Влияние способа регулирования на экономичность работы забойного турбонасоса

Lasers as production tools offer several advantages, which are especially relevant for the production of solar cells. The contactless and localized nature of the energy deposition allows new processes, such as laser selective emitter doping, laser ablation of dielectric coatings and via drilling for back contact cell concepts. A critical factor is the selection of suitable laser sources and parameters in a manner that adapts the laser process to the requirements of the material, the process nature and the solar cell properties. In this paper three laser processes are investigated with the goal to identify the most suitable laser source

Çok acı bir kayıp:Osman Cemal Kaygılı hayata gözlerini yumdu

Taha Toros Arşivi, Dosya No: 114-Osman Cemal KaygılıUnutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010

HIGH ACCURATE POINTWISE (GEO-)REFERENCING OF A K-TLS BASED MULTI-SENSOR-SYSTEM

In recent years, the requirements in the industrial production, e.g., ships or planes, have been increased. In addition to high accuracy requirements with a standard deviation of 1 mm, an efficient 3D object capturing is required. In terms of efficiency, kinematic laser scanning (k-TLS) has been proven its worth in recent years. It can be seen as an alternative to the well established static terrestrial laser scanning (s-TLS). However, current k-TLS based multi-sensor-systems (MSS) are not able to fulfil the high accuracy requirements. Thus, a new k-TLS based MSS and suitable processing algorithms have to be developed. In this contribution a new k-TLS based MSS will be presented. The main focus will lie on the (geo-)referencing process. Due to the high accuracy requirements, a novel procedure of external (geo-)referencing is used here. Hereby, a mobile platform, which is equipped with a profile laser scanner, will be tracked by a laser tracker. Due to the fact that the measurement frequency of the laser scanner is significantly higher than the measurement frequency of the laser tracker a direct point wise (geo-)referencing is not possible. To enable this a Kalman filter model is set up and implemented. In the prediction step each point is shifted according to the determined velocity of the platform. Because of the nonlinear motion of the platform an iterative extended Kalman filter (iEKF) is used here. Furthermore, test measurements of a panel with the k-TLS based MSS and with s-TLS were carried out. To compare the results, the 3D distances with the M3C2-algorithm between the s-TLS 3D point cloud and the k-TLS 3D point cloud are estimated. It can be noted, that the usage of a system model for the (geo-)referencing is essential. The results show that the mentioned high accuracy requirements have been achieved

The next frontier: Fostering innovation by improving health data access and utilization

Beneath most lively policy debates sit dry-as-dust theoretical and methodological discussions. Current disputes over the EU Adaptive Pathways initiative and the proposed US 21st Century Cures Act may ultimately rest on addressing arcane issues of data curation, standardization, and utilization. Improved extraction of inform ation on the safety and effectiveness of drugs-in-use must parallel adjustments in evidence requirements at the time of licensing. To do otherwise may compromise safety and efficacy in the name of fostering innovation

Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

© 2018 The Author(s). Following publication of the original article [1], the authors reported an error in the spelling of one of the author names. In this Correction the incorrect and correct author names are indicated and the author name has been updated in the original publication. The authors also reported an error in the Methods section of the original article. In this Correction the incorrect and correct versions of the affected sentence are indicated. The original article has not been updated with regards to the error in the Methods section

Lead-related quantum emitters in diamond

We report on quantum emission from Pb-related color centers in diamond following ion implantation and high-temperature vacuum annealing. First-principles calculations predict a negatively charged Pb-vacancy (PbV) center in a split-vacancy configuration, with a zero-phonon transition around 2.4 eV. Cryogenic photoluminescence measurements performed on emitters in nanofabricated pillars reveal several transitions, including a prominent doublet near 520 nm. The splitting of this doublet, 5.7 THz, exceeds that reported for other group-IV centers. These observations are consistent with the PbV center, which is expected to have a combination of narrow optical transitions and stable spin states, making it a promising system for quantum network nodes.U.S. Army Research Laboratory. Center for Distributed Quantum InformationNational Science Foundation (U.S.). Graduate Research Fellowship ProgramNational Science Foundation (U.S.) (Grant DMR-1231319)United States. National Aeronautics and Space Administration (Space Technology Research Fellowship)MIT-Harvard Center for Ultracold Atoms MIT International Science and Technology Initiativ

Application of pharmacogenomics and bioinformatics to exemplify the utility of human <i>ex vivo</i> organoculture models in the field of precision medicine

Here we describe a collaboration between industry, the National Health Service (NHS) and academia that sought to demonstrate how early understanding of both pharmacology and genomics can improve strategies for the development of precision medicines. Diseased tissue ethically acquired from patients suffering from chronic obstructive pulmonary disease (COPD), was used to investigate inter-patient variability in drug efficacy using ex vivo organocultures of fresh lung tissue as the test system. The reduction in inflammatory cytokines in the presence of various test drugs was used as the measure of drug efficacy and the individual patient responses were then matched against genotype and microRNA profiles in an attempt to identify unique predictors of drug responsiveness. Our findings suggest that genetic variation in CYP2E1 and SMAD3 genes may partly explain the observed variation in drug response

The influence of genotype information on psychiatrists’ treatment recommendations: more experienced clinicians know better what to ignore

Background This study applies attribute nonattendance to medical decision making. We aimed to demonstrate how this type of analysis can be used in medical decision making to assess whether psychiatrists were influenced in their treatment recommendations by information on the genotype of a patient, despite knowing the patient’s response to treatment as measured by the Positive and Negative Syndrome Scale. A patient’s genetic information may be used to predict their response to therapy; such information, however, becomes redundant, and should not influence decisions, once a clinician knows the patient’s actual response to treatment. Methods Sixty-seven psychiatrists were presented with patients’ pre- or post-treatment scores on the Positive and Negative Syndrome Scale for two hypothetical treatments for schizophrenia. Psychiatrists were also informed whether the patient possessed a genotype linked to hyper-responsiveness to one of the treatments, and were asked to recommend one of these two treatments. Attribute nonattendance assessed whether the information on genotype influenced psychiatrists’ treatment recommendations. Results Years of experience predicted whether psychiatrists were influenced by the genetic information. Psychiatrists with 1 year or less of experience had a 46% probability of considering genetic information, whereas psychiatrists with at least 15 years of experience had a lower probability (7%). Conclusions Psychiatrists and other clinicians should be cautious about allowing a patient’s genetic information to carry unnecessary weight in their clinical decision making