Vanishing viscosity limit for an expanding domain in space

We study the limiting behavior of viscous incompressible flows when the fluid domain is allowed to expand as the viscosity vanishes. We describe precise conditions under which the limiting flow satisfies the full space Euler equations. The argument is based on truncation and on energy estimates, following the structure of the proof of Kato's criterion for the vanishing viscosity limit. This work complements previous work by the authors, see [Kelliher, Comm. Math. Phys. 278 (2008), 753-773] and [arXiv:0801.4935v1].Comment: 23 pages, submitted for publicatio

Multi-informant validity evidence for the SSIS SEL Brief Scales across six European countries

The SSIS SEL Brief Scales (SSIS SELb) are multi-informant (teacher, parent, and student) measures that were developed to efficiently assess the SEL competencies of school-age youth in the United States. Recently, the SSIS SELb was translated into multiple languages for use in a multi- site study across six European countries (Croatia, Greece, Italy, Latvia, Portugal, and Romania). The purpose of the current study was to examine concurrent and predictive evidence for the SEL Composite scores from the translated versions of the SSIS SELb Scales. Results indicated that SSIS SELb Composite scores demonstrated expected positive concurrent and predictive relationships with scores from the Connor-Davidson Resilience Scale (CD-RISC) and negative relationships with scores from the problem behavior scales of the Strengths and Difficulties Questionnaire (SDQ). Although there were a few exceptions, these patterns generally were consistent across informants (parents, teachers, and students) and samples providing initial validity evidence for the Composite score from the translated versions of the SSIS SELb Scales. Limitations and future research directions are discussed.peer-reviewe

Innate Immune Response of Human Plasmacytoid Dendritic Cells to Poxvirus Infection Is Subverted by Vaccinia E3 via Its Z-DNA/RNA Binding Domain

Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus. Vaccinia, an orthopoxvirus, was used for immunization against smallpox, a contagious human disease with high mortality. Myxoma virus, a Leporipoxvirus, causes lethal disease in rabbits, but is non-pathogenic in humans. We report that myxoma virus infection of human pDCs induces IFN-α and TNF production, whereas vaccinia infection does not. Co-infection of pDCs with myxoma virus plus vaccinia blocks myxoma induction effects. We find that heat-inactivated vaccinia (Heat-VAC; by incubating the virus at 55°C for 1 h) gains the ability to induce IFN-α and TNF in primary human pDCs. Induction of IFN-α in pDCs by myxoma virus or Heat-VAC is blocked by chloroquine, which inhibits endosomal acidification required for TLR7/9 signaling, and by inhibitors of cellular kinases PI3K and Akt. Using purified pDCs from genetic knockout mice, we demonstrate that Heat-VAC-induced type I IFN production in pDCs requires the endosomal RNA sensor TLR7 and its adaptor MyD88, transcription factor IRF7 and the type I IFN feedback loop mediated by IFNAR1. These results indicate that (i) vaccinia virus, but not myxoma virus, expresses inhibitor(s) of the poxvirus sensing pathway(s) in pDCs; and (ii) Heat-VAC infection fails to produce inhibitor(s) but rather produces novel activator(s), likely viral RNA transcripts that are sensed by the TLR7/MyD88 pathway. Using vaccinia gene deletion mutants, we show that the Z-DNA/RNA binding domain at the N-terminus of the vaccinia immunomodulatory E3 protein is an antagonist of the innate immune response of human pDCs to poxvirus infection and TLR agonists. The myxoma virus ortholog of vaccinia E3 (M029) lacks the N-terminal Z-DNA/RNA binding domain, which might contribute to the immunostimulating properties of myxoma virus

A Review of Empirical Evidence and Practical Considerations For Early Childhood Classroom Observation Scales

The current article presents a critical review of empirical evidence for six observation scales commonly used in practice to evaluate the quality of the early childhood classroom environment. Specifically, the theoretical foundation, content, and psychometric properties are reviewed for each scale. Based on the strengths and limitations of the evidence for each measure, recommendations are made regarding use of these specific systems in early education settings

Student and teacher ratings of academic compentence: An examination of cross-informant agreement

Two studies were conducted with samples of middle and high school teachers and students to examine cross-informant agreement on the Academic Competence Evaluation Scales. Cross-informant agreement was examined using Pearson correlations and conditional probability indices. Results of Study 1 (N = 65) and Study 2 (N = 66) indicated that teacher and student ratings shared more variance than typically reported in prior cross-informant studies of problem or social behavior. Although teacher and student ratings shared strong correlations, there was significant disagreement when scores were dichotomized for decision making. Implications of the results for school psychology practice and future research are discussed

Newborn Screening for X-Linked Adrenoleukodystrophy in Nebraska: Initial Experiences and Challenges

X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disease caused by pathogenic variants in ABCD1 resulting in defective peroxisomal oxidation of very long-chain fatty acids. Most male patients develop adrenal insufficiency and one of two neurologic phenotypes: a rapidly progressive demyelinating disease in mid-childhood (childhood cerebral X-ALD, ccALD) or an adult-onset spastic paraparesis (adrenomyeloneuropathy, AMN). The neurodegenerative course of ccALD can be halted if patients are treated with hematopoietic stem cell transplantation at the earliest onset of white matter disease. Newborn screening for X-ALD can be accomplished by measuring C26:0-lysophosphatidylcholine in dried blood spots. In Nebraska, X-ALD newborn screening was instituted in July 2018. Over a period of 3.3 years, 82,920 newborns were screened with 13 positive infants detected (4 males, 9 females), giving a birth prevalence of 1:10,583 in males and 1:4510 in females. All positive newborns had DNA variants in ABCD1. Lack of genotype-phenotype correlations, absence of predictive biomarkers for ccALD or AMN, and a high proportion of ABCD1 variants of uncertain significance are unique challenges in counseling families. Surveillance testing for adrenal and neurologic disease in presymptomatic X-ALD males will improve survival and overall quality of life

Dimension prints and the avoidance of sets for flow solutions of non-autonomous ordinary differential equations

We provide a criterion for a generalised flow solution of a non-autonomous ordinary differential equation to avoid a subset of the phase space. This improves on that established by Aizenman for the autonomous case, where avoidance is guaranteed if the underlying vector field is sufficiently regular and the subset has sufficiently small box-counting dimension. We define the r-codimension print of a subset S⊂Rn×[0,T], which is a subset of (0,∞]2 that encodes the dimension of S in a way that distinguishes spatial and temporal detail. We prove that the subset S is avoided by a generalised flow solution with underlying vector field in Lp(0,T;Lq(Rn)) with 1⩽p,q⩽∞ if the Hölder conjugates (q⁎,p⁎) are in the r-codimension print of S