Critical impact of vegetation physiology on the continental hydrologic cycle in response to increasing CO2

Predicting how increasing atmospheric CO2 will affect the hydrologic cycle is of utmost importance for a range of applications ranging from ecological services to human life and activities. A typical perspective is that hydrologic change is driven by precipitation and radiation changes due to climate change, and that the land surface will adjust. Using Earth system models with decoupled surface (vegetation physiology) and atmospheric (radiative) CO2 responses, we here show that the CO2 physiological response has a dominant role in evapotranspiration and evaporative fraction changes and has a major effect on long-term runoff compared with radiative or precipitation changes due to increased atmospheric CO2. This major effect is true for most hydrological stress variables over the largest fraction of the globe, except for soil moisture, which exhibits a more nonlinear response. This highlights the key role of vegetation in controlling future terrestrial hydrologic response and emphasizes that the carbon and water cycles are intimately coupled over land

Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury

Increasing evidence suggests that the calcineurin (CN)-dependent transcription factor NFAT (Nuclear Factor of Activated T cells) mediates deleterious effects of astrocytes in progressive neurodegenerative conditions. However, the impact of astrocytic CN/NFAT signaling on neural function/recovery after acute injury has not been investigated extensively. Using a controlled cortical impact (CCI) procedure in rats, we show that traumatic brain injury is associated with an increase in the activities of NFATs 1 and 4 in the hippocampus at 7 d after injury. NFAT4, but not NFAT1, exhibited extensive labeling in astrocytes and was found throughout the axon/dendrite layers of CA1 and the dentate gyrus. Blockade of the astrocytic CN/NFAT pathway in rats using adeno-associated virus (AAV) vectors expressing the astrocyte-specific promoter Gfa2 and the NFAT-inhibitory peptide VIVIT prevented the injury-related loss of basal CA1 synaptic strength and key synaptic proteins and reduced the susceptibility to induction of long-term depression. In conjunction with these seemingly beneficial effects, VIVIT treatment elicited a marked increase in the expression of the prosynaptogenic factor SPARCL1 (hevin), especially in hippocampal tissue ipsilateral to the CCI injury. However, in contrast to previous work on Alzheimer\u27s mouse models, AAV-Gfa2-VIVIT had no effects on the levels of GFAP and Iba1, suggesting that synaptic benefits of VIVIT were not attributable to a reduction in glial activation per se. Together, the results implicate the astrocytic CN/NFAT4 pathway as a key mechanism for disrupting synaptic remodeling and homeostasis in the hippocampus after acute injury

Comparing proxy and model estimates of hydroclimate variability and change over the Common Era

Water availability is fundamental to societies and ecosystems, but our understanding of variations in hydroclimate (including extreme events, flooding, and decadal periods of drought) is limited because of a paucity of modern instrumental observations that are distributed unevenly across the globe and only span parts of the 20th and 21st centuries. Such data coverage is insufficient for characterizing hydroclimate and its associated dynamics because of its multidecadal to centennial variability and highly regionalized spatial signature. High-resolution (seasonal to decadal) hydroclimatic proxies that span all or parts of the Common Era (CE) and paleoclimate simulations from climate models are therefore important tools for augmenting our understanding of hydroclimate variability. In particular, the comparison of the two sources of information is critical for addressing the uncertainties and limitations of both while enriching each of their interpretations. We review the principal proxy data available for hydroclimatic reconstructions over the CE and highlight the contemporary understanding of how these proxies are interpreted as hydroclimate indicators. We also review the available last-millennium simulations from fully coupled climate models and discuss several outstanding challenges associated with simulating hydroclimate variability and change over the CE. A specific review of simulated hydroclimatic changes forced by volcanic events is provided, as is a discussion of expected improvements in estimated radiative forcings, models, and their implementation in the future. Our review of hydroclimatic proxies and last-millennium model simulations is used as the basis for articulating a variety of considerations and best practices for how to perform proxy–model comparisons of CE hydroclimate. This discussion provides a framework for how best to evaluate hydroclimate variability and its associated dynamics using these comparisons and how they can better inform interpretations of both proxy data and model simulations. We subsequently explore means of using proxy–model comparisons to better constrain and characterize future hydroclimate risks. This is explored specifically in the context of several examples that demonstrate how proxy–model comparisons can be used to quantitatively constrain future hydroclimatic risks as estimated from climate model projections

The tropical rain belts with an annual cycle and a continent model intercomparison project: TRACMIP

This paper introduces the Tropical Rain belts with an Annual cycle and a Continent Model Intercomparison Project (TRACMIP). TRACMIP studies the dynamics of tropical rain belts and their response to past and future radiative forcings through simulations with 13 comprehensive and one simplified atmosphere models coupled to a slab ocean and driven by seasonally-varying insolation. Five idealised experiments, two with an aquaplanet setup and three with a setup with an idealized tropical continent, fill the space between prescribed-SST aquaplanet simulations and realistic simulations provided by CMIP5/6. The simulations reproduce key features of present-day climate and expected future climate change, including an annual-mean intertropical convergence zone (ITCZ) that is located north of the equator and Hadley cells and eddy-driven jets that are similar to present-day climate. Quadrupling CO2 leads to a northward ITCZ shift and preferential warming in Northern high-latitudes. The simulations show interesting CO2-induced changes in the seasonal excursion of the ITCZ and indicate a possible state-dependence of climate sensitivity. The inclusion of an idealized continent modulates both the control climate and the response to increased CO2; for example, it reduces the northward ITCZ shift associated with warming and, in some models, climate sensitivity. In response to eccentricity-driven orbital seasonal insolation changes, seasonal changes in oceanic rainfall are best characterized as a meridional dipole, while seasonal continental rainfall changes tend to be symmetric about the equator. This survey illustrates TRACMIP's potential to engender a deeper understanding of global and regional climate and to address questions on past and future climate

Monsoons: global energetics and local physics as drivers of past, present and future monsoons

Global constraints on momentum and energy govern the structure of the zonal mean tropical circulation and rainfall. The continental-scale monsoon systems are also facets of a momentum- and energy-constrained global circulation, but their modern and paleo variability deviates substantially from that of the longitudinal mean through mechanisms neither fully understood nor well simulated. A framework grounded in global constraints yet encompassing the complexities of monsoon dynamics is needed to identify the causes of mismatch between theory, models, and observations and, ultimately, improve regional climate projection. In a first step towards this goal, disparate regional processes must be distilled into gross measures of energy flow in and out of continents and from the surface to the tropopause, so that monsoon dynamics may be coherently diagnosed across modern and paleo observations and across idealized and comprehensive simulations. Accounting for zonal asymmetries in the circulation, land/ocean differences in surface fluxes, and the character of convective systems, such a monsoon framework would integrate our understanding at all relevant scales: from the fine details of how moisture and energy are lifted in the updrafts of thunderclouds, up to the global circulations

Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

Glial glutamate transporter, GLT-1, is the major Na+-driven glutamate transporter to control glutamate levels in synapses and prevent glutamate-induced excitotoxicity implicated in neurodegenerative disorders including Alzheimer's disease (AD). Significant functional loss of GLT-1 has been reported to correlate well with synaptic degeneration and severity of cognitive impairment among AD patients, yet the underlying molecular mechanism and its pathological consequence in AD are not well understood. Here, we find the temporal decrease in GLT-1 levels in the hippocampus of the 3xTg-AD mouse model and that the pharmacological upregulation of GLT-1 significantly ameliorates the age-dependent pathological tau accumulation, restores synaptic proteins, and rescues cognitive decline with minimal effects on Ab pathology. In primary neuron and astrocyte coculture, naturally secreted A beta species significantly downregulate GLT-1 steady-state and expression levels. Taken together, our data strongly suggest that GLT-1 restoration is neuroprotective and A beta-induced astrocyte dysfunction represented by a functional loss of GLT-1 may serve as one of the major pathological links between Ab and tau patholog

Understanding the responses of precipitation, evaporative demand, and terrestrial water availability to planetary temperature in climate models

Thesis (Ph.D.)--University of Washington, 2014In many models of land hydrology, precipitation (P) and potential evapotranspiration (PET, a.k.a. evaporative demand) are the main inputs that determine actual evapotranspiration, runoff, soil moisture, and aridity or drought. In the first three chapters of this work, we attempt to understand the robust subtropical P declines, planet-wide PET increases, and widespread P/PET declines projected under strong greenhouse warming in CMIP5, a large suite of global climate models (GCMs). Motivated by the apparent absence of this aridification during past greenhouse eras (and the apparent aridity of the ice ages), in the final chapter we use a very simple land model coupled to an atmospheric GCM and a slab ocean to evaluate the relevance and robustness of the P/PET responses to warming across a wide range of boundary conditions and modeling choices. In the CMIP5 projections, robust P declines are almost entirely found within the equator-side flanks and extensions of the model extratropical P belts (including both dry and wet regions), not in the centers of the subtropical dry zones nor on the dry margins of the tropical wet belts. This implies that they are primarily caused by the dynamic poleward retreat of extratropically driven P, not by the thermodynamic increase in dry-zone moisture divergence (which occurs largely as an evaporation increase.) The robust P declines are largely found over the oceans and intersect land only in certain regions; most land locations see non-robust changes in P or robust increases in P. On the other hand, Penman-Monteith PET robustly increases everywhere on land, usually by a low double-digit percentage. This is because the simulated Penman-Monteith PET response is almost always dominated by the response to the local warming itself, not by the responses to concurrent changes in surface radiation, relative humidity (RH), or wind speed. For given values of the latter three variables, warming increases the numerator of the Penman-Monteith equation at a roughly Clausius-Clapeyron rate, ~ 6% K-1, but it increases the denominator more slowly, especially in colder base climates. Thus, evaporative demand increases with local warming at around 1.5-4 % K-1, where the larger values occur in colder regions. A simple analytic scaling for this sensitivity very accurately predicts the PET response field of each model. This PET increase is large enough that in each of the 16 CMIP5 models examined, the ratio P/PET declines with global warming in most land areas in the tropics, the subtropics, and the midlatitudes, implying aridification. However, in our idealized-land GCM, the weakly increasing land P response and strongly increasing PET response that enable this are not general. Depending on the prescribed ocean heat transport, continental configuration, and base planetary temperature, greenhouse warming often causes our modeled land P to strongly decrease, or sometimes to increase so strongly as to entirely suppress the PET increase (even as global-mean P increases weakly in all cases.) The former occurs when the basic-state terrestrial climate is already drier, and the latter occurs when it is quite wet. Future work may investigate what drives this broad range of land P and PET responses to warming, and whether this idealized-model behavior sheds any light on the tension between non-arid past greenhouses and the arid future projections

No Access Are Glacials Dry? Consequences for Paleoclimatology and for Greenhouse Warming

Past cold climates are often thought to have been drier than today on land, which appears to conflict with certain recent studies projecting widespread terrestrial drying with near-future warming. However, other work has found that, over large portions of the continents, the conclusion of future drying versus wetting strongly depends on the physical property of interest. Here, it is shown that this also holds in simulations of the Last Glacial Maximum (LGM): the continents have generally wetter topsoils and higher values of common climate wetness metrics than in the preindustrial, as well as generally lower precipitation and ubiquitously lower photosynthesis (likely driven by the low CO2), with streamflow responses falling in between. Using a large existing global pollen and plant fossil compilation, it is also confirmed that LGM grasslands and open woodlands grew at many sites of present-day forest, seasonal forests at many sites of present-day rain forest, and so forth (116–144 sites out of 302), while changes in the opposite sense were very few (9–17 sites out of 302) and spatially confined. These vegetation changes resemble the model photosynthesis responses but not the hydroclimate responses, while published lake-level changes resemble the latter but not the former. Thus, confidence in both the model hydrologic and photosynthesis projections is increased, and there is no significant conflict. Instead, paleo- and modern climate researchers must carefully define “wetting” and “drying” and, in particular, should not assume hydrologic drying on the basis of vegetation decline alone or assume vegetation stress on the basis of declines in hydroclimatic indicators