What the Upper Atmospheres of Giant Planets Reveal

The upper atmospheres of the Giant Planets, Jupiter, Saturn, Uranus and Neptune are transition regions between meteorological layers and outer space. As a result of their exceptionally rarefied nature, they are highly sensitive and therefore revealing probes of the forcing exerted both from above and below. This review provides an overview of these upper atmospheres and the major processes that take place within them, including their powerful auroras, the giant planet ‘energy crisis’ and the decay of Saturn’s rings into the planet. We discuss the many remote-sensing tools that have been used to understand them, for example, large ground-based observatories such as the Keck telescope, space-based observatories such as the Hubble Space Telescope and orbiters such as the Cassini spacecraft. Looking into the future, we discuss the possibilities afforded by the latest and next generation of observatories and space missions, such as the James Webb Space Telescope

Putting willpower into decision theory: the person as a team over time and intrapersonal team reasoning

In decision-theory, problems of self-control can be modelled as problems of intrapersonal cooperation, between a series of transient agents who each make choices at particular times. Early agents in the series can try to influence the actions of later agents, but there is no rational way to exert willpower. I show how willpower can be introduced into decision theory by applying the theory of team reasoning, which was originally developed to understand cooperation between individuals in groups and allows that there can be multiple levels of agency, the individual and the team. In the case of intertemporal choice, the levels are the transient agent and the person over time. Intra-personal team reasoning, understood as a psychological process of identifying with the person over time, can generate a plausible theory of rational control if the intertemporal problem is structured as a threshold public goods game. In this framework, willpower is the ability to align one’s present self with one’s extended interests by identifying with the person over time. I show how intra-personal team reasoning creates a space for resolutions in decision theory and how it resolves a puzzle that exists in accounts that understand willpower as making and then not reconsidering resolutions

Measuring GHG Emissions Across the Agri‐Food Sector Value Chain: The Development of a Bioeconomy Input‐Output Model

Increasing food production to meet rising global demand while minimising negative environmental impacts such as agricultural greenhouse gas (GHG) emissions is one of the greatest challenges facing the agri‐food sector. Sustainable food production relates not only to primary production, but also has wider value chain implications. Aninput‐output (IO) model is a modelling framework which contains information on the flow of goods and services across a value chain at a regional or national economy level. This paper provides a detailed description of the development of a Bioeconomy IO (BIO) model which is disaggregated across the subs‐sectors of the agri‐food valuechain and environmentally extended (EE) to examine environmental outputs, including GHG emissions, We focus on Ireland, where emissions from agriculture comprise 33% of national GHG emissions and where there has been a major expansion and transformation in agriculture supported by national and EU policy. In a substantial Annex to this paper, we describe the modelling assumptions made in developing the BIO model. Breaking up the value chain into components, we find that most value is generated at the processing stage of the value chain, with greaterprocessing value in more sophisticated value chains such as dairy processing. On the other hand, emissions are in general highest in primary production, albeit emissions from purchased animal feed are higher for poultry than for other value chains, given the lower animal based emissions from poultry than from cows or sheep. The level ofdisaggregation also shows that the sub‐sectors are themselves discrete value chains. The analysis highlights that emissions per unit of output are much higher for beef and sheep meat value chains than for pig and poultry. The analysis facilitated by the BIO model also allows for the mapping of emissions along the agri‐food value chain using the adapted IO EE approach. Such analysis is valuable in identifying emissions ‘hot‐spots’ along the value chains and analysing potential avenues for emission efficiencies

Ground-based observations of Saturn’s auroral ionosphere over three days:trends in H3+ temperature, density and emission with Saturn local time and planetary period oscillation

On 19–21 April 2013, the ground-based 10-m W.M. Keck II telescope was used to simultaneously measure View the MathML sourceH3+ emissions from four regions of Saturn’s auroral ionosphere: (1) the northern noon region of the main auroral oval; (2) the northern midnight main oval; (3) the northern polar cap and (4) the southern noon main oval. The View the MathML sourceH3+ emission from these regions was captured in the form of high resolution spectral images as the planet rotated. The results herein contain twenty-three View the MathML sourceH3+ temperatures, column densities and total emissions located in the aforementioned regions – ninety-two data points in total, spread over timescales of both hours and days. Thermospheric temperatures in the spring-time northern main oval are found to be cooler than their autumn-time southern counterparts by tens of K, consistent with the hypothesis that the total thermospheric heating rate is inversely proportional to magnetic field strength. The main oval View the MathML sourceH3+ density and emission is lower at northern midnight than it is at noon, in agreement with a nearby peak in the electron influx in the post-dawn sector and a minimum flux at midnight. Finally, when arranging the northern main oval View the MathML sourceH3+ parameters as a function of the oscillation period seen in Saturn’s magnetic field – the planetary period oscillation (PPO) phase – we see a large peak in View the MathML sourceH3+ density and emission at ∼115° northern phase, with a full-width at half-maximum (FWHM) of ∼44°. This seems to indicate that the influx of electrons associated with the PPO phase at 90° is responsible at least in part for the behavior of all View the MathML sourceH3+ parameters. A combination of the View the MathML sourceH3+ production and loss timescales and the ±10° uncertainty in the location of a given PPO phase are likely, at least in part, to be responsible for the observed peaks in View the MathML sourceH3+ density and emission occurring at a later time than the peak precipitation expected at 90° PPO phase

The effect of the return of serve on the server pair’s movement parameters and rally outcome in padel using cluster analysis

Purpose: The pressure exerted on racket sports players by the service has been well documented. Whilst the return of serve has been suggested through qualitative interviews as being of similar importance there is a dearth of quantitative data to support this contention. This study analyzed time, speed, and distance parameters related to the outcome of the return of serve (ROS) in Padel, a sport similar to tennis but played on a court bounded by walls and played in doubles format only. Methods: Matches (n = 18) at two tournaments, sanctioned by the Valencian Federation, in 2012 were recorded and processed using Tracker software. ROS shot type (flat or lob), ball location, players’ positions on court and movement parameters between the ROS and the third shot of the server were captured 25 times per second. Results: Both lob and flat ROS produced six main clusters, as well as a small proportion of shots deemed outliers. The clusters differentiated shots played by two different level players (National and Regional), whether the ROS was played following a first or second serve, whether the serving pair adopted a conventional or Australian formation and whether the rally ended in a short number of shots (seven or less) or not. Conclusion: It was suggested that the aim of the ROS in Padel was to prevent the serving pair winning the rally quickly, since the advantage of the serve diminished after around 6 to 8 shots. This was best achieved by good depth on lobs, regardless of the direction, and pace on low shots, predominately aimed toward the server. This approach should be further modified to include the time between serve and ROS and consideration could be given to classifying attacking and defending positions

Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar

Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias. Its activation by thrombin stimulates prothrombotic and proinflammatory signaling, whereas its activation by activated protein C (APC) stimulates cytoprotective and antiinflammatory signaling. A challenge in developing PAR1-targeted therapies is to inhibit detrimental signaling while sparing beneficial pathways. We now characterize a novel class of structurally unrelated small-molecule PAR1 antagonists, termed parmodulins, and compare the activity of these compounds to previously characterized compounds that act at the PAR1 ligand–binding site. We find that parmodulins target the cytoplasmic face of PAR1 without modifying the ligand-binding site, blocking signaling through Gαq but not Gα13 in vitro and thrombus formation in vivo. In endothelium, parmodulins inhibit prothrombotic and proinflammatory signaling without blocking APC-mediated pathways or inducing endothelial injury. In contrast, orthosteric PAR1 antagonists such as vorapaxar inhibit all signaling downstream of PAR1. Furthermore, exposure of endothelial cells to nanomolar concentrations of vorapaxar induces endothelial cell barrier dysfunction and apoptosis. These studies demonstrate how functionally selective antagonism can be achieved by targeting the cytoplasmic face of a G-protein–coupled receptor to selectively block pathologic signaling while preserving cytoprotective pathways

Asymmetric Ionospheric Jets in Jupiter's Aurora

Simultaneous infrared observations of (Formula presented.) and H2 emissions from Jupiter's northern aurora using the Near Infrared Spectrograph at Keck Observatory were used to measure the ionospheric and thermospheric wind velocities. (Formula presented.) ions supercorotate near the dawn auroral oval and subcorotate across the dusk sector and in the dawn polar region relative to the planetary rotation rate, broadly in agreement with past observations and models. An anticyclonic vortex is discovered in H2 flows, closely matching the mean magnetospheric subcorotation when the observed magnetospheric flows are averaged azimuthally. In comparing ion and neutral winds, we measure the line-of-sight effective ion drift in the neutral reference frame for the first time, revealing two blue-shifted sunward flows of ∼2 km/s. Observed (Formula presented.) and H2 emissions overlap with predictions of the Pedersen conductivity layer, suggesting two different regions of the ionosphere: (a) a deep layer, where neutral forces dominate the thermosphere and symmetric breakdown-in-corotation currents can close, and (b) a higher layer, where the observed effective ion drift allows dawn-to-dusk Pedersen currents within the upper atmosphere, in turn closing asymmetric currents within the magnetosphere. This ionospheric structure aligns well with recent Juno observations of Jupiter's aurora. The detected thermospheric vortex implies the driving of neutral flows by the momentum from the magnetosphere within the thermosphere and deeper in the atmosphere to potentially 20 mbar. Jovian neutral thermosphere might bridge the gap between current observations and modelings and perhaps be significant to the dynamics of aurora on Earth and other outer planets

Growth differentiation factor 15 and cardiovascular risk: individual patient meta-analysis

AIMS: Levels of growth differentiation factor 15 (GDF-15), a cytokine secreted in response to cellular stress and inflammation, have been associated with multiple types of cardiovascular (CV) events. However, its comparative prognostic performance across different presentations of atherosclerotic cardiovascular disease (ASCVD) remains unknown. METHODS AND RESULTS: An individual patient meta-analysis was performed using data pooled from eight trials including 53 486 patients. Baseline GDF-15 concentration was analyzed as a continuous variable and using established cutpoints ( 1800 ng/L) to evaluate its prognostic performance for CV death/hospitalization for heart failure (HHF), major adverse cardiovascular events (MACE), and their components using Cox models adjusted for clinical variables and established CV biomarkers. Analyses were further stratified on ASCVD status: acute coronary syndrome (ACS), stabilized after recent ACS, and stable ASCVD. Overall, higher GDF-15 concentration was significantly and independently associated with an increased rate of CV death/HHF and MACE (P < 0.001 for each). However, while GDF-15 showed a robust and consistent independent association with CV death and HHF across all presentations of ASCVD, its prognostic association with future myocardial infarction (MI) and stroke only remained significant in patients stabilized after recent ACS or with stable ASCVD [hazard ratio (HR): 1.24, 95% confidence interval (CI): 1.17-1.31 and HR: 1.16, 95% CI: 1.05-1.28 for MI and stroke, respectively] and not in ACS (HR: 0.98, 95% CI: 0.90-1.06 and HR: 0.87, 95% CI: 0.39-1.92, respectively). CONCLUSION: Growth differentiation factor 15 consistently adds prognostic information for CV death and HHF across the spectrum of ASCVD. GDF-15 also adds prognostic information for MI and stroke beyond clinical risk factors and cardiac biomarkers but not in the setting of ACS

Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

Basal breast cancer is associated with younger age, early relapse, and a high mortality rate. Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate the cellular basis of tumor progression during the specification of the basal breast cancer subtype from the luminal progenitor population in the MMTV-PyMT (mouse mammary tumor virus-polyoma middle tumor-antigen) mammary tumor model. We find that basal-like cancer cells resemble the alveolar lineage that is specified upon pregnancy and encompass the acquisition of an aberrant post-lactation developmental program of involution that triggers remodeling of the tumor microenvironment and metastatic dissemination. This involution mimicry is characterized by a highly interactive multicellular network, with involution cancer-associated fibroblasts playing a pivotal role in extracellular matrix remodeling and immunosuppression. Our results may partially explain the increased risk and poor prognosis of breast cancer associated with childbirth.</p