“Perversity, Futility, Jeopardy”: An Economic Analysis of the Attack on Gun Control

A relatively new way for utilizing the thermal performance of heat pipes is to use nanofluids as working fluids in the heat pipes. Heat pipes are effective heat transfer devices in which the nanofluid operates in the two phases, evaporation and condensation. The heat pipe transfers the heat supplied in e.g. a laptop, from the evaporator to condenser part. Nanofluids are mixtures consisting of nanoparticles (e.g. nano-sized silver particles) and a base fluid (e.g. water). The aim of this bachelor’s thesis has been to examine the effect of nanofluids on heat pipes on the subject of temperature parameters and thermal resistance in the heat pies, through findings in literature and an applied model. The study, based on literature and an applied model, found that higher particle conductivity and higher concentration of nanoparticles consequently decrease the thermal resistance in the heat pipes, resulting in an enhanced thermal performance of the heat pipes with nanofluids as working fluids. It is however concluded that difficulties in finding the optimal synthesis of nanofluids, the concentration level of nanoparticles and the filling ratio of nanofluids in heat pipes, set bounds to the commercial use of nanofluids in heat pipes. It is suggested that, in order to enhance the heat transfer performance of nanofluids in heat pipes, to conduct further research concerning e.g. synthesis of nanofluids and concentration level of nanoparticles in nanofluids

A Study of the Dual Role as Athletic Director and Principal

The purpose of this study was to investigate job satisfaction perceptions of individuals holding positions which combined the functions of principal and athletic direction. Specifically, this study compared actual workload with desired workload, (i.e., that which would provide a reasonable amount of job satisfaction). The study was predicated on the research findings that indicate that the amount of work is relative to a given individual as opposed to being an absolute quality. A review of the research and literature revealed that few publications have been targeted toward workload and the dual educational administrator. The implications of job-related work, as it impacts on the effectiveness of the dual administrator, required a more thorough investigation of the workload phenomenon. A Dual Administrator Survey questionnarie was developed to gain information concerning a dual administrator\u27s perceived Hetual situation of satisfaction and what he believes to be a reasonable situation pertaining to workload relative to a given factor. It is hypothesized that the actual and preceived views of the dual environment provides an evaluative result identifying a definite level of job effectiveness and satisfaction. The questionnaire was mailed to seventy-five dual administrators in Northern, Central and Southern Illinois. A response rate of ninety-six percent was obtained. It was found that: 1. Over two-thirds (68% very satisfactory, satisfactory and average) of the dual administrators surveyed experience significant job satisfaction in the dual work environment. 2. A diagnostic instrument should be developed which specifically determines job effectiveness and job satisfaction as it relates to workload for dual administrators. 3. The effectiveness of a dual administrator is not significantly related to perceived workload or lack of an assistant principal and/or assistant athletic director. Certain factors intrinsic to the job are a source of dissatisfaction for most dual administrators. Factor analyses of the principal rating of job effectiveness identified four primary categories of job-related factors that cause significant dissatisfaction: Excessive workload Time demands Interpersonal relations Disparity between what the principal accomplishes and what he would like to achieve Finally, it was recommended that the group of dual administrators experiencing high work-related dissatisfaction, as well as those individuals experiencing satisfaction from a select number of job-related factors, consult the popular literature concerning principals\u27 effectiveness and coping skills

The Planning Process and People

Planning takes place on many levels, ranging from the individual to the nation and beyond. It can be related to a tremendous variety of situations and time spans, so there is no reason to expect the planning process to be uniform in its application. The particular elements of planning, the structures and techniques used, and the degrees of complexity will vary widely, depending on the conditions, issues and units of concern. About the only elements common to any planning are the assumptions that what happens today has consequences in the future, and that people can do things in the present that will increase the probabilities of particular events and situations matching their expectations or aspirations in the future. In other words, the planning process is predicated on the notions that the present is the father of the future, and people can purposely intervene to give some direction to the flow of events.Reviewed October 1993

Simulation-based intelligent robotic agent for Space Station Freedom

A robot control package is described which utilizes on-line structural simulation of robot manipulators and objects in their workspace. The model-based controller is interfaced with a high level agent-independent planner, which is responsible for the task-level planning of the robot's actions. Commands received from the agent-independent planner are refined and executed in the simulated workspace, and upon successful completion, they are transferred to the real manipulators

Reproducibility of graph metrics of human brain structural networks

Recent interest in human brain connectivity has led to the application of graph theoretical analysis to human brain structural networks, in particular white matter connectivity inferred from diffusion imaging and fiber tractography. While these methods have been used to study a variety of patient populations, there has been less examination of the reproducibility of these methods. A number of tractography algorithms exist and many of these are known to be sensitive to user-selected parameters. The methods used to derive a connectivity matrix from fiber tractography output may also influence the resulting graph metrics. Here we examine how these algorithm and parameter choices influence the reproducibility of proposed graph metrics on a publicly available test-retest dataset consisting of 21 healthy adults. The dice coefficient is used to examine topological similarity of constant density subgraphs both within and between subjects. Seven graph metrics are examined here: mean clustering coefficient, characteristic path length, largest connected component size, assortativity, global efficiency, local efficiency, and rich club coefficient. These reproducibility of these network summary measures is examined using the intraclass correlation coefficient (ICC). Graph curves are created by treating the graph metrics as functions of a parameter such as graph density. Functional data analysis techniques are usedto examine differences in graph measures that result from the choice of fiber tracking algorithm. The graph metrics consistently showed good levels of reproducibility as measured with ICC, with the exception of some instability at low graph density levels. The global and local efficiency measures were the most robust to the choice of fiber tracking algorithm

Parallels in Practice: Applying Principles of Research Integrity and Ethics in Domestic Violence Fatality Review (DVFR)

Purpose Within the context of the big data society, new systems of data collection on domestic violence and abuse (DVA) have emerged. One such system is Domestic Violence Fatality Review (DVFR) which captures the various dimensions of gender, violence, and abuse required to form an evidence base for prevention. However, to date, there has been limited dialogue between practitioners and researchers about the ‘doing’ of DVFRs. Method As DVFR systems vary by jurisdiction, we conducted a case study of Domestic Homicide Reviews (DHRs) in England and Wales. Applying the Research Integrity Framework (RIF) developed by the four Women’s Aid Federations in the United Kingdom (UK), this article examines both the practice of DHR and how it is utilised as data in research. Results Informed by our situated perspectives as researchers and/or practitioners working in the field, our analysis demonstrates how undertaking DHR as a practitioner parallels collecting, accessing, and analysing data from DHRs as a researcher. Guiding principles are identified to help practitioners and researchers navigate the parallel challenges they confront and, critically, inform dialogue between practice and research. Conclusions Implications for both professional practice and research are presented. To increase transparency and confidence, we argue that more attention should be afforded to the methodological and ethical issues inherent in both the practice of DHRs, and their utilisation as a source of data in research. While DHRs have differences to DVFRs in other jurisdictions, these findings also have implications for these other systems which will also be discussed

Myeloid-Derived Suppressor Cells in Murine Retrovirus-Induced AIDS Inhibit T- and B-Cell Responses In Vitro That Are Used To Define the Immunodeficiency

Myeloid-derived suppressor cells (MDSCs) have been characterized in several disease settings, especially in many tumor systems. Compared to their involvement in tumor microenvironments, however, MDSCs have been less well studied in their responses to infectious disease processes, in particular to retroviruses that induce immunodeficiency. Here, we demonstrate for the first time the development of a highly immunosuppressive MDSC population that is dependent on infection by the LP-BM5 retrovirus, which causes murine acquired immunodeficiency. These MDSCs express a cell surface marker signature (CD11b Gr-1 Ly6C ) characteristic of monocyte-type MDSCs. Such MDSCs profoundly inhibit immune responsiveness by a cell dose- and substan- tially inducible nitric oxide synthase (iNOS)-dependent mechanism that is independent of arginase activity, PD-1–PD-L1 ex- pression, and interleukin 10 (IL-10) production. These MDSCs display levels of immunosuppressive function in parallel with the extent of disease in LP-BM5-infected wild-type (w.t.) versus knockout mouse strains that are differentially susceptible to patho- genesis. These MDSCs suppressed not only T-cell but also B-cell responses, which are an understudied target for MDSC inhibi- tion. The MDSC immunosuppression of B-cell responses was confirmed by the use of purified B responder cells, multiple B-cell stimuli, and independent assays measuring B-cell expansion. Retroviral load measurements indicated that the suppressive Ly6Glow/ Ly6C CD11b -enriched MDSC subset was positive for LP-BM5, albeit at a significantly lower level than that of non- fractionated splenocytes from LP-BM5-infected mice. These results, including the strong direct MDSC inhibition of B-cell re- sponsiveness, are novel for murine retrovirus-induced immunosuppression and, as this broadly suppressive function mirrors that of the LP-BM5-induced disease syndrome, support a possible pathogenic effector role for these retrovirus-induced MDSCs

The Relationships Between Prosocial Consumer Behavior, Consumer Resilience, Consumer Risk Taking Propensity and Consumer Hoarding During COVID-19

The Relationships Between Prosocial Consumer Behavior, Consumer Resilience, Consumer Risk Taking Propensity and Consumer Hoarding During COVID-1