Glioblastoma multiforme - case presentation and literature review

Glioblastoma multiforme is a most common primary brain tumor with extreme malignancy index. Presented case of 75y.o. patient diagnosed with GBM underwent full treatment : surgery and adjuvant proton-therapy. Despite new therapy development, overall survival time of GBM patients is still unacceptable

Lumbar discopathy resolved with microdiscectomy - case report

Low back pain is a widespread medical problem, fortunately most episodes are self limiting and resolve within 6 weeks. Many patients may be treated initially with conservative methods. Persistent sciatic pain or developing neurological deficits corresponding with MR scans pathologies of intervertebral disc (herniation , sequestration) are crucial for surgical qualification. We present patient with acute sciatica caused by disc herniation resolved with lumbar microdiscectomy

Carpal Tunnel Syndrome - treatment

Litak Jakub, Grochowski Cezary, Litak Joanna, Szmygin Paweł, Kulesza Bartłomiej, Kamieniak Piotr. Carpal Tunnel Syndrome – treatment. Journal of Education, Health and Sport. 2017;7(1):141-146. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.238710 http://ojs.ukw.edu.pl/index.php/johs/article/view/4160 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016). 754 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.12.2016. Revised 20.12.2016. Accepted: 11.01.2017. Zespół cieśni nadgarstka – leczenie Jakub Litak [1], Cezary Grochowski [2], Joanna Litak [3], Paweł Szmygin [1], Bartłomiej Kulesza [1], Piotr Kamieniak [1] [1] Klinika Neurochirurgii i Neurochirurgii Dziecięcej SPSK-4 w Lublinie [2] Katedra i Zakład Anatomii Prawidłowej Człowieka Uniwersytetu Medycznego w Lublinie [3] Centrum Onkologii Ziemii Lubelskiej im. Jana z Dukli Carpal Tunnel Syndrome – treatment Jakub Litak [1], Cezary Grochowski [2], Joanna Litak [3], Paweł Szmygin [1], Bartłomiej Kulesza [1], Piotr Kamieniak [1] [1] Department of Neurosurgery and Pediatric Neurosurgery SPSK-4 in Lublin [2] Department of Human Anatomy Medical University of Lublin [3] St. John`s Cancer Center in Lublin Słowa kluczowe: Zespół cieśni nadgarstka Key words: Carpal Tunnel Syndrome Abstrakt Zespół cieśni nadgarstka jest częstym schorzeniem spotykanym w praktyce lekarskiej. Obraz kliniczny i diagnostyka przewodnictwa nerwowego są podstawą rozpoznania. Leczenie dobrane adekwatnie do nasilenia dolegliwosci daje ulgę w bólu . Zaniki mięśniowe w obrębie kłębu kciuka są wskazaniem do zabiegu operacyjnego . Abstract Carpal Tunnel Syndrome is a common disease in General Practice. Clinical symptoms and Nerve Conduction Evaluation are crucial for proper diagnosis. Adequate treatment leads to pain relief. Thenar dystrophy indicates surgical treatment

Immunomodulation - hope for patient with Glioblastoma Multiforme

Glioblastoma multiforme is the most common and highly aggressive brain tumor, causing high number of death worldwide. Current therapies are not sufficient for patients. The surgical removal followed by radio- and chemotherapy became golden standard. Overall survival is still disappointing. New approach to GBM therapy is required . Immunotherapy seems to be a proper direction

Nonlinear analysis of the ripping head power time series

We investigate the power of a ripping head in the process of concrete cutting. Using nonlinear embedding methods we study the corresponding time series obtained during the cutting process. The calculated maximal Lyapunov exponent indicates the exponential divergence typical for chaotic or stochastic systems. The recurrence plots technique has been used to get nonlinear process statistics for identification and description of nonlinear dynamics, lying behind the cutting process

Gastroesophageal reflux disease - unit description, diagnosis and treatment

Many GPs are increasingly dealing with patients complaining of ailments likely to suggest gastro-esophageal reflux disease (GERD). These symptoms include heartburn, abdominal pain, and a feeling of esophageal reflux (regurgitation). GERD is one of the most common gastrointestinal diseases that gastroenterologists meet in their practice (1, 2). In North America the problem is affected from 18.1% to even 27.8% of the population. The situation is similar in Europe, where the proportion of people with reflux symptoms is in the range of 8.8% - 25.9%. Among European countries, the prevalence of GERD symptoms is higher in the north of the continent than in the south. The growing problem of overweight and obesity that makes GERD more and more recognized in the population of children and adolescents (3) is a worrying fact. Interestingly, reflux-related complaints are much less frequent in eastern Asia, affecting only 2.5% -7.8% of the population (4)

Nonlinear analysis of the ripping head power time series

We investigate the power of a ripping head in the process of concrete cutting. Using nonlinear embedding methods we study the corresponding time series obtained during the cutting process. The calculated maximal Lyapunov exponent indicates the exponential divergence typical for chaotic or stochastic systems. The recurrence plots technique has been used to get nonlinear process statistics for identification and description of nonlinear dynamics, lying behind the cutting process

A patient with an acute traumatic subdural hematoma chronically treated with rivaroxaban – a challenge for neurosurgeons

Czyżewski Wojciech, Tyzo Bartłomiej, Litak Jakub, Podkowiński Arkadiusz. A patient with an acute traumatic subdural hematoma chronically treated with rivaroxaban – a challenge for neurosurgeons. Journal of Education, Health and Sport. 2017;7(9):357-363. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.998963 http://ojs.ukw.edu.pl/index.php/johs/article/view/4897 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.08.2017. Revised: 10.09.2017. Accepted: 10.09.2017. A patient with an acute traumatic subdural hematoma chronically treated with rivaroxaban – a challenge for neurosurgeons Wojciech Czyżewski1, Bartłomiej Tyzo2, Jakub Litak2, Arkadiusz Podkowiński2 1 Medical University of Lublin, Department of Didactics and Medical Simulation 2 Department of Neurosurgery and Pediatric Neurosurgery SPSK-4 in Lublin Abstract Rivaroxaban (Xareltoâ), selective direct inhibitor of activated clotting factor Xa belongs to the new oral anticoagulatns (NOACs). Rivaroxaban works to inhibit thrombin formation, and the interruption of the intrinsic and extrinsic pathway of blood coagulation and is strongly dose-dependent. It prolongs Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) without influence on bleeding time and platelet aggregation. It is indicated as a prophylactic to cerebral infarction and peripheral thrombosis in adults with nonvalvular atrial fibrillation as well as the treatment and secondary prevention of deep vein thrombosis and pulmonary thromboembolism. We are presenting a case of an elderly female patient chronically treated with rivaroxaban, who was qualified for neurosurgical treatment in a life threatening state due to an acute subdural hematoma. Despite the lack of unequivocal guidelines for pharmacological and surgical management in cases of intracranial haemorrhage in adults whom are chronically treated with direct factor Xa inhibitors, we managed to obtain a favourable outcome. Key words: rivaroxaban, atrial fibrillation, acute subdural hematoma Pacjentka z ostrym pourazowym krwiakiem podtwardówkowym przewlekle leczona rywaroksabanem - wyzwanie dla neurochirurgii Wojciech Czyżewski1, Bartłomiej Tyzo2, Jakub Litak2, Arkadiusz Podkowiński2 1 Zakład Dydaktyki i Symulacji Medycznej Uniwersytetu Medycznego w Lublinie 2 Klinika Neurochirurgii i Neurochirurgii Dziecięcej SPSK4 w Lublinie Abstrakt Rywaroksaban (Xareltoâ), wybiórczy bezpośredni inhibitor aktywnego czynnika krzepnięcia Xa należy do tzw. nowych leków przeciwzakrzepowych. Działanie leku polega na hamowaniu wytwarzania trombiny, zahamowanie zewnątrz- i wewnątrzpochodnego szlaku krzepnięcia jest silnie zależne od przyjętej dawki. Dochodzi do wydłużenia czasu protrombinowego (PT) oraz czasu częściowej tromboplastyny po aktywacji (APTT), bez wpływu na czas krwawienia i agregację płytek. Preparat znajduje zastosowanie w profilaktyce udaru i zatorowości obwodowej u dorosłych pacjentów z niezastawkowym migotaniem przedsionków oraz leczeniu i profilaktyce wtórnej zakrzepicy żył głębokich i zatorowości płucnej. Prezentujemy przypadek pacjentki w podeszłym wieku przewlekle leczonej rywaroksabanem, która została zakwalifikowana w stanie zagrożenia życia do leczenia neurochirurgicznego z powodu ostrego krwiaka podtwardówkowego. Pomimo braku jednoznacznych wytycznych postępowania farmakologicznego oraz operacyjnego w sytuacji krwotoku wewnątrzczaszkowego u chorych leczonych bezpośrednimi inhibitorami aktywnego czynnika X, u prezentowanej pacjentki uzyskano pomyślny przebieg leczenia. Słowa kluczowe: rywaroksaban, migotanie przedsionków, ostry krwiak podtwardówkow

Ból kręgosłupa szyjnego w przebiegu radikulopatii = The cervical spine pain in radiculopathy

Litak Jakub, Grochowski Cezary, Kulesza Bartłomiej, Kamieniak Piotr. Ból kręgosłupa szyjnego w przebiegu radikulopatii = The cervical spine pain in radiculopathy. Journal of Education, Health and Sport. 2016;6(11):500-510. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.189567http://ojs.ukw.edu.pl/index.php/johs/article/view/4025   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016.   Ból kręgosłupa szyjnego w przebiegu radikulopatii Jakub Litak¹, Cezary Grochowski², Bartłomiej Kulesza¹, Piotr Kamieniak¹ ¹Oddział Neurochirurgii i Neurochirurgii Dziecięcej SPSK-4 w Lublinie²Katedra i Zakład Anatomii Prawidłowej Człowieka Uniwersytetu Medycznego w Lublinie  The cervical spine pain in radiculopathyJakub Litak¹, Cezary Grochowski², Bartłomiej Kulesza¹, Piotr Kamieniak¹ ¹Department of Neurosurgery and Pediatric Neurosurgery SPSK-4 in Lublin²Department of Human Anatomy  Medical University of Lublin  Key words: cervical discopathy, radiculopathy, neck pain    AbstraktBóle kręgosłupa szyjnego stanowią poważny problem diagnostyczny w praktyce lekarskiej . Są najczęstszą przyczyną zgłaszania się do lekarza i mają znaczący wymiar ekonomiczny. W związku z rozwojem cywilizacyjnym, stresem , siedzącym trybem życia i ograniczeniem aktywności procesy  degeneracyjno - wytwórcze w kręgosłupie szyjnym stają się bardziej powszechne. Radikulopatia szyjna jest neurologicznym stanem wywołanym kompresją lub uszkodzeniem korzeni nerwowych szyjnego odcinka kręgosłupa. Stan ten generuje ból w obrębie szyi  nie rzadko promieniuje do obręczy barkowej i kończyn górnych. Postępowanie diagnostyczne jest procesem wieloetapowym. Wywiad i badanie fizykalne pełnia znaczącą rolę a badania obrazowe uzupełniają pełną diagnozę. Farmakoterapia i ograniczenie obciążeń redukują ból w ostrej fazie.W przypadku nieskuteczności leczenia zachowawczego , przewlekłego bólu czy tez postępujących deficytów neurologicznych przeprowadzenie zabiegu operacyjnego obarczającego uciśnięte struktury nerwowe staje się jedynym słusznym postępowaniem . Słowa kluczowe: szyjna dyskopatia, radikulopatia, ból kręgosłupa szyjnego  AbstractThe cervical spine pain represents serious diagnostic medical problem .It is the most common reason for visiting the doctor and has economic dimension . According to Development of Civilization , stress , sitting lifestyle and limitation of physical  activity  Degenerative and Osteoarthritic  syndromes become more common. Cervical radiculopathy  is a neurological condition caused by compression or damage of the nerve roots ofthe cervical spine.  This leads to the occurrence of the neck pain  radiating  to the shoulders and upper extremities. Diagnostic path is a multistage process. Medical interview and physical examination perform essential role . Imaging tools complete proper diagnosis . Pharmacotherapy and short term immobilization reduce pain in a acute phase of disease . However when conservative treatment fails and the patient reports chronic  pain, progressive neurological deficits appears  , surgery may be considered  in order to decompress constricted neurological structures,  as a best relieving pain treatment . Key words: cervical discopathy, radiculopathy, neck pai

NUMERICAL ANALYSIS OF SPINAL LOADS IN SPONDYLOLISTHESIS TREATMENT USING PEDICLE SCREWS – PRELIMINARY RESEARCH

The aim of this experimental study was to analyse the influence of lumbar stabilisation used in the treatment of spondylolisthesis on the biome-chanical properties of the human lumbar spine. FEM models were built on the basis of pre-surgical CT scans, routinely used in medical practice. MIMICS software was used to process the results of the neuroimaging study and to create 3D models. Two models were built: with and without a stabiliser. A static load analysis was performed for a normal upper-body load. The simulations allowed to determine the stresses in the individual discs for both models, with and without the transpedicular stabiliser