Technologies for Cooling of Large Distributed Loads

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76549/1/AIAA-2008-7928-367.pd

Modifying the Steric Properties in the Second Coordination Sphere of Designed Peptides Leads to Enhancement of Nitrite Reductase Activity

Protein design is a useful strategy to interrogate the protein structureâ function relationship. We demonstrate using a highly modular 3â stranded coiled coil (TRIâ peptide system) that a functional typeâ 2 copper center exhibiting copper nitrite reductase (NiR) activity exhibits the highest homogeneous catalytic efficiency under aqueous conditions for the reduction of nitrite to NO and H2O. Modification of the amino acids in the second coordination sphere of the copper center increases the nitrite reductase activity up to 75â fold compared to previously reported systems. We find also that steric bulk can be used to enforce a threeâ coordinate CuI in a site, which tends toward twoâ coordination with decreased steric bulk. This study demonstrates the importance of the second coordination sphere environment both for controlling metalâ center ligation and enhancing the catalytic efficiency of metalloenzymes and their analogues.Erstklassiges aus der zweiten Reihe: Die Aktivität der Nitritreduktase kann durch Modifikation der sterischen Eigenschaften in der zweiten Koordinationssphäre eines Typâ 2â Kupferzentrums deutlich erhöht werden. à ber die Sterik lassen sich die Koordination und Reaktivität des Metalls in einem dreisträngigen â Coiledâ coilâ â TRIâ Peptidgerüst (TRIWâ H) vorgeben.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142882/1/ange201712757_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142882/2/ange201712757-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142882/3/ange201712757.pd

Modifying the Steric Properties in the Second Coordination Sphere of Designed Peptides Leads to Enhancement of Nitrite Reductase Activity

Protein design is a useful strategy to interrogate the protein structureâ function relationship. We demonstrate using a highly modular 3â stranded coiled coil (TRIâ peptide system) that a functional typeâ 2 copper center exhibiting copper nitrite reductase (NiR) activity exhibits the highest homogeneous catalytic efficiency under aqueous conditions for the reduction of nitrite to NO and H2O. Modification of the amino acids in the second coordination sphere of the copper center increases the nitrite reductase activity up to 75â fold compared to previously reported systems. We find also that steric bulk can be used to enforce a threeâ coordinate CuI in a site, which tends toward twoâ coordination with decreased steric bulk. This study demonstrates the importance of the second coordination sphere environment both for controlling metalâ center ligation and enhancing the catalytic efficiency of metalloenzymes and their analogues.Second is best: A significant increase in nitrite reductase activity is achieved by modification of the steric properties of the second coordination sphere of a typeâ 2 copper center. The steric properties can be harnessed to control metal coordination and reactivity in a 3â stranded coiled coil TRI peptide scaffold (TRIWâ H).Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142897/1/anie201712757.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142897/2/anie201712757-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142897/3/anie201712757_am.pd

Discrete Breathers in Two-Dimensional Anisotropic Nonlinear Schrodinger lattices

We study the structure and stability of discrete breathers (both pinned and mobile) in two-dimensional nonlinear anisotropic Schrodinger lattices. Starting from a set of identical one-dimensional systems we develop the continuation of the localized pulses from the weakly coupled regime (strongly anisotropic) to the homogeneous one (isotropic). Mobile discrete breathers are seen to be a superposition of a localized mobile core and an extended background of two-dimensional nonlinear plane waves. This structure is in agreement with previous results on onedimensional breather mobility. The study of the stability of both pinned and mobile solutions is performed using standard Floquet analysis. Regimes of quasi-collapse are found for both types of solutions, while another kind of instability (responsible for the discrete breather fission) is found for mobile solutions. The development of such instabilities is studied, examining typical trajectories on the unstable nonlinear manifold.Comment: 13 pages, 9 figure

Biom Biostat Int J

CC999999/Intramural CDC HHS/United States2016-06-17T00:00:00Z27331197PMC491222

Tunneling of quantum rotobreathers

We analyze the quantum properties of a system consisting of two nonlinearly coupled pendula. This non-integrable system exhibits two different symmetries: a permutational symmetry (permutation of the pendula) and another one related to the reversal of the total momentum of the system. Each of these symmetries is responsible for the existence of two kinds of quasi-degenerated states. At sufficiently high energy, pairs of symmetry-related states glue together to form quadruplets. We show that, starting from the anti-continuous limit, particular quadruplets allow us to construct quantum states whose properties are very similar to those of classical rotobreathers. By diagonalizing numerically the quantum Hamiltonian, we investigate their properties and show that such states are able to store the main part of the total energy on one of the pendula. Contrary to the classical situation, the coupling between pendula necessarily introduces a periodic exchange of energy between them with a frequency which is proportional to the energy splitting between quasi-degenerated states related to the permutation symmetry. This splitting may remain very small as the coupling strength increases and is a decreasing function of the pair energy. The energy may be therefore stored in one pendulum during a time period very long as compared to the inverse of the internal rotobreather frequency.Comment: 20 pages, 11 figures, REVTeX4 styl

Society for Cardiovascular Magnetic Resonance (SCMR) guidance for re-activation of cardiovascular magnetic resonance practice after peak phase of the COVID-19 pandemic

During the peak phase of the COVID-19 pandemic, alterations of standard operating procedures were necessary for health systems to protect patients and healthcare workers and ensure access to vital hospital resources. As the peak phase passes, re-activation plans are required to safely manage increasing clinical volumes. In the context of cardiovascular magnetic resonance (CMR), re-activation objectives include continued performance of urgent CMR studies and resumption of CMR in patients with semi-urgent and elective indications in an environment that is safe for both patients and health care workers

Reducing Legionella Colonization of Water Systems with Monochloramine

Monochloramine reduced colonization in building hot water systems