Modelling the optimal sequence of biologic therapies in plaque psoriasis in Spain

Aim: The purpose of this manuscript was to illustrate the impact of the place in the treatment sequence on the cost and cost-effectiveness of different biologics for patients with moderate-to-severe plaque psoriasis. Materials and methods: We developed a treatment sequence model and focused on seven different biological treatment options and 840 combinations of treatment sequences. The model converted cost of treatment to a cost per responder by dividing treatment cost by expected number of patients achieving PASI100 after 52 weeks of treatment. We used Spanish ex-factory price levels, dosing recommendations and real-world data on drug survival to calculate the treatment costs. Results: The most cost-effective treatment sequence was brodalumab-risankizumab-guselkumab-ixekizumab, with a cost per responder of €139,281 during the first five years of treatment. In comparison, if brodalumab was not recommended as first-line therapy, total costs would increase by 7.4% to €149,616. If brodalumab was not recommended as any of the first four lines of treatment, total costs would increase by 13.1% to €157,527 relative to the most cost-effective treatment sequence. Conclusions: A sequential therapy model may improve efficiency in the treatment of psoriasis. According to our results, brodalumab as the first-line therapy in Spain leads to the most cost-effective treatment sequence

Effect of the Front and Back Illumination on Sub-Terahertz Detection Using n-Channel Strained-Silicon MODFETs

[EN] Plasma waves in semiconductor gated 2-D systems can be used to efficiently detect Terahertz (THz) electromagnetic radiation. This work reports on the response of a strained-Si Modulation-doped Field-Effect Transistor (MODFET) under front and back sub-THz illumination. The response of the MODFET has been characterized using a two-tones solid-state continuous wave source at 0.15 and 0.30 THz. The DC drain-to-source voltage of 500-nm gate length transistors transducing the sub-THz radiation (photovoltaic mode) exhibited a non-resonant response in agreement with literature results. Two configurations of the illumination were investigated: (i) front side illumination in which the transistor was shined on its top side, and (ii) back illumination side where the device received the sub-THz radiation on its bottom side, i.e., on the Si substrate. Under excitation at 0.15 THz clear evidence of the coupling of terahertz radiation by the bonding wires was found, this coupling leads to a stronger response under front illumination than under back illumination. When the radiation is shifted to 0.3 THz, as a result of a lesser efficient coupling of the EM radiation through the bonding wires, the response under front illumination was considerably weakened while it was strengthened under back illumination. Electromagnetic simulations explained this behavior as the magnitude of the induced electric field in the channel of the MODFET was considerably stronger under back illumination.This research was funded by the Ministerio de Ciencia, Investigacion y Universidades of Spain andFEDER (ERDF: European Regional Development Fund) under the Research Grants numbers RTI2018-097180-B-100 and TEC2016-78028-C3-3-P and FEDER/Junta de Castilla y Leon Research Grant number SA256P18. Also by Conselleria d'Educacio, lnvestigacio, Cultura i Esport, Generalitat Valenciana (Spain) through the grant AIC0/2019/018. The APC received no external funding.Delgado-Notario, JA.; Calvo-Gallego, J.; Velázquez-Pérez, JE.; Ferrando Bataller, M.; Fobelets, K.; Meziani, YM. (2020). Effect of the Front and Back Illumination on Sub-Terahertz Detection Using n-Channel Strained-Silicon MODFETs. Applied Sciences. 10(17):1-9. https://doi.org/10.3390/app10175959S191017Lewis, R. A. (2019). A review of terahertz detectors. Journal of Physics D: Applied Physics, 52(43), 433001. doi:10.1088/1361-6463/ab31d5Dragoman, D., & Dragoman, M. (2004). Terahertz fields and applications. Progress in Quantum Electronics, 28(1), 1-66. doi:10.1016/s0079-6727(03)00058-2Mittleman, D. M. (2017). Perspective: Terahertz science and technology. Journal of Applied Physics, 122(23), 230901. doi:10.1063/1.5007683Pawar, A. Y., Sonawane, D. D., Erande, K. B., & Derle, D. V. (2013). Terahertz technology and its applications. Drug Invention Today, 5(2), 157-163. doi:10.1016/j.dit.2013.03.009Federici, J., & Moeller, L. (2010). Review of terahertz and subterahertz wireless communications. Journal of Applied Physics, 107(11), 111101. doi:10.1063/1.3386413Federici, J. F., Schulkin, B., Huang, F., Gary, D., Barat, R., Oliveira, F., & Zimdars, D. (2005). THz imaging and sensing for security applications—explosives, weapons and drugs. Semiconductor Science and Technology, 20(7), S266-S280. doi:10.1088/0268-1242/20/7/018Dyakonov, M., & Shur, M. (1993). Shallow water analogy for a ballistic field effect transistor: New mechanism of plasma wave generation by dc current. Physical Review Letters, 71(15), 2465-2468. doi:10.1103/physrevlett.71.2465Dyakonov, M., & Shur, M. (1996). Detection, mixing, and frequency multiplication of terahertz radiation by two-dimensional electronic fluid. IEEE Transactions on Electron Devices, 43(3), 380-387. doi:10.1109/16.485650Tauk, R., Teppe, F., Boubanga, S., Coquillat, D., Knap, W., Meziani, Y. M., … Shur, M. S. (2006). Plasma wave detection of terahertz radiation by silicon field effects transistors: Responsivity and noise equivalent power. Applied Physics Letters, 89(25), 253511. doi:10.1063/1.2410215Rumyantsev, S. L., Fobelets, K., Veksler, D., Hackbarth, T., & Shur, M. S. (2008). Strained-Si modulation doped field effect transistors as detectors of terahertz and sub-terahertz radiation. Semiconductor Science and Technology, 23(10), 105001. doi:10.1088/0268-1242/23/10/105001Javadi, E., Delgado-Notario, J. A., Masoumi, N., Shahabadi, M., Velázquez-Pérez, J. E., & Meziani, Y. M. (2018). Continuous Wave Terahertz Sensing Using GaN HEMTs. physica status solidi (a), 215(11), 1700607. doi:10.1002/pssa.201700607Delgado-Notario, J. A., Clericò, V., Diez, E., Velázquez-Pérez, J. E., Taniguchi, T., Watanabe, K., … Meziani, Y. M. (2020). Asymmetric dual-grating gates graphene FET for detection of terahertz radiations. APL Photonics, 5(6), 066102. doi:10.1063/5.0007249Lewis, R. A. (2014). A review of terahertz sources. Journal of Physics D: Applied Physics, 47(37), 374001. doi:10.1088/0022-3727/47/37/374001Delgado-Notario, J., Velazquez-Perez, J., Meziani, Y., & Fobelets, K. (2018). Sub-THz Imaging Using Non-Resonant HEMT Detectors. Sensors, 18(2), 543. doi:10.3390/s18020543Gaspari, V., Fobelets, K., Velazquez-Perez, J. E., Ferguson, R., Michelakis, K., Despotopoulos, S., & Papavassilliou, C. (2004). Effect of temperature on the transfer characteristic of a 0.5 μm-gate Si:SiGe depletion-mode n-MODFET. Applied Surface Science, 224(1-4), 390-393. doi:10.1016/j.apsusc.2003.08.066Fobelets, K., Jeamsaksiri, W., Papavasilliou, C., Vilches, T., Gaspari, V., Velazquez-Perez, J. E., … König, U. (2004). Comparison of sub-micron Si:SiGe heterojunction nFETs to Si nMOSFET in present-day technologies. Solid-State Electronics, 48(8), 1401-1406. doi:10.1016/j.sse.2004.01.017Delgado Notario, J. A., Javadi, E., Calvo-Gallego, J., Diez, E., Velázquez, J. E., Meziani, Y. M., & Fobelets, K. (2016). Sub-Micron Gate Length Field Effect Transistors as Broad Band Detectors of Terahertz Radiation. International Journal of High Speed Electronics and Systems, 25(03n04), 1640020. doi:10.1142/s0129156416400206Sakowicz, M., Łusakowski, J., Karpierz, K., Grynberg, M., Gwarek, W., Boubanga, S., … Studart, N. (2010). A High Mobility Field-Effect Transistor as an Antenna for sub-THz Radiation. doi:10.1063/1.3295528Knap, W., Teppe, F., Meziani, Y., Dyakonova, N., Lusakowski, J., Boeuf, F., … Shur, M. S. (2004). Plasma wave detection of sub-terahertz and terahertz radiation by silicon field-effect transistors. Applied Physics Letters, 85(4), 675-677. doi:10.1063/1.177503

Titulos, y exercicios literarios de el Dr. D. Iayme Francisco de Rufas, colegial actual del insigne Real Colegio de S. Vicente Martyr de la Vniuersidad de Huesca : yo Raymundo de Sanclemnte, secretario de la Vniuersidad, y Estudio General de la ciudad de Huesca ..

Tít. tomado de las primeras palabras del textoEn p. 2 consta el año 1715Letra capital tip

Responsivity enhancement of a strained silicon field-effect transistor detector at 0.3 THz using the terajet effect

[EN] We report on the enhancement of responsivity by more than one order of magnitude of a silicon-based sub-terahertz detector when a mesoscopic dielectric particle was used to localize incident radiation to a sub-wavelength volume and focus it directly onto the detector. A strained-silicon modulation field-effect transistor was used as a direct detector on an incident terahertz beam at 0.3 THz. A systematic study in which Teflon cubes were placed in front of the detector to focus the terahertz beam was performed. In this study, cubes with different sizes were investigated, and an enhancement of the responsivity up to 11 dB was observed for a cube with an edge length of 3.45 mm (or 3.45 lambda). Electromagnetic simulation results were in good agreement with the experimental ones and demonstrated that the size of the mesoscopic particle plays an important role in focalizing the electric field within an area below the diffraction limit. This approach provides an efficient, uncostly, and easy to implement method to substantially improve the responsivity and noise equivalent power of sub-terahertz detectors.Tomsk Polytechnic University Development Program; Ministerio de Ciencia, Innovacion y Universidades (PID2019-107885GB-C32, RTI2018-097180-B-100, TEC2016-78028-C3-3-P); Junta de Castilla y Leon (SA121P20, SA256P18); Conselleria d'Educacio, Investigacio, Cultura i Esport (AIC0/2019/018); European Regional Development Fund; Fundacja na rzeczNauki Polskiej (CENTERA-IRA MAB/2018/9)Minin, IV.; Minin, OV.; Salvador-Sánchez, J.; Delgado-Notario, JA.; Calvo-Gallego, J.; Ferrando Bataller, M.; Fobelets, K.... (2021). Responsivity enhancement of a strained silicon field-effect transistor detector at 0.3 THz using the terajet effect. Optics Letters. 46(13):3061-3064. https://doi.org/10.1364/OL.43117530613064461

Fuera de texto: El comentario textual y audiovisual en las asignaturas del Área de Estética y Teoría de las Artes de la Universidad de Salamanca

Memoria ID-029 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2020-2021

Long-term etanercept survival in patients with psoriatic arthritis: a multicenter retrospective analysis in daily clinical practice in Spain

Although several randomized clinical trials and observational studies have evaluated the effectiveness, safety and drug survival of etanercept (ETN) in the treatment of psoriatic arthritis (PsA), long-term data regarding these aspects are currently scarce. For this reason, we sought to investigate the long-term survival and safety of ETN in PsA patients in 4 tertiary care Spanish hospitals over a 13-year observation period (from 2004 to 2017). The records of 85 PsA patients were reviewed. ETN showed an excellent survival profile, with rates of treatment discontinuation at 1, 3, 5 and 10 years of 15, 37, 46 and 59%, respectively. In our cohort, a trend toward longer drug survival in patients with shorter disease duration and those who were treated with ETN as their first biologic agent was observed. On the other hand, combination therapy with conventional disease-modifying antirheumatic drugs did not provide greater improvement on the long-term drug survival. Only 12% of the patients reported adverse events (AEs) during therapy, being most of them of mild to moderate intensity, and in only 7% AEs led to drug discontinuation. To the best of our knowledge, the present study shows the largest follow-up period of ETN-treated population analyzed in a real-life setting, and these results demonstrate the positive safety profile and long-term effectiveness of this biologic agent in the management of PsA patients

The DERMACLEAR study: Verification results of a natural language processing system in dermatology

BackgroundAccurately determining the epidemiology of dermatological diseases such as hidradenitis suppurativa (HS), psoriasis (PsO), chronic urticaria (CU) and/or atopic dermatitis (AD) is challenging due to variations in prevalence and disease severity in the reported literature.ObjectivesThe DERMACLEAR study aims to use natural language processing (NLP) to assess the proportions of patients with HS, PsO, CU and/or AD, and obtain information on patient profiles, patient journeys, and disease and healthcare burden in Spain. Here, the study design and objectives of the DERMACLEAR study are described and the precision of the NLP system used is assessed.MethodsThis study will retrospectively collect patient information from electronic health records (EHRs) at dermatology departments from seven tertiary hospitals in Spain. The NLP system was developed by IOMED Medical Solutions and was verified internally (IOMED scientific team) and externally (principal investigators of each hospital) to determine its precision in identifying patients with HS, PsO, CU and/or AD. Furthermore, internal verification was performed on other medical variables relevant to the study.ResultsTo date, the DERMACLEAR study has retrospectively collected data from 54,458 patients with HS, PsO, CU and/or AD (HS: 5045; PsO: 32,559; CU: 8397; AD: 12,492). The average precision of the NLP system to identify patients diagnosed with HS, PsO, CU, and/or AD across all hospitals exceeded 95% via external and internal verification.ConclusionsResults from the DERMACLEAR study will increase the real-world evidence of clinical practice, obtaining a large amount of information on patients with the studied diseases. The NLP system used is precise in identifying patients diagnosed with HS, PsO, CU and/or AD, and other medical variables from EHRs, highlighting that it is a valid system to use in the DERMACLEAR study

Desarrollo de un sistema interactivo para el estudio de la órbita y su contenido: anatomía macroscópica

En este proyecto se ha desarrollado un sistema interactivo para mejorar el proceso de enseñanza-aprendizaje en la docencia de la anatomía macroscópica de la órbita y su contenido por medio de preparaciones anatómicas. Se pretende facilitar el aprendizaje de forma autónoma en español e inglés y, la autoevaluación sobre los conocimientos adquiridos.Unidad Docente de Anatomía y EmbriologíaFac. de Óptica y OptometríaFALSEsubmitte

Efectividad y seguridad en el tratamiento de la psoriasis vulgar con terapias anti interleucina 17A en condiciones de práctica clínica habitual

Programa de Doctorat en Medicina i Recerca Translacional / Tesi realitzada a l'Hospital Universitari de Bellvitge[spa] Los objetivos principales de este trabajo de tesis es evaluar la efectividad y seguridad en el tratamiento de pacientes con psoriasis con los agentes biológicos anti IL-17A aprobados (secukinumab e ixekizumab) en condiciones de práctica clínica habitual así como identificar variables clínicas que potencialmente puedan interferir en la efectividad o seguridad de estos fármacos. - Con diseño de estudios observacionales, retrospectivos, multicéntricos que incluyen pacientes adultos con psoriasis moderada-severa tratados con secukinumab e ixekizumab. - Los resultados han sido objeto de dos artículos que incluyen las cohortes más extensas a fecha de publicación de pacientes tratados con secukinumab o ixekizumab en condiciones de vida real. - Secukinumab e ixekizumab pueden considerarse terapias con buen perfil de seguridad y elevada efectividad, pero con algunas diferencias entre los resultados clínicos observados en los ensayos clínicos y los de pacientes tratados en condiciones de práctica clínica habitual