Health effects of gasoline exposure. I. Exposure assessment for U.S. distribution workers.

Personal exposures were estimated for a large cohort of workers in the U.S. domestic system for distributing gasoline by trucks and marine vessels. This assessment included development of a rationale and methodology for extrapolating vapor exposures prior to the availability of measurement data, analysis of existing measurement data to estimate task and job exposures during 1975-1985, and extrapolation of truck and marine job exposures before 1975. A worker's vapor exposure was extrapolated from three sets of factors: the tasks in his or her job associated with vapor sources, the characteristics of vapor sources (equipment and other facilities) at the work site, and the composition of petroleum products producing vapors. Historical data were collected on the tasks in job definitions, on work-site facilities, and on product composition. These data were used in a model to estimate the overall time-weighted-average vapor exposure for jobs based on estimates of task exposures and their duration. Task exposures were highest during tank filling in trucks and marine vessels. Measured average annual, full-shift exposures during 1975-1985 ranged from 9 to 14 ppm of total hydrocarbon vapor for truck drivers and 2 to 35 ppm for marine workers on inland waterways. Extrapolated past average exposures in truck operations were highest for truck drivers before 1965 (range 140-220 ppm). Other jobs in truck operations resulted in much lower exposures. Because there were few changes in marine operations before 1979, exposures were assumed to be the same as those measured during 1975-1985. Well-defined exposure gradients were found across jobs within time periods, which were suitable for epidemiologic analyses

Constraining melt geometries beneath the Afar Depression, Ethiopia from teleseismic receiver functions: the anisotropic H-κ stacking technique

Understanding the nature of the crust has long been a goal for seismologists when imaging the Earth. This is particularly true in volcanic regions where imaging melt storage and migration can have important implications for the size and nature of an eruption. Receiver functions and the H-κ stacking (Hκ) technique are often used to constrain crustal thickness (H) and the ratio of P to S wave velocities (κ). In this paper, I show that it is essential to consider anisotropy when performing Hκ. I show that in a medium with horizontally transverse isotropy a strong variation in κ with back azimuth is present, which characterizes the anisotropic medium. In a vertically transverse isotropic medium, no variation in κ with back azimuth is observed, but κ is increased across all back azimuths. Thus, estimates of κ are more difficult to relate to composition than previously thought. I extend these models to melt-induced anisotropy and show that similar patterns are observed, but with more significant variations and increases in κ. Based on these observations, I develop a new anisotropic H-κ stacking technique which inverts Hκ data for melt fraction, aspect ratio, and orientation of melt inclusions. I apply this to data for the Afar Depression and show that melt is stored in interconnected stacked sills in the lower crust, which likely supply the recent volcanic eruptions and dike intrusions. This new technique can be applied to any anisotropic medium where it can provide constraints on the average crustal anisotropy

A Role for Actin, Cdc1p, and Myo2p in the Inheritance of Late Golgi Elements in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e

In Saccharomyces cerevisiae, Golgi elements are present in the bud very early in the cell cycle. We have analyzed this Golgi inheritance process using fluorescence microscopy and genetics. In rapidly growing cells, late Golgi elements show an actin-dependent concentration at sites of polarized growth. Late Golgi elements are apparently transported into the bud along actin cables and are also retained in the bud by a mechanism that may involve actin. A visual screen for mutants defective in the inheritance of late Golgi elements yielded multiple alleles of CDC1. Mutations in CDC1 severely depolarize the actin cytoskeleton, and these mutations prevent late Golgi elements from being retained in the bud. The efficient localization of late Golgi elements to the bud requires the type V myosin Myo2p, further suggesting that actin plays a role in Golgi inheritance. Surprisingly, early and late Golgi elements are inherited by different pathways, with early Golgi elements localizing to the bud in a Cdc1p- and Myo2p-independent manner. We propose that early Golgi elements arise from ER membranes that are present in the bud. These two pathways of Golgi inheritance in S. cerevisiae resemble Golgi inheritance pathways in vertebrate cells

Seismicity of the central Afar rift and implications for Tendaho dam hazards

Temporary broadband seismic networks deployed from 2007 to 2011 around the Afar triple junction of the East African Rift System provide insights into seismicity patterns of the actively deforming crust around the 1.86 km3 impounded lake system behind the Tendaho dam. The observed seismicity correlates well with the active magmatic centres around central Afar. The area around the dam site is characterized by a network of intersecting NNE- and NW-trending faults. Seismicity clusters observed in the specified time interval indicate that both fault sets are active and are potential sources of seismogenic hazards. The dam neighbourhood is naturally active and it is a challenge to associate the observed seismic activity to either a change in magmato-tectonic conditions or attribute it to the influence of reservoir load. It is evident that the dam region experi- ences high levels of seismic and volcano-tectonic unrest, regardless of the origin of the activity. The spatial overlap of narrow zones of crustal seismicity and upper mantle low velocity zones observed in S-wave tomography models suggests that melt production zones guide the distribution of strain during continental rupture. Given its volcanically and seismically active setting, the Tendaho dam site and the surrounding region require continuous monitoring for the safety of downstream popu- lations and development infrastructures in the Afar National Regional State of Ethiopia

A new flood risk assessment framework for evaluating the effectiveness of policies to improve urban flood resilience

This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this record.To better understand the impacts of flooding such that authorities can plan for adapting measures to cope with future scenarios, we have developed a modified Drivers-Pressures-State-Impact-Response (DPSIR) framework to allow policy makers to evaluate strategies for improving flood resilience in cities. We showed that this framework proved an effective approach to assessing and improving urban flood resilience, albeit with some limitations. This framework has difficulties in capturing all the important relationships in cities, especially with regards to feedbacks. There is therefore a need to develop improved techniques for understanding components and their relationships. While this research showed that risk assessment is possible even at the mega-city scale, new techniques will support advances in this field. Finally, a chain of models engenders uncertainties. However, the resilience approach promoted in this research, is an effective manner to work with uncertainty by providing the capacity to cope and respond to multiple scenariosResearch on the CORFU (Collaborative research on flood resilience in urban areas) project was funded by the European Commission through Framework Programme 7, Grant Number 244047. The work in this paper was partially funded by the PEARL (Preparing for Extreme And Rare events in coastaL regions) project, supported by the European Union's Seventh Framework Programme under Grant Agreement No 603663

Allocation mechanisms, incentives, and endemic institutional externalities

Whether an economic agent’s decision creates an externality often depends on the institutional context in which the decision was made. Indeed, in orthodox economics, a technological or exogenous externality occurs just in case one agent’s economic welfare or production possibilities are directly affected by the market decisions of other agents. A pecuniary externality occurs just in case one consumer’s economic welfare or producer’s profit is affected indirectly by price changes caused by changes in other agents’ decisions. Similarly, an institutional or endogenous externality may arise whenever allocations are determined by a mechanism that is not strategy proof for some agent. Then even a resource balance constraint creates an institutional externality except in special cases such as when no individual agent’s action can affect market clearing prices — i.e., there are no pecuniary externalities

Advances in plant virus evolution: translating evolutionary insights into better disease management

[EN] Recent studies in plant virus evolution are revealing that genetic structure and behavior of virus and viroid populations can explain important pathogenic properties of these agents, such as host resistance breakdown, disease severity, and host shifting, among others. Genetic variation is essential for the survival of organisms. The exploration of how these subcellular parasites generate and maintain a certain frequency of mutations at the intra- and inter-host levels is revealing novel molecular virus plant interactions. They emphasize the role of host environment in the dynamic genetic composition of virus populations. Functional genomics has identified host factors that are transcriptionally altered after virus infections. The analyses of these data by means of systems biology approaches are uncovering critical plant genes specifically targeted by viruses during host adaptation. Also, a next-generation re-sequencing approach of a whole virus genome is opening new avenues to study virus recombination and the relationships between intra-host virus composition and pathogenesis. Altogether, the analyzed data indicate that systematic disruption of some specific parameters of evolving virus populations could lead to more efficient ways of disease prevention, eradication, or tolerable virus plant coexistence.Acosta-Leal, R.; Duffy, S.; Xiong, Z.; Hammond, R.; Elena Fito, SF. (2011). Advances in plant virus evolution: translating evolutionary insights into better disease management. Phytopathology. 101(10):1136-1148. doi:10.1094/ PHYTO-01-11-0017S113611481011

Isolation and primary cultures of human intrahepatic bile ductular epithelium

A technique for the isolation of human intrahepatic bile ductular epithelium, and the establishment of primary cultures using a serum- and growth-factor-supplemented medium combined with a connective tissue substrata is described. Initial cell isolates and monolayer cultures display phenotypic characteristics of biliary epithelial cells (low molecular weight prekeratin positive; albumin, alphafetoprotein, and Factor VIII-related antigen negative). Ultrastructural features of the cultured cells show cell polarization with surface microvilli, numerous interepithelial junctional complexes and cytoplasmic intermediate prekeratin filaments. © 1988 Tissue Culture Association, Inc

Massive Electrodynamics and Magnetic Monopoles

Including torsion in the geometric framework of the Weyl-Dirac theory we build up an action integral, and obtain from it a gauge covariant (in the Weyl sense) general relativistic massive electrodynamics. Photons having an arbitrary mass, electric, and magnetic currents (Dirac's monopole) coexist within this theory. Assuming that the space-time is torsionless, taking the photons mass zero, and turning to the Einstein gauge we obtain Maxwell's electrodynamics.Comment: LaTex File, 9 pages, no figure

The seismic signature of Upper‐Mantle Plumes: application to the Northern East African Rift

Several seismic and numerical studies proposed that below, some hotspots upper‐mantle plumelets rise from a thermal boundary layer below 660 km depth, fed by a deeper plume source. We recently found tomographic evidence of multiple upper‐mantle upwellings, spaced by several 100 km, rising through the transition zone below the northern East African Rift. To better test this interpretation, we run 3‐D numerical simulations of mantle convection for Newtonian and non‐Newtonian rheologies, for both thermal instabilities rising from a lower boundary layer, and the destabilization of a thermal anomaly placed at the base of the box (700–800 km depth). The thermal structures are converted to seismic velocities using a thermodynamic approach. Resolution tests are then conducted for the same P and S data distribution and inversion parameters as our traveltime tomography. The Rayleigh Taylor models predict simultaneous plumelets in different stages of evolution rising from a hot layer located below the transition zone, resulting in seismic structure that looks more complex than the simple vertical cylinders that are often anticipated. From the wide selection of models tested, we find that the destabilization of a 200 °C, 100 km thick thermal anomaly with a non‐Newtonian rheology, most closely matches the magnitude and the spatial and temporal distribution of the anomalies below the rift. Finally, we find that for reasonable upper‐mantle viscosities, the synthetic plume structures are similar in scale and shape to the actual low‐velocity anomalies, providing further support for the existence of upper‐mantle plumelets below the northern East African Rift