Development of a French Paper-and-Pencil Implicit Association Test to Measure Athletes’ Implicit Doping Attitude (IAT-Dop)

Although explicit measures of doping attitude are widely used, they are susceptible to bias due to social desirability. The current computerized measures of implicit attitudes are time-consuming and based on expensive software solutions. Recently, paper-and-pencil (p&p) Implicit Association Tests (IAT) have been developed, making it possible to test several participants simultaneously, anywhere, and with no need of computerized equipment and software. The present series of studies aimed at developing a French version of a p&p IAT to measure athletes’ attitudes toward doping (Chan et al., 2017): the IAT-Dop. Four studies, including 212 participants (Mage = 25.49, SD = 5.73), followed Bardin et al. (2016) and Boateng et al. (2018) validation recommendations: (a) development of a preliminary version of the IAT-Dop based on the proposal of Chan’s tool (2017), (b) dimensionality and criterion validity tests demonstrating the structure of the p&p version, (c) test-retest reliability, and (d) first approach to construct validity. The results showed that the IAT-Dop was able to measure implicit attitudes toward doping and was stable across time. Significant correlations between the computerized and p&p versions confirmed the construct validity. The p&p IAT-Dop showed several advantages over the computerized version (Lemm et al., 2008), including lower cost and ease of administration. By offering accurate measures and an easier, faster, and cheaper way to measure doping attitudes, this tool should contribute to the better assessment and understanding of the mechanisms related to doping, and it might be a useful new indicator in the evaluation of prevention programs

Effect of real-time computer-aided polyp detection system (ENDO-AID) on adenoma detection in endoscopists-in-training: a randomized trial

Background The effect of computer-aided polyp detection (CADe) on adenoma detection rate (ADR) among endoscopists-in-training remains unknown. Methods We performed a single-blind, parallel-group, randomized controlled trial in Hong Kong between April 2021 and July 2022 (NCT04838951). Eligible subjects undergoing screening/surveillance/diagnostic colonoscopies were randomized 1:1 to receive colonoscopies with CADe (ENDO-AID(OIP-1), Olympus Co., Japan) or not (control) during withdrawal. Procedures were performed by endoscopists-in-training with <500 procedures and <3 years’ experience. Randomization was stratified by patient age, sex, and endoscopist experience (beginner vs intermediate-level, <200 vs 200-500 procedures). Image enhancement and distal attachment devices were disallowed. Subjects with incomplete colonoscopies or inadequate bowel preparation were excluded. Treatment allocation was blinded to outcome assessors. The primary outcome was ADR. Secondary outcomes were ADR for different adenoma sizes and locations, mean number of adenomas, and non-neoplastic resection rate. Results 386 and 380 subjects were randomized to CADe and control groups, respectively. The overall ADR was significantly higher in CADe than control group (57.5% vs 44.5%, adjusted relative risk 1.41, 95%CI 1.17-1.72, p<0.001). The ADRs for <5mm (40.4% vs 25.0%) and 5-10mm adenomas (36.8% vs 29.2%) were higher in CADe group. The ADRs were higher in CADe group in both right (42.0% vs 30.8%) and left colon (34.5% vs 27.6%), but there was no significant difference in advanced ADR. The ADRs were higher in CADe group among beginners (60.0% vs 41.9%) and intermediate-level endoscopists (56.5% vs 45.5%). Mean number of adenomas (1.48 vs 0.86) and non-neoplastic resection rate were higher in CADe group (52.1% vs 35.0%). Conclusions Among endoscopists-in-training, the use of CADe during colonoscopies was associated with increased overall ADR. (ClinicalTrials.gov: NCT04838951

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Context-Aware Image Compression.

We describe a physics-based data compression method inspired by the photonic time stretch wherein information-rich portions of the data are dilated in a process that emulates the effect of group velocity dispersion on temporal signals. With this coding operation, the data can be downsampled at a lower rate than without it. In contrast to previous implementation of the warped stretch compression, here the decoding can be performed without the need of phase recovery. We present rate-distortion analysis and show improvement in PSNR compared to compression via uniform downsampling

Comparison of compression performance with the colour portrait image.

<p>(A) The 8X uniformly downsampled image and (B) the 10.2X warp stretch-compressed image are shown with (C) the original image and (D-E) their respective reconstructions, while (F-H) are, in turn, their respective close-up portions. Further zoom-ins on the rims of the glasses are shown in (I-K), highlighting the failure of uniform downsampling to capture this sharp feature. The downsampling rate for the uniform case was adjusted such that the resultant file sizes for both warped and uniform compression become equal; however, since all three colour channels share the same warp kernel, the overhead burden is reduced by a third in this scenario. After reconstruction, the warped case (E,H,K) achieved a PSNR of 39.1 dB, which was 3.11 dB better than the uniform downsampling case (D,G,I).</p