Concordance of fine needle aspiration cytology and final histology of salivary gland tumours

BACKGROUND : Fine needle aspiration cytology (FNAC) is a widely used diagnostic tool to evaluate salivary gland tumours. The Milan system for reporting salivary gland cytopathology allows for standardisation and facilitates cytological-histological correlation. However, FNAC findings can still pose a diagnostic challenge. The accuracy of FNAC should be assessed at each centre. The aim of this study was to assess the concordance of FNAC and final histology of salivary gland tumours in three academic hospitals affiliated with the University of Pretoria, South Africa. METHODS : The study was a cross-sectional retrospective analytical study of 214 patients who underwent an operation for salivary gland tumours. All patients with FNAC and histology results between 2007-2017 were included. Patients were recruited from three University of Pretoria, South Africa, affiliated hospitals: Steve Biko Academic, Kalafong Provincial Tertiary and Tembisa Provincial Tertiary Hospital. RESULTS : Of the 214 patients with salivary gland tumours, the majority were located in the parotid gland (56.1%). Pleomorphic adenoma was the most common tumour (62.6%). The FNAC sensitivity, specificity and diagnostic accuracy (receiver operating characteristic) were 92.7%, 98.1% and 0.95 respectively. The concordance between salivary gland tumour FNAC and final histology was 96.95% with a Cohen's kappa coefficient of 0.91 (p = 0.0001. CONCLUSION : There is strong concordance between FNAC and histology of salivary gland tumours. FNAC is an accurate, minimally invasive diagnostic tool with high sensitivity and specificity. It provides the clinician with a reliable preoperative diagnosis determining whether the salivary gland tumour is benign or malignant.https://journals.co.za/journal/m.sajsam2024SurgerySDG-03:Good heatlh and well-bein

Spontaneous Breaking of Lorentz Invariance

We describe how a stable effective theory in which particles of the same fermion number attract may spontaneously break Lorentz invariance by giving non-zero fermion number density to the vacuum (and therefore dynamically generating a chemical potential term). This mecanism yields a finite vacuum expectation value $$which we consider in the context of proposed models that require such a breaking of Lorentz invariance in order to yield composite degrees of freedom that act approximately like gauge bosons. We also make general remarks about how the background source provided by$$ could relate to work on signals of Lorentz violation in electrodynamics.Comment: revtex4, 11 pages, 5 figures; v2:references added; v3:more references added, typos fixed, some points in sect. IV clarified; v4:even more references added, discussion in sect. V extended; v5:replaced to match published version (minor corrections of form

Accelerated Levi-Civita-Bertotti-Robinson Metric in D-Dimensions

A conformally flat accelerated charge metric is found in an arbitrary dimension $D$. It is a solution of the Einstein-Maxwell-null fluid with a cosmological constant in $D \ge 4$ dimensions. When the acceleration is zero our solution reduces to the Levi-Civita-Bertotti-Robinson metric. We show that the charge loses its energy, for all dimensions, due to the acceleration.Comment: Latex File, 12 page

The Stability of the Weak Skyrmions

We consider a set of gauge invariant terms in higher order effective Lagrangians of the strongly interacting scalar of the electroweak theory. The terms are introduced in the framework of the hidden gauge symmetry formalism. The usual gauge term is known to stabilize the skyrmion but only in the large vector mass limit. We find that adding higher-order gauge terms is insufficient to insure stability. We then proceed to analyze other gauge invariant interaction terms. Some of the conclusions also apply to QCD skyrmions.Comment: 3 pages, revtex v3, (optional), LAVAL-PHY-11-9

The universe seen at different scales

A large-scale smoothed-out model of the universe ignores small-scale inhomogeneities, but the averaged effects of those inhomogeneities may alter both observational and dynamical relations at the larger scale. This article discusses these effects, and comments briefly on the relation to gravitational entropy.Comment: 17 pages; matches published version in Phys. Lett. A (Einstein special issue

Coronal Temperature Diagnostic Capability of the Hinode/X-Ray Telescope Based on Self-Consistent Calibration

The X-Ray Telescope (XRT) onboard the Hinode satellite is an X-ray imager that observes the solar corona with unprecedentedly high angular resolution (consistent with its 1" pixel size). XRT has nine X-ray analysis filters with different temperature responses. One of the most significant scientific features of this telescope is its capability of diagnosing coronal temperatures from less than 1 MK to more than 10 MK, which has never been accomplished before. To make full use of this capability, accurate calibration of the coronal temperature response of XRT is indispensable and is presented in this article. The effect of on-orbit contamination is also taken into account in the calibration. On the basis of our calibration results, we review the coronal-temperature-diagnostic capability of XRT

Production of topological defects at the end of inflation

Hybrid inflation within supersymmetric grand unified theories, as well as inflation through brane collisions within braneworld cosmological models, lead to the formation of one-dimensional defects. Observational data, mainly from the cosmic microwave background temperature anisotropies but also from the gravitational wave background, impose constraints on the free parameters of the models. I review these inflationary models and discuss the constraints from the currently available data.Comment: 9 pages, Invited talk in the Conference "Challenges in Particle Astrophysics" -- 6th Rencontres du Vietnam, Hanoi (Vietnam) 6-12 Aug. 200

Cryo-EM structure of the four-subunit Rhodobacter sphaeroides cytochrome bc1 complex in styrene maleic acid nanodiscs

Cytochrome bc1 complexes are ubiquinol:cytochrome c oxidoreductases, and as such, they are centrally important components of respiratory and photosynthetic electron transfer chains in many species of bacteria and in mitochondria. The minimal complex has three catalytic components, which are cytochrome b, cytochrome c1, and the Rieske iron–sulfur subunit, but the function of mitochondrial cytochrome bc1 complexes is modified by up to eight supernumerary subunits. The cytochrome bc1 complex from the purple phototrophic bacterium Rhodobacter sphaeroides has a single supernumerary subunit called subunit IV, which is absent from current structures of the complex. In this work we use the styrene–maleic acid copolymer to purify the R. sphaeroides cytochrome bc1 complex in native lipid nanodiscs, which retains the labile subunit IV, annular lipids, and natively bound quinones. The catalytic activity of the four-subunit cytochrome bc1 complex is threefold higher than that of the complex lacking subunit IV. To understand the role of subunit IV, we determined the structure of the four-subunit complex at 2.9 Å using single particle cryogenic electron microscopy. The structure shows the position of the transmembrane domain of subunit IV, which lies across the transmembrane helices of the Rieske and cytochrome c1 subunits. We observe a quinone at the Qo quinone-binding site and show that occupancy of this site is linked to conformational changes in the Rieske head domain during catalysis. Twelve lipids were structurally resolved, making contacts with the Rieske and cytochrome b subunits, with some spanning both of the two monomers that make up the dimeric complex

Transfer Matrices and Partition-Function Zeros for Antiferromagnetic Potts Models. V. Further Results for the Square-Lattice Chromatic Polynomial

We derive some new structural results for the transfer matrix of square-lattice Potts models with free and cylindrical boundary conditions. In particular, we obtain explicit closed-form expressions for the dominant (at large |q|) diagonal entry in the transfer matrix, for arbitrary widths m, as the solution of a special one-dimensional polymer model. We also obtain the large-q expansion of the bulk and surface (resp. corner) free energies for the zero-temperature antiferromagnet (= chromatic polynomial) through order q^{-47} (resp. q^{-46}). Finally, we compute chromatic roots for strips of widths 9 <= m <= 12 with free boundary conditions and locate roughly the limiting curves.Comment: 111 pages (LaTeX2e). Includes tex file, three sty files, and 19 Postscript figures. Also included are Mathematica files data_CYL.m and data_FREE.m. Many changes from version 1: new material on series expansions and their analysis, and several proofs of previously conjectured results. Final version to be published in J. Stat. Phy