The use of Hemopure® at Groote Schuur hospital, Cape Town: 4 case studies

Hemopure® is a cell-free haemoglobin solution that is made from bovine haemoglobin that is designed to carry oxygen in the plasma. It is approved for use in South Africa for the treatment of acute surgical anaemia. We describe the use of Hemopure® at a large tertiary hospital in Cape Town where there is a blood bank on the premises. Four patients received Hemopure® during situations of acute, life-threatening anaemia. Two patients were Jehovah’s Witnesses and in two cases the blood bank was not able to find compatible blood due to the presence of antibodies in the patient’s blood. Patients were carefully monitored by the anaesthetists or intensive care staff, who were managing the patient. No adverse reactions were experienced. Hemopure® was indispensable in managing these critically ill patients

New geometry for planar UV written refractive index sensors

We shall present some of our recent results from our work on UV written planar waveguide refractive index sensors. Refractive index of an analyte is measured through the perturbation of an optical mode, interrogation of the modal index is achieved via the reflected spectra from a Bragg grating defined in the same process as the channel waveguide. Here we introduce a new geometry which embraces the benefits of planar technology to realise new integrated devices. The geometry allows several different sensors to be defined on the same substrate each offering complementary information. Such information may include index as a function of penetration depth for surface binding analytes, interrogation wavelength for dispersion analysis, enhanced sensitivity in specific index ranges and temperature compensation. We shall also outline the inherent fabrication advantages and device feature benefits, including a reduction in return loss, spectral artefacts and a suggested reduction in stress induced birefringence. The silica sensing surface opposed to gold used in SPR devices opens new avenues to exploit surface binding. With a marked reduction in complexity and cost these devices may have significant impact in future sensor markets

Macroscopic, Radiographic and Histopathologic Changes of Claws with Laminitis and Laminitis-Related Disorders in Zero-Grazed Dairy Cows

Laminitis and laminitis-related claw disorders are prevalent in zero-grazed dairy cows. Confinement and limited movement influences claw size and shape. Abnormal claw size and shape causes imbalanced body weight distribution on the claws. Claw horn growth and wear is impaired, further aggravating laminitis disorders. The objective of this study was to determine: macroscopic disorders on the claws, as well as radiographic features and histopathologic changes on the claws with laminitis/laminitis-related disorders. A total of 159 dairy cow forelimb and hind limb feet (318 claws) were collected from an abattoir and a slaughter slab around Nairobi, Kenya. The claws were examined for macroscopic abnormalities, dorso-palmar or dorso-plantar radiography done, sagittal claw sections done, corium gross changes observed and corium tissues harvested for histopathology. Macroscopic disorders observed were: sole bruising, claw deformities, heel erosion, subclinical laminitis sole haemorrhages, double soles, chronic laminitis and white line separation. Radiographic changes observed mainly on distal phalanges were dilated vascular channels, irregular margins, exostoses/periostitis, distal phalangeal narrowing and lysis. Histopathologic changes in the corium included arterio-venous shunts, vascular wall rupture and thickening, vascular proliferation and thrombosis, corium and connective tissue oedema, degeneration, haemorrhages and spongiosis. Hence macroscopic, radiographic and histopathologic changes in laminitis claws affect locomotion

Letter from James B. Brooke & M.F. Brooke to James B. Finley

The Brookes have suffered a great deal of ill health during the past fall. They write to thank Finley for his kind letters and remembrances. Abstract Number - 354https://digitalcommons.owu.edu/finley-letters/1552/thumbnail.jp

Letter from James B. Brooke & M.F. Brooke to James B. Finley

Grandson James warns Finley that he should take care of his health since he is no longer a young man. He apologizes for not having written sooner and then writes news of the family (wife is Margaret Fisher Brooke). Many have suffered from bilious attacks but are generally well now. He plans to go home about the first of April. Abstract Number - 275https://digitalcommons.owu.edu/finley-letters/1273/thumbnail.jp

Early detection of problem implants using infrared thermography

Thermal imaging of feedlot cattle ears is a noninvasive diagnostic tool that aids in identifying properly placed or abscessed growth-promoting implants. Thirty-two calves were used to determine if abscessed and normal, functional implants could be identified and differentiated using infrared thermography. Infrared images were taken at implantation on days 2, 4, 7, 14, and 21 after implantation. Abscessed implants were easily identified. Use of thermal imaging can verify implant administration and, thus, has the potential to immediately impact feedlot quality assurance programs

An infected enlarging abdominal aortic aneurysm after acute cholecystitis

AbstractINTRODUCTIONAn abdominal aortic aneurysm (AAA) infection is rare and can be difficult to manage, with high morbidity and mortality. We present a patient who suffered an infected AAA after undergoing a laparoscopic cholecystectomy and discuss the surgical management options.PRESENTATION OF CASEA 69-year-old male presents with a rapidly enlarging AAA 4 weeks following laparoscopic cholecystectomy. He was managed with open debridement, washout and repair of the aneurysm, but suffered ongoing sequelae of Escherichia coli sepsis.DISCUSSIONThe options for surgical management of infected AAA include open, endovascular and combined approaches. Recent papers report successful use of endovascular repair of infected AAAs but this is an ongoing area of research.CONCLUSIONInfection of an AAA is associated with high mortality and long-term morbidity and requires optimal treatment. Surgical options include open debridement and repair, endovascular aneurysm repair (EVAR) or a combined approach

Syntheses, structures, and infrared spectra of the hexa(cyanido) complexes of silicon, germanium, and tin

The rare octahedral EC6 coordination skeleton type is unknown for complexes with coordination centers consisting of group 14 elements. Here, the first examples of such EC6 species, the hexacoordinate homoleptic cyanido complexes E(CN)62–, E = Si, Ge, Sn, have been synthesized from element halides SiCl4, GeCl4 and SnF4 and isolated as salts with PPN counterions (PPN+ = (Ph3P)2N+) on a scale of 0.2–1 g. Characterization by spectroscopic techniques and by structure determination through single crystal crystallographic methods show that these pseudohalogen complexes have effective octahedral symmetry in solution and in the solid state. Infrared spectra obtained in solution reveal that the T1u symmetric IR-active vibrations in all three complexes have unusually small oscillator strengths. The observed reluctance of Si(CN)62–, Ge(CN)62–, and Sn(CN)62– to form from chloro-precursors was rationalized in terms of Gibbs free energies, which were found by ab initio calculations at the CCSD(T)-F12b/aug-cc-pVTZ(-PP)-F12 level of theory to be small or even positive. The work demonstrates that E(CN)62– complexes of silicon, germanium and tin are in fact stable at room temperature and exist as well-defined units in the presence of noncoordinating counterions. The results add to our understanding of the chemistry of pseudohalogens and structure and bonding

Dakota Gold®-brand dried distiller’s grains with solubles: effects on finishing performance and carcass characteristics

A 153-day trial was conducted using 345 heifers to determine optimal level of Dakota Gold dried distiller’s grains with solubles (DDGS) in finishing diets based on steam-flaked corn. Diets contained six levels of DDGS: 0%, 15%, 30%, 45%, 60%, and 75%. DDGS affected average daily gain, final weight and hot carcass weight, all of which increased with 15% DDGS and then decreased as additional DDGS was added. Growth performance of heifers fed 30% DDGS was similar to those fed no DDGS. In general, heifers were overfinished, with 61% being Yield Grade 3 or greater and 83% grading Choice or Prime. Backfat tended to decrease with addition of DDGS, and kidney, pelvic, and heart fat and marbling scores tended to be greatest for intermediate levels of DDGS. Percentage of carcasses grading Choice or Prime tended to be lower for heifers fed 60 or 75% DDGS

A randomised controlled trial of treatments of childhood anxiety disorder in the context of maternal anxiety disorder: clinical and cost-effectiveness outcomes

Background: This study evaluated whether clinical and economic outcomes from CBT for child anxiety disorders in the context of maternal anxiety disorders are improved by adding treatment focused on (i) maternal anxiety disorders, or (ii) mother-child interactions. Methods: 211 children (7 – 12 years, 85% White British, 52% female) with a primary anxiety disorder, whose mothers also had a current anxiety disorder, were randomised to receive (i) child-focused CBT with non-specific control interventions (CCBT+Con), (ii) CCBT with CBT for the maternal anxiety disorder (CCBT+MCBT), or (iii) CCBT with an intervention targeting the mother-child interaction (CCBT+MCI). A cost-utility analysis from a societal perspective was conducted using mother/child combined Quality Adjusted Life Years (QALYs). [Trial registration: https://doi.org/10.1186/ISRCTN19762288]. Results: MCBT was associated with immediate reductions in maternal anxiety compared to the non-specific control; however, after children had also received CCBT, maternal outcomes in the CCBT+MCI and CCBT+Con arms improved and CCBT+MCBT was no longer superior. Neither CCBT+MCBT nor CCBT+MCI conferred a benefit over CCBT+Con in terms of child anxiety disorder diagnoses post-treatment [primary outcome] (adj RR: 1.22 (95% CI 0.88, 1.67), p = .23; adj RR: 1.21 (95% CI 0.88, 1.65), p = .24 respectively) or global improvement ratings (adj RR 1.25 (95% CI 0.99, 1.57), p = .06; adj RR 1.18 (95% CI 0.93, 1.50), p = .17) or six and 12 months later. No significant differences between the groups were found on the main economic outcome measures (child/mother combined QALY mean difference: CCBT+MCBT vs CCBT+Con: -0.04 (95% CI -0.12, 0.04), p = 0.29; CCBT+MCI vs CCBT+Con: 0.02 (95% CI -0.05, -0.09), p = 0.54). CCBT+MCI was associated with non-significantly higher costs than CCBT (mean difference: £154 (95% CI -£1239, £1547), p = 0.83) but, when taking into account sampling uncertainty, it may be cost-effective compared with CCBT alone. Conclusions: Good outcomes were achieved for children and their mothers across treatment arms. There was no evidence of significant clinical benefit from supplementing CCBT with either CBT for the maternal anxiety disorder or treatment focussed on mother-child interactions, but the addition of MCI (and not MCBT) may be cost-effective. Keywords: Child; anxiety; mother; parent-child interaction; CBT