Influence of a knee brace intervention on perceived pain and patellofemoral loading in recreational athletes

Background: The current investigation aimed to investigate the effects of an intervention using knee bracing on pain symptoms and patellofemoral loading in male and female recreational athletes. Methods: Twenty participants (11 males & 9 females) with patellofemoral pain were provided with a knee brace which they wore for a period of 2 weeks. Lower extremity kinematics and patellofemoral loading were obtained during three sport specific tasks, jog, cut and single leg hop. In addition their self-reported knee pain scoreswere examined using the Knee injury and Osteoarthritis Outcome Score. Datawere collected before and after wearing the knee brace for 2 weeks. Findings: Significant reductions were found in the run and cut movements for peak patellofemoral force/pressure and in all movements for the peak knee abduction moment when wearing the brace. Significant improvements were also shown for Knee injury and Osteoarthritis Outcome Score subscale symptoms (pre: male= 70.27, female = 73.22 & post: male = 85.64, female = 82.44), pain (pre: male = 72.36, female = 78.89 & post: male = 85.73, female = 84.20), sport (pre: male = 60.18, female = 59.33 & post: male = 80.91, female =79.11), function and daily living (pre: male = 82.18, female = 86.00 & post: male = 88.91, female = 90.00) and quality of life (pre: male= 51.27, female= 54.89 & post: male= 69.36, female= 66.89). Interpretation:Male and female recreational athleteswho suffer frompatellofemoral pain can be advised to utilise knee bracing as a conservative method to reduce pain symptoms

Time Averaged Quantum Dynamics and the Validity of the Effective Hamiltonian Model

We develop a technique for finding the dynamical evolution in time of an averaged density matrix. The result is an equation of evolution that includes an Effective Hamiltonian, as well as decoherence terms in Lindblad form. Applying the general equation to harmonic Hamiltonians, we confirm a previous formula for the Effective Hamiltonian together with a new decoherence term which should in general be included, and whose vanishing provides the criteria for validity of the Effective Hamiltonian approach. Finally, we apply the theory to examples of the AC Stark Shift and Three- Level Raman Transitions, recovering a new decoherence effect in the latter.Comment: 7 pages, 2 figure

A high-resolution model of the external and induced magnetic field at the Earth’s surface in the northern hemisphere

We describe a method of producing high-resolution models of the Earth’s combined external and induced magnetic field (EIMF) using the method of Empirical Orthogonal Functions (EOFs) applied to the SuperMAG archive of ground-based magnetometer data. EOFs partition the variance of a system into independent modes, allowing us to extract the spatiotemporal patterns of greatest dynamical importance without applying the a priori assumptions of other methods (such as spherical harmonic analysis, parameterised averaging, or multi-variate regression). We develop an approach based on that of Beckers and Rixen [2003] and use the EOF modes to infill missing data in a self-consistent manner. Applying our method to a north polar case study spanning February 2001 (chosen for its proximity to solar maximum and good data coverage), we demonstrate that 41.7% and 9.4% of variance is explained by the leading two modes, respectively describing the temporal variations of the Disturbance Polar types 2 and 1 (DP2 and DP1) patterns. A further 14.1% of variance is explained by four modes that describe separate aspects of the motion of the DP1 and DP2 systems. Thus, collectively over 65% of variance is described by the leading 6 modes and is attributable to DP1 and DP2. This attribution is based on inspection of the spatial morphology of the modes, and analysis of the temporal variation of the mode amplitudes with respect to solar wind measures and substorm occurrence. This study is primarily a demonstration of the technique and a prelude to a model spanning the full solar cycle

Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy

Journal Article“The final publication is available at Springer via http://dx.doi.org/10.1007/s10103-012-1188-y"Methyl aminolevulinate photodynamic therapy (MAL-PDT) (a topical treatment used for a number of precancerous skin conditions) utilizes the combined interaction of a photosensitizer (protoporphyrin IX (PpIX)), light of the appropriate wavelength, and molecular oxygen to produce singlet oxygen and other reactive oxygen species which induce cell death. During treatment, localized oxygen depletion occurs and is thought to contribute to decreased efficacy. The aim of this study was to investigate whether an oxygen pressure injection (OPI) device had an effect on localized oxygen saturation levels and/or PpIX fluorescence of skin lesions during MAL-PDT. This study employed an OPI device to apply oxygen under pressure to the skin lesions of patients undergoing standard MAL-PDT. Optical reflectance spectrometry and fluorescence imaging were used to noninvasively monitor the localized oxygen saturation and PpIX fluorescence of the treatment area, respectively. No significant changes in oxygen saturation were observed when these data were combined for the group with OPI and compared to the group that received standard MAL-PDT without OPI. Additionally, no significant difference in PpIX photobleaching or clinical outcome at 3 months between the groups of patients was observed, although the group that received standard MAL-PDT demonstrated a significant increase (p < 0.05) in PpIX fluorescence initially and both groups produced a significant decrease (p < 0.05) after light irradiation. In conclusion, with this sample size, this OPI device was not found to be an effective method with which to improve tissue oxygenation during MAL-PDT. Further investigation is therefore required to find a more effective method of MAL-PDT enhancement. © 2012 Springer-Verlag London Ltd

The Neon Abundance in the Ejecta of QU Vul From Late-Epoch IR Spectra

We present ground-based SpectroCam-10 mid-infrared, MMT optical, and Spitzer Space Telescope IRS mid-infrared spectra taken 7.62, 18.75, and 19.38 years respectively after the outburst of the old classical nova QU Vulpeculae (Nova Vul 1984 #2). The spectra of the ejecta are dominated by forbidden line emission from neon and oxygen. Our analysis shows that neon was, at the first and last epochs respectively, more than 76 and 168 times overabundant by number with respect to hydrogen compared to the solar value. These high lower limits to the neon abundance confirm that QU Vul involved a thermonuclear runaway on an ONeMg white dwarf and approach the yields predicted by models of the nucleosynthesis in such events.Comment: ApJ 2007 accepted, 18 pages, including 5 figures, 1 tabl

New Promise for Electron Bulk Energization in Solar Flares: Preferential Fermi Acceleration of Electrons over Protons in Reconnection-driven Magnetohydrodynamic Turbulence

The hard X-ray luminosity of impulsive solar flares indicates that electrons in the low corona are bulk energized to energies of order 25 keV. LaRosa & Moore pointed out that the required bulk energization could be produced by cascading MHD turbulence generated by Alfvénic outflows from sites of strongly driven reconnection. LaRosa, Moore, & Shore proposed that the compressive component of the cascading turbulence dissipates into the electrons via Fermi acceleration. However, for this to be a viable electron bulk energization mechanism, the rate of proton energization by the same turbulence cannot exceed the electron energization rate. In this paper we estimate the relative efficiency of electron and proton Fermi acceleration in the compressive MHD turbulence expected in the reconnection outflows in impulsive solar flares. We find that the protons pose no threat to the electron energization. Particles extract energy from the MHD turbulence by mirroring on magnetic compressions moving along the magnetic field at the Alfvén speed. The mirroring rate, and hence the energization rate, is a sensitive function of the particle velocity distribution. In particular, there is a lower speed limit Vmin ≍ VA, below which the pitch-angle distribution of the particles is so highly collapsed to the magnetic field in the frame of the magnetic compressions that there is no mirroring and hence no Fermi acceleration. For coronal conditions, the proton thermal speed is much less than the Alfvén speed and proton Fermi acceleration is negligible. In contrast, nearly all of the electrons are super-Alfvénic, so their pitch-angle distribution is nearly isotropic in the frame of the magnetic compressions. Consequently, the electrons are so vigorously mirrored that they are Fermi accelerated to hard X-ray energies in a few tenths of a second by the magnetic compressions on scales of 105-103 cm in the cascading MHD turbulence. We conclude that dissipation of reconnection-generated MHD turbulence by electron Fermi acceleration plausibly accounts for the electron bulk energization in solar flares

Measurement master equation

We derive a master equation describing the evolution of a quantum system subjected to a sequence of observations. These measurements occur randomly at a given rate and can be of a very general form. As an example, we analyse the effects of these measurements on the evolution of a two-level atom driven by an electromagnetic field. For the associated quantum trajectories we find Rabi oscillations, Zeno-effect type behaviour and random telegraph evolution spawned by mini quantum jumps as we change the rates and strengths of measurement.Comment: 14 pages and 8 figures, Optics Communications in pres

A prospective adaptive utility trial to validate performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer in patients with prostate-specific antigen 2-10ng/ml at initial biopsy

BACKGROUND: Discriminating indolent from clinically significant prostate cancer (PCa) in the initial biopsy setting remains an important issue. Prospectively evaluated diagnostic assays are necessary to ensure efficacy and clinical adoption. OBJECTIVE: Performance and utility assessment of ExoDx Prostate (IntelliScore) (EPI) urine exosome gene expression assay versus standard clinical parameters for discriminating Grade Group (GG) ≥2 PCa from GG1 PCa and benign disease on initial biopsy. DESIGN, SETTING, AND PARTICIPANTS: A two-phase adaptive clinical utility study (NCT03031418) comparing EPI results with biopsy outcomes in men, with age ≥50 yr and prostate-specific antigen (PSA) 2-10ng/ml, scheduled for initial prostate biopsy. After EPI performance assessment during phase I, a clinical implementation document (ie, CarePath) was developed for utilizing the EPI test in phase II, where the biopsy decision is uncertain. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Performance evaluation of the EPI test in patients enrolled in phase I and publication of a consensus CarePath for phase II. RESULTS AND LIMITATIONS: In a total of 503 patients, with median age of 64 yr, median PSA 5.4ng/ml, 14% African American, 70% Caucasian, 53% positive biopsy rate (22% GG1, 17% GG2, and 15% ≥ GG3), EPI was superior to an optimized model of standard clinical parameters with an area under the curve (AUC) 0.70 versus 0.62, respectively, comparable with previously published results (n=519 patients, EPI AUC 0.71). Validated cut-point 15.6 would avoid 26% of unnecessary prostate biopsies and 20% of total biopsies, with negative predictive value (NPV) 89% and missing 7% of ≥GG2 PCa. Alternative cut-point 20 would avoid 40% of unnecessary biopsies and 31% of total biopsies, with NPV 89% and missing 11% of ≥GG2 PCa. The clinical investigators reached consensus recommending use of the 15.6 cut-point for phase II. Outcome of the decision impact cohort in phase II will be reported separately. CONCLUSIONS: EPI is a noninvasive, easy-to-use, gene expression urine assay, which has now been successfully validated in over 1000 patients across two prospective validation trials to stratify risk of ≥GG2 from GG1 cancer and benign disease. The test improves identification of patients with higher grade disease and would reduce the total number of unnecessary biopsies. PATIENT SUMMARY: It is challenging to predict which men are likely to have high-grade prostate cancer (PCa) at initial biopsy with prostate-specific antigen 2-10ng/ml. This study further demonstrates that the ExoDx Prostate (IntelliScore) test can predict ≥GG2 PCa at initial biopsy and defer unnecessary biopsies better than existing risk calculator\u27s and standard clinical data

Determining the ideal mattress firmness based on anthropometric measurements

Introduction: Mattresses need to provide enough support to keep spinal alignment close to a neutral posture, whilst minimising muscle activity and providing optimum pressure relief. There is limited evidence to sug­gest that a 'one size fits all' mattress provides the appropriate support for individuals with diverse body shapes, so a greater understanding of how different mattresses affect the human body is key. By having a more objective approach to choosing a mattress an individual may have an improved quality of sleep. Materials and methods: A ten-camera infrared movement analysis sys­tem recorded the movement of retro-reflective markers placed on the Upper-Mid Thoracic, Mid-Lower Thoracic, Lower Thoracic-Upper Lumbar, Upper-Lower Lumbar and Lower Lumbar-Pelvic areas of the spine. A static image of the spine was taken in a standing position and was used to define each individual's neutral posture. Deviations away from this neutral po­sition were assessed under three different conditions in side lying. Three visually identical mattresses were tested, internally each mattress con­tained a different firmness of spring unit (soft, medium, firm) with an identical gel foam comfort layer. In addition, height, weight, shoulder width and hip circumference measurements were taken to determine differences in body types. Results: Spinal alignment was assessed on 59 healthy participants and no significant differences were seen between the different mattress config­urations. However, further analysis showed significant differences in spi­nal alignment between the different mattress conditions within different body shape subgroups. Subgroups were defined using body weight, height, BMI, shoulder width and hip circumference. Those with a higher body weight had a more neutral spinal alignment when on a firmer mattress, whereas those with a lower body weight were better suited to a softer mattress. Shorter people were better aligned on a softer mattress, and a medium mattress kept the spine in a more neutral position amongst taller people. There were no differentiating factors between shoulder width or BMI groups. However, those with a larger hip circumference had signifi­cantly greater spinal deviations when on a softer mattress. implying that a softer mattress should be avoided by this subgroup. Conclusions: This study suggests that a ·one size fits all' approach to mattresses may not be appropriate. Contrasting body types need different levels of support to improve overall spinal alignment, allowing the inter­vertebral disc to re-hydrate, and spinal muscles to relax throughout the night. The use of simple anthropometric measurements could make the selection of the most appropriate mattress easier for the general public. Acknowledgements: This is part of an Innovate UK Knowledge Transfer Partnership between the University of Central Lancashire and Silentnight Group Ltd