Light Monopoles, Electric Vortices and Instantons

The physics of the bare Seiberg-Witten action, without supersymmetric partners, is considered in the framework of standard Quantum Field Theory. The topological analysis related to the solutions of the Seiberg-Witten equations is performed and the phase structure of the model is analysed.Comment: 9 pages, late

Kink fluctuation asymptotics and zero modes

In this paper we propose a refinement of the heat kernel/zeta function treatment of kink quantum fluctuations in scalar field theory, further analyzing the existence and implications of a zero energy fluctuation mode. Improved understanding of the interplay between zero modes and the kink heat kernel expansion delivers asymptotic estimations of one-loop kink mass shifts with remarkably higher precision than previously obtained by means of the standard Gilkey-DeWitt heat kernel expansion.Comment: 21 pages, 8 figures, to be published in The European Physical Journal

Ghosts, knots and Kontsevich integrals

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Fusion rules, topological quantum mechanics and three-manifolds

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Trial surfaces, gauge fields and planar solitons

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A multi-technique dating study of two Lower Palaeolithic sites from the Cher Valley (Middle Loire Catchment, France): Lunery-la Terre-des-Sablons and Brinay-la Noira

We present the results of a new dating study carried out at Lunery-la Terre-des-Sablons (LTS) and Brinay-la Noira (BN), two key Lower Palaeolithic sites located in deposits associated to the Cher River (Middle Loire Catchment, France). These sites preserve abundant Mode 1 and Mode 2 lithic industries, and are considered as among the oldest evidence of hominin presence in Western Europe north of the 45°N latitude. Following a multi-technique approach combining electron spin resonance (ESR), single-grain thermally-transferred optically stimulated luminescence (TT-OSL) dating of quartz grains and palaeomagnetism, we obtained new chronological constraints for the sedimentary sequence, and the associated lithic assemblages, at the two sites. The new independent dating results derived from each method are consistent and in overall agreement with existing ESR and terrestrial cosmogenic nuclide (TCN) burial age estimates, except for the Lowermost Unit 3 at LTS. By integrating all of the previous and new dating results, we derive combined age estimates of 772-735 ka and 665 ± 29 ka for the fluvial sands at LTS (Unit 1) and BN, respectively. These two distinct aggradation phases may tentatively be correlated to interglacial/glacial transitions associated with Marine Isotope Stage (MIS) 19-18 for the former and MIS 17-16 for the latter. At BN, an age range of 638–676 ka may be proposed for the hominin occupation after combining numerical age results and geological evidence. This result is consistent with the initial chronology proposed by Moncel et al. (2013) [Moncel, M.H., Despriée, J., Voinchet, P., Tissoux, H., Moreno, D., Bahain, J. J., Courcimault, G., Falgueres, C. (2013). Early evidence of Acheulean settlement in north-western Europe – la Noira site, a 700 000 year-old occupation in the Centre of France. Plos One, 8(11): 1–22] and confirms that BN is among the oldest Acheulean occurrences in Western Europe. At LTS, the mean age of 710 ± 50 ka obtained for the sandy layer in Unit 3 provides a minimum age constraint for the archaeological level located below. The major sedimentary disconformity observed between the fluvial deposits and the underlying pebble layers hosting the lithic artefacts suggests that the true age of the artefacts might be significantly older, probably Early Pleistocene given their similarities with other Mode 1 assemblages identified in Western Europe. However, further refinement of the Mode 1 chronological inference at LTS remains difficult at this stage. Finally, these new dating results show the importance of using the Multiple Centre approach for ESR dating of quartz grains, and confirm the value of combining different dating methods in order to build more robust chronologies for Lower Palaeolithic sites in Europe. From a methodological point of view, the dating results presented here are especially encouraging for the reliability of the ESR method applied to optically bleached quartz grains. This is one of the very first studies demonstrating that quartz samples independently dated by two different laboratories may produce generally reproducible ESR age results.Mathieu Duval, Pierre Voinchet, Lee J.Arnold, Josep M.Parés, Walter Minnella, Verónica Guilarte ... et al

Consensus statement on the diagnosis, management, and treatment of Angiodema mediated by Bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis

Background: There are no Spanish guidelines or consensus statement on bradykinin-induced angioedema. Aim: To review the pathophysiology, genetics, and clinical symptoms of the different types of bradykinin-induced angioedema and to draft a consensus statement in light of currently available scientifi c evidence and the experience of experts. This statement will serve as a guideline to health professionals. Methods: The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema (SGBA), a working group of the Spanish Society of Allergology and Clinical Immunology. A review was conducted of scientifi c papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to C1 inhibitor defi ciency, hereditary angioedema related to estrogens, angioedema induced by angiotensin-converting enzyme inhibitors). Several discussion meetings of the SGBA were held in Madrid to reach the consensus. Results: The pathophysiology, genetics, and clinical symptoms of the different types of angioedema are reviewed. Diagnostic approaches are discussed and the consensus reached is described. Conclusions: A review of bradykinin-induced angioedema and a consensus on diagnosis are presentedIntroducción: No existen guías previas españolas sobre el manejo del angioedema mediado por bradicinina. Objetivos: Revisar la fi siopatología, genética y clínica y alcanzar un consenso sobre el diagnóstico de los diferentes tipos de angioedema mediado por bradicinina a la luz de la evidencia científi ca disponible y la experiencia de los expertos, que sirva como guía para profesionales de la salud. Métodos: SGBA/GEAB, un grupo de trabajo de la SEAIC dirigió el consenso. Se realizó una revisión de los documentos científi cos publicados sobre los diferentes tipos de angioedema mediado por bradicinina [angioedema hereditario o adquirido por defi ciencia de inhibidor de la C1 esterasa, angioedema hereditario relacionado con estrógenos (AEH tipo III, AEH-FXII), angioedema inducido por IECA (inhibidores del enzima convertidor de angiotensina]. Hubo varias reuniones del SGBA/GEAB para alcanzar el consenso. Resultados: Se revisan la fi siopatología, genética y clínica de los diferentes tipos de angioedema por bradicinina. Por otro lado, se discuten los procedimientos diagnósticos y se describe el consenso alcanzado sobre el diagnóstico. Conclusiones: Se presenta una revisión del angioedema mediado por bradicinina y un consenso sobre el diagnóstico del angioedema mediado por bradicina.Dr. Teresa Caballero is a researcher with the Hospital La Paz Health Research Institute (IdiPaz) program for promoting research activities (2009). Publication of this manuscript is sponsored by the Spanish Society of Allergy and Clinical Immunology (SEAIC) and IdiPa