Early Indicators of Autism Spectrum Disorders in the Second Year of Life

Three groups of 18 children were selected for this study, one group with autism spectrum disorders (ASD), one group with developmental delays in which ASD was ruled out (DD), and one group with typical development (TD), from a pool of 3026 children who were screened with the Communication and Symbolic Behavior Scales Developmental Profile (CSBS DP, Wetherby & Prizant, 2002) Infant-Toddler Checklist under 24 months of age. The CSBS DP Behavior Sample was videotaped on selected children as a second-level evaluation during the second year of life. The Infant-Toddler Checklist had a sensitivity and specificity of 88.9% for this sample of children. Significant group differences were found on the Infant-Toddler Checklist and the Behavior Sample, however, these differences did not distinguish children with ASD and DD with high accuracy. The videotapes of the Behavior Sample were reanalyzed to identify red flags of ASD. Nine red flags differentiated children in the ASD group from both the DD and TD groups and four red flags differentiated children in the ASD Group from the TD group but not the DD group. These 13 red flags were found to discriminate the three groups with a correct classification rate of 94.4%.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44624/1/10803_2004_Article_492544.pd

Multiple forms of equine alpha lactalbumin: evidence for N-glycosylated and deaminated forms

International audienc

Réussir son mémoire en psycho: Elaboration et rédaction du travail d'étude et de recherche

info:eu-repo/semantics/publishe

Constraints on the source of resurgent doming inferred from analogue and numerical modeling – Implications on the current feeding system of the Yenkahe dome-Yasur volcano complex (Vanuatu).

International audienceResurgence, defined as the post-collapse long-term uplift of a caldera floor, is commonly attributed to a renewed rise of magma. The Yenkahe dome (Vanuatu) exhibits a common morphology - elongated with a graben on top - among resurgent domes, and is also one of the most active structures of the kind. In this study, we performed a joint analysis based on analogue and finite element numerical models to (1) constrain the width and depth of the long-term deformation intrusive source of the Yenkahe dome and (2) discuss the close association between the Yenkahe dome and the active Yasur cone. We consider the resurgent deformation at the surface to be driven by the uplift of a magma reservoir roof in depth. As the edifice deformation response depends on the medium and the source properties, the mechanical behavior of the upper crust and the nature of the source are modeled using two very different sets of hypotheses. Analogue modeling uses silicone putty, an analogue for a large viscous magma body, intruding a sand-plaster mixture reproducing a Mohr-Coulomb behavior for the crust. Numerical models consider the vertical displacement of a rigid indenter, allowing the conservation of a flat-shaped roof, into an elastoplastic material. Numerical and analogue models show different resurgent dome structures at depth but similar dome and graben morphologies in the surface. Inverse faults - or equivalent shearing zones - delimiting the dome provide an explanation for the confined nature of resurgent doming and the persistent volcanic activity on the dome border represented by the Yasur volcano. Analogue and numerical models together provide an estimation range of 1-1.8 km for the intrusive deformation source depth, and 1.3-2 km for its width. The proposed association between the Yenkahe dome and the Yasur volcano is compatible with such a shallow depth of the magma reservoir, and argues for a discontinuous resurgence process. (C) 2015 Elsevier B.V. All rights reserved

Gender-dependent regulation of G-protein-gated inwardly rectifying potassium current in dorsal raphe neurons in knock-out mice devoid of the 5-hydroxytryptamine transporter

Agonists at G-protein-coupled receptors in neurons of the dorsal raphe nucleus (DRN) of knock-out mice devoid of the serotonin transporter (5-HTT-/-) exhibit lower efficacy to inhibit cellular discharge than in wild-type counterparts. Using patch-clamp whole-cell recordings, we found that a G-protein-gated inwardly rectifying potassium (GIRK) current is involved in the inhibition of spike discharge induced by 5-HT1A agonists (5-carboxamidotryptamine (5-CT) and (\ub1)-2-dipropylamino-8-hydroxy-1,2,3, 4-tetrahydronaphthalene hydrobromide (8-OH-DPAT); 50 nM-30 \u3bcM) in both wild-type and 5-HTT-/- female and male mice. These effects were mimicked by 5\u2032-guanylyl-imido-diphosphate (Gpp(NH)p; 400 \u3bcM) dialysis into cells with differences between genders. The 5-HTT-/- knock-out mutation reduced the current density induced by Gpp(NH)p in females but not in males. These data suggest that the decreased response of 5-HT1A receptors to agonists in 5-HTT-/-mutants reflects notably alteration in the coupling between G-proteins and GIRK channels in females but not in males. Accordingly, gender differences in central 5-HT neurotransmission appear to depend-at least in part-on sex-related variations in corresponding receptor-G protein signaling mechanisms