A simple method for demonstrating macroscopically the location of polyphenolic compounds in grape berries

Slices of berries of several varieties of Vitis vinifera were stained with HCl, vanillin-HCl or FeCl3 to demonstrate macroscopically that the bulk of the polyphenolic compounds occur in the skins, seeds and conducting tissue of grape berries at all stages of development.Eine einfache Methode zur makroskopischen Lokalisation polyphenolischer Verbindungen in WeinbeerenSchnitte von Beeren verschiedener Vitis vinifera-Sorten wurden mit HCl, Vanillin-HCl oder FeCl3 angefärbt, um makroskopisch zu zeigen, daß der Hauptanteil der polyphenolischen Verbindungen in allen Entwicklungsphasen in der Schale, den Samen und den Leitbündeln der Weinbeere lokalisiert ist

Advancing the time of ripeness of grapes by the application of methyl 2-(ureidooxy) propionate (a growth retardant)

Methyl 2-(ureidooxy) propionate (MUP), a plant growth retardant, hastened the ripening of grape berries of Vitis vinifera L. cultivars Mataro and Sultana by about 2 weeks and 1 week, respectively. The vines were sprayed with 0.1 % solution of MUP about halfway :through the first rapid growth phase of the fruit and again 2 weeks later. Terminal and lateral shoot growth was inhibited. Ripening of berries was advanced as measured by development of colour, and changes in titratable acid and reducing sugar content. The earlier ripening of the berries may have been due to hormonal changes but the advancement was much greater than that found previously with abscisic acid or ethylene applied during the slow growth stage of berry development.Die Beschleunigung des Reifezeitpunktes von Trauben durch die Anwendung vonMethyl-2-(ureidooxy)-Propionat, einen WachstumsdämpferMethyl-2-(ureidooxy)-Propionat (MUP), welches das Pflanzenwachstum verlangsamt, beschleunigte bei den Vitis-vinifera-Sorten Mataro und Sultana die Beerenreife um etwa 2 Wochen bzw. 1 Woche. Die Reben wurden etwa in der Mitte der ersten raschen Wachstumsphase der Beeren und ein weiteres Mal 2 Wochen später mit einer 0,1%igen MUP-Lösung besprüht. Das terminale und laterale Triebwachstum war gehemmt. Die Beerenreife war beschleunigt, wie die Entwicklung der Beerenfarbe und die Veränderungen im Gehalt an titrierbarer Säure und reduzierenden Zuckern zeigten. Die frühzeitigere Beerenreife könnte auf hormonale Veränderungen zurückgehen; allerdings war die Reife viel stärker beschleunigt als im Fall früherer Versuche, in denen während der langen Wachstumsphase der Beerenentwicklung Abscisinsäure oder Äthylen angewandt worden waren

Predicting the influence of a p2-symmetric substrate on molecular self-organization with an interaction-site model

An interaction-site model can a priori predict molecular selforganisation on a new substrate in Monte Carlo simulations. This is experimentally confirmed with scanning tunnelling microscopy on Fre´chet dendrons of a pentacontane template. Local and global ordering motifs, inclusion molecules and a rotated unit cell are correctly predicted

Feel My Pain: Design and Evaluation of Painpad, a Tangible Device for Supporting Inpatient Self-Logging of Pain

Monitoring patients' pain is a critical issue for clinical caregivers, particularly among staff responsible for providing analgesic relief. However, collecting regularly scheduled pain readings from patients can be difficult and time-consuming for clinicians. In this paper we present Painpad, a tangible device that was developed to allow patients to engage in self-logging of their pain. We report findings from two hospital-based field studies in which Painpad was deployed to a total of 78 inpatients recovering from ambulatory surgery. We find that Painpad results in improved frequency and compliance with pain logging, and that self-logged scores may be more faithful to patients' experienced pain than corresponding scores reported to nurses. We also show that older adults may prefer tangible interfaces over tablet-based alternatives for reporting their pain, and we contribute design lessons for pain logging devices intended for use in hospital settings

Paying clinicians to join clinical trials : a review of guidelines and interview study of trialists

Background: The motivations of clinicians to participate in clinical trials have been little studied. This project explored the potential role of payment for participation in publicly funded clinical trials in the UK. The aims were to review relevant guidelines and to collate and analyse views of clinical trialists on the role of payments and other factors that motivated clinicians to join clinical trials. Methods: Review of guidelines governing payments to clinicians for recruitment to trials. Semistructured interviews with a range of NHS clinical trial leaders, analysed using qualititative methods. Results: While UK guidelines had little to say specifically on payments linked to recruitment, all payments have become highly regulated and increasingly transparent. Interview participants believed that expenses arising from research should be covered. Payments in excess of expenses were seen as likely to increase participation but with the risk of reducing quality. Motivations such as interest in the topic, the scope for patients to benefit and intellectual curiosity were considered more important. Barriers to involvement included bureaucracy and lack of time. Discussion: Limited scope exists for paying clinicians over-and-above the cost of their time to be involved in research. Most trialists favour full payment of all expenses related to research. Conclusion: Payment of clinicians beyond expenses is perceived to be a less important motivating factor than researching important, salient questions, and facilitating research by reducing bureaucracy and delay

Survey to explore understanding of the principles of aseptic technique: Qualitative content analysis with descriptive analysis of confidence and training

BACKGROUND: In many countries, aseptic procedures are undertaken by nurses in the general ward setting, but variation in practice has been reported, and evidence indicates that the principles underpinning aseptic technique are not well understood. METHODS: A survey was conducted, employing a brief, purpose-designed, self-reported questionnaire. RESULTS: The response rate was 72%. Of those responding, 65% of nurses described aseptic technique in terms of the procedure used to undertake it, and 46% understood the principles of asepsis. The related concepts of cleanliness and sterilization were frequently confused with one another. Additionally, 72% reported that they not had received training for at least 5 years; 92% were confident of their ability to apply aseptic technique; and 90% reported that they had not been reassessed since their initial training. Qualitative analysis confirmed a lack of clarity about the meaning of aseptic technique. CONCLUSION: Nurses' understanding of aseptic technique and the concepts of sterility and cleanliness is inadequate, a finding in line with results of previous studies. This knowledge gap potentially places patients at risk. Nurses' understanding of the principles of asepsis could be improved. Further studies should establish the generalizability of the study findings. Possible improvements include renewed emphasis during initial nurse education, greater opportunity for updating knowledge and skills post-qualification, and audit of practice

Gluon distributions in nucleons and pions at a low resolution scale

In this paper we study the gluon distribution functions in nucleons and pions at a low resolution $Q^2$ scale. This is an important issue since parton densities at low $Q^2$ have always been taken as an external input which is adjusted through DGLAP evolution to fit the experimental data at higher scales. Here, in the framework of a model recently developed, it is shown that the hypothetical cloud of {\it neutral} pions surrounding nucleons and pions appears to be responsible for the characteristic valence-like gluon distributions needed at the inital low scale. As an additional result, we get the remarkable prediction that neutral and charged pions have different intrinsic sea flavor contents.Comment: final version to appear in Phys. Rev. D. Discussion on several points enlarge

Chiral extrapolation of lattice moments of proton quark distributions

We present the resolution of a long-standing discrepancy between the moments of parton distributions calculated from lattice QCD and their experimental values. We propose a simple extrapolation formula for the moments of the nonsinglet quark distribution u-d, as a function of quark mass, which embodies the general constraints imposed by the chiral symmetry of QCD. The inclusion of the leading nonanalytic behavior leads to an excellent description of both the lattice data and the experimental values of the moments.Comment: 9 pages, 1 figure, to appear in Physical Review Letter