Dust Devil Tracks

Dust devils that leave dark- or light-toned tracks are common on Mars and they can also be found on the Earth’s surface. Dust devil tracks (hereinafter DDTs) are ephemeral surface features with mostly sub-annual lifetimes. Regarding their size, DDT widths can range between ∼1 m and ∼1 km, depending on the diameter of dust devil that created the track, and DDT lengths range from a few tens of meters to several kilometers, limited by the duration and horizontal ground speed of dust devils. DDTs can be classified into three main types based on their morphology and albedo in contrast to their surroundings; all are found on both planets: (a) dark continuous DDTs, (b) dark cycloidal DDTs, and (c) bright DDTs. Dark continuous DDTs are the most common type on Mars. They are characterized by their relatively homogenous and continuous low albedo surface tracks. Based on terrestrial and martian in situ studies, these DDTs most likely form when surficial dust layers are removed to expose larger-grained substrate material (coarse sands of ≥500 μm in diameter). The exposure of larger-grained materials changes the photometric properties of the surface; hence leading to lower albedo tracks because grain size is photometrically inversely proportional to the surface reflectance. However, although not observed so far, compositional differences (i.e., color differences) might also lead to albedo contrasts when dust is removed to expose substrate materials with mineralogical differences. For dark continuous DDTs, albedo drop measurements are around 2.5 % in the wavelength range of 550–850 nm on Mars and around 0.5 % in the wavelength range from 300–1100 nm on Earth. The removal of an equivalent layer thickness around 1 μm is sufficient for the formation of visible dark continuous DDTs on Mars and Earth. The next type of DDTs, dark cycloidal DDTs, are characterized by their low albedo pattern of overlapping scallops. Terrestrial in situ studies imply that they are formed when sand-sized material that is eroded from the outer vortex area of a dust devil is redeposited in annular patterns in the central vortex region. This type of DDT can also be found in on Mars in orbital image data, and although in situ studies are lacking, terrestrial analog studies, laboratory work, and numerical modeling suggest they have the same formation mechanism as those on Earth. Finally, bright DDTs are characterized by their continuous track pattern and high albedo compared to their undisturbed surroundings. They are found on both planets, but to date they have only been analyzed in situ on Earth. Here, the destruction of aggregates of dust, silt and sand by dust devils leads to smooth surfaces in contrast to the undisturbed rough surfaces surrounding the track. The resulting change in photometric properties occurs because the smoother surfaces have a higher reflectance compared to the surrounding rough surface, leading to bright DDTs. On Mars, the destruction of surficial dust-aggregates may also lead to bright DDTs. However, higher reflective surfaces may be produced by other formation mechanisms, such as dust compaction by passing dust devils, as this may also cause changes in photometric properties. On Mars, DDTs in general are found at all elevations and on a global scale, except on the permanent polar caps. DDT maximum areal densities occur during spring and summer in both hemispheres produced by an increase in dust devil activity caused by maximum insolation. Regionally, dust devil densities vary spatially likely controlled by changes in dust cover thicknesses and substrate materials. This variability makes it difficult to infer dust devil activity from DDT frequencies. Furthermore, only a fraction of dust devils leave tracks. However, DDTs can be used as proxies for dust devil lifetimes and wind directions and speeds, and they can also be used to predict lander or rover solar panel clearing events. Overall, the high DDT frequency in many areas on Mars leads to drastic albedo changes that affect large-scale weather patterns

Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America.

BACKGROUND: Cardiovascular disease and non-AIDS malignancies have become major causes of death among HIV-infected individuals. The relative impact of lifestyle and HIV-related factors are debated. METHODS: We estimated associations of smoking with mortality more than 1 year after antiretroviral therapy (ART) initiation among HIV-infected individuals enrolled in European and North American cohorts. IDUs were excluded. Causes of death were assigned using standardized procedures. We used abridged life tables to estimate life expectancies. Life-years lost to HIV were estimated by comparison with the French background population. RESULTS: Among 17 995 HIV-infected individuals followed for 79 760 person-years, the proportion of smokers was 60%. The mortality rate ratio (MRR) comparing smokers with nonsmokers was 1.94 [95% confidence interval (95% CI) 1.56-2.41]. The MRRs comparing current and previous smokers with never smokers were 1.70 (95% CI 1.23-2.34) and 0.92 (95% CI 0.64-1.34), respectively. Smokers had substantially higher mortality from cardiovascular disease, non-AIDS malignancies than nonsmokers [MRR 6.28 (95% CI 2.19-18.0) and 2.67 (95% CI 1.60-4.46), respectively]. Among 35-year-old HIV-infected men, the loss of life-years associated with smoking and HIV was 7.9 (95% CI 7.1-8.7) and 5.9 (95% CI 4.9-6.9), respectively. The life expectancy of virally suppressed, never-smokers was 43.5 years (95% CI 41.7-45.3), compared with 44.4 years among 35-year-old men in the background population. Excess MRRs/1000 person-years associated with smoking increased from 0.6 (95% CI -1.3 to 2.6) at age 35 to 43.6 (95% CI 37.9-49.3) at age at least 65 years. CONCLUSION: Well treated HIV-infected individuals may lose more life years through smoking than through HIV. Excess mortality associated with smoking increases markedly with age. Therefore, increases in smoking-related mortality can be expected as the treated HIV-infected population ages. Interventions for smoking cessation should be prioritized

Precision dosing of doxapram in preterm infants using continuous pharmacodynamic data and model-based pharmacokinetics: an illustrative case series

IntroductionCurrent drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly alter pharmacokinetics and pharmacodynamics. Evaluation of drug therapy in these patients is very difficult because objective pharmacodynamic parameters are generally lacking. By integrating continuous physiological data with model-based drug exposure and data on adverse drug reactions (ADRs), we aimed to show the potential benefit for optimized individual pharmacotherapy.Materials and MethodsContinuous data on oxygen saturation (SpO(2)), fraction of inspired oxygen (FiO(2)) and composite parameters, including the SpO(2)/FiO(2) ratio and the cumulative oxygen shortage under the 89% SpO(2) limit, served as indicators for doxapram effectiveness. We analyzed these continuous effect data, integrated with doxapram exposure and ADR parameters, obtained in preterm infants around the start of doxapram therapy. The exposures to doxapram and the active metabolite keto-doxapram were simulated using a population pharmacokinetic model. Infants were selected and retrospectively compared on the indication to start doxapram, the first response to doxapram, a potential dose-response relationship, and the administered dosage over time. Recommendations were made for individual improvements of therapy.ResultsWe provide eight cases of continuous doxapram administration that illustrate a correct and incorrect indication to start doxapram, responders and non-responders to therapy, and unnecessary over-exposure with ADRs. Recommendations for improvement of therapy include: objective evaluation of added effect of doxapram after start, prevention of overdosing by earlier down-titration or termination of therapy, and the prevention of hypoxia and agitation by measuring specific parameters at strategical time-points.ConclusionReal-time and non-invasive effect monitoring of drug therapy combined with model-based exposure provides relevant information to clinicians and can importantly improve therapy. The variability between and within patients emphasizes the importance of individual, objective evaluation of pharmacotherapy. These measurements, together with data on ADRs, allow for precision medicine in neonatology that should be brought to the bedside.Pharmacolog

Isothermal Plasma Wave Properties of the Schwarzschild de-Sitter Black Hole in a Veselago Medium

In this paper, we study wave properties of isothermal plasma for the Schwarzschild de-Sitter black hole in a Veselago medium. We use ADM 3+1 formalism to formulate general relativistic magnetohydrodynamical (GRMHD) equations for the Schwarzschild de-Sitter spacetime in Rindler coordinates. Further, Fourier analysis of the linearly perturbed GRMHD equations for the rotating (non-magnetized and magnetized) background is taken whose determinant leads to a dispersion relation. We investigate wave properties by using graphical representation of the wave vector, the refractive index, change in refractive index, phase and group velocities. Also, the modes of wave dispersion are explored. The results indicate the existence of the Veselago medium.Comment: 24 pages, 12 figures, accepted for publication in Astrophys. Space Sci. arXiv admin note: text overlap with arXiv:1101.0884 and arxiv:1007.285

Egocentric activity monitoring and recovery

This paper presents a novel approach for real-time egocentric activity recognition in which component atomic events are characterised in terms of binary relationships between parts of the body and manipulated objects. The key contribution is to summarise, within a histogram, the relationships that hold over a fixed time interval. This histogram is then classified into one of a number of atomic events. The relationships encode both the types of body parts and objects involved (e.g. wrist, hammer) together with a quantised representation of their distance apart and the normalised rate of change in this distance. The quantisation and classifier are both configured in a prior learning phase from training data. An activity is represented by a Markov model over atomic events. We show the application of the method in the prediction of the next atomic event within a manual procedure (e.g. assembling a simple device) and the detection of deviations from an expected procedure. This could be used for example in training operators in the use or servicing of a piece of equipment, or the assembly of a device from components. We evaluate our approach (’Bag-of-Relations’) on two datasets: ‘labelling and packaging bottles’ and ‘hammering nails and driving screws’, and show superior performance to existing Bag-of-Features methods that work with histograms derived from image features [1]. Finally, we show that the combination of data from vision and inertial (IMU) sensors outperforms either modality alone

Use of Continuous Physiological Monitor Data to Evaluate Doxapram Therapy in Preterm Infants

Introduction: Evaluation of pharmacotherapy during intensive care treatment is commonly based on subjective, intermittent interpretations of physiological parameters. Realtime visualization and analysis may improve drug effect evaluation. We aimed to evaluate the effects of the respiratory stimulant doxapram objectively in preterm infants using continuous physiological parameters. Methods: In this longitudinal observational study, preterm infants who receiv

Interacting New Agegraphic Dark Energy in a Cyclic Universe

The main goal of this work is investigation of NADE in the cyclic universe scenario. Since, cyclic universe is explained by a phantom phase ($\omega<-1$), it is shown when there is no interaction between matter and dark energy, ADE and NADE do not produce a phantom phase, then can not describe cyclic universe. Therefore, we study interacting models of ADE and NADE in the modified Friedmann equation. We find out that, in the high energy regime, which it is a necessary part of cyclic universe evolution, only NADE can describe this phantom phase era for cyclic universe. Considering deceleration parameter tells us that the universe has a deceleration phase after an acceleration phase, and NADE is able to produce a cyclic universe. Also it is found valuable to study generalized second law of thermodynamics. Since the loop quantum correction is taken account in high energy regime, it may not be suitable to use standard treatment of thermodynamics, so we turn our attention to the result of \citep{29}, which the authors have studied thermodynamics in loop quantum gravity, and we show that which condition can satisfy generalized second law of thermodynamics.Comment: 8 pages, 3 figure

Universal Correlations in Pion-less EFT with the Resonating Group Model: Three and Four Nucleons

The Effective Field Theory "without pions" at next-to-leading order is used to analyze universal bound state and scattering properties of the 3- and 4-nucleon system. Results of a variety of phase shift equivalent nuclear potentials are presented for bound state properties of 3H and 4He, and for the singlet S-wave 3He-neutron scattering length a_0(3He-n). The calculations are performed with the Refined Resonating Group Method and include a full treatment of the Coulomb interaction and the leading-order 3-nucleon interaction. The results compare favorably with data and values from AV18(+UIX) model calculations. A new correlation between a_0(3He-n) and the 3H binding energy is found. Furthermore, we confirm at next-to-leading order the correlations, already found at leading-order, between the 3H binding energy and the 3H charge radius, and the Tjon line. With the 3H binding energy as input, we get predictions of the Effective Field Theory "without pions" at next-to-leading order for the root mean square charge radius of 3H of (1.6\pm 0.2) fm, for the 4He binding energy of (28\pm 2.5) MeV, and for Re(a_0(3He-n)) of (7.5\pm 0.6)fm. Including the Coulomb interaction, the splitting in binding energy between 3H and 3He is found to be (0.66\pm 0.03) MeV. The discrepancy to data of (0.10\mp 0.03) MeV is model independently attributed to higher order charge independence breaking interactions. We also demonstrate that different results for the same observable stem from higher order effects, and carefully assess that numerical uncertainties are negligible. Our results demonstrate the convergence and usefulness of the pion-less theory at next-to-leading order in the 4He channel. We conclude that no 4-nucleon interaction is needed to renormalize the theory at next-to-leading order in the 4-nucleon sector.Comment: 24 pages revtex4, including 8 figures as .eps files embedded with includegraphicx, leading-order results added, calculations include the LO three-nucleon interaction explicitly, comment on Wigner bound added, minor modification

The North Sea Benthos Project: planning, management and objectives

The ICES Benthos Ecology Working Group is integrating recent macrobenthic infaunal data (1999-2001) available from various sources, including national monitoring surveys, in North Sea soft bottom sediments. lt is expected to cover most of the North Sea. The main goal is an overall comparison with the North Sea Benthos Survey data of 1986, in order to determine whether there have been any significant changes and, if so, what may be the causal influences (e.g., climate change, fishing impacts). The work will contribute valuable information on several other topics such as habitat classification and the distribution of endangered species. Therefore, in addition to physico-chemical measurements of sediments samples alongside the benthic fauna, information on water depths, temperature, water quality and salinity will be incorporated in the analysis of species and community distributions. Also, we will use existing ecological and hydrographical models for currents, bottom shear stress and carbon input, along with information on the distribution of habitat types, to explain the observed distribution patterns. At the ASC, an overview of the data available will be presented as well as the anticipated outcomes, and the first steps taken to deal with taxonomic differences and other issues affecting the capability to integrate submitted information