Increasing meal frequency in combination with exercise mitigates postprandial triacylglycerol

Background: This study examined how manipulating meal frequency, with and without exercise, affects postprandial triacylglycerol (TAG). Methods: Fourteen sedentary men completed four 2-day trials in a non-counterbalanced random crossover order: (i) consumption of one large high fat milkshake without exercise (1-CON); (ii) consumption of two smaller high fat milkshakes without exercise (2-CON); (iii) consumption of one large high fat milkshake with exercise (1-EX); and (iv) consumption of two small high fat milkshakes with exercise (2-EX) – total energy intake was standardized across trials. On Day 1, participants rested (1-CON and 2- CON) or walked briskly for 60 minutes (1-EX and 2-EX). On Day 2, participants consumed either a single large high-fat milkshake (75% fat) (1-CON and 1-EX) for breakfast or two smaller iso-energetic milkshakes (2-CON and 2-EX) for breakfast and lunch. Plasma TAG were measured fasting and for 7 hours after breakfast. Results: Peak incremental TAG was 30% lower on 2-EX than 1-CON (P = .041; d = 0.38). Postprandial TAG increased more rapidly in the first 4 hours in 1-CON than other trials, but at 6 hours TAG was exaggerated in 2-CON compared with 1-CON. Conclusions: Increasing meal frequency after exercise, without altering overall fat intake, attenuates postprandial TAG

A Study of Single-Particle Parity-Nonconserving Nuclear Matrix Elements

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

Effective Two Higgs Doublets in Nonminimal Supersymmetric Models

The Higgs sectors of supersymmetric extensions of the Standard Model have two doublets in the minimal version (MSSM), and two doublets plus a singlet in two others: with (UMSSM) and without (NMSSM) an extra U(1)'. A very concise comparison of these three models is possible if we assume that the singlet has a somewhat larger breaking scale compared to the electroweak scale. In that case, the UMSSM and the NMSSM become effectively two-Higgs-doublet models (THDM), like the MSSM. As expected, the mass of the lightest CP-even neutral Higgs boson has an upper bound in each case. We find that in the NMSSM, this bound exceeds not very much that of the MSSM, unless tan(beta) is near one. However, the upper bound in the UMSSM may be substantially enhanced.Comment: 8 pages, 1 table, 3 figure

Active Amplification of the Terrestrial Albedo to Mitigate Climate Change: An Exploratory Study

This study explores the potential to enhance the reflectance of solar insolation by the human settlement and grassland components of the Earth's terrestrial surface as a climate change mitigation measure. Preliminary estimates derived using a static radiative transfer model indicate that such efforts could amplify the planetary albedo enough to offset the current global annual average level of radiative forcing caused by anthropogenic greenhouse gases by as much as 30 percent or 0.76 W/m2. Terrestrial albedo amplification may thus extend, by about 25 years, the time available to advance the development and use of low-emission energy conversion technologies which ultimately remain essential to mitigate long-term climate change. However, additional study is needed to confirm the estimates reported here and to assess the economic and environmental impacts of active land-surface albedo amplification as a climate change mitigation measure.Comment: 21 pages, 3 figures. In press with Mitigation and Adaptation Strategies for Global Change, Springer, N

Prediction of storm transfers and annual loads with data-based mechanistic models using high-frequency data

Excess nutrients in surface waters, such as phosphorus (P) from agriculture, result in poor water quality, with adverse effects on ecological health and costs for remediation. However, understanding and prediction of P transfers in catchments have been limited by inadequate data and over-parameterised models with high uncertainty. We show that, with high temporal resolution data, we are able to identify simple dynamic models that capture the P load dynamics in three contrasting agricultural catchments in the UK. For a flashy catchment, a linear, second-order (two pathways) model for discharge gave high simulation efficiencies for short-term storm sequences and was useful in highlighting uncertainties in out-of-bank flows. A model with nonlinear rainfall input was appropriate for predicting seasonal or annual cumulative P loads where antecedent conditions affected the catchment response. For second-order models, the time constant for the fast pathway varied between 2 and 15 h for all three catchments and for both discharge and P, confirming that high temporal resolution data are necessary to capture the dynamic responses in small catchments (10–50 km2/. The models led to a better understanding of the dominant nutrient transfer modes, which will be helpful in determining phosphorus transfers following changes in precipitation patterns in the future

Nucleosynthesis Constraints on a Massive Gravitino in Neutralino Dark Matter Scenarios

The decays of massive gravitinos into neutralino dark matter particles and Standard Model secondaries during or after Big-Bang nucleosynthesis (BBN) may alter the primordial light-element abundances. We present here details of a new suite of codes for evaluating such effects, including a new treatment based on PYTHIA of the evolution of showers induced by hadronic decays of massive, unstable particles such as a gravitino. We also develop an analytical treatment of non-thermal hadron propagation in the early universe, and use this to derive analytical estimates for light-element production and in turn on decaying particle lifetimes and abundances. We then consider specifically the case of an unstable massive gravitino within the constrained minimal supersymmetric extension of the Standard Model (CMSSM). We present upper limits on its possible primordial abundance before decay for different possible gravitino masses, with CMSSM parameters along strips where the lightest neutralino provides all the astrophysical cold dark matter density. We do not find any CMSSM solution to the cosmological Li7 problem for small m_{3/2}. Discounting this, for m_{1/2} ~ 500 GeV and tan beta = 10 the other light-element abundances impose an upper limit m_{3/2} n_{3/2}/n_\gamma < 3 \times 10^{-12} GeV to < 2 \times 10^{-13} GeV for m_{3/2} = 250 GeV to 1 TeV, which is similar in both the coannihilation and focus-point strips and somewhat weaker for tan beta = 50, particularly for larger m_{1/2}. The constraints also weaken in general for larger m_{3/2}, and for m_{3/2} > 3 TeV we find a narrow range of m_{3/2} n_{3/2}/n_\gamma, at values which increase with m_{3/2}, where the Li7 abundance is marginally compatible with the other light-element abundances.Comment: 74 pages, 40 Figure

Stable, Time-Dependent, Exact Solutions for Brane Models with a Bulk Scalar Field

We derive two classes of brane-world solutions arising in the presence of a bulk scalar field. For static field configurations, we adopt a time-dependent, factorizable metric ansatz that allows for radion stabilization. The solutions are characterized by a non-trivial warping along the extra dimension, even in the case of a vanishing bulk cosmological constant, and lead to a variety of inflationary, time-dependent solutions of the 3D scale factor on the brane. We also derive the constraints necessary for the stability of these solutions under time-dependent perturbations of the radion field, and we demonstrate the existence of phenomenologically interesting, stable solutions with a positive cosmological constant on the brane.Comment: 24 pages, latex, 4 eps figur

Constrained Supersymmetric Flipped SU(5) GUT Phenomenology

We explore the phenomenology of the minimal supersymmetric flipped SU(5) GUT model (CFSU(5)), whose soft supersymmetry-breaking (SSB) mass parameters are constrained to be universal at some input scale, $M_{in}$, above the GUT scale, $M_{GUT}$. We analyze the parameter space of CFSU(5) assuming that the lightest supersymmetric particle (LSP) provides the cosmological cold dark matter, paying careful attention to the matching of parameters at the GUT scale. We first display some specific examples of the evolutions of the SSB parameters that exhibit some generic features. Specifically, we note that the relationship between the masses of the lightest neutralino and the lighter stau is sensitive to $M_{in}$, as is the relationship between the neutralino mass and the masses of the heavier Higgs bosons. For these reasons, prominent features in generic $(m_{1/2}, m_0)$ planes such as coannihilation strips and rapid-annihilation funnels are also sensitive to $M_{in}$, as we illustrate for several cases with tan(beta)=10 and 55. However, these features do not necessarily disappear at large $M_{in}$, unlike the case in the minimal conventional SU(5) GUT. Our results are relatively insensitive to neutrino masses.Comment: 23 pages, 8 figures; (v2) added explanations and corrected typos, version to appear in EPJ

Invasive versus medical management in patients with prior coronary artery bypass surgery with a non-ST segment elevation acute coronary syndrome: a pilot randomized controlled trial

Background: The benefits of routine invasive management in patients with prior coronary artery bypass grafts presenting with non-ST elevation acute coronary syndromes are uncertain because these patients were excluded from pivotal trials. Methods: In a multicenter trial, non-ST elevation acute coronary syndromes patients with prior coronary artery bypass graft were prospectively screened in 4 acute hospitals. Medically stabilized patients were randomized to invasive management (invasive group) or noninvasive management (medical group). The primary outcome was adherence with the randomized strategy by 30 days. A blinded, independent Clinical Event Committee adjudicated predefined composite outcomes for efficacy (all-cause mortality, rehospitalization for refractory ischemia/angina, myocardial infarction, hospitalization because of heart failure) and safety (major bleeding, stroke, procedure-related myocardial infarction, and worsening renal function). Results: Two hundred seventeen patients were screened and 60 (mean±SD age, 71±9 years, 72% male) were randomized (invasive group, n=31; medical group, n=29). One-third (n=10) of the participants in the invasive group initially received percutaneous coronary intervention. In the medical group, 1 participant crossed over to invasive management on day 30 but percutaneous coronary intervention was not performed. During 2-years’ follow-up (median [interquartile range], 744 [570–853] days), the composite outcome for efficacy occurred in 13 (42%) subjects in the invasive group and 13 (45%) subjects in the medical group. The composite safety outcome occurred in 8 (26%) subjects in the invasive group and 9 (31%) subjects in the medical group. An efficacy or safety outcome occurred in 17 (55%) subjects in the invasive group and 16 (55%) subjects in the medical group. Health status (EuroQol 5 Dimensions) and angina class in each group were similar at 12 months. Conclusions: More than half of the population experienced a serious adverse event. An initial noninvasive management strategy is feasible. A substantive health outcomes trial of invasive versus noninvasive management in non-ST elevation acute coronary syndromes patients with prior coronary artery bypass grafts appears warranted. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01895751