Gumsense - a high power low power sensor node

The development of increasingly complex algorithms for sensor networks has made it difficult for researchers to implement their design on typical sensor network hardware with limited computing resources. The demands on hardware can also mean that small microcontrollers are not the ideal platform for testing computationally and/or memory intensive algorithms. Researchers would also like access to high level programming languages and a wider range of open source libraries. To address this problem we have designed and implemented an architecture, Gumsense which combines a low power micro-controller (8MHz MSP430) with a powerful processor (100-600MHz ARM) on a Gumstix board running Linux. This Open Embedded OS supports a wide variety of programming languages, package management and development tools. A similar hybrid approach was also used in the LEAP platform. The microcontroller wakes up frequently to manage tasks such as activating sensors and gathering data. The intended use-case is to power-up the ARM board and storage only during the brief periods it is needed, for example performing computation or communication

The Role of Volunteered Geographic Information towards 3D Property Cadastral Systems (2): A Purpose Driven Web Application

VGI has not proved to be readily suitable to replace well-established accurate methods and technologies such as those of full standard cadastral surveys. Even so, VGI potentialities as relevant source of geospatial data have been widely acknowledged. As such, some authors have defended that VGI may in fact play an important role such as at a local cadastral jurisdiction level towards local spatial data infrastructures. As far as property cadastre is concerned, the full extent 3D complexity inside a property is in many instances only known to their occupants, thus making crowd sourcing perhaps the only economically feasible approach for its capture. While the crowd cannot be expected to conduct a full cadastral survey, it may be possible to ask them to indicate at least the location of complex 3D situations and thus to facilitate local authorities’ understanding of the extent of some cadastral issues. As such, it was argued in our previous work that geoinformation from the crowd might in fact be taken into account as an interim step before a full surveyed 3D cadastre is eventually achieved. As such, possible room for VGI in the context of 3D cadastre was discussed, and a hierarchical framework of levels of data acquisition to be used at local cadastral jurisdiction level was proposed. Such framework is revisited in this paper.Given context above, this paper focuses primarily on two aspects. Firstly, to review technical requirements of the official cadastral process in Portugal in order to identify which sorts of cadastral data are likely to be acquirable/not acquirable through VGI. Secondly, to design and to implement the prototype of a web-based application (IGV3Dcad) envisaged for general public usage to flag different land and property ownership situations. Having information about the extent of the 2D/3D issue is also fundamental to making a decision as to whether a 3D cadastral approach is actually needed and hence to further invest resources in even more expensive 3D survey

Diagnosis and outcome of oesophageal Crohn's disease

BACKGROUND AND AIMS: Crohn's disease (CD) can involve any part of the gastrointestinal tract. We aimed to characterize clinical, endoscopic, histologic features and treatment outcomes of CD patients with oesophageal involvement. METHODS: We collected cases through a retrospective multicentre European Crohn's and Colitis Organisation CONFER [COllaborative Network For Exceptionally Rare case reports] project. Clinical data were recorded in a standardized case report form. RESULTS: A total of 40 patients were reported [22 males, mean (±SD, range) age at oesophageal CD diagnosis: 25 (±13.3, 10-71) years and mean time of follow-up: 67 (±68.1, 3-240) months]. Oesophageal involvement was established at CD diagnosis in 26 patients (65%) and during follow-up in 14. CD was exclusively located in the oesophagus in 2 patients. Thirteen patients (32.2%) were asymptomatic at oesophageal disease diagnosis. Oesophageal strictures were present in 5 patients and fistulizing oesophageal disease in one. Eight patients exhibited granulomas on biopsies. Proton-pump inhibitors (PPIs) were administered in 37 patients (92.5%). Three patients underwent endoscopic dilation for symptomatic strictures and none oesophageal-related surgery. Diagnosis in pre-established CD resulted in treatment modifications in 9/14 patients. Clinical remission of oesophageal disease was seen in 33/40 patients (82.5%) after a mean time of 7 (±5.6, 1-18) months. Follow-up endoscopy was performed in 29/40 patients and 26/29 (89.7%) achieved mucosal healing. CONCLUSION: In this case series the endoscopic and histologic characteristics of isolated oesophageal CD were similar to those reported in other sites of involvement. Treatment was primarily conservative, with PPIs administered in the majority of patients and modifications in pre-existing IBD-related therapy occurring in two thirds of them. Clinical and endoscopic remission was achieved in more than 80% of the patients.info:eu-repo/semantics/publishedVersio

EuroSDR GeoBIM project a study in Europe on how to use the potentials of BIM and GEO data in practice

In both the Geo and BIM domains, it is widely acknowledged that the integration of geo-data and BIM-data is beneficial and a crucial step in facing the multi-disciplinary challenges of our built environment. The result of this integration - broadly termed as GeoBIM - has a range of potential uses from district study to road safety. However, from the data perspective, this integration raises the question of how to integrate very detailed design and construction data from the BIM domain with contextual geospatial data (both 2D and 3D) that model a very diverse range of aspects of the wider built and natural environment. This paper reports work carried out during the second phase of the EuroSDR GeoBIM project, which sets out to understand the general status of GeoBIM across Europe with particular focus from a National Mapping and Cadastral Agency perspective. The first phase of the project reviewed the current status of GeoBIM in participating countries and identified the need for specific detailed use cases to overcome both the lack of awareness and the lack of understanding of the potential of GeoBIM. We present both an update on the current status of GeoBIM, and additional details of one of the selected use cases relating to planning/development permits. For the latter, we have been able to develop a detailed workflow highlighting specific data exchange points within the process to issue a development permit, allowing a more in-depth identification of both the roles and data needs at each stage

Handheld device for non-contact thermometry via optically detected magnetic resonance of proximate diamond sensors

Optically detected magnetic resonance (ODMR) spectroscopy of defect-rich semiconductors is being increasingly exploited for realising a variety of practical quantum sensing devices. A prime example is the on-going development of compact magnetometers based on the nitrogen-vacancy (NV) defect in diamond for the remote sensing of magnetic signals with high accuracy and sensitivity. In these applications, the ODMR-active material is integrated into the overall apparatus to form a self-contained sensor. However, some emerging applications require the sensing material to be in physical contact with an external object of interest, thus requiring an independent readout device. Here we present an ODMR-meter, a compact device specially designed to allow convenient, contactless monitoring of ODMR in a target object, and demonstrate its application to temperature monitoring with NV defects. Our prototype is composed of a handheld readout head (integrating all the necessary optical components and a microwave antenna) and a control box connected to a laptop computer, all made primarily from commercial off-the-shelf components. We test our device using an NV-rich bulk diamond as the object, demonstrate a temperature sensitivity of $10~{\rm mK}/\sqrt{\rm Hz}$ in static conditions, and demonstrate the feasibility of handheld operation. The limitations to measurement speed, sensitivity and accuracy are discussed. The presented device may find immediate use in medical and industrial applications where accurate thermometry is required, and can be extended to magnetic field measurements

The position profiles of order cancellations in an emerging stock market

Order submission and cancellation are two constituent actions of stock trading behaviors in order-driven markets. Order submission dynamics has been extensively studied for different markets, while order cancellation dynamics is less understood. There are two positions associated with a cancellation, that is, the price level in the limit-order book (LOB) and the position in the queue at each price level. We study the profiles of these two order cancellation positions through rebuilding the limit-order book using the order flow data of 23 liquid stocks traded on the Shenzhen Stock Exchange in the year 2003. We find that the profiles of relative price levels where cancellations occur obey a log-normal distribution. After normalizing the relative price level by removing the factor of order numbers stored at the price level, we find that the profiles exhibit a power-law scaling behavior on the right tails for both buy and sell orders. When focusing on the order cancellation positions in the queue at each price level, we find that the profiles increase rapidly in the front of the queue, and then fluctuate around a constant value till the end of the queue. These profiles are similar for different stocks. In addition, the profiles of cancellation positions can be fitted by an exponent function for both buy and sell orders. These two kinds of cancellation profiles seem universal for different stocks investigated and exhibit minor asymmetry between buy and sell orders. Our empirical findings shed new light on the order cancellation dynamics and pose constraints on the construction of order-driven stock market models.Comment: 17 pages, 6 figures and 6 table

Novel polymorphisms influencing transcription of the human CHRM2 gene in airway smooth muscle

Muscarinic receptors are a functionally important family of G-protein-coupled receptors. Using a combination of rapid amplification of 5′ cDNA ends and reporter gene assays, we characterized the 5′ untranslated region of the CHRM2 gene as expressed in human airway smooth muscle (HASM) cells. A splice site is present 46 bp upstream from the ATG start codon. Five exons with alternative splicing patterns are present upstream of this splice site, separated by introns ranging from 87 bp to > 145 kb. There is evidence for the gene being under the control of a TATA-less promoter with Sp1, GATA, and activator protein-2 binding sites. Multiple transcription start sites (TSSs) were identified. We identified a novel 0.5-kb hypervariable region located 648 bp upstream of the most 5′ TSS, a multiallelic (CA) tandem repeat 96 bp downstream of the most 5′ TSS, and a common C→A SNP located 136 bp upstream of the most 5′ TSS. Functional studies in primary HASM cells and the BEAS-2B cell line demonstrated highest promoter activity to be upstream of the most 3′ TSS, with potential repressor elements operating in a cell type-dependent manner, located upstream of the most 5′ TSS. We present functional data to show that the CA repeat may influence the transcription of the gene in HASM and BEAS-2B cells.peer-reviewe

The stroke oxygen pilot study: a randomized control trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months

Introduction: Post-stroke hypoxia is common, and may adversely affect outcome. We have recently shown that oxygen supplementation may improve early neurological recovery. Here, we report the six-month outcomes of this pilot study. Methods: Patients with a clinical diagnosis of acute stroke were randomized within 24 h of admission to oxygen supplementation at 2 or 3 L/min for 72 h or to control treatment (room air). Outcomes (see below) were assessed by postal questionnaire at 6 months. Analysis was by intention-to-treat, and statistical significance was set at p#0.05. Results: Out of 301 patients randomized two refused/withdrew consent and 289 (148 in the oxygen and 141 in the control group) were included in the analysis: males 44%, 51%; mean (SD) age 73 (12), 71 (12); median (IQR) National Institutes of Health Stroke Scale score 6 (3, 10), 5 (3, 10) for the two groups respectively. At six months 22 (15%) patients in the oxygen group and 20 (14%) in the control group had died; mean survival in both groups was 162 days (p= 0.99). Median (IQR) scores for the primary outcome, the modified Rankin Scale, were 3 (1, 5) and 3 (1, 4) for the oxygen and control groups respectively. The covariate-adjusted odds ratio was 1.04 (95% CI 0.67, 1.60), indicating that the odds of a lower (i.e. better) score were non-significantly higher in the oxygen group (p= 0.86). The mean differences in the ability to perform basic (Barthel Index) and extended activities of daily living (NEADL), and quality of life (EuroQol) were also non-significant. Conclusions: None of the key outcomes differed at 6 months between the groups. Although not statistically significant and generally of small magnitude, the effects were predominantly in favour of the oxygen group; a larger trial, powered to show differences in longer-term functional outcomes, is now on-going. Trial Registration: Controlled-Trials.com ISRCTN12362720; Eudract.ema.europa.eu 2004-001866-4