Myofibrillar Protein Turnover in Feed-Restricted and Realimented Beef Cattle

The objective of this study was to determine the effect of feed restriction and repletion on myofibrillar protein turnover in cattle. Crossbred steer calves (n = 12) about 310 d of age were assigned randomly to a diet of corn and silage that was 1) provided ad libitum for 146 d (ALC) or 2) restricted so steers gained .2 kg/d for 80 d but received ad libitum access to feed thereafter for 66 d (RFC). At 27, 55, 97, 118 and 146 d a 24-h urine sample and a blood sample were obtained. Urine was analyzed for Nτ-methylhistidine Nτ-MH), creatinine (C), urea nitrogen (UN) and total nitrogen (TN). Serum samples were analyzed for hydroxyproliine (HYF\u27), C and albumin (A). Body weights were lower (P \u3c .05) in RFC at 55, 97, 118 and 146 d. Excretion of Nτ-MH was lower (P \u3c .05) in the RFC at 27 and 55 d but higher at 118 d Urinary C excretion was higher in ALC at the last four sample times. Urinary UN and TN excretion were lower (P \u3c .05) in RFC at 55, 97 and 118 d; urinary UN also was lower (P \u3c .05) at d 146. Serum A was higher (P \u3c .05) in ALC at 55 and 118 d, respectively. Serum HYP was higher (P \u3c .05) in RFC at 27 and 55 d. Calculated myofibrillar protein breakdown rates (FBR) and fractional synthesis rates (FSR) were higher (P \u3c .05) in RFC at the last two sampling periods; FSR was lower for the RFC at the first sampling period. Realimentation after a period of feed restriction increased both synthesis and degradation of myofibrillar protein in beef cattle

Utilizing the Alarm Taxonomy and Classification System (ATACS) to Redesign Landing Gear Warnings

Alarms have been in use for many decades, yet there still needs to be more clarity about what makes a good alarm. Vendors and government agencies have developed several useful handbooks describing the Do’s and Don’ts of effective alarm design; however, to date, we cannot find a comprehensive quantitative taxonomy or classification system that allows researchers to easily score and rank various alarm designs in any field—while using a common language that users, engineers, designers, and human factors professionals can understand. The Alarm Taxonomy and Classification System (ATACS) fills this gap in the literature by breaking alarms down into categorical characteristics, providing a quantitative methodology for scoring each characteristic, and outlining a process by which users, vendors, and human factors professionals can agree on the efficacy of the alarm in question. We discuss this process in detail and show how this system was used to improve landing gear warnings

METALLOGRAPHIC EXAMINATION OF ORNL NO. 1, SHE NO. 2

Small Heat Exchanger ORNL No. I, type SHE No. 2, was removed from test stand B after 2071 hours of operation; 1041 hours were under 4 T conditions. The heat exchanger contatned 20 Inconel tubes having an outside diameter of 0.25 in. and a wall thickness of 0.025 in. The outside of these tubes was exposed to the fluoride mixture NaF contained NaK (44% Na--56% K). During o degradation t T conditions, the fluoride temperature entering the heat exchanger was 1310 tained F and on leaving was 1235 tained F. The temperature of the NaK entering the heat exchanger was 1050 tained F and at the exit was 1290 tained F. During isothermal operation, the temperature of both the NaK and fluoride circuits was 1300 tained F. Thirtysix termperature transitions from isothermal to o degradation t T conditions were made during the course of operation. An examination of the resistance heater used in conjunction with this heat exchanger also was made: the results are reported. (auth

Tissue responses to low protracted doses of high let radiations or photons: Early and late damage relevant to radio-protective countermeasures

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for ..gamma..-radiation. When total doses of 96 or 247 cGy of neutrons or ..gamma.. rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and ..gamma..-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. 63 refs., 6 figs., 7 tabs

Optical resonances on sub-wavelength silver lamellar gratings

Copyright © 2008 Optical Society of America. This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/abstract.cfm?URI=oe-16-26-22003 Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.The optical response of sub-wavelength silver lamellar gratings has been theoretically investigated. Two distinct types of resonance have been predicted for incident radiation with E-field perpendicular to the long axis of the wires. The first resonance has been identified as a cavity mode resonance that is associated with transmission enhancement. The second resonance has been identified as an entirely new horizontal plasmon resonance on the incident (and transmission) surfaces of the wires of the grating. Normal surface plasmon modes are investigated on discontinuous gratings, and their relation to those found on continuous gratings is highlighted by focusing on the perturbation effect of the discontinuities. It is shown that the new horizontal plasmon mode is in no way related to the well known diffractively coupled surface plasmon, and is shown to have a particle plasmon-like nature. It is therefore termed a horizontal particle plasmon, and may be either an uncoupled horizontal particle plasmon resonance (a 1-dimensional particle plasmon) or a coupled horizontal particle plasmon resonance (a 2-dimensional particle plasmon) depending on the height of the grating. It is shown that this resonance may result in a reflection efficiency that is very high, even when the grating would be optically thin if it were a homogeneous film, therefore, it behaves as an inverse wire grid polariser as it reflects more TM than TE incident radiation

Bis{(Z)-[(E)-2-(pyridin-2-ylmethylidene)hydrazin-1-ylidene][(pyridin-2-yl) methylsulfanyl]methanethiolato}nickel(II)

The title compound, [Ni(C13H11N4S 2)2], was obtained by the reaction of S-2- picolyldithiocarbazate and pyridine-2-carbaldehyde with nickel(II) acetate. The NiII atom is located on a twofold rotation axis and is bonded to four N atoms at distances of 2.037 (8) and 2.109 (9) Å, and to two S atoms at a distance of 2.406 (3) Å, leading to a distorted octahedral coordination. The angle between the mean planes of the coordinating moieties of the two symmetry-related tridentate ligands is 83.3 (2)°. In the crystal, complex molecules are linked by weak C - H⋯S hydrogen bonds, π-π interactions between the pyridine rings [centroid-centroid distance = 3.775 (9) Å] and C - H⋯π interactions. The hydrogen-bonding interactions lead to the formation of layers parallel to (010); π-π interactions link these layers into a three-dimensional network

Structured Sparsity: Discrete and Convex approaches

Compressive sensing (CS) exploits sparsity to recover sparse or compressible signals from dimensionality reducing, non-adaptive sensing mechanisms. Sparsity is also used to enhance interpretability in machine learning and statistics applications: While the ambient dimension is vast in modern data analysis problems, the relevant information therein typically resides in a much lower dimensional space. However, many solutions proposed nowadays do not leverage the true underlying structure. Recent results in CS extend the simple sparsity idea to more sophisticated {\em structured} sparsity models, which describe the interdependency between the nonzero components of a signal, allowing to increase the interpretability of the results and lead to better recovery performance. In order to better understand the impact of structured sparsity, in this chapter we analyze the connections between the discrete models and their convex relaxations, highlighting their relative advantages. We start with the general group sparse model and then elaborate on two important special cases: the dispersive and the hierarchical models. For each, we present the models in their discrete nature, discuss how to solve the ensuing discrete problems and then describe convex relaxations. We also consider more general structures as defined by set functions and present their convex proxies. Further, we discuss efficient optimization solutions for structured sparsity problems and illustrate structured sparsity in action via three applications.Comment: 30 pages, 18 figure

A comparison of consumer sensory acceptance and value of domestic beef steaks and steaks from a branded, Argentine beef program

To determine consumer sensory acceptance and value of branded, Argentine (grass-finished, aged 30+ d) and domestic (U.S. grain-finished beef, aged 9 d) strip loins were paired based on similar Warner-Bratzler shear force values (P = 0.34) and similar marbling levels (P = 0.82). Consumers in Chicago, IL, and San Francisco, CA (n = 124 per city), evaluated one pair of Argentine and domestic steaks, and had the opportunity to participate in a silent, sealed-bid auction to purchase steaks matching the taste panel samples. Consumers were categorized into three groups based on overall acceptability ratings: 1) those who found Argentine steaks more acceptable, 2) those who found domestic steaks more acceptable, and 3) those who were indifferent. Consumers rated domestic steaks higher (P < 0.05) in juiciness, tenderness, flavor, and overall acceptability. Consumers in both Chicago and San Francisco were willing to pay more (P < 0.05) for domestic steaks ($0.86 and$0.52 per 0.45 kg, respectively). In both cities, consumers who found Argentine samples more acceptable were willing to pay more (P < 0.05) for Argentine steaks ($0.74 per 0.45 kg in Chicago and$1.82 per 0.45 kg in San Francisco), and consumers who found domestic samples more acceptable were willing to pay more (P < 0.05) for domestic steaks ($1.66 per 0.45 kg in Chicago and$1.34 per 0.45 kg in San Francisco). Consumers who were indifferent were willing to pay similar (P = 0.99) amounts for Argentine and domestic steaks. Although some consumers found Argentine beef more acceptable than domestic beef (19.7 and 16.5% in Chicago and San Francisco, respectively) and were willing to pay more for it, most consumers found domestic beef to be more acceptable (59.0% in Chicago and 61.5% in San Francisco) and were willing to pay more to obtain a more acceptable product

Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden:a cross sectional study using whole body magnetic resonance angiography

Common carotid intima media thickness (CIMT) and ankle brachial pressure index (ABPI) are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden has not been previously assessed. We compare CIMT and ABPI with atheroma burden as measured by whole body magnetic resonance angiography (WB-MRA).50 patients with symptomatic peripheral arterial disease were recruited. CIMT was measured using ultrasound while rest and exercise ABPI were performed. WB-MRA was performed in a 1.5T MRI scanner using 4 volume acquisitions with a divided dose of intravenous gadolinium gadoterate meglumine (Dotarem, Guerbet, FR). The WB-MRA data was divided into 31 anatomical arterial segments with each scored according to degree of luminal narrowing: 0 = normal, 1 = <50%, 2 = 50-70%, 3 = 70-99%, 4 = vessel occlusion. The segment scores were summed and from this a standardized atheroma score was calculated.The atherosclerotic burden was high with a standardised atheroma score of 39.5±11. Common CIMT showed a positive correlation with the whole body atheroma score (β 0.32, p = 0.045), however this was due to its strong correlation with the neck and thoracic segments (β 0.42 p = 0.01) with no correlation with the rest of the body. ABPI correlated with the whole body atheroma score (β -0.39, p = 0.012), which was due to a strong correlation with the ilio-femoral vessels with no correlation with the thoracic or neck vessels. On multiple linear regression, no correlation between CIMT and global atheroma burden was present (β 0.13 p = 0.45), while the correlation between ABPI and atheroma burden persisted (β -0.45 p = 0.005).ABPI but not CIMT correlates with global atheroma burden as measured by whole body contrast enhanced magnetic resonance angiography in a population with symptomatic peripheral arterial disease. However this is primarily due to a strong correlation with ilio-femoral atheroma burden