA approach to directly assess AR activity in prostate cancer cells. Reduction of AR expression in the two androgen-sensitive prostate cancer cell lines, LNCaP and LAPC4, significantly decreased AR-mediated transcription and cell growth. Intriguingly, in two androgen-insensitive prostate cell lines, LNCaP-C42B4 and CWR22Rv1, knockdown of AR expression showed a more pronounced effect on AR-induced transcription and cell growth than androgen depletion. Using cDNA microarrays, we also compared the transcriptional profiles induced by either androgen depletion or AR knockdown. Although a significant number of transcripts appear to be regulated by both androgen depletion and AR knockdown, we observed a subset of transcripts affected only by androgen depletion but not by AR knockdown, and vice versa. Finally, we demonstrated a direct role for AR in promoting tumor formation and growth in a xenograft model. Taken together, our results elucidate an important role for the AR in androgen-insensitive prostate cancer cells, and suggest that AR can be used as a therapeutic target for androgen-insensitive prostate cancers