Optimal Management of Marine Inspection with Autonomous Underwater Vehicles

t New technologies and system communications are being applied in the industry, improving the efficiency and effectiveness. This paper is focused on novel technologies, software and materials that allow to explore deep ocean floor. Autonomous underwater vehicles require planning navigation models and algorithms. Sensors equipped in underwater vehicles allow to inspect and analyse inaccessible areas. Monitor and control measurement process is required to ensure suitable underwater operations. This paper presents a model using the main inspection process variables. The model calculates the field of view of the autonomous underwater vehicle to be determined according to the type of sensor, the orientation and the distance from the floor. This study aims at stabilising the fundaments to develop an autonomous route for the autonomous underwater vehicles and optimize its operation performance

Underwater Image Processing: State of the Art of Restoration and Image Enhancement Methods

The underwater image processing area has received considerable attention within the last decades, showing important achievements. In this paper we review some of the most recent methods that have been specifically developed for the underwater environment. These techniques are capable of extending the range of underwater imaging, improving image contrast and resolution. After considering the basic physics of the light propagation in the water medium, we focus on the different algorithms available in the literature. The conditions for which each of them have been originally developed are highlighted as well as the quality assessment methods used to evaluate their performance

What do Cochrane systematic reviews say about non-surgical interventions for urinary incontinence in women?

ABSTRACT BACKGROUND: Urinary incontinence is a highly prevalent condition that impacts self-esteem and overall quality of life. Many non-surgical treatment options are available, ranging from pharmacological approaches to pelvic exercises. We aimed to summarize the available evidence regarding these non-surgical interventions. DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP). METHODS: A sensitive search was conducted to identify all Cochrane systematic reviews that fulfilled the inclusion criteria. Titles and abstracts were screened by two authors. RESULTS: We included 20 Cochrane systematic reviews: 4 assessing methods of vesical training, 3 evaluating pharmacological interventions, 4 studying pelvic floor muscle training approaches and 9 aimed at other alternatives (such as urethral injections, weighted vaginal cone use, acupuncture, biostimulation and radiofrequency therapy). The reviews found that the evidence regarding the benefits of these diverse interventions ranged in quality from low to high. CONCLUSIONS: This review included 20 Cochrane systematic reviews that provided evidence (of diverse quality) for non-pharmacological interventions for patients with urinary incontinence. Moderate to high quality of evidence was found favoring the use of pelvic floor muscle training among women with urinary incontinence. To establish solid conclusions for all the other comparisons, further studies of good methodological quality are needed.</div

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A

It is essential to improve therapies for controlling excessive bleeding in patients with haemorrhagic disorders. As activated blood platelets mediate the primary response to vascular injury, we hypothesize that storage of coagulation Factor VIII within platelets may provide a locally inducible treatment to maintain haemostasis for haemophilia A. Here we show that haematopoietic stem cell gene therapy can prevent the occurrence of severe bleeding episodes in dogs with haemophilia A for at least 2.5 years after transplantation. We employ a clinically relevant strategy based on a lentiviral vector encoding the ITGA2B gene promoter, which drives platelet-specific expression of human FVIII permitting storage and release of FVIII from activated platelets. One animal receives a hybrid molecule of FVIII fused to the von Willebrand Factor propeptide-D2 domain that traffics FVIII more effectively into α-granules. The absence of inhibitory antibodies to platelet-derived FVIII indicates that this approach may have benefit in patients who reject FVIII replacement therapies. Thus, platelet FVIII may provide effective long-term control of bleeding in patients with haemophilia A