1,013 research outputs found
Contribució de l'Hospital central de la Quinta de Salut l'aliança al desenvolupament de la medicina social i de les especialitats mèdiques a Catalunya
Anaí, una forma de publicación en la web
El presente artículo presenta la estrategia de creación de
contenidos para la web desarrollada en la Universidad de
Navarra. El objetivo de esta estrategia es lograr un sistema
de creación de contenidos descentralizado, gracias al cual
un profesor o una persona de administración o servicios,
con conocimientos informáticos medios e incluso escasos
pueda desarrollar contenidos de calidad
Repensar la enseñanza universitaria desde las tecnologías de la información y la comunicación. Algunas experiencias de universidades de los Estados Unidos
Se ofrecen aquí algunas experiencias de Universidades de
los Estados Unidos que puedan ayudar a repensar la enseñanza
universitaria desde las tecnologías de la información
y la comunicación
Correlation, Network and Multifractal Analysis of Global Financial Indices
We apply RMT, Network and MF-DFA methods to investigate correlation, network
and multifractal properties of 20 global financial indices. We compare results
before and during the financial crisis of 2008 respectively. We find that the
network method gives more useful information about the formation of clusters as
compared to results obtained from eigenvectors corresponding to second largest
eigenvalue and these sectors are formed on the basis of geographical location
of indices. At threshold 0.6, indices corresponding to Americas, Europe and
Asia/Pacific disconnect and form different clusters before the crisis but
during the crisis, indices corresponding to Americas and Europe are combined
together to form a cluster while the Asia/Pacific indices forms another
cluster. By further increasing the value of threshold to 0.9, European
countries France, Germany and UK constitute the most tightly linked markets. We
study multifractal properties of global financial indices and find that
financial indices corresponding to Americas and Europe almost lie in the same
range of degree of multifractality as compared to other indices. India, South
Korea, Hong Kong are found to be near the degree of multifractality of indices
corresponding to Americas and Europe. A large variation in the degree of
multifractality in Egypt, Indonesia, Malaysia, Taiwan and Singapore may be a
reason that when we increase the threshold in financial network these countries
first start getting disconnected at low threshold from the correlation network
of financial indices. We fit Binomial Multifractal Model (BMFM) to these
financial markets.Comment: 32 pages, 25 figures, 1 tabl
Scalar--flat K\"ahler metrics with conformal Bianchi V symmetry
We provide an affirmative answer to a question posed by Tod \cite{Tod:1995b},
and construct all four-dimensional Kahler metrics with vanishing scalar
curvature which are invariant under the conformal action of Bianchi V group.
The construction is based on the combination of twistor theory and the
isomonodromic problem with two double poles. The resulting metrics are
non-diagonal in the left-invariant basis and are explicitly given in terms of
Bessel functions and their integrals. We also make a connection with the LeBrun
ansatz, and characterise the associated solutions of the SU(\infty) Toda
equation by the existence a non-abelian two-dimensional group of point
symmetries.Comment: Dedicated to Maciej Przanowski on the occasion of his 65th birthday.
Minor corrections. To appear in CQ
γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation
BACKGROUND: The histone variant histone H2A.X comprises up to 25% of the H2A complement in mammalian cells. It is rapidly phosphorylated following exposure of cells to double-strand break (DSB) inducing agents such as ionising radiation. Within minutes of DSB generation, H2AX molecules are phosphorylated in large chromatin domains flanking DNA double-strand breaks (DSBs); these domains can be observed by immunofluorescence microscopy and are termed gammaH2AX foci. H2AX phosphorylation is believed to have a role mounting an efficient cellular response to DNA damage. Theoretical considerations suggest an essentially random chromosomal distribution of X-ray induced DSBs, and experimental evidence does not consistently indicate otherwise. However, we observed an apparently uneven distribution of gammaH2AX foci following X-irradiation with regions of the nucleus devoid of foci. METHODOLOGY/PRINCIPLE FINDINGS: Using immunofluorescence microscopy, we show that focal phosphorylation of histone H2AX occurs preferentially in euchromatic regions of the genome following X-irradiation. H2AX phosphorylation has also been demonstrated previously to occur at stalled replication forks induced by UV radiation or exposure to agents such as hydroxyurea. In this study, treatment of S-phase cells with hydroxyurea lead to efficient H2AX phosphorylation in both euchromatin and heterochromatin at times when these chromatin compartments were undergoing replication. This suggests a block to H2AX phosphorylation in heterochromatin that is at least partially relieved by ongoing DNA replication. CONCLUSIONS/SIGNIFICANCE: We discuss a number of possible mechanisms that could account for the observed pattern of H2AX phosphorylation. Since gammaH2AX is regarded as forming a platform for the recruitment or retention of other DNA repair and signaling molecules, these findings imply that the processing of DSBs in heterochromatin differs from that in euchromatic regions. The differential responses of heterochromatic and euchromatic compartments of the genome to DSBs will have implications for understanding the processes of DNA repair in relation to nuclear and chromatin organization
Balancing Minimum Spanning and Shortest Path Trees
This paper give a simple linear-time algorithm that, given a weighted
digraph, finds a spanning tree that simultaneously approximates a shortest-path
tree and a minimum spanning tree. The algorithm provides a continuous
trade-off: given the two trees and epsilon > 0, the algorithm returns a
spanning tree in which the distance between any vertex and the root of the
shortest-path tree is at most 1+epsilon times the shortest-path distance, and
yet the total weight of the tree is at most 1+2/epsilon times the weight of a
minimum spanning tree. This is the best tradeoff possible. The paper also
describes a fast parallel implementation.Comment: conference version: ACM-SIAM Symposium on Discrete Algorithms (1993
Impact of Unexpected Events, Shocking News and Rumours on Foreign Exchange Market Dynamics
We analyze the dynamical response of the world's financial community to
various types of unexpected events, including the 9/11 terrorist attacks as
they unfolded on a minute-by-minute basis. We find that there are various
'species' of news, characterized by how quickly the news get absorbed, how much
meaning and importance is assigned to it by the community, and what subsequent
actions are then taken. For example, the response to the unfolding events of
9/11 shows a gradual collective understanding of what was happening, rather
than an immediate realization. For news items which are not simple economic
statements, and hence whose implications are not immediately obvious, we
uncover periods of collective discovery during which collective opinions seem
to oscillate in a remarkably synchronized way. In the case of a rumour, our
findings also provide a concrete example of contagion in inter-connected
communities. Practical applications of this work include the possibility of
producing selective newsfeeds for specific communities, based on their likely
impact
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