Effect of the alien invasive bivalve Corbicula fluminea on the nutrient dynamics under climate change scenarios

The main aim of this study was to evaluate the impact of the alien invasive bivalve Corbicula fluminea (Müller, 1774) in the nutrient dynamics of temperate estuarine systems (oligohaline areas) under climate change scenarios. The scenarios simulated shifts in climatic conditions, following salinity (0 or 5) and temperature (24 or 30 °C) changes, usual during drought and heat wave events. The effect of the individual size/age (different size classes with fixed biomass) and density (various densities of <1 cm clams) on the bioturbation-associated nutrient dynamics were also evaluated under an 18-day laboratory experimental setup. Results highlight the significant effect of C. fluminea on the ecosystem nutrient dynamics, enhancing the efflux of both phosphate and dissolved inorganic nitrogen (DIN) from the sediments to the water column. Both drought and heat wave events will have an impact on the DIN dynamics within C. fluminea colonized systems, favouring a higher NH4-N efflux. The population structure of C. fluminea will have a decisive role on the impact of the species, with stronger nutrient effluxes associated with a predominantly juvenile population structure.publishe

Complete Calabi-Yau metrics from Kahler metrics in D=4

In the present work the local form of certain Calabi-Yau metrics possessing a local Hamiltonian Killing vector is described in terms of a single non linear equation. The main assumptions are that the complex $(3,0)$-form is of the form $e^{ik}\widetilde{\Psi}$, where $\widetilde{\Psi}$ is preserved by the Killing vector, and that the space of the orbits of the Killing vector is, for fixed value of the momentum map coordinate, a complex 4-manifold, in such a way that the complex structure of the 4-manifold is part of the complex structure of the complex 3-fold. The link with the solution generating techniques of [26]-[28] is made explicit and in particular an example with holonomy exactly SU(3) is found by use of the linearization of [26], which was found in the context of D6 branes wrapping a holomorphic 1-fold in a hyperkahler manifold. But the main improvement of the present method, unlike the ones presented in [26]-[28], does not rely in an initial hyperkahler structure. Additionally the complications when dealing with non linear operators over the curved hyperkahler space are avoided by use of this method.Comment: Version accepted for publication in Phys.Rev.

Genotoxic effect of exposure to metal(loid)s. A molecular epidemiology survey of populations living and working in Panasqueira mine area, Portugal

Previous studies investigating the exposure to metal(loid)s of populations living in the Panasqueira mine area of central Portugal found a higher internal dose of elements such as arsenic, chromium, lead, manganese, molybdenum and zinc in exposed individuals. The aims of the present study were to evaluate the extent of genotoxic damage caused by environmental and occupational exposure in individuals previously tested for metal(loid) levels in different biological matrices, and the possible modulating role of genetic polymorphisms involved in metabolism and DNA repair. T-cell receptor mutation assay, comet assay, micronucleus (MN) test and chromosomal aberrations (CA) were performed in a group of 122 subjects working in the Panasqueira mine or living in the same region. The modifying effect of polymorphisms in GSTA2, GSTM1, GSTP1, GSTT1, XRCC1, APEX1, MPG, MUTYH, OGG1, PARP1, PARP4, ERCC1, ERCC4, and ERCC5 genes was investigated. Significant increases in the frequency of all biomarkers investigated were found in exposed groups, however those environmentally exposed were generally higher. Significant influences of polymorphisms were observed for GSTM1 deletion and OGG1 rs1052133 on CA frequencies, APEX1 rs1130409 on DNA damage, ERCC1 rs3212986 on DNA damage and CA frequency, and ERCC4 rs1800067 on MN and CA frequencies. Our results show that the metal(loid) contamination in the Panasqueira mine area induced genotoxic damage both in individuals working in the mine or living in the area. The observed effects are closely associated to the internal exposure dose, and are more evident in susceptible genotypes. The urgent intervention of authorities is required to protect exposed populations

Information vs Engagement in parliamentary websites – a case study of Brazil and the UK

Parliamentary websites have become the main window of parliament to the outside world. More than a gimmick, they are an essential element in the promotion of a relationship between parliament and citizens. This paper develops a comparative analysis of the websites of the lower chambers of the Brazilian and the British parliaments, respectively the Chamber of Deputies and the House of Commons. We structure this analysis around three dimensions: 1) information about the institution; 2) information about parliamentary activity; and 3) tools to promote engagement with the public. The choice of two very different case studies enables us to consider more clearly the specific purposes of these parliamentary websites. We consider in particular if these parliaments' institutional differences affect their websites. The websites' analysis is complemented by semi-structured elite interviews with parliamentary staff who manage the services provided by these websites. Our analysis shows that both websites achieve much higher levels of complexity in the information area than in engagement. But it also shows that the Brazilian parliament website includes far more tools designed for public interaction than its UK counterpart. The indexes and interviews show that both institutions are highly committed to disseminating data and information to citizens. This is seen as a path towards achieving higher accountability and improving knowledge about parliamentary processes and, consequently, improving public image and levels of trust. Whilst there is a strong focus on the provision of information, there is still little evidence of enabling citizen participation in the legislative process. This is partly due to a tension between conceptions of representative democracy and those of participatory democracy. The articulation between these different types of democracy still has a long way to be resolved, although parliaments are slowly introducing participatory tools

Thermal Correlators in Holographic Models with Lifshitz scaling

We study finite temperature effects in two distinct holographic models that exhibit Lifshitz scaling, looking to identify model independent features in the dual strong coupling physics. We consider the thermodynamics of black branes and find different low-temperature behavior of the specific heat. Deformation away from criticality leads to non-trivial temperature dependence of correlation functions and we study how the characteristic length scale in the two point function of scalar operators varies as a function of temperature and deformation parameters.Comment: 28 pages, 8 figures; typos corrected, references added, published versio

On higher derivative gravity, c-theorems and cosmology

We consider higher derivative gravity lagrangians in 3 and 4 dimensions, which admit simple c-theorems, including upto six derivative curvature invariants. Following a suggestion by Myers, these lagrangians are restricted such that the fluctuations around (anti) de Sitter spaces have second order linearized equations of motion. We study c-theorems both in the context of AdS/CFT and cosmology. In the context of cosmology, the monotonic function is the entropy defined on the apparent horizon through Wald's formula. Exact black hole solutions which are asymptotically (anti) de Sitter are presented. An interesting lower bound for entropy is found in de Sitter space. Some aspects of cosmology in both D=3 and D=4 are discussed.Comment: 23 pages, v3: clarifications added, references adde

Type IIB orientifolds on Gepner points

We study various aspects of orientifold projections of Type IIB closed string theory on Gepner points in different dimensions. The open string sector is introduced, in the usual constructive way, in order to cancel RR charges carried by orientifold planes. Moddings by cyclic permutations of the internal N=2 superconformal blocks as well as by discrete phase symmetries are implemented. Reduction in the number of generations, breaking or enhancements of gauge symmetries and topology changes are shown to be induced by such moddings. Antibranes sector is also considered; in particular we show how non supersymmetric models with antibranes and free of closed and open tachyons do appear in this context. A systematic study of consistent models in D=8 dimensions and some illustrative examples in D=6 and D=4 dimensions are presented.Comment: 67 pages, no figures References added, typos correcte

Study on the performance of different craniofacial superimposition approaches (II): Best practices proposal

Craniofacial superimposition, although existing for one century, is still a controversial technique within the scientific community. Objective and unbiased validation studies over a significant number of cases are required to establish a more solid picture on the reliability. However, there is lack of protocols and standards in the application of the technique leading to contradictory information concerning reliability. Instead of following a uniform methodology, every expert tends to apply his own approach to the problem, based on the available technology and deep knowledge on human craniofacial anatomy, soft tissues, and their relationships. The aim of this study was to assess the reliability of different craniofacial superimposition methodologies and the corresponding technical approaches to this type of identification. With all the data generated, some of the most representative experts in craniofacial identification joined in a discussion intended to identify and agree on the most important issues that have to be considered to properly employ the craniofacial superimposition technique. As a consequence, the consortium has produced the current manuscript, which can be considered the first standard in the field; including good and bad practices, sources of error and uncertainties, technological requirements and desirable features, and finally a common scale for the craniofacial matching evaluation. Such a document is intended to be part of a more complete framework for craniofacial superimposition, to be developed during the FP7-founded project MEPROCS, which will favour and standardize its proper application

COVID-19 vaccine effectiveness against hospitalisation and death of people in clinical risk groups during the Delta variant period: English primary care network cohort study.

BACKGROUND: COVID-19 vaccines have been shown to be highly effective against hospitalisation and death following COVID-19 infection. COVID-19 vaccine effectiveness estimates against severe endpoints among individuals with clinical conditions that place them at increased risk of critical disease are limited. METHODS: We used English primary care medical record data from the Oxford-Royal College of General Practitioners Research and Surveillance Centre sentinel network (N > 18 million). Data were linked to the National Immunisation Management Service database, Second Generation Surveillance System for virology test data, Hospital Episode Statistics, and death registry data. We estimated adjusted vaccine effectiveness (aVE) against COVID-19 infection followed by hospitalisation and death among individuals in specific clinical risk groups using a cohort design during the delta-dominant period. We also report mortality statistics and results from our antibody surveillance in this population. FINDINGS: aVE against severe endpoints was high, 14-69d following a third dose aVE was 96.4% (95.1%-97.4%) and 97.9% (97.2%-98.4%) for clinically vulnerable people given a Vaxzevria and Comirnaty primary course respectively. Lower aVE was observed in the immunosuppressed group: 88.6% (79.1%-93.8%) and 91.9% (85.9%-95.4%) for Vaxzevria and Comirnaty respectively. Antibody levels were significantly lower among the immunosuppressed group than those not in this risk group across all vaccination types and doses. The standardised case fatality rate within 28 days of a positive test was 3.9/1000 in people not in risk groups, compared to 12.8/1000 in clinical risk groups. Waning aVE with time since 2nd dose was also demonstrated, for example, Comirnaty aVE against hospitalisation reduced from 96.0% (95.1-96.7%) 14-69days post-dose 2-82.9% (81.4-84.2%) 182days+ post-dose 2. INTERPRETATION: In all clinical risk groups high levels of vaccine effectiveness against severe endpoints were seen. Reduced vaccine effectiveness was noted among the immunosuppressed group

Election proximity and representation focus in party-constrained environments

Do elected representatives have a time-constant representation focus or do they adapt their focus depending on election proximity? In this article, we examine these overlooked theoretical and empirical puzzles by looking at how reelection-seeking actors adapt their legislative behavior according to the electoral cycle. In parliamentary democracies, representatives need to serve two competing principals: their party and their district. Our analysis hinges on how representatives make a strategic use of parliamentary written questions in a highly party-constrained institutional context to heighten their reselection and reelection prospects. Using an original data set of over 32,000 parliamentary questions tabled by Portuguese representatives from 2005 to 2015, we examine how time interacts with two key explanatory elements: electoral vulnerability and party size. Results show that representation focus is not static over time and, in addition, that electoral vulnerability and party size shape strategic use of parliamentary questions