On The Linguistic Effects Of Articulatory Ease, With A Focus On Sign Languages

Spoken language has a well-known drive for ease of articulation, which Kirchner (1998, 2004) analyzes as reduction of the total magnitude of all biomechanical forces involved. We extend Kirchner\u27s insights from vocal articulation to manual articulation, with a focus on joint usage, and we discuss ways that articulatory ease might be realized in sign languages. In particular, moving more joints and/or joints more proximal to the torso results in greater mass being moved, and thus more articulatory force being expended, than moving fewer joints or moving more distal joints. We predict that in casual conversation, where articulatory ease is prized, moving fewer joints should be favored over moving more, and moving distal joints should be favored over moving proximal joints. We report on the results of our study of the casual signing of fluent signers of American Sign Language, which confirm our predictions: in comparison to citation forms of signs, the casual variants produced by the signers in our experiment exhibit an overall decrease in average joint usage, as well as a general preference for more distal articulation than is used in citation form. We conclude that all language, regardless of modality, is shaped by a fundamental drive for ease of articulation. Our work advances a cross-modality approach for considering ease of articulation, develops a potentially important vocabulary for describing variations in signs, and demonstrates that American Sign Language exhibits variation that can be accounted for in terms of ease of articulation. We further suggest that the linguistic drive for ease of articulation is part of a broader tendency for the human body to reduce biomechanical effort in all physical activities

WHY DO THEY GO? COMMUNITY COLLEGE STUDENTS AND POST-SECONDARY PURSUITS IN CENTRAL APPALACHIA

This dissertation focuses on how rural community college students make decisions regarding their post-secondary plans. To understand these decision processes, I interviewed students, faculty and administrators at Southeast Community and Technical College in Harlan County, Kentucky. The literature informing my research reflects on rural college going patterns. Most studies connect place and post-secondary plans. Central Appalachia has among the lowest population percentages with Bachelor degrees in the country. Studies argue this is because of limited application for such degrees in the region. Matching their education and training to local job market requirements, people hesitate to complete advanced degrees when little if any local application requires such additional education. This study discusses how place informs and shapes students’ decisions around college and degree selection. Unlike those who connect advanced education with outmigration patterns, my research highlights students who pursue post-secondary training in hopes of applying these degrees locally to build their communities and families’ quality of life in a rural place. From the twenty-eight student and fifteen faculty and administrator interviews conducted, rationales regarding the purpose of post-secondary degrees and training surfaced. Through selected follow up oral histories, students further described the application of their degrees towards terminal, transfer and/or transformative ends. Their articulated positions regarding the purpose and application of higher education in Central Appalachia adds to the continuing studies on how advanced degrees informs students’ decisions to stay or leave rural areas. From the Southeast interview data, I provide a critique of policy directives related to advanced education and economic development. Given many of the urban assumptions embedded in development theory, my study was interested in how these rural students, in a place considered underdeveloped partly because of low college attendance rates, attain and then apply their degrees and the rationale they articulate in doing so. As US policy makers continue to require advanced education for more and more of their citizens, my research shows the complications and complexities such rhetoric evokes when people, committed to rural places and ways of life, apply them in their local contexts

How inclusion is defined and implemented in elementary classrooms

The purpose of this thesis is to explore the various interpretations of inclusion and how we can implement it to a greater and more successful degree in elementary schools. Individuals with disabilities are discriminated against in many education systems, where additionally the law is not being upheld. This thesis provides an accessible, coherent framework for practicing teachers and future educators to gain a better understanding of the definitions of inclusion, the barriers they may encounter, and the best practices to guide them towards inclusive success

Seeking approval from universities to research the views of their staff : do gatekeepers provide a barrier to ethical research?

A “gatekeeper” controls access to an organization; “gatekeeper approval” is often needed before external research can take place within an organization. We explore the need for gatekeeper approval for research with university staff employing, as a case study, a project which collected data in Australia. This case study addresses known issues, seemingly rarely addressed in the literature. The Human Research Ethics Committee (HREC)'s requirement for approval from individual universities to approach their staff brought significant consequences, exacerbated by the lack of university procedures for such approvals. Simultaneously, since invitations could legitimately be distributed via other avenues, such approval was superfluous. We recommend the HREC's blanket requirement for institutional approval instead be considered on a case-by-case basis depending on the risk of the research, and perhaps waived for low-risk research where participants are able to provide informed consent, and that universities establish processes to deal with requests from external researchers. © The Author(s) 2022

Inhibitor binding mode and allosteric regulation of Na+-glucose symporters.

Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes. Current therapeutics are phlorizin derivatives that contain a sugar moiety bound to an aromatic aglycon tail. Here, we develop structural models of human SGLT1/2 in complex with inhibitors by combining computational and functional studies. Inhibitors bind with the sugar moiety in the sugar pocket and the aglycon tail in the extracellular vestibule. The binding poses corroborate mutagenesis studies and suggest a partial closure of the outer gate upon binding. The models also reveal a putative Na+ binding site in hSGLT1 whose disruption reduces the transport stoichiometry to the value observed in hSGLT2 and increases inhibition by aglycon tails. Our work demonstrates that subtype selectivity arises from Na+-regulated outer gate closure and a variable region in extracellular loop EL5

Interviews with Wilson G. Shelley, Paul Sissel, Lark Lyn Gunther, Ida L. Phillips, May Swanson and Frank Gull

Interviews with Wilson G. Shelley, Paul Sissel, Lark Lyn Gunther, Ida L. Phillips, May Swanson and Frank Gull. This recording is unavailable.https://scholars.fhsu.edu/sackett/1101/thumbnail.jp

Health Inequity in the Northern Territory, Australia

INTRODUCTION: Understanding health inequity is necessary for addressing the disparities in health outcomes in many populations, including the health gap between Indigenous and non-Indigenous Australians. This report investigates the links between Indigenous health outcomes and socioeconomic disadvantage in the Northern Territory of Australia (NT).METHODS: Data sources include deaths, public hospital admissions between 2005 and 2007, and Socio-Economic Indexes for Areas from the 2006 Census. Age-sex standardisation, standardised rate ratio, concentration index and Poisson regression model are used for statistical analysis.RESULTS: There was a strong inverse association between socioeconomic status (SES) and both mortality and morbidity rates. Mortality and morbidity rates in the low SES group were approximately twice those in the medium SES group, which were, in turn, 50% higher than those in the high SES group. The gradient was present for most disease categories for both deaths and hospital admissions. Residents in remote and very remote areas experienced higher mortality and hospital morbidity than non-remote areas. Approximately 25-30% of the NT Indigenous health disparity may be explained by socioeconomic disadvantage.CONCLUSIONS: Socioeconomic disadvantage is a shared common denominator for the main causes of deaths and principal diagnoses of hospitalisations for the NT population. Closing the gap in health outcomes between Indigenous and non-Indigenous populations will require improving the socioeconomic conditions of Indigenous Australians