Relation between Childhood Obesity and Adult Cardiovascular Risk

The incidence of overweight and obesity is rising at an alarming pace in the pediatric population, just as in the adult population. The adult comorbidities associated with this risk factor are well-recognized and are being further elucidated continually. Additionally, we are gradually developing a better understanding of the risks of overweight and obesity among children while they are still young. However, there is now a growing body of evidence showing that childhood obesity not only leads all too frequently to adult obesity, but is in itself a risk factor for cardiometabolic syndrome and resultant cardiovascular risk in adulthood. If current trends continue, the problem of pediatric overweight and obesity will become of unmanageable proportions once these individuals reach adulthood. Future research efforts toward understanding this complex problem will need to focus on those overweight and obese children who later went on to change their metabolic course and become normal-weight adults

Logarithmic asymptotics of the densities of SPDEs driven by spatially correlated noise

We consider the family of stochastic partial differential equations indexed by a parameter \eps\in(0,1], \begin{equation*} Lu^{\eps}(t,x) = \eps\sigma(u^\eps(t,x))\dot{F}(t,x)+b(u^\eps(t,x)), \end{equation*} (t,x)\in(0,T]\times\Rd with suitable initial conditions. In this equation, $L$ is a second-order partial differential operator with constant coefficients, $\sigma$ and $b$ are smooth functions and $\dot{F}$ is a Gaussian noise, white in time and with a stationary correlation in space. Let p^\eps_{t,x} denote the density of the law of u^\eps(t,x) at a fixed point (t,x)\in(0,T]\times\Rd. We study the existence of \lim_{\eps\downarrow 0} \eps^2\log p^\eps_{t,x}(y) for a fixed $y\in\R$. The results apply to a class of stochastic wave equations with $d\in\{1,2,3\}$ and to a class of stochastic heat equations with $d\ge1$.Comment: 39 pages. Will be published in the book " Stochastic Analysis and Applications 2014. A volume in honour of Terry Lyons". Springer Verla

The broad iron Kalpha line of Cygnus X-1 as seen by XMM-Newton in the EPIC-pn modified timing mode

We present the analysis of the broadened, flourescent iron Kalpha line in simultaneous XMM-Newton and RXTE data from the black hole Cygnus X-1. The XMM-Newton data were taken in a modified version of the timing mode of the EPIC-pn camera. In this mode the lower energy threshold of the instrument is increased to 2.8 keV to avoid telemetry drop outs due to the brightness of the source, while at the same time preserving the signal-to-noise ratio in the Fe Kalpha band. We find that the best-fit spectrum consists of the sum of an exponentially cut off power-law and relativistically smeared, ionized reflection. The shape of the broadened Fe Kalpha feature is due to strong Compton broadening combined with relativistic broadening. Assuming a standard, thin accretion disk, the black hole is close to rotating maximally.Comment: Astron. Astrophys., in pres

TRH: Pathophysiologic and clinical implications

Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin. ACTH and GH may increase in response to exogenous TRH in pituitary ACTH and GH hypersecretion syndromes and in some extrapituitary diseases. The pathophysiological implications of extrahypothalamic TRH in humans are essentially unknown. The TSH response to TRH is nowadays widely used as a diganostic amplifier in thyroid diseases being suppressed in borderline and overt hyperthyroid states and increased in primary thyroid failure. In hypothyroid states of hypothalamic origin, TSH increases in response to exogenous TRH often with a delayed and/or exaggerated time course. But in patients with pituitary tumors and suprasellar extension TSH may also respond to TRH despite secondary hypothyroidism. This TSH increase may indicate a suprasellar cause for the secondary hypothyroidism, probably due to portal vessel occlusion. The TSH released in these cases is shown to be biologically inactive

Multidecadal variability of atmospheric methane, 1000–1800 C.E.

We present a new high-precision, high-resolution record of atmospheric methane from the West Antarctic Ice Sheet (WAIS) Divide ice core covering 1000–1800 C.E., a time period known as the late preindustrial Holocene (LPIH). The results are consistent with previous measurements from the Law Dome ice core, the only other high-resolution record of methane for this time period, and confirm most of the observed variability. Multidecadal variability in methane concentrations throughout the LPIH is weakly correlated or uncorrelated with reconstructions of temperature and precipitation from a variety of geographic regions. Correlations with temperature are dominated by changes in Northern Hemisphere high latitude temperatures between 1400 and 1600 C.E. during the onset of the Little Ice Age. Times of war and plague when large population losses could have reduced anthropogenic emissions are coincident with short periods of decreasing global methane concentrations.Keywords: biogeochemistry, ice core, methane, trace ga

Progression of osteoarthritis of the hand and metacarpal bone loss. A twenty-year followup of incident cases

We examined the prospective relationship between metacarpal bone mass and osteoarthritis (OA) of the hand, using incidence data from the historical cohort in the Tecumseh Community Health Study (Tecumseh, MI). Women were examined for radiographic evidence of OA and for bone mass twice, 20–23 years apart (1962–1965 and 1985; 683 subjects with an age range of 55–74 in 1985). Two measures of OA were evaluated: the highest score assigned to any of the 32 wrist/hand joints, and the sum of scores for all wrist/hand joints. After adjustment for age, women who were classified as having OA (by either measure of OA) in 1985 were more likely to have more cortical area at baseline, which indicates greater bone mass. Women who developed OA in the 23-year period were more likely to experience a significantly greater widening of the medullary cavity over time, an indicator of increased bone resorption. Women with increasing levels of OA involvement also had an increased likelihood of greater cortical area loss. We conclude that women who later developed OA were more likely to have higher baseline bone mass than women who did not develop OA, but these women also had a greater likelihood of bone loss over time.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/37786/1/1780340106_ftp.pd

Constraining N2O emissions since 1940 using firn air isotope measurements in both hemispheres

N2O is currently the third most important anthropogenic greenhouse gas in terms of radiative forcing and its atmospheric mole fraction is rising steadily. To quantify the growth rate and its causes over the past decades, we performed a multi-site reconstruction of the atmospheric N2O mole fraction and isotopic composition using new and previously published firn air data collected from Greenland and Antarctica in combination with a firn diffusion and densification model. The multi-site reconstruction showed that while the global mean N2O mole fraction increased from (290±1)nmolmol-1 in 1940 to (322±1)nmolmol-1 in 2008, the isotopic composition of atmospheric N2O decreased by (-2.2±0.2)% for δ15Nav, (-1.0±0.3)% for δ18O, (-1.3±0.6)% for δ15Nα, and (-2.8±0.6)% for δ15Nβ over the same period. The detailed temporal evolution of the mole fraction and isotopic composition derived from the firn air model was then used in a two-box atmospheric model (comprising a stratospheric box and a tropospheric box) to infer changes in the isotopic source signature over time. The precise value of the source strength depends on the choice of the N2O lifetime, which we choose to fix at 123 years. The average isotopic composition over the investigated period is δ15Nav Combining double low line (-7.6±0.8)% (vs. air-N2), δ18O Combining double low line (32.2±0.2)% (vs. Vienna Standard Mean Ocean Water-VSMOW) for δ18O, δ15Nα Combining double low line (-3.0±1.9)% and δ15Nβ Combining double low line (-11.7±2.3)%. δ15Nav, and δ15Nβ show some temporal variability, while for the other signatures the error bars of the reconstruction are too large to retrieve reliable temporal changes. Possible processes that may explain trends in 15N are discussed. The 15N site preference (Combining double low line δ15Nα-δ15Nβ) provides evidence of a shift in emissions from denitrification to nitrification, although the uncertainty envelopes are large

On the Role of the Accretion Disk in Black Hole Disk-Jet Connections

Models of jet production in black hole systems suggest that the properties of the accretion disk - such as its mass accretion rate, inner radius, and emergent magnetic field - should drive and modulate the production of relativistic jets. Stellar-mass black holes in the "low/hard" state are an excellent laboratory in which to study disk-jet connections, but few coordinated observations are made using spectrometers that can incisively probe the inner disk. We report on a series of 20 Suzaku observations of Cygnus X-1 made in the jet-producing low/hard state. Contemporaneous radio monitoring was done using the Arcminute MicroKelvin Array radio telescope. Two important and simple results are obtained: (1) the jet (as traced by radio flux) does not appear to be modulated by changes in the inner radius of the accretion disk; and (2) the jet is sensitive to disk properties, including its flux, temperature, and ionization. Some more complex results may reveal aspects of a coupled disk-corona-jet system. A positive correlation between the reflected X-ray flux and radio flux may represent specific support for a plasma ejection model of the corona, wherein the base of a jet produces hard X-ray emission. Within the framework of the plasma ejection model, the spectra suggest a jet base with v/c ~ 0.3, or the escape velocity for a vertical height of z ~ 20 GM/c^2 above the black hole. The detailed results of X-ray disk continuum and reflection modeling also suggest a height of z ~ 20 GM/c^2 for hard X-ray production above a black hole, with a spin in the range 0.6 < a < 0.99. This height agrees with X-ray time lags recently found in Cygnus X-1. The overall picture that emerges from this study is broadly consistent with some jet-focused models for black hole spectral energy distributions in which a relativistic plasma is accelerated at z = 10-100 GM/c^2.Comment: Accepted for publication in Ap