An overview of initiatives to innovate land tenure recordation:2011 to present

Fit-for-purpose inspired approaches to land tenure recordation are being developed and implemented mainly in the form of pilot projects in various countries and application contexts. These approaches combine mobile digital technologies and flexible database structures with community based approaches for capturing and managing tenure rights. We discuss 10 such initiatives. A basic commonality of the initiatives is the general approach to tenure recordation through community based digital data capture, in many cases via mobile applications – where formal land registration does not suffice or has failed and acknowledging the diversity of land tenure regimes. Looking at the initiatives in more detail a number of differences become apparent in terms of financing mechanisms and organizational characteristics, as well as process design and application domains. Our discussion provides a basis to point out directions for future research as well as points of consideration for evaluation of implementation efforts and the aim of achieving citizens’ tenure securit

Absorption Line Studies in the Halo

Significant progress has been made over the last few years to explore the gaseous halo of the Milky Way by way of absorption spectroscopy. I review recent results on absorption line studies in the halo using various instruments, such as the Far Ultraviolet Spectroscopic Explorer, the Space Telescope Imaging Spectrograph, and others. The new studies imply that the infall of low-metallicity gas, the interaction with the Magellanic Clouds, and the Galactic Fountain are responsible for the phenomenon of the intermediate- and high-velocity clouds in the halo. New measurements of highly-ionized gas in the vicinity of the Milky Way indicate that these clouds are embedded in a corona of hot gas that extends deep into the intergalactic space.Comment: 7 pages, 1 figure; Invited review at the conference "How does the Galaxy work ?", Granada/Spain, June 200

Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma

In Burkitt lymphoma/leukemia (BL), achievement of complete remission with first-line chemotherapy remains a challenging issue, as most patients who respond remain disease-free, whereas those refractory have few options of being rescued with salvage therapies. The mechanisms underlying BL chemoresistance and how it can be circumvented remain undetermined. We previously reported the frequent inactivation of the proapoptotic BIM gene in B-cell lymphomas. Here we show that BIM epigenetic silencing by concurrent promoter hypermethylation and deacetylation occurs frequently in primary BL samples and BL-derived cell lines. Remarkably, patients with BL with hypermethylated BIM presented lower complete remission rate (24% vs 79%; P = .002) and shorter overall survival (P = .007) than those with BIM-expressing lymphomas, indicating that BIM transcriptional repression may mediate tumor chemoresistance. Accordingly, by combining in vitro and in vivo studies of human BL-xenografts grown in immunodeficient RAG2(-/-)γc(-/-) mice and of murine B220(+)IgM(+) B-cell lymphomas generated in Eμ-MYC and Eμ-MYC-BIM(+/-) transgenes, we demonstrate that lymphoma chemoresistance is dictated by BIM gene dosage and is reversible on BIM reactivation by genetic manipulation or after treatment with histone-deacetylase inhibitors. We suggest that the combination of histone-deacetylase inhibitors and high-dose chemotherapy may overcome chemoresistance, achieve durable remission, and improve survival of patients with BL

FDG-PET: a new diagnostic approach in hip prosthesis infection

Infection following hip arthroplasties can present a diagnostic challenge. No test is 100 % sensitive and 100 % specific; this prospective study was undertaken to evaluate the utility of FDG-PET imaging for diagnosing infected joint replacements. 24 hip joint replacements were studied prospectively and we have complete diagnoses with clinical signs and symptoms, laboratory test, radiography, joint aspiration, radionuclide imaging including FDG-PET, and histopathologic examination. 11 of 24 prostheses were infected. The sensitivity and specificity of PET for detecting infection associated with prostheses were 64,3 % and 64,7 % respectively, in our hands. FDG imaging is not useful in patients with suspected prosthetic infection like a screening tes

Heavy neutrino signals at large hadron colliders

We study the LHC discovery potential for heavy Majorana neutrino singlets in the process pp -> W+ -> l+ N -> l+ l+ jj (l=e,mu) plus its charge conjugate. With a fast detector simulation we show that backgrounds involving two like-sign charged leptons are not negligible and, moreover, they cannot be eliminated with simple sequential kinematical cuts. Using a likelihood analysis it is shown that, for heavy neutrinos coupling only to the muon, LHC has 5 sigma sensitivity for masses up to 200 GeV in the final state mu+- mu+- jj. This reduction in sensitivity, compared to previous parton-level estimates, is driven by the ~ 10^2-10^3 times larger background. Limits are also provided for e+- e+- jj and e+- mu+- jj final states, as well as for Tevatron. For heavy Dirac neutrinos the prospects are worse because backgrounds involving two opposite charge leptons are much larger. For this case, we study the observability of the lepton flavour violating signal e+- mu-+ jj. As a by-product of our analysis, heavy neutrino production has been implemented within the ALPGEN framework.Comment: Latex 36 pages, 49 PS figures. Major extension incorporating analysis for e+- e+-, e+- mu+- and e+- mu-+ final states. Final version to appear in JHE

On zero sets in the Dirichlet space

We study the zeros sets of functions in the Dirichlet space. Using Carleson formula for Dirichlet integral, we obtain some new families of zero sets. We also show that any closed subset of E \subset \TT with logarithmic capacity zero is the accumulation points of the zeros of a function in the Dirichlet space. The zeros satisfy a growth restriction which depends on $E$.Comment: Journal of Geometric Analysis (2011

The magnesium isotope record of cave carbonate archives

Here we explore the potential of magnesium (δ<sup>26</sup>Mg) isotope time-series data as continental climate proxies in speleothem calcite archives. For this purpose, a total of six Pleistocene and Holocene stalagmites from caves in Germany, Morocco and Peru and two flowstones from a cave in Austria were investigated. These caves represent the semi-arid to arid (Morocco), the warm-temperate (Germany), the equatorial-humid (Peru) and the cold-humid (Austria) climate zones. Changes in the calcite magnesium isotope signature with time are compared against carbon and oxygen isotope records from these speleothems. Similar to other proxies, the non-trivial interaction of a number of environmental, equilibrium and disequilibrium processes governs the δ<sup>26</sup>Mg fractionation in continental settings. These include the different sources of magnesium isotopes such as rainwater or snow as well as soil and host rock, soil zone biogenic activity, shifts in silicate versus carbonate weathering ratios and residence time of water in the soil and karst zone. Pleistocene stalagmites from Morocco show the lowest mean δ<sup>26</sup>Mg values (GDA: −4.26 ± 0.07‰ and HK3: −4.17 ± 0.15‰), and the data are well explained in terms of changes in aridity over time. The Pleistocene to Holocene stalagmites from Peru show the highest mean value of all stalagmites (NC-A and NC-B δ<sup>26</sup>Mg: −3.96 ± 0.04‰) but only minor variations in Mg-isotope composition, which is consistent with the rather stable equatorial climate at this site. Holocene stalagmites from Germany (AH-1 mean δ<sup>26</sup>Mg: −4.01 ± 0.07‰; BU 4 mean δ<sup>26</sup>Mg: −4.20 ± 0.10‰) suggest changes in outside air temperature was the principal driver rather than rainfall amount. The alpine Pleistocene flowstones from Austria (SPA 52: −3.00 ± 0.73‰; SPA 59: −3.70 ± 0.43‰) are affected by glacial versus interglacial climate change with outside air temperature affecting soil zone activity and weathering balance. Several δ<sup>26</sup>Mg values of the Austrian and two δ<sup>26</sup>Mg values of the German speleothems are shifted to higher values due to sampling in detrital layers (Mg-bearing clay minerals) of the speleothems. The data and their interpretation shown here highlight the potential but also the limitations of the magnesium isotope proxy applied in continental climate research. An obvious potential lies in its sensitivity for even subtle changes in soil-zone parameters, a hitherto rather poorly understood but extremely important component in cave archive research. Limitations are most obvious in the low resolution and high sample amount needed for analysis. Future research should focus on experimental and conceptual aspects including quantitative and well-calibrated leaching and precipitation experiments

Degeneracies when T=0 Two Body Matrix Elements are Set Equal to Zero and Regge's 6j Symmetry Relations

The effects of setting all T=0 two body interaction matrix elements equal to a constant (or zero) in shell model calculations (designated as $=0$) are investigated. Despite the apparent severity of such a procedure, one gets fairly reasonable spectra. We find that using $=0$ in single j shell calculations degeneracies appear e.g. the $I={1/2} ^{-}$ and ${13/2}^{-}$ states in $^{43}$Sc are at the same excitation energies; likewise the I=$3_{2}^{+}$,$7_{2}^{+}$,9$^{+}_{1}$ and 10$^{+}_{1}$ states in $^{44}$Ti. The above degeneracies involve the vanishing of certain 6j and 9j symbols. The symmetry relations of Regge are used to explain why these vanishings are not accidental. Thus for these states the actual deviation from degeneracy are good indicators of the effects of the T=0 matrix elements. A further indicator of the effects of the T=0 interaction in an even - even nucleus is to compare the energies of states with odd angular momentum with those that are even

Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasis

In humans, coagulation factor V (FV) deficiency is a rare, clinically heterogeneous bleeding disorder, suggesting that genetic modifiers may contribute to disease expressivity. Zebrafish possess many distinct advantages including high fecundity, optical clarity, external development, and homology with the mammalian hemostatic system, features that make it ideal for genetic studies. Our aim was to study the role of FV in zebrafish through targeted mutagenesis and apply the model to the study of human F5 variants. CRISPR-mediated genome editing of the zebrafish f5 locus was performed, generating mutants homozygous for a 49 base pair deletion in exon 4. Thrombus formation secondary to vascular endothelial injury was absent in f52/2 mutant embryos and larvae. Despite this severe hemostatic defect, homozygous mutants survived before succumbing to severe hemorrhage in adulthood. Human F5 variants of uncertain significance from patients with FV deficiency were evaluated, and the causative mutations identified and stratified by their ability to restore thrombus formation in larvae. Analysis of these novel mutations demonstrates variable residual FV function, with minimal activity being required to restore hemostasis in response to laser-induced endothelial injury. This in vivo evaluation may be beneficial for patients whose factor activity levels lack correlation with bleeding symptomatology, although limitations exist. Furthermore, homozygous mutant embryos tolerate what is a severe and lethal defect in mammals, suggesting the possibility of species-specific factors enabling survival, and allowing further study not possible in the mouse. Identification of these factors or other genetic modifiers could lead to novel therapeutic modalities

Statistics of Coulomb Blockade Peak Spacings within the Hartree-Fock Approximation

We study the effect of electronic interactions on the addition spectra and on the energy level distributions of two-dimensional quantum dots with weak disorder using the self-consistent Hartree-Fock approximation for spinless electrons. We show that the distribution of the conductance peak spacings is Gaussian with large fluctuations that exceed, in agreement with experiments, the mean level spacing of the non-interacting system. We analyze this distribution on the basis of Koopmans' theorem. We show furthermore that the occupied and unoccupied Hartree-Fock levels exhibit Wigner-Dyson statistics.Comment: 5 pages, 2 figures, submitted for publicatio