A System for the Generation of Synthetic Wide Area Aerial Surveillance Imagery

The development, benchmarking and validation of aerial Persistent Surveillance (PS) algorithms requires access to specialist Wide Area Aerial Surveillance (WAAS) datasets. Such datasets are difficult to obtain and are often extremely large both in spatial resolution and temporal duration. This paper outlines an approach to the simulation of complex urban environments and demonstrates the viability of using this approach for the generation of simulated sensor data, corresponding to the use of wide area imaging systems for surveillance and reconnaissance applications. This provides a cost-effective method to generate datasets for vehicle tracking algorithms and anomaly detection methods. The system fuses the Simulation of Urban Mobility (SUMO) traffic simulator with a MATLAB controller and an image generator to create scenes containing uninterrupted door-to-door journeys across large areas of the urban environment. This ‘pattern-of-life’ approach provides three-dimensional visual information with natural movement and traffic flows. This can then be used to provide simulated sensor measurements (e.g. visual band and infrared video imagery) and automatic access to ground-truth data for the evaluation of multi-target tracking systems

Cross-modal extinction in a boy with severely autistic behaviour and high verbal intelligence

Anecdotal reports from individuals with autism suggest a loss of awareness to stimuli from one modality in the presence of stimuli from another. Here we document such a case in a detailed study of T.M., a 13-year-old boy with autism in whom significant autistic behaviors are combined with an uneven IQ profile of superior verbal and low performance abilities. Although T.M.'s speech is often unintelligible and his behavior is dominated by motor stereotypies and impulsivity, he can communicate by typing or pointing independently within a letter board. A series of experiments using simple and highly salient visual, auditory, and tactile stimuli demonstrated a hierarchy of cross-modal extinction, in which auditory information extinguished other modalities at various levels of processing. T.M. also showed deficits in shifting and sustaining attention. These results provide evidence for mono-channel perception in autism and suggest a general pattern of winner-takes-all processing in which a stronger stimulus-d riven representation dominates behavior, extinguishing weaker representations

Iridum-catalysed C–H Borylation of β-aryl-aminopropionic acids

Iridium-catalysed catalytic, regioselective C–H borylation of β-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected β-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrated through telescoped functionalisation reaction to give diverse building blocks for medicinal chemistry. The C-H borylation is also effective for dipeptide substrates. We have exemplified this methodology in the synthesis of a pan av integrin antagonist

An experimental test of non-local realism

Most working scientists hold fast to the concept of 'realism' - a viewpoint according to which an external reality exists independent of observation. But quantum physics has shattered some of our cornerstone beliefs. According to Bell's theorem, any theory that is based on the joint assumption of realism and locality (meaning that local events cannot be affected by actions in space-like separated regions) is at variance with certain quantum predictions. Experiments with entangled pairs of particles have amply confirmed these quantum predictions, thus rendering local realistic theories untenable. Maintaining realism as a fundamental concept would therefore necessitate the introduction of 'spooky' actions that defy locality. Here we show by both theory and experiment that a broad and rather reasonable class of such non-local realistic theories is incompatible with experimentally observable quantum correlations. In the experiment, we measure previously untested correlations between two entangled photons, and show that these correlations violate an inequality proposed by Leggett for non-local realistic theories. Our result suggests that giving up the concept of locality is not sufficient to be consistent with quantum experiments, unless certain intuitive features of realism are abandoned.Comment: Minor corrections to the manuscript, the final inequality and all its conclusions do not change; description of corrections (Corrigendum) added as new Appendix III; Appendix II replaced by a shorter derivatio

Autoxidation of the sea ice biomarker proxy IPSO <inf>25</inf> in the near-surface oxic layers of Arctic and Antarctic sediments

© 2019 Over the last decade or so, the mono- and di-unsaturated highly branched isoprenoid (HBI) lipids IP 25 (Ice Proxy with 25 carbon atoms) and IPSO 25 (Ice Proxy for the Southern Ocean with 25 carbon atoms) have emerged as useful proxies for sea ice in the Arctic and Antarctic, respectively. A more complete understanding of their respective proxy signatures, however, requires more detailed knowledge of their stability in the water column and in sediments. In the current study, we focused on the autoxidation of IPSO 25 , first by performing laboratory-based oxidation reactions on a purified sample and characterizing products based on detailed mass spectral analysis. We then analysed for the same oxidation products in near-surface sediments retrieved from the Arctic and the Antarctic, and some suspended organic matter from the Antarctic. Our data show that IPSO 25 is susceptible to partial autoxidation within the oxic layers of Arctic and Antarctic sediments, while the same processes appear not to be so important in the water column. Although the number of primary autoxidation reactions identified in sediments was not as large as in laboratory experiments, there was evidence for their subsequent modification by biotic degradation. Quantifying the extent of degradation of IPSO 25 and IP 25 in sediments, and thus the impact of such process on the use of these biomarkers as paleo sea ice proxies, remains challenging at this stage, since most of the primary oxidation products do not accumulate, likely due to secondary biodegradation reactions. Some interesting differences in reactivity were also observed between IPSO 25 and IP 25 present in the same Arctic sediments. This suggests that factors other than environmental control may influence the IPSO 25 /IP 25 ratio (i.e. DIP 25 ) in Arctic sediments

Quantum Storage of Photonic Entanglement in a Crystal

Entanglement is the fundamental characteristic of quantum physics. Large experimental efforts are devoted to harness entanglement between various physical systems. In particular, entanglement between light and material systems is interesting due to their prospective roles as "flying" and stationary qubits in future quantum information technologies, such as quantum repeaters and quantum networks. Here we report the first demonstration of entanglement between a photon at telecommunication wavelength and a single collective atomic excitation stored in a crystal. One photon from an energy-time entangled pair is mapped onto a crystal and then released into a well-defined spatial mode after a predetermined storage time. The other photon is at telecommunication wavelength and is sent directly through a 50 m fiber link to an analyzer. Successful transfer of entanglement to the crystal and back is proven by a violation of the Clauser-Horne-Shimony-Holt (CHSH) inequality by almost three standard deviations (S=2.64+/-0.23). These results represent an important step towards quantum communication technologies based on solid-state devices. In particular, our resources pave the way for building efficient multiplexed quantum repeaters for long-distance quantum networks.Comment: 5 pages, 3 figures + supplementary information; fixed typo in ref. [36

(Re)presenting heritage: laser scanning and 3D visualisations for cultural resilience and community engagement.

Cultural heritage is increasingly being viewed as an economic asset for geographic areas who aim to capitalise in the surge in interest in local history and heritage tourism from members of the public. Digital technologies have developed that facilitate new forms of engagement with heritage and allow local areas to showcase their history, potentially broadening interest to a wider audience, thus acting as a driver for cultural and economic resilience. The research presented in this paper explores this through interdisciplinary research utilising laser scanning and visualisation in combination with social research in Elgin. 3D data capture technologies were used to develop and test 3D data visualisations and protocols through which the urban built heritage can be digitally recorded. The main focus of this paper surrounds the application and perceptions of these technologies. Findings suggest that the primary driver for cultural heritage developments was economic (with an emphasis on tourism) but further benefits and key factors of community engagement, social learning and cultural resilience were also reported. Stakeholder engagement and partnership working, in particular, were identified as critical factors of success. The findings from the community engagement events demonstrate that laser scanning and visualisation provide a novel and engaging mechanism for co-producing heritage assets. There is a high level of public interest in such technologies and users who engaged with these models reported that they gained new perspectives (including spatial and temporal perspectives) on the built heritage of the area

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis already at micromolar concentrations, cholangiocytes are continuously exposed to millimolar concentrations as present in bile. We present a hypothesis suggesting that biliary secretion of HCO(3)(-) in man serves to protect cholangiocytes against bile acid-induced damage by fostering the deprotonation of apolar bile acids to more polar bile salts. Here, we tested if bile acid-induced toxicity is pH-dependent and if anion exchanger 2 (AE2) protects against bile acid-induced damage. Methods: A human cholangiocyte cell line was exposed to chenodeoxycholate (CDC), or its glycine conjugate, from 0.5 mM to 2.0 mM at pH 7.4, 7.1, 6.7 or 6.4, or after knockdown of AE2. Cell viability and apoptosis were determined by WST and caspase-3/-7 assays, respectively. Results: Glycochenodeoxycholate (GCDC) uptake in cholangiocytes is pH-dependent. Furthermore, CDC and GCDC (pK(a) 4-5) induce cholangiocyte toxicity in a pH-dependent manner: 0.5 mM CDC and 1 mM GCDC at pH 7.4 had no effect on cell viability, but at pH 6.4 decreased viability by >80% and increased caspase activity almost 10- and 30-fold, respectively. Acidification alone had no effect. AE2 knockdown led to 3- and 2-fold enhanced apoptosis induced by 0.75 mM CDC or 2 mM GCDC at pH 7.4. Discussion: These data support our hypothesis of a biliary HCO(3)(-) umbrella serving to protect human cholangiocytes against bile acid-induced injury. AE2 is a key contributor to this protective mechanism. The development and progression of cholangiopathies, such as primary biliary cirrhosis, may be a consequence of genetic and acquired functional defects of genes involved in maintaining the biliary HCO(3)(-) umbrella. Copyright (C) 2011 S. Karger AG, Base