104 research outputs found
Charting the landscape of N=4 flux compactifications
We analyse the vacuum structure of isotropic Z_2 x Z_2 flux
compactifications, allowing for a single set of sources. Combining algebraic
geometry with supergravity techniques, we are able to classify all vacua for
both type IIA and IIB backgrounds with arbitrary gauge and geometric fluxes.
Surprisingly, geometric IIA compactifications lead to a unique theory with four
different vacua. In this case we also perform the general analysis allowing for
sources compatible with minimal supersymmetry. Moreover, some relevant examples
of type IIB non-geometric compactifications are studied. The computation of the
full N=4 mass spectrum reveals the presence of a number of non-supersymmetric
and nevertheless stable AdS_4 vacua. In addition we find a novel dS_4 solution
based on a non-semisimple gauging.Comment: Minor corrections and references added. Version published in JHE
Minimal Stability in Maximal Supergravity
Recently, it has been shown that maximal supergravity allows for
non-supersymmetric AdS critical points that are perturbatively stable. We
investigate this phenomenon of stability without supersymmetry from the
sGoldstino point of view. In particular, we calculate the projection of the
mass matrix onto the sGoldstino directions, and derive the necessary conditions
for stability. Indeed we find a narrow window allowing for stable SUSY breaking
points. As a by-product of our analysis, we find that it seems impossible to
perturb supersymmetric critical points into non-supersymmetric ones: there is a
minimal amount of SUSY breaking in maximal supergravity.Comment: 27 pages, 1 figure. v2: two typos corrected, published versio
A geometric bound on F-term inflation
We discuss a general bound on the possibility to realise inflation in any
minimal supergravity with F-terms. The derivation crucially depends on the
sGoldstini, the scalar field directions that are singled out by spontaneous
supersymmetry breaking. The resulting bound involves both slow-roll parameters
and the geometry of the K\"ahler manifold of the chiral scalars. We analyse the
inflationary implications of this bound, and in particular discuss to what
extent the requirements of single field and slow-roll can both be met in F-term
inflation.Comment: 14 pages, improved analysis, references added, matches published
versio
Compactification on negatively curved manifolds
We show that string/M theory compactifications to maximally symmetric
space-times using manifolds whose scalar curvature is everywhere negative, must
have significant warping, large stringy corrections, or both.Comment: 18 pages, JHEP3.cl
Moduli backreaction and supersymmetry breaking in string-inspired inflation models
We emphasize the importance of effects from heavy fields on supergravity
models of inflation. We study, in particular, the backreaction of stabilizer
fields and geometric moduli in the presence of supersymmetry breaking. Many
effects do not decouple even if those fields are much heavier than the inflaton
field. We apply our results to successful models of Starobinsky-like inflation
and natural inflation. In most scenarios producing a plateau potential it
proves difficult to retain the flatness of the potential after backreactions
are taken into account. Some of them are incompatible with non-perturbative
moduli stabilization. In natural inflation there exist a number of models which
are not constrained by backreactions at all. In those cases the correction
terms from heavy fields have the same inflaton-dependence as the uncorrected
potential, so that inflation may be possible even for very large gravitino
masses.Comment: 29 pages, 1 figure, comments added, subsection 2.3 added, published
versio
Flux moduli stabilisation, Supergravity algebras and no-go theorems
We perform a complete classification of the flux-induced 12d algebras
compatible with the set of N=1 type II orientifold models that are T-duality
invariant, and allowed by the symmetries of the T^6/(Z_2 x Z_2) isotropic
orbifold. The classification is performed in a type IIB frame, where only H_3
and Q fluxes are present. We then study no-go theorems, formulated in a type
IIA frame, on the existence of Minkowski/de Sitter (Mkw/dS) vacua. By deriving
a dictionary between the sources of potential energy for the three moduli (S, T
and U) in types IIA and IIB, we are able to combine algebra results and no-go
theorems. The outcome is a systematic procedure for identifying
phenomenologically viable models where Mkw/dS vacua may exist. We present a
complete table of the allowed algebras and the viability of their resulting
scalar potential, and we point at the models which stand any chance of
producing a fully stable vacuum.Comment: Version published in JHE
The Energy & Raw Materials Factory: Role and Potential Contribution to the Circular Economy of the Netherlands
Water is an abundant resource worldwide, but fresh and clean water is scarce in many areas of the world. Increases in water consumption and climate change will affect global water security even further in the near future. With increasing numbers of people living in metropolitan areas, water, energy, and materials need to be used carefully, reused and renewed. Resource scarcity is the driver behind the circular economy. The recovery of materials and energy can add significant new value streams and improve cost recovery and water quality. In this paper, we present the creation of the Energy & Raw Materials Factory (ERMF) of the Dutch Water Authorities, also known as the Resource Factory, as one of the solutions to this global challenge of water in the circular economy. Resources like cellulose, bioplastics, phosphate, alginate-like exopolymers from aerobic granular sludge (bio-ALE), and biomass can be recovered. Bio-ALE is an alginate-like polymer of sugars and proteins and can be used in agriculture and horticulture, the paper industry, medical, and construction industries. The ERMF demands significant investments but the return on investment is high both from a financial and environmental perspective, provided that markets can be realized. Experiences in the Netherlands show that the concept of the ERMF is viable and adds to the creation of a circular economy. Achieving climate neutrality and production of new and promising resources like bio-ALE are possible. The ERMF can contribute to the sustainable development goals (SDGs) of the United Nations on water and sanitation, once fully operational
An Atlas of the Speed of Copy Number Changes in Animal Gene Families and Its Implications
The notion that gene duplications generating new genes and functions is commonly accepted in evolutionary biology. However, this assumption is more speculative from theory rather than well proven in genome-wide studies. Here, we generated an atlas of the rate of copy number changes (CNCs) in all the gene families of ten animal genomes. We grouped the gene families with similar CNC dynamics into rate pattern groups (RPGs) and annotated their function using a novel bottom-up approach. By comparing CNC rate patterns, we showed that most of the species-specific CNC rates groups are formed by gene duplication rather than gene loss, and most of the changes in rates of CNCs may be the result of adaptive evolution. We also found that the functions of many RPGs match their biological significance well. Our work confirmed the role of gene duplication in generating novel phenotypes, and the results can serve as a guide for researchers to connect the phenotypic features to certain gene duplications
BRCA1 mutations and other sequence variants in a population-based sample of Australian women with breast cancer
The frequency, in women with breast cancer, of mutations and other variants in the susceptibility gene, BRCA1, was investigated using a population-based caseâcontrol-family study. Cases were women living in Melbourne or Sydney, Australia, with histologically confirmed, first primary, invasive breast cancer, diagnosed before the age of 40 years, recorded on the state Cancer Registries. Controls were women without breast cancer, frequency-matched for age, randomly selected from electoral rolls. Full manual sequencing of the coding region of BRCA1 was conducted in a randomly stratified sample of 91 cases; 47 with, and 44 without, a family history of breast cancer in a first- or second-degree relative. All detected variants were tested in a random sample of 67 controls. Three cases with a (protein-truncating) mutation were detected. Only one case had a family history; her mother had breast cancer, but did not carry the mutation. The proportion of Australian women with breast cancer before age 40 who carry a germline mutation in BRCA1 was estimated to be 3.8% (95% Cl 0.3â12.6%). Seven rare variants were also detected, but for none was there evidence of a strong effect on breast cancer susceptibility. Therefore, on a population basis, rare variants are likely to contribute little to breast cancer incidence. © 1999 Cancer Research Campaig
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