151 research outputs found
Wage and Cost Study of Oregon Assisted Living and Residential Care Providers, 2022
Senate Bill 703 directed Oregon Department of Human Services (ODHS) to conduct a study of licensed residential care (RCF) and assisted living (ALF) facilities, including those with a memory care (MC) endorsement, to evaluate: a) Total cost to provide care to residents, b) the sufficiency of the Medicaid reimbursement paid to facilities to meet the total cost of care, and c) the average compensation paid to direct care workers by the facilities by geographic region. ODHS contracted with the Institute on Aging (IOA) at Portland State University (PSU) to conduct a study to achieve these three objectives. In the fall of 2022, IOA developed and conducted the study in collaboration with ODHS staff, with multiple opportunities for input from community partners, including consumer advocates and direct care worker partners, long term care trade associations, and attendees of the Long-Term Care Facility Provider Workforce Recovery Workgroup. This report describes the findings of the resulting study, which uses multiple data sources, including data collected by IOA from over 150 ALF/RCF providers and Medicaid reimbursement data provided to IOA by ODHS.
Prepared for: Oregon Department of Human Services Office of Aging and People with Disabilities
A study completed by the Institute on Aging at Portland State University with funding from and in partnership with Oregon Department of Human Service
2022 Adult Foster Home Resident and Community Characteristics Report on Adult Foster Homes
This report describes results from a study of Oregon adult foster homes (AFH), including home and owner characteristics; monthly charges and payment sources; resident characteristics, personal and health-related needs; and owners’ experiences with supports and challenges due to the COVID-19 pandemic. The study’s purpose was to collect and report data that can inform and advise policymakers, state and county agency staff, aging advocates and AFH owners about the status of AFHs in Oregon. The report includes information collected between December 2021 and March 2022 and, where possible, compares it to findings from prior years of this study and to other reports and articles about AFHs and other types of community-based care
Patrocinio de programas de actividad física por parte de la industria de bebidas azucaradas: ¿salud pública o relaciones públicas?
La creciente evidencia acerca de los vínculos entre consumo de bebidas azucaradas, obesidad y otras enfermedades crónicas plantea la necesidad de implementar acciones políticas que transciendan las intervenciones centradas exclusivamente en la responsabilidad individual. Temiendo que ello afecte sus objetivos comerciales en América Latina, la industria de bebidas azucaradas lleva a cabo un intenso cabildeo político en altas esferas gubernamentales de la región. Esta estrategia esta acompañada de los llamados programas de responsabilidad social empresarial dirigidos a financiar iniciativas que promocionan la actividad física. Estos esfuerzos, aparentemente altruistas, están dirigidos a mejorar la imagen pública de esta industria y a lograr mayor influencia política ante regulaciones contrarias a sus intereses. Si este sector de la industria desea contribuir con el bienestar humano, como públicamente lo expresa, debería evitar obstruir iniciativas legislativas dirigidas a regular la comercialización, mercadeo y oferta de sus productos
2022 Community-Based Care: Resident and Community Characteristics Report on Assisted Living, Residential Care, and Memory Care Communities
This report summarizes findings from the 8th annual study of Oregon community-based care settings, including assisted living and residential care facilities, and memory care communities. This study was conducted during fall 2021 and winter 2022
Television viewing and its association with overweight in Colombian children: results from the 2005 National Nutrition Survey: A cross sectional study
<p>Abstract</p> <p>Background</p> <p>There has been an ongoing discussion about the relationship between time spent watching television and childhood obesity. This debate has special relevance in the Latin American region were the globalization process has increased the availability of screen-based entertainment at home. The aim of this study is to examine the association between television viewing and weight status in Colombian children.</p> <p>Methods</p> <p>This cross sectional investigation included children aged 5 to12 yrs from the National Nutrition Survey in Colombia (ENSIN 2005). Weight and height were measured in 11,137 children in order to calculate body mass index. Overweight was defined by international standards. Time spent viewing television was determined for these children through parental reports. Multiple logistic regression analyses were conducted for different subgroups and adjusted for potential confounders in order to study the association between television viewing and weight status in this population.</p> <p>Results</p> <p>Among the surveyed children, 41.5% viewed television less than two hours/day; 36.8% between two and 3.9 hours/day and 21.7% four or more hours/day. The prevalence of overweight (obesity inclusive) in this population was 11.1%. Children who were classified as excessive television viewers (between two and 3.9 hours/day or 4 or more hours/day) were more likely to be overweight (OR: 1.44 95% CI: 1.41–1.47 and OR: 1.32 95% CI: 1.30–1.34, respectively) than children who reported to watch television less than 2 hours/day. Stratified analyses by age, gender and urbanization levels showed similar results.</p> <p>Conclusion</p> <p>Television viewing was positively associated with the presence of overweight in Colombian children. A positive association between urbanization level and television viewing was detected. Considering that the majority of Colombian children lives in densely populated cities and appear to engage in excessive television viewing these findings are of public health relevance for the prevention of childhood obesity.</p
Sponsorship of physical activity programs by the sweetened beverages industry : public health or public relations?
La creciente evidencia acerca de los vínculos entre consumo de bebidas
azucaradas, obesidad y otras enfermedades crónicas plantea la necesidad de
implementar acciones políticas que transciendan las intervenciones centradas
exclusivamente en la responsabilidad individual. Temiendo que ello afecte sus
objetivos comerciales en América Latina, la industria de bebidas azucaradas
lleva a cabo un intenso cabildeo político en altas esferas gubernamentales
de la región. Esta estrategia esta acompañada de los llamados programas
de responsabilidad social empresarial dirigidos a fi nanciar iniciativas que
promocionan la actividad física. Estos esfuerzos, aparentemente altruistas,
están dirigidos a mejorar la imagen pública de esta industria y a lograr mayor
infl uencia política ante regulaciones contrarias a sus intereses. Si este sector
de la industria desea contribuir con el bienestar humano, como públicamente
lo expresa, debería evitar obstruir iniciativas legislativas dirigidas a regular
la comercialización, mercadeo y oferta de sus productos.Q3Q2The growing evidence on the association between consumption of sugarsweetened beverages, obesity and other chronic diseases has highlighted the
need to implement policy actions that go beyond programs exclusively focused
on individual responsibility. In order to protect their commercial goals in Latin
America, the sugar-sweetened beverage industry practices intense lobbying at
high government levels in several countries across the region. This strategy is
accompanied by corporate social responsibility programs that fund initiatives
promoting physical activity. These efforts, although appearing altruistic, are
intended to improve the industry’s public image and increase political infl uence
in order to block regulations counter to their interests. If this industry wants
to contribute to human well being, as it has publicly stated, it should avoid
blocking legislative actions intended to regulate the marketing, advertising
and sale of their products.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000154547Revista Nacional - Indexad
Patrocínio de programas de atividade física por parte das indústrias de bebidas açucaradas: saúde pública ou relações públicas?
La creciente evidencia acerca de los vínculos entre consumo de bebidas azucaradas, obesidad y otras enfermedades crónicas plantea la necesidad de implementar acciones políticas que transciendan las intervenciones centradas exclusivamente en la responsabilidad individual. Temiendo que ello afecte sus objetivos comerciales en América Latina, la industria de bebidas azucaradas lleva a cabo un intenso cabildeo político en altas esferas gubernamentales de la región. Esta estrategia esta acompañada de los llamados programas de responsabilidad social empresarial dirigidos a financiar iniciativas que promocionan la actividad física. Estos esfuerzos, aparentemente altruistas, están dirigidos a mejorar la imagen pública de esta industria y a lograr mayor influencia política ante regulaciones contrarias a sus intereses. Si este sector de la industria desea contribuir con el bienestar humano, como públicamente lo expresa, debería evitar obstruir iniciativas legislativas dirigidas a regular la comercialización, mercadeo y oferta de sus productos.The growing evidence on the association between consumption of sugar-sweetened beverages, obesity and other chronic diseases has highlighted the need to implement policy actions that go beyond programs exclusively focused on individual responsibility. In order to protect their commercial goals in Latin America, the sugar-sweetened beverage industry practices intense lobbying at high government levels in several countries across the region. This strategy is accompanied by corporate social responsibility programs that fund initiatives promoting physical activity. These efforts, although appearing altruistic, are intended to improve the industry's public image and increase political influence in order to block regulations counter to their interests. If this industry wants to contribute to human well being, as it has publicly stated, it should avoid blocking legislative actions intended to regulate the marketing, advertising and sale of their products.A crescente evidência sobre os vínculos entre consumo de bebidas açucaradas, obesidade e outras doenças crônicas levanta a necessidade de implementar ações políticas que transcendam as intervenções centradas exclusivamente na responsabilidade individual. Temendo que isso afete seus objetivos, a indústria de bebidas açucaradas realiza um extenso lobby político em altas esferas governamentais da região. Essa estratégia tem sido acompanhada dos chamados programas de responsabilidade socioempresarial dirigidos a financiar iniciativas que promovam a atividade física. Esses esforços, aparentemente altruístas, visam melhorar a imagem pública dessas indústrias e obter maior influência política diante de regulações contrárias a seus interesses. Se esse setor da indústria deseja contribuir realmente com o bem-estar humano, como publicamente expressa, deveria evitar obstruir iniciativas dirigidas a regular a comercialização, comércio e oferta de seus produtos
Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. The increasingly recognized relevance of epigenetic changes in cancer immunology prompted us to determine the impact of the DNA methylation profiles of CART19 cells on the clinical course.
Methods: We recruited 114 patients with B-cell malignancies, comprising 77 patients with acute lymphoblastic leukemia and 37 patients with non-Hodgkin lymphoma who were treated with CART19 cells. Using a comprehensive DNA methylation microarray, we determined the epigenomic changes that occur in the patient T cells upon transduction of the CAR vector. The effects of the identified DNA methylation sites on clinical response, cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, event-free survival, and overall survival were assessed. All statistical tests were 2-sided.
Results: We identified 984 genomic sites with differential DNA methylation between CAR-untransduced and CAR-transduced T cells before infusion into the patient. Eighteen of these distinct epigenetic loci were associated with complete response (CR), adjusting by multiple testing. Using the sites linked to CR, an epigenetic signature, referred to hereafter as the EPICART signature, was established in the initial discovery cohort (n = 79), which was associated with CR (Fisher exact test, P < .001) and enhanced event-free survival (hazard ratio [HR] = 0.36; 95% confidence interval [CI] = 0.19 to 0.70; P = .002; log-rank P = .003) and overall survival (HR = 0.45; 95% CI = 0.20 to 0.99; P = .047; log-rank P = .04;). Most important, the EPICART profile maintained its clinical course predictive value in the validation cohort (n = 35), where it was associated with CR (Fisher exact test, P < .001) and enhanced overall survival (HR = 0.31; 95% CI = 0.11 to 0.84; P = .02; log-rank P = .02).
Conclusions: We show that the DNA methylation landscape of patient CART19 cells influences the efficacy of the cellular immunotherapy treatment in patients with B-cell malignancy.Supported by CERCA Programme/Generalitat de Catalunya, Health Department PERIS #SLT/002/16/00374, AGAUR-project #2017SGR1080; MCI/AEI/ERDF project #RTI2018-094049-B-I00; ERC EPIPHARM; Cellex Foundation; “la Caixa” Foundation (LCF/PR/GN18/51140001 and LCF/PR/GN18/50310007), RF-2016–02364388, Accelerator Award—Cancer Research UK/AIRC—INCAR Associazione Italiana Ricerca per la Ricerca sul Cancro (AIRC) Project 5 × 1000 no. 9962, AIRC IG 2018 id. 21724, AIRC MFAG id. 21769 and id. 20450; MIUR (Grant PRIN 2017); and RCR-2019–23669115
The beneficial effect of testing: An event-related potential study
The enhanced memory performance for items that are tested as compared to being restudied (the testing effect) is a frequently reported memory phenomenon. According to the episodic context account of the testing effect, this beneficial effect of testing is related to a process which reinstates the previously learnt episodic information. Few studies have explored the neural correlates of this effect at the time point when testing takes place, however. In this study, we utilized the ERP correlates of successful memory encoding to address this issue, hypothesizing that if the benefit of testing is due to retrieval-related processes at test then subsequent memory effects (SMEs) should resemble the ERP correlates of retrieval-based processing in their temporal and spatial characteristics. Participants were asked to learn Swahili-German word pairs before items were presented in either a testing or a restudy condition. Memory performance was assessed immediately and 1-day later with a cued recall task. Successfully recalling items at test increased the likelihood that items were remembered over time compared to items which were only restudied. An ERP subsequent memory contrast (later remembered vs. later forgotten tested items), which reflects the engagement of processes that ensure items are recallable the next day were topographically comparable with the ERP correlate of immediate recollection (immediately remembered vs. immediately forgotten tested items). This result shows that the processes which allow items to be more memorable over time share qualitatively similar neural correlates with the processes that relate to successful retrieval at test. This finding supports the notion that testing is more beneficial than restudying on memory performance over time because of its engagement of retrieval processes, such as the re-encoding of actively retrieved memory representations. © 2015 Bai, Bridger, Zimmerand Mecklinger
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