Effect of real-time computer-aided polyp detection system (ENDO-AID) on adenoma detection in endoscopists-in-training: a randomized trial

Background The effect of computer-aided polyp detection (CADe) on adenoma detection rate (ADR) among endoscopists-in-training remains unknown. Methods We performed a single-blind, parallel-group, randomized controlled trial in Hong Kong between April 2021 and July 2022 (NCT04838951). Eligible subjects undergoing screening/surveillance/diagnostic colonoscopies were randomized 1:1 to receive colonoscopies with CADe (ENDO-AID(OIP-1), Olympus Co., Japan) or not (control) during withdrawal. Procedures were performed by endoscopists-in-training with <500 procedures and <3 years’ experience. Randomization was stratified by patient age, sex, and endoscopist experience (beginner vs intermediate-level, <200 vs 200-500 procedures). Image enhancement and distal attachment devices were disallowed. Subjects with incomplete colonoscopies or inadequate bowel preparation were excluded. Treatment allocation was blinded to outcome assessors. The primary outcome was ADR. Secondary outcomes were ADR for different adenoma sizes and locations, mean number of adenomas, and non-neoplastic resection rate. Results 386 and 380 subjects were randomized to CADe and control groups, respectively. The overall ADR was significantly higher in CADe than control group (57.5% vs 44.5%, adjusted relative risk 1.41, 95%CI 1.17-1.72, p<0.001). The ADRs for <5mm (40.4% vs 25.0%) and 5-10mm adenomas (36.8% vs 29.2%) were higher in CADe group. The ADRs were higher in CADe group in both right (42.0% vs 30.8%) and left colon (34.5% vs 27.6%), but there was no significant difference in advanced ADR. The ADRs were higher in CADe group among beginners (60.0% vs 41.9%) and intermediate-level endoscopists (56.5% vs 45.5%). Mean number of adenomas (1.48 vs 0.86) and non-neoplastic resection rate were higher in CADe group (52.1% vs 35.0%). Conclusions Among endoscopists-in-training, the use of CADe during colonoscopies was associated with increased overall ADR. (ClinicalTrials.gov: NCT04838951

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Dynamic causality analysis of COVID-19 pandemic risk and oil market changes

Crude oil draws attention in recent research as its demand may indicate world economic growth trend in the post-COVID-19 era. In this paper, we study the dynamic lead-lag relationship between the COVID-19 pandemic and crude oil future prices. We perform rolling-sample tests to evidence whether two pandemic risk scores derived from network analysis, including a preparedness risk score and a severity risk score, Granger-cause changes in oil future prices. In our empirical analysis, we observe 49% to 60% of days in 2020 to 2021 during which the pandemic scores significantly affected oil futures. We also find an asymmetric lead-lag relationship, indicating that there is a tendency for oil futures to move significantly when the pandemic is less severe but not when it is more severe. This study adopts preparedness risk score and severity risk score as proxy variables to measure the impact of the COVID-19 pandemic risk on oil market. The asymmetric lead-lag behavior between pandemic risk and oil future prices provides insights on oil demand and consumption during the COVID-19 pandemic

Standardized local assortativity in networks and systemic risk in financial markets.

The study of assortativity allows us to understand the heterogeneity of networks and the implication of network resilience. While a global measure has been predominantly used to characterize this network feature, there has been little research to suggest a local coefficient to account for the presence of local (dis)assortative patterns in diversely mixed networks. We build on existing literature and extend the concept of assortativity with the proposal of a standardized scale-independent local coefficient to observe the assortative characteristics of each entity in networks that would otherwise be smoothed out with a global measure. This coefficient provides a lens through which the granular level of details can be observed, as well as capturing possible pattern (dis)formation in dynamic networks. We demonstrate how the standardized local assortative coefficient discovers the presence of (dis)assortative hubs in static networks on a granular level, and how it tracks systemic risk in dynamic financial networks

Fig 7 -

Density ridge plot of the conditional multiple correlation of , l = 0, ⋯, N, and the loss Lj,t+1 given (left panel), and conditional multiple correlation of , dj,t−l, l = 0, ⋯, N, and the loss Lj,t+1 given (right panel), where N = 0, ⋯, 5; the solid black line represents the median of each distribution.</p

Density ridge plot of , where <i>k</i> = 1, ⋯, 10; the solid black line represents the median of each distribution.

Density ridge plot of , where k = 1, ⋯, 10; the solid black line represents the median of each distribution.</p

Fig 6 -

Density ridge plot of the conditional multiple correlation of , l = 0, ⋯, N, and the loss Lj,t+1 (left panel), and the conditional multiple correlation of , dj,t−l, l = 0, ⋯, N, and the loss Lj,t+1 (right panel), where N = 0, ⋯, 5; the solid black line represents the median of each distribution.</p

Network statistics of five randomly selected dates.

Network statistics of five randomly selected dates.</p