VALUING AMBIGUITY: THE CASE OF GENETICALLY ENGINEERED GROWTH ENHANCERS

A split-valuation method is developed and implemented to elicit the willingness to pay to consume- or avoid consuming- a product of ambiguous quality. The split-valuation method uses experimental auction markets to separate and value the positive and negative attributes of the ambiguous good. The results show that the method can be used to successfully value a good ambiguous quality. Our application reveals that for a sample of students at a midwestern land-grant institution, the average respondent is willing to pay a premium for meat produced with the use of a genetically engineered growth enhancer that has 30% to 60% fewer calories and is 10% to 20% leaner.Consumer/Household Economics,

EXPERIMENTAL METHODS IN CONSUMER PREFERENCE STUDIES

Controlled experimental auctions can be used to elicit preferences for food products. We describe results from two series of experiments in which subjects revealed their willingness-to-pay for safer food. In one series, the risk reduction technology was not specified; in the other, it was identified as food irradiation. The results provide some evidence on the acceptability of food irradiation as a risk reduction technology.Consumer/Household Economics,

Improving Phrap-Based Assembly of the Rat Using “Reliable” Overlaps

The assembly methods used for whole-genome shotgun (WGS) data have a major impact on the quality of resulting draft genomes. We present a novel algorithm to generate a set of “reliable” overlaps based on identifying repeat k-mers. To demonstrate the benefits of using reliable overlaps, we have created a version of the Phrap assembly program that uses only overlaps from a specific list. We call this version PhrapUMD. Integrating PhrapUMD and our “reliable-overlap” algorithm with the Baylor College of Medicine assembler, Atlas, we assemble the BACs from the Rattus norvegicus genome project. Starting with the same data as the Nov. 2002 Atlas assembly, we compare our results and the Atlas assembly to the 4.3 Mb of rat sequence in the 21 BACs that have been finished. Our version of the draft assembly of the 21 BACs increases the coverage of finished sequence from 93.4% to 96.3%, while simultaneously reducing the base error rate from 4.5 to 1.1 errors per 10,000 bases. There are a number of ways of assessing the relative merits of assemblies when the finished sequence is available. If one views the overall quality of an assembly as proportional to the inverse of the product of the error rate and sequence missed, then the assembly presented here is seven times better. The UMD Overlapper with options for reliable overlaps is available from the authors at http://www.genome.umd.edu. We also provide the changes to the Phrap source code enabling it to use only the reliable overlaps

The CS sulphation motifs 4C3, 7D4, 3B3[-]; and perlecan identify stem cell populations and niches, activated progenitor cells and transitional tissue development in the fetal human elbow

We compared the immunohistochemical distribution of (i) the novel chondroitin sulphate (CS) sulphation motifs 7D4, 4C3 and 3B3[-], (ii) native heparan sulphate (HS) and Δ-HS ‘stubs’ generated by heparitinase III digestion and (iii) the HS-proteoglycan, perlecan, in the foetal human elbow joint. Putative stem cell populations associated with hair bulbs, humeral perichondrium, humeral and ulnar rudiment stromal/perivascular tissues expressed the CS motifs 4C3, 7D4 and 3B3[-] as well as perlecan in close association but not co-localised. Chondrocytes in the presumptive articular cartilage of the foetal elbow expressed the 4C3 and 7D4 CS sulphation motifs consistent with earlier studies on the expression of these motifs in knee cartilage following joint cavitation. The present study also indicated that hair bulbs, skin, perichondrium and rudiment stroma were all perlecan rich progenitor cell niches that contributed to the organisation and development of the human foetal elbow joint and associated connective tissues. One of the difficulties in determining the precise role of stem cells in tissue development and repair processes is their short engraftment period and the lack of specific markers which differentiate the activated stem cell lineages from the resident cells. The CS sulphation motifs 7D4, 4C3 and 3B3[-] decorate cell surface proteoglycans on activated stem/progenitor cells and thus can be used to identify these cells in transitional areas of tissue development and in repair tissues and may be applicable to determining a more precise mode of action of stem cells in these processes. Isolation of perlecan from 12-14 week gestational age foetal knee rudiments demonstrated that perlecan in these foetal tissues was a HS-CS hybrid proteoglyca

Progress with air quality management in the 60 years since the UK clean air act, 1956. Lessons, failures, challenges and opportunities

© 2016 WIT Press, www.witpress.com. This paper explores the challenges, opportunities and progress made with managing air quality since the United Kingdom parliament passed the Clean Air Act, 1956. It seeks to identify the factors contributing to successful management of air quality and the factors that have acted, or continue to do so, as barriers to progress. The public health catastrophe of the 1952 London Smog created the political momentum for the 1956 Act to be passed. The nature of the contemporary air pollution challenge is reviewed in terms of the public health burden, the economic cost and the governmental response. The contemporary response is considered inadequate for the scale and intensity of the problem

The Effectiveness of Smoking Cessation, Alcohol Reduction, Diet and Physical Activity Interventions in Improving Maternal and Infant Health Outcomes: A Systematic Review of Meta-Analyses

Diet, physical activity, smoking and alcohol behaviour-change interventions delivered in pregnancy aim to prevent adverse pregnancy outcomes. This review reports a synthesis of evidence from meta-analyses on the effectiveness of interventions at reducing risk of adverse health outcomes. Sixty-five systematic reviews (63 diet and physical activity; 2 smoking) reporting 602 meta-analyses, published since 2011, were identified; no data were identified for alcohol interventions. A wide range of outcomes were reported, including gestational weight gain, hypertensive disorders, gestational diabetes (GDM) and fetal growth. There was consistent evidence from diet and physical activity interventions for a significantly reduced mean gestational weight gain (ranging from −0.21 kg (95% confidence interval −0.34, −0.08) to −5.77 kg (95% CI −9.34, −2.21). There was evidence from larger diet and physical activity meta-analyses for a significant reduction in postnatal weight retention, caesarean delivery, preeclampsia, hypertension, GDM and preterm delivery, and for smoking interventions to significantly increase birth weight. There was no statistically significant evidence of interventions having an effect on low or high birthweight, neonatal intensive care unit admission, Apgar score or mortality outcomes. Priority areas for future research to capitalise on pregnancy as an opportunity to improve the lifelong wellbeing of women and their children are highlighted

Massive Ice Control on Permafrost Coast Erosion and Sensitivity

High overall rates of permafrost cliff retreat, coupled with spatial variability, have been accompanied by increased uncertainty over future landscape dynamics. We map long‐term (>80 years) retreat of the shoreline and photogrammetrically analyze historic aerial imagery to quantify the processes at a permafrost coast site with massive ground ice. Retreat rates have been relatively constant, but topographic changes show that subsidence is a potentially critical but often ignored component of coastal sensitivity, exceeding landward recession by over three times during the last 24 years. We calibrate novel passive seismic surveys along clear and variable exposures of massive ground ice and then spatially map key subsurface layers. Combining decadal patterns of volumetric change with new ground ice variation maps enables past trends to be interpreted, future volumetric geomorphic behavior to be better constrained, and improves the assessment of permafrost coast sensitivity and the release of carbon‐bearing material

Passive Polymer Application for Turbidity Reduction

2012 S.C. Water Resources Conference - Exploring Opportunities for Collaborative Water Research, Policy and Managemen

Highly sensitive contact pressure measurements using FBG patch in endotracheal tube cuff

A method for measuring the contact pressure between an endotracheal tube cuff and the trachea was designed and developed by using a fibre Bragg grating (FBG) based optical fibre sensor. The FBG sensor is encased in an epoxy based UV-cured cuboid patch and transduces the transversely loaded pressure into an axial strain that induces wavelength shift of the Bragg reflection. The polymer patch was created by using a PTFE based mould and increases tensile strength and sensitivity of the bare fibre FBG to pressure to 2.10×10-2 nm/kPa. The characteristics of the FBG patch allow for continuous measurement of contact pressure. The measurement of contact pressure was demonstrated by the use of a 3D printed model of a human trachea. The influence of temperature on the measurements is reduced significantly by the use of a second FBG sensor patch that is not in contact with the trachea. Intracuff pressure measurements performed using a commercial manometer agreed well with the FBG contact pressure measurements. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

Simulating Radiating and Magnetized Flows in Multi-Dimensions with ZEUS-MP

This paper describes ZEUS-MP, a multi-physics, massively parallel, message- passing implementation of the ZEUS code. ZEUS-MP differs significantly from the ZEUS-2D code, the ZEUS-3D code, and an early "version 1" of ZEUS-MP distributed publicly in 1999. ZEUS-MP offers an MHD algorithm better suited for multidimensional flows than the ZEUS-2D module by virtue of modifications to the Method of Characteristics scheme first suggested by Hawley and Stone (1995), and is shown to compare quite favorably to the TVD scheme described by Ryu et. al (1998). ZEUS-MP is the first publicly-available ZEUS code to allow the advection of multiple chemical (or nuclear) species. Radiation hydrodynamic simulations are enabled via an implicit flux-limited radiation diffusion (FLD) module. The hydrodynamic, MHD, and FLD modules may be used in one, two, or three space dimensions. Self gravity may be included either through the assumption of a GM/r potential or a solution of Poisson's equation using one of three linear solver packages (conjugate-gradient, multigrid, and FFT) provided for that purpose. Point-mass potentials are also supported. Because ZEUS-MP is designed for simulations on parallel computing platforms, considerable attention is paid to the parallel performance characteristics of each module. Strong-scaling tests involving pure hydrodynamics (with and without self-gravity), MHD, and RHD are performed in which large problems (256^3 zones) are distributed among as many as 1024 processors of an IBM SP3. Parallel efficiency is a strong function of the amount of communication required between processors in a given algorithm, but all modules are shown to scale well on up to 1024 processors for the chosen fixed problem size.Comment: Accepted for publication in the ApJ Supplement. 42 pages with 29 inlined figures; uses emulateapj.sty. Discussions in sections 2 - 4 improved per referee comments; several figures modified to illustrate grid resolution. ZEUS-MP source code and documentation available from the Laboratory for Computational Astrophysics at http://lca.ucsd.edu/codes/currentcodes/zeusmp2