Healthy Lifestyle Behaviors and Disparities between the United States mainland compared to Puerto Rico, Guam, and United States Virgin Islands (i. e., United States territories)

Background: No studies have compared the lifestyle behaviors between Puerto Rico, Guam, and the U. S. Virgin Islands to that of the United States mainland. Documenting and addressing health disparities between these geographically and culturally distinct areas are important public health objectives. Differences in health status between and among the United States mainland and territories merit systematic and careful analyses. Methods: Four key healthy lifestyle characteristics include tobacco use, body mass index, physical activity, and fruit/vegetable consumption. Data from the 2009 Behavioral Risk Factor Surveillance System (N=420,481) were used to examine United States mainland and territorial differences among the four key healthy lifestyle behaviors. Descriptive statistics were summarized with chi-square tests for independence and multiple adjusted logistic regression models were used to examine differences in health compliance rates while controlling for age, gender, income, and education. Frequencies determined whether Healthy People 2010 goals were met by each location. Results: Differences were found between the United States mainland and territories for smoking rates, body mass index, physical activity, and consumption of fruit/vegetables. None of the countries met all four Healthy People 2010 goals. Discussion: Even though, each location had unique challenges, Puerto Ricans’ health behaviors were significantly less favorable than residents in the other countries. We document prevalence rates and differences by country for each of the four healthy lifestyle characteristics. This study highlights the need for more research in these understudied areas as well as the importance of effective health promotion and disease prevention programs for all United States citizens including the mainland and all territories

A Family History of Lethal Prostate Cancer and Risk of Aggressive Prostate Cancer in Patients Undergoing Radical Prostatectomy.

We investigated whether a family history of lethal prostate cancer (PCa) was associated with high-risk disease or biochemical recurrence in patients undergoing radical prostatectomy. A cohort of radical prostatectomy patients was stratified into men with no family history of PCa (NFH); a first-degree relative with PCa (FH); and those with a first-degree relative who had died of PCa (FHD). Demographic, operative and pathologic outcomes were analyzed. Freedom from biochemical recurrence was examined using Kaplan-Meier log rank. A multivariate Cox logistic regression analysis was also performed. We analyzed 471 men who underwent radical prostatectomy at our institution with known family history. The three groups had: 355 patients (75%) in NFH; 97 patients (21%) in FH; and 19 patients (4%) in FHD. The prevalence of a Gleason score ≥8, higher pathologic T stage, and biochemical recurrence (BCR) rates did not significantly differ between groups. On Kaplan-Meier analysis there were no differences in short-term BCR rates (p = 0.212). In this cohort of patients undergoing radical prostatectomy, those with first-degree relatives who died of PCa did not have an increased likelihood of high-risk or aggressive PCa or shorter-term risk of BCR than those who did not

Interference management for co-channel mobile femtocells technology in LTE networks

The dense deployment of Femtocells within the Macrocell's coverage is expected to dominate the future of Long Term Evolution (LTE) networks. While Mobile Femtocells (Mobile-Femtos) could be the solution for vehicular networks when there is a need to improve the vehicular User Equipment (UE) performance by mitigating the impact of penetration loss and path-loss issues. The deployed Femtocells have operated in a co-channel deployment due to the scarcity of spectrums. This issue causes interference between Femtocells and Macrocells as well it causes extra overhead on the LTE networks because of the co-tire interference between adjacent Femtocells. In this paper two interference scenarios are considered, the interference between Mobile-Femto and Macrocell, and the interference between the Mobile Femtos themselves. Therefore, to avoid the generated interference between Femtocells, the controlled transmission powers as well as the coverage planning techniques have been discussed. While in the worst-case scenarios, a frequency reuse scheme has been proposed to avoid the generated interference effectively and dynamically between the Mobile-Femtos as well as their UEs and between the Macrocell UEs

Performance evaluation of mobile users served by fixed and mobile femtocells in LTE networks

This paper investigates the concept of Mobile Femtocell with considering the feasibility of deploying Mobile Femtocells in public transportation vehicles such as trains, buses or private cars that form its own cell inside vehicles to serve vehicular and mobile User Equipments. This study is the launch of cell-edge mobile users who have always suffered degradation in the Quality of Service (QoS). Therefore, an investigation on the performance of LTE cell-edge mobile User Equipment e.g. users’ throughput, SINR, SNR, SIR, spectral efficiency and Handover performance, have been considered with deploying Fixed Femtocells and Mobile Femtocells in Long Term Evolution network. Two scenarios have been proposed in this study; Fixed Femtocells with mobile users and Mobile Femtocells with mobile users. More scenarios maybe considered in the case of Mobile Femtocell’s handover procedure. MATLAB simulation has been used for the purpose of simulating the designed scenarios and implementing the integrated mathematical equations. The simulated results have demonstrated the benefits of having Mobile Femtocells over the Fixed Femtocells in terms of mobile User Equipments’ performance

Mobility management for vehicular user equipment in LTE/mobile femtocell networks

Vehicular User Equipment (UE) performance during mobility faces two issues relating to signaling and transmission, namely Handover (HO) and link adaptation. This paper shows that both processes are experiencing degradation during mobility and that vehicular UEs suffer from call drops and loss of connections. Therefore, this work presents an effective technique using Mobile-Femtos to improve vehicular UEs' HO process and link quality. Results show that vehicular UEs attached to a Mobile-Femto achieved better signalling and Link Ergodic capacity and as a consequence the outage probability was reduced. The achieved results indicated that deploying Mobile-Femtos under 25dB Vehicular Penetration Loss (VPL) has improved the vehicular UE Link Ergodic capacity by 1% and reduced the signal outage probability by 1.8% compared to the eNB direct transmission. Consequently, Drop Calls Probability (DCP) and Block Calls Probability (BCP) have been reduced by 7% and 14% respectively compared to the direct transmission from the eNB

Mobile femtocell utilisation in LTE vehicular environment: vehicular penetration loss elimination and performance enhancement

Mobile computing is fast becoming a vital part of everyday life in which User Equipment (UE) demand being reachable anywhere and at anytime, as they spend much time travellingfrom one place to another, often by trains or buses. The ultimate aim of passengers is the ability to be connected to the Internet while they are moving from one place to another with their mobile devices. Providing indoor coverage on trains and buses directly with outdoor Base Stations (BSs) may not be a good solution due to the high density of use and path losses in the LTE network. This limitation can result in poor signal quality inside the train, and offering broadband services is not always possible. Clearly improvement to broadband access on buses and trains could be achieved by installing more BSs close to railway and bus routes and terminals. However, this solution is not ideal for the Internet Service Providers (ISPs) due to the high investment needed to deploy many more BSs. In addition, such a solution will introduce additional complexity by increasing the number of Handovers (HOs). This issue has focused the research community effort on developing solutions that take advantage of the existing wireless infrastructure without increasing the number of BSs. One method being considered is the development of more efficient methods and technologies to manage the UE’s mobility in seamless ways. In this paper we propose adoption of Mobile Femtocell (Mobile-Femto) technology as a solution to mitigate the Vehicular Penetration Loss (VPL) and Path Loss, with consequent improvement to the vehicular UE’s performance in LTE networks. Our results, using a Matlab simulation model, showed a noticeable improvement in the achieved Ergodic capacity by 5% under a VPL of 40dB while 90% of vehicular UEs spectral efficiency has improved by 1.3b/cu under a VPL of 25dB. In addition, 80% of vehicular UEs have improved their throughput and SINR by 300kb/s and 4dB respectively after implementing the Mobile-Femto into the Macrocell in LTE networks

Precision Genomic Practice in Oncology: Pharmacist Role and Experience in an Ambulatory Care Clinic

Recent advancements in molecular testing, the availability of cost-effective technology, and novel approaches to clinical trial design have facilitated the implementation of tumor genome sequencing into standard of care oncology practices. Current models of precision oncology practice include specialized clinics or consultation services based on a molecular tumor board (MTB) approach. MTBs are comprised of interprofessional teams of clinicians and scientists who evaluate tumors at the molecular level to guide patient-specific targeted therapy. The practice of precision oncology utilizing MTB-based models is an emerging approach, transforming precision genomics from a novel concept into clinical practice. This rapid shift in practice from cytotoxic therapy to targeted medicine poses challenges, yet brings exciting opportunities to clinical pharmacists practicing in hematology and oncology. Only a few precision genomics programs in the United States have a strong pharmacy presence with oncology pharmacists serving in leadership roles in research, interpreting genomic sequencing, making treatment recommendations, and facilitating off-label drug procurement. This article describes the experience of the precision medicine clinic at the Indiana University Health Simon Cancer Center, with emphasis on the role of the pharmacist in the precision oncology initiative

Examination of Traditional Medicine and Herbal Pharmacology and the Implications for Teaching and Education: A Ghanaian Case Study

This article presents the preliminary findings of a pilot study of the practice, uses, and effectiveness of traditional medicine in Ghana. Based on in-depth interviews with local key practitioners and users of traditional medicine, the article points to some of the educational significance of local cultural knowledge on the environment and the relevance of such knowledge for science education in Ghana. In the discussion the authors briefly highlight general themes relating to local understandings of traditional medicine, the distinctions between traditional and plant medicine, contestations between traditional medicine and orthodox medicine, local conceptions of health and a healthy individual, the economics of health, and the lessons of science and public education. Although the findings of the study are preliminary, the article argues that much is to be gained for educational purposes through the critical study of traditional medicine, particularly in terms of the promotion of science and community education in Ghana

Synthesis, characterization and evaluation of antiinflammatory properties of novel α, β-unsaturated ketones

Purpose: To prepare and characterize alicyclic aromatic chalcone derivatives, and study their antibiotic and anti-inflammatory properties.Methods: Claisen-Schmidt (aldol condensation) base-catalyzed condensation was used for preparation of chalcone derivatives (compounds I - IV), and the products were characterized using ultraviolet-visible spectroscopy (UV), FT-IR spectroscopy, proton nuclear magnetic resonance (1H-NMR), carbone 13CNMR and mass spectroscopy (MS). The antibacterial effect of the compounds was determined against Baci. cereus, Staph. Aureus, E. coli, and Pseudomonas Aeruginosa. In addition, their anti-inflammatory effects were assayed using cotton granule-induced granuloma in mice. The results were compared with those for diclofenac, a standard drug. The synthesized derivatives were subjected to theoretical studies on their stabilities, and some chemical parameters were calculated using density function theory [DFT].Results: Using Claisen-Schmidt reaction, it was possible to prepare stable chalcone derivatives, such as derivatives of 2-(3-phenyl  acryloyl)cyclopentan-1-one, with good results. Depending on the substituted group, it was also shown that the derivatives had effective biological effects. Compound IV displayed a noticeable antibacterial effect against Staph. aureus and E. coli. The prepared chalcone derivatives exerted markedly variable anti-inflammatory effects.Conclusion: These results indicate that Claisen-Schmidt reaction is not limited to the preparation of chalcone derivatives from diphenyl structures  only. Stable alicyclic aromatic structures can also be used. This results in derivatives with good biological effects. Keywords: Chalcones, Claisen-Schmidt, Anti-inflammatory effects, Granuloma, Aldol Condensatio