Mapping a Continental Shelf and Slope in the 1990s: A Tale of Three Multibeams

Increasing societal pressures on the U.S. continental shelves adjacent to dense population centers have brought to light the lack of accurate base maps in these areas. Existing bathymetric maps and random sidescan sonar surveys are either not accurate enough or do not provide the coverage necessary to make policy decisions. Until the mid 1990s, it was not financially prudent nor technically efficient to map the shallow shelves. However, the availability of high-resolution multibeam mapping systems now allow efficient and accurate mapping of the continental margins. In 1996 the U.S. Geological Survey began a large-scale seafloor mapping campaign on the continental shelf and slope adjacent to Los Angeles, CA. The first survey used a Kongsberg Simrad EM1000 (95 kHz). The survey continued in 1998 by mapping the slope and proximal basins from Newport to Long Beach, CA, using a Kongsberg Simrad EM300 (30 kHz). The area was completed in May 1999 by mapping the entire shelf adjacent to Long Beach, CA using an EM3000D (a dual-headed 300-kHz system). The mapping used both INS from the vehicle motion sensor and DGPS to provide position accuracies of ~1 m. All the data were processed in the field in near realtime using software developed at the Univ. of New Brunswick. Because of the different systems used and the range of water depths, the spatial resolution of the processed data varies from \u3c0.5 m on the inner shelf to 8 m on the basin floors. Perspective overviews of backscatter draped over bathymetry reveals a host of geological features unknown to exist in this area. These features include shallow, linear gullys, barchan dunes, small-scale bedforms in shallow troughs, major canyon system complexes, large- and smallscale mass movements, faults, and large areas of outcrop. The effects on sediment transport of man-made features, such as sewer outfall pipes and dredge-disposal fields, are clearly delineated on the new maps. The maps provide the fundamental base maps for studies as varied as those involving benthic habitats, marine disposal sites, sediment transport, and tectonic ma

Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci

Toll-like receptors (TLRs) are pattern recognition receptors that recognize conserved molecular patterns expressed by pathogens. Pneumolysin, an intracellular toxin found in all Streptococcus pneumoniae clinical isolates, is an important virulence factor of the pneumococcus that is recognized by TLR4. Although TLR2 is considered the most important receptor for Gram-positive bacteria, our laboratory previously could not demonstrate a decisive role for TLR2 in host defence against pneumonia caused by a serotype 3 S. pneumoniae. Here we tested the hypothesis that in the absence of TLR2, S. pneumoniae can still be sensed by the immune system through an interaction between pneumolysin and TLR4. C57BL/6 wild-type (WT) and TLR2 knockout (KO) mice were intranasally infected with either WT S. pneumoniae D39 (serotype 2) or the isogenic pneumolysin-deficient S. pneumoniae strain D39 PLN. TLR2 did not contribute to antibacterial defence against WT S. pneumoniae D39. In contrast, pneumolysin-deficient S. pneumoniae only grew in lungs of TLR2 KO mice. TLR2 KO mice displayed a strongly reduced early inflammatory response in their lungs during pneumonia caused by both pneumolysin-producing and pneumolysin-deficient pneumococci. These data suggest that pneumolysin-induced TLR4 signalling can compensate for TLR2 deficiency during respiratory tract infection with S. pneumoniae

Bounds on Four-Fermion Contact Interactions Induced by String Resonances

Based on tree-level open-string scattering amplitudes in the low string-scale scenario, we derive the massless fermion scattering amplitudes. The amplitudes are required to reproduce those of the Standard Model at tree level in the low energy limit. We then obtain four-fermion contact interactions by expanding in inverse powers of the string scale and explore the constraints on the string scale from low energy data. The Chan-Paton factors and the string scale are treated as free parameters. We find that data from the neutral and charged current processes at HERA, Drell-Yan process at the Tevatron, and from LEP-II put lower bounds on the string scale M_S >= 0.9-1.3 TeV for typical values of the Chan-Paton factors, which are comparable to Tevatron bounds on Z' and W' masses.Comment: 13 pages, 1 ps figure, version to appear in PR

Supersymmetric Regularization, Two-Loop QCD Amplitudes and Coupling Shifts

We present a definition of the four-dimensional helicity (FDH) regularization scheme valid for two or more loops. This scheme was previously defined and utilized at one loop. It amounts to a variation on the standard 't Hooft-Veltman scheme and is designed to be compatible with the use of helicity states for "observed" particles. It is similar to dimensional reduction in that it maintains an equal number of bosonic and fermionic states, as required for preserving supersymmetry. Supersymmetry Ward identities relate different helicity amplitudes in supersymmetric theories. As a check that the FDH scheme preserves supersymmetry, at least through two loops, we explicitly verify a number of these identities for gluon-gluon scattering (gg to gg) in supersymmetric QCD. These results also cross-check recent non-trivial two-loop calculations in ordinary QCD. Finally, we compute the two-loop shift between the FDH coupling and the standard MS-bar coupling, alpha_s. The FDH shift is identical to the one for dimensional reduction. The two-loop coupling shifts are then used to obtain the three-loop QCD beta function in the FDH and dimensional reduction schemes.Comment: 44 pages, minor corrections and clarifications include

A Pre-Landing Assessment of Regolith Properties at the InSight Landing Site

This article discusses relevant physical properties of the regolith at the Mars InSight landing site as understood prior to landing of the spacecraft. InSight will land in the northern lowland plains of Mars, close to the equator, where the regolith is estimated to be ≥3--5 m thick. These investigations of physical properties have relied on data collected from Mars orbital measurements, previously collected lander and rover data, results of studies of data and samples from Apollo lunar missions, laboratory measurements on regolith simulants, and theoretical studies. The investigations include changes in properties with depth and temperature. Mechanical properties investigated include density, grain-size distribution, cohesion, and angle of internal friction. Thermophysical properties include thermal inertia, surface emissivity and albedo, thermal conductivity and diffusivity, and specific heat. Regolith elastic properties not only include parameters that control seismic wave velocities in the immediate vicinity of the Insight lander but also coupling of the lander and other potential noise sources to the InSight broadband seismometer. The related properties include Poisson’s ratio, P- and S-wave velocities, Young’s modulus, and seismic attenuation. Finally, mass diffusivity was investigated to estimate gas movements in the regolith driven by atmospheric pressure changes. Physical properties presented here are all to some degree speculative. However, they form a basis for interpretation of the early data to be returned from the InSight mission.Additional co-authors: Nick Teanby and Sharon Keda

Global Retinoblastoma Presentation and Analysis by National Income Level

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4) were female. Most patients (n = 3685 84.7%) were from low-and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 62.8%), followed by strabismus (n = 429 10.2%) and proptosis (n = 309 7.4%). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 95% CI, 12.94-24.80, and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 95% CI, 4.30-7.68). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs. © 2020 American Medical Association. All rights reserved

Effects of polyethylene bags, ethylene absorbent and 1-methylcyclopropene on the storage of Japanese pears

Storage of the ‘Nijisseiki’ cultivar of Japanese pears was studied over three seasons for periods up to 36 weeks at 0°C. Storage in 50 pm thick low-density polyethylene (LDPE) bags at 0°C considerably delayed yellowing in all experiments, even after fruit was removed to 20°C for 1 week at the end of storage. The addition of an ethylene absorbent made from potassium permanganate on aluminium oxide (Purafil II) further delayed yellowing. Carbon dioxide levels in both treatments varied, but were generally in the range 2-3%. Oxygen levels remained high, generally 16-19%. In bags without Purafil, ethylene levels rose slightly during storage and were generally about 0.15 pi I 1. When Purafil was included in the bags, the ethylene level was reduced 10-fold or more. A sensory test indicated that the use of LDPE bags and ethylene absorbent resulted in fruit with better eating quality than fruit stored in air. Disorders over the 3-year investigation were low even after long-term storage. The use of polyethylene bags reduced the severity of flesh browning, and flesh spot decay was virtually absent. Tire use of bags increased the severity of core browning. Inclusion of an ethylene absorbent in bags reduced the severity of disorders, particularly core browning. Treatment of the fruit with 1 -methylcyclopropene (1-MCP), before or during storage, resulted in higher ethylene levels in the polyethylene bags. At the concentrations used, 1-MCP did not improve the storage of ‘Nijisseiki’ compared to the use of polyethylene bags with Purafil II